Motif ID: Maf_Nrl
Z-value: 0.754
Transcription factors associated with Maf_Nrl:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Maf | ENSMUSG00000055435.6 | Maf |
| Nrl | ENSMUSG00000040632.9 | Nrl |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Maf | mm10_v2_chr8_-_115706994_115707096 | 0.24 | 3.7e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.5 | 7.4 | GO:2000111 | cellular response to parathyroid hormone stimulus(GO:0071374) positive regulation of macrophage apoptotic process(GO:2000111) |
| 2.3 | 7.0 | GO:0051892 | negative regulation of cardioblast differentiation(GO:0051892) |
| 1.5 | 7.6 | GO:0015671 | oxygen transport(GO:0015671) |
| 0.9 | 2.8 | GO:0035585 | calcium-mediated signaling using extracellular calcium source(GO:0035585) |
| 0.9 | 2.7 | GO:2000987 | positive regulation of fear response(GO:1903367) positive regulation of behavioral fear response(GO:2000987) |
| 0.8 | 2.4 | GO:0001830 | trophectodermal cell fate commitment(GO:0001830) |
| 0.7 | 3.0 | GO:0001550 | ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165) |
| 0.7 | 2.2 | GO:1900141 | regulation of oligodendrocyte apoptotic process(GO:1900141) negative regulation of oligodendrocyte apoptotic process(GO:1900142) |
| 0.7 | 3.4 | GO:0001661 | conditioned taste aversion(GO:0001661) |
| 0.6 | 5.8 | GO:0061470 | interleukin-21 production(GO:0032625) T follicular helper cell differentiation(GO:0061470) interleukin-21 secretion(GO:0072619) |
| 0.5 | 2.7 | GO:0042636 | negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279) |
| 0.5 | 1.6 | GO:2000670 | positive regulation of dendritic cell apoptotic process(GO:2000670) |
| 0.5 | 2.1 | GO:0038128 | ERBB2 signaling pathway(GO:0038128) |
| 0.5 | 3.0 | GO:0015015 | heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015) |
| 0.5 | 3.0 | GO:0072318 | clathrin coat disassembly(GO:0072318) |
| 0.5 | 3.4 | GO:0070494 | regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495) |
| 0.5 | 2.3 | GO:0010701 | positive regulation of norepinephrine secretion(GO:0010701) |
| 0.4 | 1.6 | GO:0010511 | regulation of phosphatidylinositol biosynthetic process(GO:0010511) |
| 0.4 | 1.1 | GO:0015712 | hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760) |
| 0.4 | 1.8 | GO:0018364 | peptidyl-glutamine methylation(GO:0018364) |
| 0.3 | 1.0 | GO:0007181 | transforming growth factor beta receptor complex assembly(GO:0007181) |
| 0.3 | 1.0 | GO:0021557 | oculomotor nerve development(GO:0021557) |
| 0.3 | 0.9 | GO:0015920 | regulation of phosphatidylcholine catabolic process(GO:0010899) lipopolysaccharide transport(GO:0015920) |
| 0.3 | 2.1 | GO:0016185 | synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185) |
| 0.3 | 2.8 | GO:0006027 | glycosaminoglycan catabolic process(GO:0006027) |
| 0.3 | 1.3 | GO:2000427 | eosinophil chemotaxis(GO:0048245) T cell extravasation(GO:0072683) positive regulation of apoptotic cell clearance(GO:2000427) |
| 0.2 | 1.9 | GO:0005513 | detection of calcium ion(GO:0005513) |
| 0.2 | 1.4 | GO:2000210 | positive regulation of anoikis(GO:2000210) |
| 0.2 | 1.1 | GO:2000065 | negative regulation of aldosterone metabolic process(GO:0032345) negative regulation of aldosterone biosynthetic process(GO:0032348) negative regulation of cortisol biosynthetic process(GO:2000065) |
| 0.2 | 1.4 | GO:0030644 | cellular chloride ion homeostasis(GO:0030644) |
| 0.2 | 2.4 | GO:0046958 | nonassociative learning(GO:0046958) |
| 0.2 | 1.1 | GO:0015960 | diadenosine polyphosphate biosynthetic process(GO:0015960) diadenosine tetraphosphate metabolic process(GO:0015965) diadenosine tetraphosphate biosynthetic process(GO:0015966) |
| 0.2 | 0.6 | GO:1900623 | positive regulation of keratinocyte proliferation(GO:0010838) regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625) |
| 0.2 | 1.2 | GO:1900028 | negative regulation of ruffle assembly(GO:1900028) |
| 0.2 | 6.0 | GO:0030818 | negative regulation of cAMP biosynthetic process(GO:0030818) |
| 0.2 | 1.4 | GO:1901525 | negative regulation of macromitophagy(GO:1901525) |
| 0.2 | 1.4 | GO:0032534 | regulation of microvillus assembly(GO:0032534) |
| 0.2 | 0.5 | GO:0002030 | inhibitory G-protein coupled receptor phosphorylation(GO:0002030) |
| 0.2 | 0.7 | GO:0060745 | mammary gland branching involved in pregnancy(GO:0060745) |
| 0.2 | 0.5 | GO:0003345 | proepicardium cell migration involved in pericardium morphogenesis(GO:0003345) |
| 0.2 | 1.7 | GO:0018230 | peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231) |
| 0.2 | 1.5 | GO:0060347 | heart trabecula formation(GO:0060347) |
| 0.1 | 6.7 | GO:0018279 | protein N-linked glycosylation via asparagine(GO:0018279) |
| 0.1 | 0.4 | GO:0048209 | regulation of vesicle targeting, to, from or within Golgi(GO:0048209) |
| 0.1 | 1.1 | GO:0006003 | fructose 2,6-bisphosphate metabolic process(GO:0006003) |
| 0.1 | 1.8 | GO:0043653 | mitochondrial fragmentation involved in apoptotic process(GO:0043653) |
| 0.1 | 1.4 | GO:0051901 | positive regulation of mitochondrial depolarization(GO:0051901) |
| 0.1 | 0.4 | GO:0070315 | G1 to G0 transition involved in cell differentiation(GO:0070315) |
| 0.1 | 0.4 | GO:1905051 | regulation of base-excision repair(GO:1905051) positive regulation of base-excision repair(GO:1905053) |
| 0.1 | 0.6 | GO:1901838 | positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901838) |
| 0.1 | 1.2 | GO:0032693 | negative regulation of interleukin-10 production(GO:0032693) |
| 0.1 | 0.4 | GO:0002554 | serotonin secretion by platelet(GO:0002554) interleukin-3 production(GO:0032632) beta selection(GO:0043366) |
| 0.1 | 3.6 | GO:0032467 | positive regulation of cytokinesis(GO:0032467) |
| 0.1 | 0.3 | GO:0038003 | opioid receptor signaling pathway(GO:0038003) regulation of opioid receptor signaling pathway(GO:2000474) |
| 0.1 | 1.3 | GO:1902474 | positive regulation of protein localization to synapse(GO:1902474) |
| 0.1 | 2.1 | GO:0071577 | zinc II ion transmembrane transport(GO:0071577) |
| 0.1 | 0.5 | GO:0006680 | glucosylceramide catabolic process(GO:0006680) |
| 0.1 | 0.5 | GO:0007603 | phototransduction, visible light(GO:0007603) |
| 0.1 | 1.1 | GO:0036123 | histone H3-K9 dimethylation(GO:0036123) |
| 0.1 | 0.6 | GO:2000672 | negative regulation of motor neuron apoptotic process(GO:2000672) |
| 0.1 | 1.0 | GO:0019243 | methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727) |
| 0.1 | 0.6 | GO:0001927 | exocyst assembly(GO:0001927) |
| 0.1 | 1.5 | GO:0060670 | branching involved in labyrinthine layer morphogenesis(GO:0060670) |
| 0.1 | 1.4 | GO:0021527 | spinal cord association neuron differentiation(GO:0021527) |
| 0.1 | 0.7 | GO:0051461 | protein import into peroxisome matrix, docking(GO:0016560) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461) |
| 0.1 | 0.8 | GO:0060068 | vagina development(GO:0060068) |
| 0.1 | 0.2 | GO:0042573 | retinoic acid metabolic process(GO:0042573) |
| 0.1 | 4.6 | GO:0045600 | positive regulation of fat cell differentiation(GO:0045600) |
| 0.1 | 2.8 | GO:1902230 | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902230) |
| 0.1 | 0.9 | GO:0006610 | ribosomal protein import into nucleus(GO:0006610) |
| 0.1 | 0.6 | GO:0060528 | secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528) |
| 0.1 | 0.4 | GO:1901552 | positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142) |
| 0.1 | 0.2 | GO:0090427 | embryonic nail plate morphogenesis(GO:0035880) negative regulation of keratinocyte differentiation(GO:0045617) positive regulation of hair follicle maturation(GO:0048818) regulation of catagen(GO:0051794) positive regulation of catagen(GO:0051795) frontal suture morphogenesis(GO:0060364) activation of meiosis(GO:0090427) |
| 0.1 | 0.8 | GO:0032486 | Rap protein signal transduction(GO:0032486) |
| 0.1 | 0.4 | GO:1901911 | diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911) |
| 0.1 | 1.7 | GO:2000310 | regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310) |
| 0.1 | 0.3 | GO:0070535 | histone H2A K63-linked ubiquitination(GO:0070535) |
| 0.1 | 0.4 | GO:0033034 | positive regulation of myeloid cell apoptotic process(GO:0033034) |
| 0.1 | 0.4 | GO:2000507 | positive regulation of energy homeostasis(GO:2000507) |
| 0.1 | 0.6 | GO:1901621 | negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621) |
| 0.1 | 0.6 | GO:0048934 | peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935) |
| 0.1 | 3.8 | GO:0045806 | negative regulation of endocytosis(GO:0045806) |
| 0.1 | 0.9 | GO:0006829 | zinc II ion transport(GO:0006829) |
| 0.1 | 0.5 | GO:0046826 | negative regulation of protein export from nucleus(GO:0046826) |
| 0.1 | 0.2 | GO:0019805 | quinolinate biosynthetic process(GO:0019805) |
| 0.1 | 0.3 | GO:0051835 | positive regulation of synapse structural plasticity(GO:0051835) |
| 0.1 | 1.1 | GO:0043496 | regulation of protein homodimerization activity(GO:0043496) |
| 0.1 | 0.7 | GO:0050849 | negative regulation of calcium-mediated signaling(GO:0050849) |
| 0.0 | 0.7 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.0 | 0.1 | GO:0021577 | hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589) |
| 0.0 | 0.5 | GO:0006228 | UTP biosynthetic process(GO:0006228) |
| 0.0 | 0.6 | GO:0048672 | positive regulation of collateral sprouting(GO:0048672) |
| 0.0 | 0.1 | GO:0046900 | tetrahydrofolylpolyglutamate metabolic process(GO:0046900) |
| 0.0 | 0.7 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.0 | 1.9 | GO:0019933 | cAMP-mediated signaling(GO:0019933) |
| 0.0 | 0.8 | GO:0048268 | clathrin coat assembly(GO:0048268) |
| 0.0 | 1.4 | GO:0031648 | protein destabilization(GO:0031648) |
| 0.0 | 1.3 | GO:0007601 | visual perception(GO:0007601) |
| 0.0 | 0.8 | GO:0046856 | phosphatidylinositol dephosphorylation(GO:0046856) |
| 0.0 | 1.6 | GO:0006487 | protein N-linked glycosylation(GO:0006487) |
| 0.0 | 0.5 | GO:0002115 | store-operated calcium entry(GO:0002115) |
| 0.0 | 0.9 | GO:2000036 | regulation of stem cell population maintenance(GO:2000036) |
| 0.0 | 1.1 | GO:0006284 | base-excision repair(GO:0006284) |
| 0.0 | 1.0 | GO:0072583 | clathrin-mediated endocytosis(GO:0072583) |
| 0.0 | 2.7 | GO:0043149 | contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149) |
| 0.0 | 1.1 | GO:0045880 | positive regulation of smoothened signaling pathway(GO:0045880) |
| 0.0 | 1.4 | GO:0032418 | lysosome localization(GO:0032418) |
| 0.0 | 0.7 | GO:0006099 | tricarboxylic acid cycle(GO:0006099) |
| 0.0 | 3.0 | GO:0030307 | positive regulation of cell growth(GO:0030307) |
| 0.0 | 0.6 | GO:0071539 | protein localization to centrosome(GO:0071539) |
| 0.0 | 0.3 | GO:0050667 | homocysteine metabolic process(GO:0050667) |
| 0.0 | 0.3 | GO:0006744 | ubiquinone biosynthetic process(GO:0006744) |
| 0.0 | 0.2 | GO:0035280 | miRNA loading onto RISC involved in gene silencing by miRNA(GO:0035280) |
| 0.0 | 0.6 | GO:0046677 | response to antibiotic(GO:0046677) |
| 0.0 | 0.1 | GO:0006995 | cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562) |
| 0.0 | 0.3 | GO:0030970 | retrograde protein transport, ER to cytosol(GO:0030970) |
| 0.0 | 6.5 | GO:0007186 | G-protein coupled receptor signaling pathway(GO:0007186) |
| 0.0 | 0.0 | GO:0060124 | positive regulation of growth hormone secretion(GO:0060124) |
| 0.0 | 0.7 | GO:1904893 | negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893) |
| 0.0 | 1.0 | GO:0051453 | regulation of intracellular pH(GO:0051453) |
| 0.0 | 0.7 | GO:0007029 | endoplasmic reticulum organization(GO:0007029) |
| 0.0 | 0.1 | GO:0036010 | protein localization to endosome(GO:0036010) |
| 0.0 | 0.7 | GO:0050810 | regulation of steroid biosynthetic process(GO:0050810) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 7.6 | GO:0005833 | hemoglobin complex(GO:0005833) |
| 0.9 | 2.7 | GO:0043512 | inhibin A complex(GO:0043512) |
| 0.7 | 2.8 | GO:0031095 | platelet dense tubular network membrane(GO:0031095) |
| 0.5 | 2.2 | GO:0042567 | insulin-like growth factor ternary complex(GO:0042567) |
| 0.4 | 1.3 | GO:0005940 | septin ring(GO:0005940) |
| 0.4 | 1.3 | GO:0044299 | C-fiber(GO:0044299) |
| 0.4 | 1.5 | GO:0070436 | Grb2-EGFR complex(GO:0070436) |
| 0.4 | 1.1 | GO:0043540 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540) |
| 0.3 | 3.4 | GO:0048787 | presynaptic active zone membrane(GO:0048787) |
| 0.3 | 2.0 | GO:0031428 | box C/D snoRNP complex(GO:0031428) |
| 0.3 | 3.6 | GO:0030057 | desmosome(GO:0030057) |
| 0.2 | 1.1 | GO:0033553 | rDNA heterochromatin(GO:0033553) |
| 0.2 | 0.9 | GO:0038039 | G-protein coupled receptor heterodimeric complex(GO:0038039) |
| 0.2 | 0.5 | GO:0016533 | cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533) |
| 0.2 | 0.7 | GO:0017071 | intracellular cyclic nucleotide activated cation channel complex(GO:0017071) |
| 0.2 | 4.0 | GO:0071565 | nBAF complex(GO:0071565) |
| 0.2 | 0.9 | GO:0016602 | CCAAT-binding factor complex(GO:0016602) |
| 0.1 | 1.7 | GO:0002178 | palmitoyltransferase complex(GO:0002178) |
| 0.1 | 1.6 | GO:0070852 | cell body fiber(GO:0070852) |
| 0.1 | 2.1 | GO:0043196 | varicosity(GO:0043196) |
| 0.1 | 2.4 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.1 | 0.7 | GO:0097550 | transcriptional preinitiation complex(GO:0097550) |
| 0.1 | 2.7 | GO:0005771 | multivesicular body(GO:0005771) |
| 0.1 | 1.0 | GO:0030130 | clathrin coat of trans-Golgi network vesicle(GO:0030130) |
| 0.1 | 1.3 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
| 0.1 | 0.4 | GO:0019815 | B cell receptor complex(GO:0019815) |
| 0.1 | 0.7 | GO:0005786 | signal recognition particle, endoplasmic reticulum targeting(GO:0005786) |
| 0.1 | 1.8 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.1 | 1.2 | GO:0030008 | TRAPP complex(GO:0030008) |
| 0.1 | 0.6 | GO:0031313 | extrinsic component of endosome membrane(GO:0031313) |
| 0.1 | 0.7 | GO:0045252 | oxoglutarate dehydrogenase complex(GO:0045252) |
| 0.1 | 4.7 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.1 | 2.7 | GO:0044298 | cell body membrane(GO:0044298) |
| 0.1 | 4.9 | GO:0005905 | clathrin-coated pit(GO:0005905) |
| 0.1 | 0.6 | GO:0034709 | methylosome(GO:0034709) |
| 0.1 | 3.8 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.1 | 0.3 | GO:0000839 | Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839) |
| 0.1 | 1.0 | GO:0031528 | microvillus membrane(GO:0031528) |
| 0.1 | 0.4 | GO:0016281 | eukaryotic translation initiation factor 4F complex(GO:0016281) |
| 0.0 | 0.5 | GO:0042622 | photoreceptor outer segment membrane(GO:0042622) |
| 0.0 | 0.6 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.0 | 0.4 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
| 0.0 | 0.6 | GO:0035631 | CD40 receptor complex(GO:0035631) |
| 0.0 | 0.8 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.0 | 0.8 | GO:0000421 | autophagosome membrane(GO:0000421) |
| 0.0 | 0.6 | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex(GO:0017101) |
| 0.0 | 0.8 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
| 0.0 | 7.9 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.0 | 0.6 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
| 0.0 | 0.8 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.0 | 1.4 | GO:0030136 | clathrin-coated vesicle(GO:0030136) |
| 0.0 | 2.4 | GO:0005795 | Golgi stack(GO:0005795) |
| 0.0 | 1.9 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.0 | 7.1 | GO:0014069 | postsynaptic density(GO:0014069) |
| 0.0 | 0.5 | GO:0000145 | exocyst(GO:0000145) |
| 0.0 | 2.2 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.0 | 1.1 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.0 | 0.8 | GO:0031902 | late endosome membrane(GO:0031902) |
| 0.0 | 0.1 | GO:0005677 | chromatin silencing complex(GO:0005677) |
| 0.0 | 1.6 | GO:0030139 | endocytic vesicle(GO:0030139) |
| 0.0 | 0.2 | GO:0070578 | RISC-loading complex(GO:0070578) |
| 0.0 | 0.4 | GO:0005942 | phosphatidylinositol 3-kinase complex(GO:0005942) |
| 0.0 | 2.7 | GO:0030017 | sarcomere(GO:0030017) |
| 0.0 | 0.6 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.0 | 3.9 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.0 | 1.7 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.0 | 0.7 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 7.6 | GO:0031721 | hemoglobin alpha binding(GO:0031721) |
| 1.7 | 6.7 | GO:0003836 | beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836) |
| 1.4 | 4.1 | GO:0016494 | C-X-C chemokine receptor activity(GO:0016494) C-X-C chemokine binding(GO:0019958) |
| 1.1 | 3.4 | GO:0070905 | serine binding(GO:0070905) |
| 0.9 | 3.4 | GO:0005008 | hepatocyte growth factor-activated receptor activity(GO:0005008) |
| 0.8 | 3.0 | GO:0017095 | heparan sulfate 6-O-sulfotransferase activity(GO:0017095) |
| 0.7 | 2.7 | GO:0086075 | gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075) gap junction channel activity involved in cell communication by electrical coupling(GO:1903763) |
| 0.5 | 1.6 | GO:0004993 | G-protein coupled serotonin receptor activity(GO:0004993) |
| 0.5 | 7.4 | GO:0003680 | AT DNA binding(GO:0003680) |
| 0.5 | 2.7 | GO:0070699 | type II activin receptor binding(GO:0070699) |
| 0.3 | 1.4 | GO:0004111 | creatine kinase activity(GO:0004111) |
| 0.3 | 3.0 | GO:0005025 | transforming growth factor beta receptor activity, type I(GO:0005025) |
| 0.3 | 1.3 | GO:0031727 | CCR2 chemokine receptor binding(GO:0031727) |
| 0.3 | 2.8 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.3 | 0.9 | GO:0001875 | lipopolysaccharide receptor activity(GO:0001875) |
| 0.3 | 0.8 | GO:0005128 | erythropoietin receptor binding(GO:0005128) |
| 0.3 | 0.8 | GO:0034597 | phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597) |
| 0.2 | 0.7 | GO:0031798 | type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052) |
| 0.2 | 2.1 | GO:0031749 | D2 dopamine receptor binding(GO:0031749) |
| 0.2 | 1.0 | GO:0008427 | calcium-dependent protein kinase inhibitor activity(GO:0008427) |
| 0.2 | 0.6 | GO:0050501 | hyaluronan synthase activity(GO:0050501) |
| 0.2 | 1.6 | GO:0017034 | Rap guanyl-nucleotide exchange factor activity(GO:0017034) |
| 0.2 | 0.5 | GO:0004348 | glucosylceramidase activity(GO:0004348) |
| 0.2 | 2.3 | GO:0015271 | outward rectifier potassium channel activity(GO:0015271) |
| 0.2 | 0.5 | GO:0030549 | acetylcholine receptor activator activity(GO:0030549) |
| 0.2 | 3.1 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.2 | 1.1 | GO:0070095 | fructose-6-phosphate binding(GO:0070095) |
| 0.2 | 0.9 | GO:0004965 | G-protein coupled GABA receptor activity(GO:0004965) |
| 0.1 | 3.9 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.1 | 1.5 | GO:0005168 | neurotrophin TRKA receptor binding(GO:0005168) |
| 0.1 | 1.1 | GO:0046974 | histone methyltransferase activity (H3-K9 specific)(GO:0046974) |
| 0.1 | 0.7 | GO:0030942 | endoplasmic reticulum signal peptide binding(GO:0030942) |
| 0.1 | 0.7 | GO:0005052 | peroxisome matrix targeting signal-1 binding(GO:0005052) |
| 0.1 | 0.6 | GO:0008545 | JUN kinase kinase activity(GO:0008545) |
| 0.1 | 0.4 | GO:0008534 | oxidized purine nucleobase lesion DNA N-glycosylase activity(GO:0008534) |
| 0.1 | 1.9 | GO:0015269 | calcium-activated potassium channel activity(GO:0015269) |
| 0.1 | 1.0 | GO:0004416 | hydroxyacylglutathione hydrolase activity(GO:0004416) |
| 0.1 | 1.8 | GO:0008649 | rRNA methyltransferase activity(GO:0008649) |
| 0.1 | 1.1 | GO:0015114 | phosphate ion transmembrane transporter activity(GO:0015114) |
| 0.1 | 1.9 | GO:0055103 | ligase regulator activity(GO:0055103) |
| 0.1 | 1.8 | GO:0005078 | MAP-kinase scaffold activity(GO:0005078) |
| 0.1 | 1.3 | GO:0004576 | oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579) |
| 0.1 | 1.1 | GO:0019104 | DNA N-glycosylase activity(GO:0019104) |
| 0.1 | 0.7 | GO:0004591 | oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591) |
| 0.1 | 0.6 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.1 | 0.5 | GO:0004826 | phenylalanine-tRNA ligase activity(GO:0004826) |
| 0.1 | 2.7 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.1 | 1.5 | GO:0004551 | nucleotide diphosphatase activity(GO:0004551) |
| 0.1 | 0.5 | GO:0047391 | alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391) |
| 0.1 | 1.5 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.1 | 0.4 | GO:0005166 | neurotrophin p75 receptor binding(GO:0005166) |
| 0.1 | 0.8 | GO:0048185 | activin binding(GO:0048185) |
| 0.1 | 2.2 | GO:0005159 | insulin-like growth factor receptor binding(GO:0005159) |
| 0.1 | 0.3 | GO:0050347 | trans-hexaprenyltranstransferase activity(GO:0000010) trans-octaprenyltranstransferase activity(GO:0050347) |
| 0.1 | 1.0 | GO:0032050 | clathrin heavy chain binding(GO:0032050) |
| 0.1 | 2.1 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.1 | 1.1 | GO:0015197 | peptide transporter activity(GO:0015197) |
| 0.1 | 0.6 | GO:0004128 | cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128) |
| 0.1 | 12.1 | GO:0004930 | G-protein coupled receptor activity(GO:0004930) |
| 0.1 | 1.7 | GO:0019707 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
| 0.1 | 0.8 | GO:0035612 | AP-2 adaptor complex binding(GO:0035612) |
| 0.1 | 2.9 | GO:0005179 | hormone activity(GO:0005179) |
| 0.1 | 1.0 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
| 0.1 | 0.4 | GO:0004716 | receptor signaling protein tyrosine kinase activity(GO:0004716) |
| 0.0 | 1.4 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
| 0.0 | 0.5 | GO:0008526 | phosphatidylinositol transporter activity(GO:0008526) |
| 0.0 | 0.4 | GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813) |
| 0.0 | 5.8 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
| 0.0 | 0.2 | GO:0030144 | alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144) |
| 0.0 | 2.6 | GO:0043621 | protein self-association(GO:0043621) |
| 0.0 | 0.6 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
| 0.0 | 0.5 | GO:0015279 | store-operated calcium channel activity(GO:0015279) |
| 0.0 | 2.4 | GO:0030295 | protein kinase activator activity(GO:0030295) |
| 0.0 | 0.1 | GO:0008330 | protein tyrosine/threonine phosphatase activity(GO:0008330) |
| 0.0 | 0.5 | GO:0008432 | JUN kinase binding(GO:0008432) |
| 0.0 | 1.7 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.0 | 4.3 | GO:0004725 | protein tyrosine phosphatase activity(GO:0004725) |
| 0.0 | 0.7 | GO:0005520 | insulin-like growth factor binding(GO:0005520) |
| 0.0 | 1.8 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.0 | 0.5 | GO:0045499 | chemorepellent activity(GO:0045499) |
| 0.0 | 0.9 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.0 | 2.0 | GO:0005496 | steroid binding(GO:0005496) |
| 0.0 | 0.5 | GO:0004550 | nucleoside diphosphate kinase activity(GO:0004550) |
| 0.0 | 0.4 | GO:0042608 | T cell receptor binding(GO:0042608) |
| 0.0 | 1.5 | GO:0004714 | transmembrane receptor protein tyrosine kinase activity(GO:0004714) |
| 0.0 | 0.6 | GO:0008327 | methyl-CpG binding(GO:0008327) |
| 0.0 | 0.9 | GO:0001221 | transcription cofactor binding(GO:0001221) |
| 0.0 | 0.7 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.0 | 0.5 | GO:0017160 | Ral GTPase binding(GO:0017160) |
| 0.0 | 0.1 | GO:0005124 | scavenger receptor binding(GO:0005124) |
| 0.0 | 0.1 | GO:0070051 | fibrinogen binding(GO:0070051) |
| 0.0 | 0.1 | GO:0005149 | interleukin-1 receptor binding(GO:0005149) |
| 0.0 | 0.2 | GO:1990226 | histone methyltransferase binding(GO:1990226) |
| 0.0 | 0.6 | GO:0016876 | aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876) |
| 0.0 | 0.8 | GO:0019003 | GDP binding(GO:0019003) |
| 0.0 | 0.2 | GO:0004029 | aldehyde dehydrogenase (NAD) activity(GO:0004029) |
| 0.0 | 0.2 | GO:0035198 | miRNA binding(GO:0035198) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 8.0 | PID_MAPK_TRK_PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.2 | 1.3 | PID_SHP2_PATHWAY | SHP2 signaling |
| 0.1 | 4.0 | PID_FRA_PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.1 | 4.7 | ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
| 0.1 | 3.5 | PID_ARF6_PATHWAY | Arf6 signaling events |
| 0.1 | 3.5 | PID_ALK1_PATHWAY | ALK1 signaling events |
| 0.1 | 5.0 | PID_ER_NONGENOMIC_PATHWAY | Plasma membrane estrogen receptor signaling |
| 0.1 | 2.1 | PID_IL8_CXCR1_PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.0 | 0.9 | PID_GMCSF_PATHWAY | GMCSF-mediated signaling events |
| 0.0 | 1.8 | PID_BMP_PATHWAY | BMP receptor signaling |
| 0.0 | 1.8 | PID_ATR_PATHWAY | ATR signaling pathway |
| 0.0 | 1.8 | PID_CERAMIDE_PATHWAY | Ceramide signaling pathway |
| 0.0 | 1.0 | PID_ARF_3PATHWAY | Arf1 pathway |
| 0.0 | 1.2 | PID_ERBB2_ERBB3_PATHWAY | ErbB2/ErbB3 signaling events |
| 0.0 | 1.0 | PID_IL6_7_PATHWAY | IL6-mediated signaling events |
| 0.0 | 1.0 | PID_FANCONI_PATHWAY | Fanconi anemia pathway |
| 0.0 | 1.1 | ST_WNT_BETA_CATENIN_PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 0.6 | PID_P38_MK2_PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.0 | 1.4 | PID_MYC_REPRESS_PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 1.1 | PID_RB_1PATHWAY | Regulation of retinoblastoma protein |
| 0.0 | 0.6 | PID_LIS1_PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.0 | 0.3 | PID_ATM_PATHWAY | ATM pathway |
| 0.0 | 0.7 | PID_TCR_PATHWAY | TCR signaling in naïve CD4+ T cells |
| 0.0 | 0.6 | PID_TRKR_PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.0 | 0.7 | PID_ERA_GENOMIC_PATHWAY | Validated nuclear estrogen receptor alpha network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 2.7 | REACTOME_GLYCOPROTEIN_HORMONES | Genes involved in Glycoprotein hormones |
| 0.7 | 6.7 | REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.5 | 1.6 | REACTOME_SEROTONIN_RECEPTORS | Genes involved in Serotonin receptors |
| 0.3 | 4.3 | REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.3 | 5.8 | REACTOME_GAP_JUNCTION_DEGRADATION | Genes involved in Gap junction degradation |
| 0.3 | 2.8 | REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.2 | 7.4 | REACTOME_ERK_MAPK_TARGETS | Genes involved in ERK/MAPK targets |
| 0.2 | 2.0 | REACTOME_INTRINSIC_PATHWAY | Genes involved in Intrinsic Pathway |
| 0.1 | 4.6 | REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.1 | 2.1 | REACTOME_ZINC_TRANSPORTERS | Genes involved in Zinc transporters |
| 0.1 | 0.6 | REACTOME_HYALURONAN_METABOLISM | Genes involved in Hyaluronan metabolism |
| 0.1 | 1.1 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.1 | 1.5 | REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING | Genes involved in Spry regulation of FGF signaling |
| 0.1 | 0.5 | REACTOME_OLFACTORY_SIGNALING_PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.1 | 1.1 | REACTOME_BASE_FREE_SUGAR_PHOSPHATE_REMOVAL_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY | Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway |
| 0.1 | 3.0 | REACTOME_LYSOSOME_VESICLE_BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
| 0.1 | 3.4 | REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING | Genes involved in Sema4D in semaphorin signaling |
| 0.1 | 2.4 | REACTOME_SIGNALING_BY_BMP | Genes involved in Signaling by BMP |
| 0.1 | 0.9 | REACTOME_HDL_MEDIATED_LIPID_TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.1 | 1.9 | REACTOME_CGMP_EFFECTS | Genes involved in cGMP effects |
| 0.1 | 1.3 | REACTOME_ACTIVATION_OF_GENES_BY_ATF4 | Genes involved in Activation of Genes by ATF4 |
| 0.1 | 1.7 | REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.1 | 1.2 | REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.1 | 1.7 | REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR | Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor |
| 0.1 | 2.3 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.1 | 0.8 | REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.0 | 0.7 | REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.0 | 0.8 | REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.0 | 1.7 | REACTOME_GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.0 | 0.5 | REACTOME_CRMPS_IN_SEMA3A_SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.0 | 0.7 | REACTOME_REGULATION_OF_SIGNALING_BY_CBL | Genes involved in Regulation of signaling by CBL |
| 0.0 | 0.6 | REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1 | Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 |
| 0.0 | 3.6 | REACTOME_G_ALPHA_I_SIGNALLING_EVENTS | Genes involved in G alpha (i) signalling events |
| 0.0 | 2.0 | REACTOME_ASPARAGINE_N_LINKED_GLYCOSYLATION | Genes involved in Asparagine N-linked glycosylation |
| 0.0 | 0.4 | REACTOME_MTORC1_MEDIATED_SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.0 | 1.1 | REACTOME_GLUCOSE_TRANSPORT | Genes involved in Glucose transport |
| 0.0 | 0.6 | REACTOME_METABOLISM_OF_NON_CODING_RNA | Genes involved in Metabolism of non-coding RNA |
| 0.0 | 0.2 | REACTOME_TRYPTOPHAN_CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.0 | 0.7 | REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 | Genes involved in Nuclear signaling by ERBB4 |
| 0.0 | 0.5 | REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.0 | 0.4 | REACTOME_GLYCOSPHINGOLIPID_METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.0 | 1.0 | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
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