Motif ID: Maf_Nrl

Z-value: 0.754

Transcription factors associated with Maf_Nrl:

Gene SymbolEntrez IDGene Name
Maf ENSMUSG00000055435.6 Maf
Nrl ENSMUSG00000040632.9 Nrl

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mafmm10_v2_chr8_-_115706994_1157070960.243.7e-02Click!


Activity profile for motif Maf_Nrl.

activity profile for motif Maf_Nrl


Sorted Z-values histogram for motif Maf_Nrl

Sorted Z-values for motif Maf_Nrl



Network of associatons between targets according to the STRING database.



First level regulatory network of Maf_Nrl

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_+_83504032 7.442 ENSMUST00000163888.1
ENSMUST00000005722.7
 Mef2c

myocyte enhancer factor 2C

chr1_-_136260873 7.317 ENSMUST00000086395.5
 Gpr25
G protein-coupled receptor 25
chr7_-_103853199 7.141 ENSMUST00000033229.3
 Hbb-y
hemoglobin Y, beta-like embryonic chain
chr15_-_93519499 6.999 ENSMUST00000109255.2
 Prickle1
prickle homolog 1 (Drosophila)
chr15_-_67113909 6.741 ENSMUST00000092640.5
 St3gal1
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
chr2_-_118373347 5.072 ENSMUST00000039160.2
 Gpr176
G protein-coupled receptor 176
chr14_-_49525840 4.677 ENSMUST00000138884.1
ENSMUST00000074368.4
ENSMUST00000123534.1
 Slc35f4


solute carrier family 35, member F4


chr6_-_138422898 4.632 ENSMUST00000161450.1
ENSMUST00000163024.1
ENSMUST00000162185.1
 Lmo3


LIM domain only 3


chr5_+_110544326 4.587 ENSMUST00000040001.7
 Galnt9
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 9
chr15_+_83779999 4.516 ENSMUST00000046168.5
 Mpped1
metallophosphoesterase domain containing 1
chr1_+_90203980 4.076 ENSMUST00000065587.4
ENSMUST00000159654.1
 Ackr3

atypical chemokine receptor 3

chr15_+_83779975 4.025 ENSMUST00000163723.1
 Mpped1
metallophosphoesterase domain containing 1
chr7_+_29309429 3.960 ENSMUST00000137848.1
 Dpf1
D4, zinc and double PHD fingers family 1
chr2_-_151632471 3.765 ENSMUST00000137936.1
ENSMUST00000146172.1
ENSMUST00000094456.3
ENSMUST00000148755.1
ENSMUST00000109875.1
ENSMUST00000028951.7
ENSMUST00000109877.3
 Snph






syntaphilin






chr19_+_38264761 3.470 ENSMUST00000087252.5
 Lgi1
leucine-rich repeat LGI family, member 1
chr14_-_102982630 3.452 ENSMUST00000184744.1
 KCTD12
mmu-mir-5130
chr6_+_17491216 3.433 ENSMUST00000080469.5
 Met
met proto-oncogene
chr6_+_110645572 3.417 ENSMUST00000071076.6
ENSMUST00000172951.1
 Grm7

glutamate receptor, metabotropic 7

chr3_-_120886691 3.331 ENSMUST00000182099.1
ENSMUST00000183168.1
ENSMUST00000183276.1
ENSMUST00000182124.1
 6530403H02Rik



RIKEN cDNA 6530403H02 gene



chr3_-_141931523 2.977 ENSMUST00000106232.1
 Bmpr1b
bone morphogenetic protein receptor, type 1B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 123 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 7.6 GO:0015671 oxygen transport(GO:0015671)
2.5 7.4 GO:2000111 cellular response to parathyroid hormone stimulus(GO:0071374) positive regulation of macrophage apoptotic process(GO:2000111)
2.3 7.0 GO:0051892 negative regulation of cardioblast differentiation(GO:0051892)
0.1 6.7 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.0 6.5 GO:0007186 G-protein coupled receptor signaling pathway(GO:0007186)
0.2 6.0 GO:0030818 negative regulation of cAMP biosynthetic process(GO:0030818)
0.6 5.8 GO:0061470 interleukin-21 production(GO:0032625) T follicular helper cell differentiation(GO:0061470) interleukin-21 secretion(GO:0072619)
0.1 4.6 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.1 3.8 GO:0045806 negative regulation of endocytosis(GO:0045806)
0.1 3.6 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.7 3.4 GO:0001661 conditioned taste aversion(GO:0001661)
0.5 3.4 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.7 3.0 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.5 3.0 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.5 3.0 GO:0072318 clathrin coat disassembly(GO:0072318)
0.0 3.0 GO:0030307 positive regulation of cell growth(GO:0030307)
0.9 2.8 GO:0035585 calcium-mediated signaling using extracellular calcium source(GO:0035585)
0.3 2.8 GO:0006027 glycosaminoglycan catabolic process(GO:0006027)
0.1 2.8 GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902230)
0.9 2.7 GO:2000987 positive regulation of fear response(GO:1903367) positive regulation of behavioral fear response(GO:2000987)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.9 GO:0031965 nuclear membrane(GO:0031965)
1.0 7.6 GO:0005833 hemoglobin complex(GO:0005833)
0.0 7.1 GO:0014069 postsynaptic density(GO:0014069)
0.1 4.9 GO:0005905 clathrin-coated pit(GO:0005905)
0.1 4.7 GO:0009925 basal plasma membrane(GO:0009925)
0.2 4.0 GO:0071565 nBAF complex(GO:0071565)
0.0 3.9 GO:0000139 Golgi membrane(GO:0000139)
0.1 3.8 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.3 3.6 GO:0030057 desmosome(GO:0030057)
0.3 3.4 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.7 2.8 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.9 2.7 GO:0043512 inhibin A complex(GO:0043512)
0.1 2.7 GO:0005771 multivesicular body(GO:0005771)
0.1 2.7 GO:0044298 cell body membrane(GO:0044298)
0.0 2.7 GO:0030017 sarcomere(GO:0030017)
0.1 2.4 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 2.4 GO:0005795 Golgi stack(GO:0005795)
0.5 2.2 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.0 2.2 GO:0043195 terminal bouton(GO:0043195)
0.1 2.1 GO:0043196 varicosity(GO:0043196)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 97 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 12.1 GO:0004930 G-protein coupled receptor activity(GO:0004930)
1.9 7.6 GO:0031721 hemoglobin alpha binding(GO:0031721)
0.5 7.4 GO:0003680 AT DNA binding(GO:0003680)
1.7 6.7 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 5.8 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 4.3 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
1.4 4.1 GO:0016494 C-X-C chemokine receptor activity(GO:0016494) C-X-C chemokine binding(GO:0019958)
0.1 3.9 GO:0017075 syntaxin-1 binding(GO:0017075)
1.1 3.4 GO:0070905 serine binding(GO:0070905)
0.9 3.4 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.2 3.1 GO:0005540 hyaluronic acid binding(GO:0005540)
0.8 3.0 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.3 3.0 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.1 2.9 GO:0005179 hormone activity(GO:0005179)
0.3 2.8 GO:0005212 structural constituent of eye lens(GO:0005212)
0.7 2.7 GO:0086075 gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075) gap junction channel activity involved in cell communication by electrical coupling(GO:1903763)
0.5 2.7 GO:0070699 type II activin receptor binding(GO:0070699)
0.1 2.7 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 2.6 GO:0043621 protein self-association(GO:0043621)
0.0 2.4 GO:0030295 protein kinase activator activity(GO:0030295)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.0 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.1 5.0 PID_ER_NONGENOMIC_PATHWAY Plasma membrane estrogen receptor signaling
0.1 4.7 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.1 4.0 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 3.5 PID_ARF6_PATHWAY Arf6 signaling events
0.1 3.5 PID_ALK1_PATHWAY ALK1 signaling events
0.1 2.1 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.0 1.8 PID_BMP_PATHWAY BMP receptor signaling
0.0 1.8 PID_ATR_PATHWAY ATR signaling pathway
0.0 1.8 PID_CERAMIDE_PATHWAY Ceramide signaling pathway
0.0 1.4 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.2 1.3 PID_SHP2_PATHWAY SHP2 signaling
0.0 1.2 PID_ERBB2_ERBB3_PATHWAY ErbB2/ErbB3 signaling events
0.0 1.1 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 1.1 PID_RB_1PATHWAY Regulation of retinoblastoma protein
0.0 1.0 PID_ARF_3PATHWAY Arf1 pathway
0.0 1.0 PID_IL6_7_PATHWAY IL6-mediated signaling events
0.0 1.0 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.0 0.9 PID_GMCSF_PATHWAY GMCSF-mediated signaling events
0.0 0.7 PID_TCR_PATHWAY TCR signaling in naïve CD4+ T cells

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.4 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.7 6.7 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.3 5.8 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.1 4.6 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.3 4.3 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 3.6 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.1 3.4 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.1 3.0 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.3 2.8 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.7 2.7 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.1 2.4 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.1 2.3 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 2.1 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.2 2.0 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.0 2.0 REACTOME_ASPARAGINE_N_LINKED_GLYCOSYLATION Genes involved in Asparagine N-linked glycosylation
0.1 1.9 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.1 1.7 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.1 1.7 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 1.7 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.5 1.6 REACTOME_SEROTONIN_RECEPTORS Genes involved in Serotonin receptors