Motif ID: Mafa

Z-value: 1.161


Transcription factors associated with Mafa:

Gene SymbolEntrez IDGene Name
Mafa ENSMUSG00000047591.4 Mafa

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mafamm10_v2_chr15_-_75747922_75747922-0.673.9e-11Click!


Activity profile for motif Mafa.

activity profile for motif Mafa


Sorted Z-values histogram for motif Mafa

Sorted Z-values for motif Mafa



Network of associatons between targets according to the STRING database.



First level regulatory network of Mafa

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_-_98032983 24.273 ENSMUST00000162295.1
 Clstn2
calsyntenin 2
chr14_+_119138415 23.537 ENSMUST00000065904.3
 Hs6st3
heparan sulfate 6-O-sulfotransferase 3
chr9_-_98033181 21.791 ENSMUST00000035027.6
 Clstn2
calsyntenin 2
chr4_+_102254739 20.945 ENSMUST00000106907.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr4_+_102254993 19.312 ENSMUST00000106908.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr1_-_136260873 18.454 ENSMUST00000086395.5
 Gpr25
G protein-coupled receptor 25
chr1_-_169747634 14.388 ENSMUST00000027991.5
ENSMUST00000111357.1
 Rgs4

regulator of G-protein signaling 4

chr16_+_91269759 13.549 ENSMUST00000056882.5
 Olig1
oligodendrocyte transcription factor 1
chr16_-_17576631 12.503 ENSMUST00000164545.1
ENSMUST00000164490.1
ENSMUST00000172164.1
 Slc7a4


solute carrier family 7 (cationic amino acid transporter, y+ system), member 4


chr11_-_66525795 9.831 ENSMUST00000123454.1
 Shisa6
shisa homolog 6 (Xenopus laevis)
chr11_-_66525964 8.894 ENSMUST00000066679.6
 Shisa6
shisa homolog 6 (Xenopus laevis)
chr19_+_27217011 8.812 ENSMUST00000164746.1
ENSMUST00000172302.1
 Vldlr

very low density lipoprotein receptor

chr19_+_27217357 8.803 ENSMUST00000047645.6
ENSMUST00000167487.1
 Vldlr

very low density lipoprotein receptor

chr2_-_125506385 8.690 ENSMUST00000028633.6
 Fbn1
fibrillin 1
chr1_-_38836090 8.477 ENSMUST00000147695.1
 Lonrf2
LON peptidase N-terminal domain and ring finger 2
chr8_-_70487314 7.769 ENSMUST00000045286.7
 Tmem59l
transmembrane protein 59-like
chr5_-_142509653 7.335 ENSMUST00000110784.1
 Radil
Ras association and DIL domains
chr7_+_54835959 6.837 ENSMUST00000082373.6
 Luzp2
leucine zipper protein 2
chr13_+_4233730 6.797 ENSMUST00000081326.6
 Akr1c19
aldo-keto reductase family 1, member C19
chr18_-_36197343 6.442 ENSMUST00000115713.1
ENSMUST00000115712.1
 Nrg2

neuregulin 2

chr10_+_58813359 6.430 ENSMUST00000135526.2
ENSMUST00000153031.1
 Sh3rf3

SH3 domain containing ring finger 3

chr5_-_124187150 5.970 ENSMUST00000161938.1
 Pitpnm2
phosphatidylinositol transfer protein, membrane-associated 2
chr9_-_51077064 5.582 ENSMUST00000098782.3
 Layn
layilin
chr4_+_42035113 5.463 ENSMUST00000098127.1
 Gm10597
predicted gene 10597
chr8_+_93810832 5.162 ENSMUST00000034198.8
ENSMUST00000125716.1
 Gnao1

guanine nucleotide binding protein, alpha O

chr9_-_48835932 5.002 ENSMUST00000093852.3
 Zbtb16
zinc finger and BTB domain containing 16
chr5_+_111417263 4.821 ENSMUST00000094463.4
 Mn1
meningioma 1
chr16_-_74411292 4.770 ENSMUST00000117200.1
 Robo2
roundabout homolog 2 (Drosophila)
chr12_-_86884808 4.613 ENSMUST00000038422.6
 Irf2bpl
interferon regulatory factor 2 binding protein-like
chr2_-_166155272 4.405 ENSMUST00000088086.3
 Sulf2
sulfatase 2
chrX_-_73869804 4.194 ENSMUST00000066576.5
ENSMUST00000114430.1
 L1cam

L1 cell adhesion molecule

chr4_+_43406435 3.934 ENSMUST00000098106.2
ENSMUST00000139198.1
 Rusc2

RUN and SH3 domain containing 2

chrX_+_152178945 3.925 ENSMUST00000096275.4
 Iqsec2
IQ motif and Sec7 domain 2
chr9_-_105131775 3.917 ENSMUST00000035179.6
 Nudt16
nudix (nucleoside diphosphate linked moiety X)-type motif 16
chr10_-_75932468 3.829 ENSMUST00000120281.1
ENSMUST00000000924.6
 Mmp11

matrix metallopeptidase 11

chr12_+_3365108 3.579 ENSMUST00000020999.5
 Kif3c
kinesin family member 3C
chr6_-_35308110 3.366 ENSMUST00000031868.4
 Slc13a4
solute carrier family 13 (sodium/sulfate symporters), member 4
chr4_-_35845204 3.266 ENSMUST00000164772.1
ENSMUST00000065173.2
 Lingo2

leucine rich repeat and Ig domain containing 2

chr7_-_67759735 3.252 ENSMUST00000074233.4
ENSMUST00000051389.8
 Synm

synemin, intermediate filament protein

chr17_-_46752170 3.030 ENSMUST00000121671.1
ENSMUST00000059844.6
 Cnpy3

canopy 3 homolog (zebrafish)

chr13_+_93771656 2.530 ENSMUST00000091403.4
 Arsb
arylsulfatase B
chr16_-_74411776 2.527 ENSMUST00000116586.2
 Robo2
roundabout homolog 2 (Drosophila)
chr11_-_107337556 2.456 ENSMUST00000040380.6
 Pitpnc1
phosphatidylinositol transfer protein, cytoplasmic 1
chr11_-_59787636 2.415 ENSMUST00000125307.1
 Pld6
phospholipase D family, member 6
chr8_-_105565985 2.198 ENSMUST00000013304.7
 Atp6v0d1
ATPase, H+ transporting, lysosomal V0 subunit D1
chrX_-_95444789 2.179 ENSMUST00000084535.5
 Amer1
APC membrane recruitment 1
chr10_-_84440591 2.163 ENSMUST00000020220.8
 Nuak1
NUAK family, SNF1-like kinase, 1
chr1_+_87183310 1.919 ENSMUST00000044533.8
 Prss56
protease, serine 56
chr10_-_81600857 1.896 ENSMUST00000151858.1
ENSMUST00000142948.1
ENSMUST00000072020.2
 Tle6


transducin-like enhancer of split 6, homolog of Drosophila E(spl)


chr17_-_47010513 1.778 ENSMUST00000113337.2
ENSMUST00000113335.2
 Ubr2

ubiquitin protein ligase E3 component n-recognin 2

chr17_-_47611449 1.758 ENSMUST00000024783.8
 Bysl
bystin-like
chr4_+_59003121 1.451 ENSMUST00000095070.3
ENSMUST00000174664.1
 Dnajc25
Gm20503
DnaJ (Hsp40) homolog, subfamily C, member 25
predicted gene 20503
chr11_+_50174839 1.407 ENSMUST00000020647.3
 3010026O09Rik
RIKEN cDNA 3010026O09 gene
chr19_+_5474681 1.337 ENSMUST00000165485.1
ENSMUST00000166253.1
ENSMUST00000167371.1
ENSMUST00000167855.1
ENSMUST00000070118.7
 Efemp2




epidermal growth factor-containing fibulin-like extracellular matrix protein 2




chr8_-_84937347 1.327 ENSMUST00000109741.2
ENSMUST00000119820.1
 Mast1

microtubule associated serine/threonine kinase 1

chr11_-_119228461 1.096 ENSMUST00000036113.3
 Tbc1d16
TBC1 domain family, member 16
chr2_+_36230426 1.025 ENSMUST00000062069.5
 Ptgs1
prostaglandin-endoperoxide synthase 1
chr8_+_105373265 1.014 ENSMUST00000160650.1
 Plekhg4
pleckstrin homology domain containing, family G (with RhoGef domain) member 4
chr5_-_24423516 0.894 ENSMUST00000030814.6
 Cdk5
cyclin-dependent kinase 5
chr13_+_55445301 0.889 ENSMUST00000001115.8
ENSMUST00000099482.3
 Grk6

G protein-coupled receptor kinase 6

chr9_-_109059711 0.846 ENSMUST00000061973.4
 Trex1
three prime repair exonuclease 1
chr5_+_24423805 0.842 ENSMUST00000153274.1
 Slc4a2
solute carrier family 4 (anion exchanger), member 2
chrX_-_20950597 0.782 ENSMUST00000009550.7
 Elk1
ELK1, member of ETS oncogene family
chr14_+_64588112 0.754 ENSMUST00000181808.1
 A930011O12Rik
RIKEN cDNA A930011O12 gene
chr17_+_47611570 0.696 ENSMUST00000024778.2
 Med20
mediator complex subunit 20
chr7_+_140856957 0.685 ENSMUST00000026558.6
 Ric8
resistance to inhibitors of cholinesterase 8 homolog (C. elegans)
chr4_+_21931291 0.617 ENSMUST00000029908.7
 Faxc
failed axon connections homolog (Drosophila)
chr13_+_96924674 0.553 ENSMUST00000171324.1
 Gcnt4
glucosaminyl (N-acetyl) transferase 4, core 2 (beta-1,6-N-acetylglucosaminyltransferase)
chr17_-_71475285 0.289 ENSMUST00000127430.1
 Smchd1
SMC hinge domain containing 1
chr1_-_121327776 0.277 ENSMUST00000160688.1
 Insig2
insulin induced gene 2
chr1_+_171213969 0.055 ENSMUST00000005820.4
ENSMUST00000075469.5
ENSMUST00000155126.1
 Nr1i3


nuclear receptor subfamily 1, group I, member 3


chrX_-_122397351 0.028 ENSMUST00000079490.4
 Nap1l3
nucleosome assembly protein 1-like 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.9 23.5 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
3.5 17.6 GO:0034436 glycoprotein transport(GO:0034436)
3.1 40.3 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
2.9 8.7 GO:1903011 negative regulation of bone development(GO:1903011)
2.4 7.3 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
1.1 4.4 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
1.0 5.0 GO:0048133 NK T cell differentiation(GO:0001865) germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) regulation of NK T cell differentiation(GO:0051136) positive regulation of NK T cell differentiation(GO:0051138) germline stem cell asymmetric division(GO:0098728)
1.0 3.9 GO:0046709 IDP metabolic process(GO:0046707) IDP catabolic process(GO:0046709)
0.9 18.7 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.7 4.8 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.6 50.3 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.5 2.4 GO:0010636 positive regulation of mitochondrial fusion(GO:0010636)
0.4 1.8 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.4 4.6 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
0.4 2.2 GO:2001012 mesenchymal cell differentiation involved in kidney development(GO:0072161) mesenchymal cell differentiation involved in renal system development(GO:2001012)
0.3 12.5 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.3 0.9 GO:0010360 negative regulation of anion channel activity(GO:0010360)
0.3 1.0 GO:0010700 negative regulation of norepinephrine secretion(GO:0010700)
0.2 14.4 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.2 3.4 GO:0008272 sulfate transport(GO:0008272)
0.2 2.2 GO:0035507 regulation of myosin-light-chain-phosphatase activity(GO:0035507)
0.2 3.8 GO:0030574 collagen catabolic process(GO:0030574)
0.2 3.9 GO:1900454 positive regulation of long term synaptic depression(GO:1900454)
0.2 0.6 GO:0002121 inter-male aggressive behavior(GO:0002121)
0.2 1.9 GO:0060136 embryonic process involved in female pregnancy(GO:0060136)
0.1 13.5 GO:0048663 neuron fate commitment(GO:0048663)
0.1 0.9 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.1 5.2 GO:0051926 negative regulation of calcium ion transport(GO:0051926)
0.1 3.3 GO:0003009 skeletal muscle contraction(GO:0003009)
0.1 0.3 GO:0060821 inactivation of X chromosome by DNA methylation(GO:0060821)
0.1 1.8 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.1 8.5 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436)
0.1 6.4 GO:0007173 epidermal growth factor receptor signaling pathway(GO:0007173)
0.1 7.3 GO:0034446 substrate adhesion-dependent cell spreading(GO:0034446)
0.1 2.5 GO:0007584 response to nutrient(GO:0007584)
0.0 3.6 GO:0072384 organelle transport along microtubule(GO:0072384)
0.0 3.3 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 1.1 GO:0001919 regulation of receptor recycling(GO:0001919)
0.0 0.5 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.0 10.7 GO:0007186 G-protein coupled receptor signaling pathway(GO:0007186)
0.0 0.8 GO:0071480 cellular response to gamma radiation(GO:0071480)
0.0 0.8 GO:0051453 regulation of intracellular pH(GO:0051453)
0.0 1.0 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 0.4 GO:0035458 cellular response to interferon-beta(GO:0035458)
0.0 2.5 GO:0006869 lipid transport(GO:0006869)
0.0 0.7 GO:0035914 skeletal muscle cell differentiation(GO:0035914)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 40.3 GO:0000930 gamma-tubulin complex(GO:0000930)
1.5 17.6 GO:0034361 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.7 8.7 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.4 18.7 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.4 3.3 GO:0060053 neurofilament cytoskeleton(GO:0060053)
0.4 3.6 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.3 4.1 GO:0044294 dendritic growth cone(GO:0044294)
0.3 0.9 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.2 7.3 GO:0030673 axolemma(GO:0030673)
0.2 46.1 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 5.2 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 5.0 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.5 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0 0.3 GO:0001740 Barr body(GO:0001740)
0.0 13.5 GO:0005667 transcription factor complex(GO:0005667)
0.0 2.5 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 1.8 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.7 GO:0016592 mediator complex(GO:0016592)
0.0 1.0 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 14.9 GO:0005615 extracellular space(GO:0005615)
0.0 4.7 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 2.1 GO:0001650 fibrillar center(GO:0001650)
0.0 2.4 GO:0005741 mitochondrial outer membrane(GO:0005741)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
5.9 23.5 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
5.9 17.6 GO:0034437 very-low-density lipoprotein particle binding(GO:0034189) glycoprotein transporter activity(GO:0034437)
2.1 6.4 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
1.2 40.3 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
1.2 6.9 GO:0004065 arylsulfatase activity(GO:0004065)
0.9 5.2 GO:0051429 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.8 7.3 GO:0008046 axon guidance receptor activity(GO:0008046)
0.7 4.2 GO:0033691 sialic acid binding(GO:0033691)
0.7 3.9 GO:0098519 nucleotide phosphatase activity, acting on free nucleotides(GO:0098519)
0.5 5.0 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.4 14.4 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.3 8.7 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.3 5.6 GO:0005540 hyaluronic acid binding(GO:0005540)
0.3 0.9 GO:0030549 acetylcholine receptor activator activity(GO:0030549) ErbB-3 class receptor binding(GO:0043125)
0.3 1.8 GO:0070728 leucine binding(GO:0070728)
0.2 2.5 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.2 0.9 GO:0004703 G-protein coupled receptor kinase activity(GO:0004703)
0.2 3.3 GO:0019215 intermediate filament binding(GO:0019215)
0.2 8.5 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.2 2.2 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.1 12.5 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
0.1 3.9 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 0.4 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.1 13.5 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.1 30.9 GO:0005509 calcium ion binding(GO:0005509)
0.0 2.4 GO:0004521 endoribonuclease activity(GO:0004521)
0.0 3.5 GO:0019894 kinesin binding(GO:0019894)
0.0 0.8 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 3.8 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 2.2 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 5.0 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 2.2 GO:0002039 p53 binding(GO:0002039)
0.0 1.0 GO:0004601 peroxidase activity(GO:0004601)
0.0 6.0 GO:0005543 phospholipid binding(GO:0005543)
0.0 0.1 GO:0004887 thyroid hormone receptor activity(GO:0004887)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 13.9 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.5 8.7 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.5 6.4 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.3 5.2 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.1 4.2 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.1 8.2 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 0.8 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.9 PID_EPHA_FWDPATHWAY EPHA forward signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 5.2 REACTOME_G_PROTEIN_ACTIVATION Genes involved in G-protein activation
1.0 41.2 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.6 23.5 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.3 3.0 REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR Genes involved in Trafficking and processing of endosomal TLR
0.3 6.4 REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.3 2.5 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.3 3.8 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.2 14.4 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events
0.2 7.3 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.1 4.2 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.1 3.6 REACTOME_KINESINS Genes involved in Kinesins
0.1 8.7 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 2.2 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 1.0 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 0.8 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.0 2.4 REACTOME_GLYCEROPHOSPHOLIPID_BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.0 4.5 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.6 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins