Motif ID: Mafa

Z-value: 1.161


Transcription factors associated with Mafa:

Gene SymbolEntrez IDGene Name
Mafa ENSMUSG00000047591.4 Mafa

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mafamm10_v2_chr15_-_75747922_75747922-0.673.9e-11Click!


Activity profile for motif Mafa.

activity profile for motif Mafa


Sorted Z-values histogram for motif Mafa

Sorted Z-values for motif Mafa



Network of associatons between targets according to the STRING database.



First level regulatory network of Mafa

PNG image of the network

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Top targets:


Showing 1 to 20 of 72 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_-_98032983 24.273 ENSMUST00000162295.1
Clstn2
calsyntenin 2
chr14_+_119138415 23.537 ENSMUST00000065904.3
Hs6st3
heparan sulfate 6-O-sulfotransferase 3
chr9_-_98033181 21.791 ENSMUST00000035027.6
Clstn2
calsyntenin 2
chr4_+_102254739 20.945 ENSMUST00000106907.2
Pde4b
phosphodiesterase 4B, cAMP specific
chr4_+_102254993 19.312 ENSMUST00000106908.2
Pde4b
phosphodiesterase 4B, cAMP specific
chr1_-_136260873 18.454 ENSMUST00000086395.5
Gpr25
G protein-coupled receptor 25
chr1_-_169747634 14.388 ENSMUST00000027991.5
ENSMUST00000111357.1
Rgs4

regulator of G-protein signaling 4

chr16_+_91269759 13.549 ENSMUST00000056882.5
Olig1
oligodendrocyte transcription factor 1
chr16_-_17576631 12.503 ENSMUST00000164545.1
ENSMUST00000164490.1
ENSMUST00000172164.1
Slc7a4


solute carrier family 7 (cationic amino acid transporter, y+ system), member 4


chr11_-_66525795 9.831 ENSMUST00000123454.1
Shisa6
shisa homolog 6 (Xenopus laevis)
chr11_-_66525964 8.894 ENSMUST00000066679.6
Shisa6
shisa homolog 6 (Xenopus laevis)
chr19_+_27217011 8.812 ENSMUST00000164746.1
ENSMUST00000172302.1
Vldlr

very low density lipoprotein receptor

chr19_+_27217357 8.803 ENSMUST00000047645.6
ENSMUST00000167487.1
Vldlr

very low density lipoprotein receptor

chr2_-_125506385 8.690 ENSMUST00000028633.6
Fbn1
fibrillin 1
chr1_-_38836090 8.477 ENSMUST00000147695.1
Lonrf2
LON peptidase N-terminal domain and ring finger 2
chr8_-_70487314 7.769 ENSMUST00000045286.7
Tmem59l
transmembrane protein 59-like
chr5_-_142509653 7.335 ENSMUST00000110784.1
Radil
Ras association and DIL domains
chr7_+_54835959 6.837 ENSMUST00000082373.6
Luzp2
leucine zipper protein 2
chr13_+_4233730 6.797 ENSMUST00000081326.6
Akr1c19
aldo-keto reductase family 1, member C19
chr18_-_36197343 6.442 ENSMUST00000115713.1
ENSMUST00000115712.1
Nrg2

neuregulin 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 50.3 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
3.1 40.3 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
3.9 23.5 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.9 18.7 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
3.5 17.6 GO:0034436 glycoprotein transport(GO:0034436)
0.2 14.4 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.1 13.5 GO:0048663 neuron fate commitment(GO:0048663)
0.3 12.5 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 10.7 GO:0007186 G-protein coupled receptor signaling pathway(GO:0007186)
2.9 8.7 GO:1903011 negative regulation of bone development(GO:1903011)
0.1 8.5 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436)
2.4 7.3 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.1 7.3 GO:0034446 substrate adhesion-dependent cell spreading(GO:0034446)
0.1 6.4 GO:0007173 epidermal growth factor receptor signaling pathway(GO:0007173)
0.1 5.2 GO:0051926 negative regulation of calcium ion transport(GO:0051926)
1.0 5.0 GO:0048133 NK T cell differentiation(GO:0001865) germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) regulation of NK T cell differentiation(GO:0051136) positive regulation of NK T cell differentiation(GO:0051138) germline stem cell asymmetric division(GO:0098728)
0.7 4.8 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.4 4.6 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
1.1 4.4 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
1.0 3.9 GO:0046709 IDP metabolic process(GO:0046707) IDP catabolic process(GO:0046709)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 46.1 GO:0045211 postsynaptic membrane(GO:0045211)
1.5 40.3 GO:0000930 gamma-tubulin complex(GO:0000930)
0.4 18.7 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
1.5 17.6 GO:0034361 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.0 14.9 GO:0005615 extracellular space(GO:0005615)
0.0 13.5 GO:0005667 transcription factor complex(GO:0005667)
0.7 8.7 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.2 7.3 GO:0030673 axolemma(GO:0030673)
0.1 5.2 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 5.0 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 4.7 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.3 4.1 GO:0044294 dendritic growth cone(GO:0044294)
0.4 3.6 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.4 3.3 GO:0060053 neurofilament cytoskeleton(GO:0060053)
0.0 2.5 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 2.4 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 2.1 GO:0001650 fibrillar center(GO:0001650)
0.0 1.8 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 1.0 GO:0001750 photoreceptor outer segment(GO:0001750)
0.3 0.9 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 40.3 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 30.9 GO:0005509 calcium ion binding(GO:0005509)
5.9 23.5 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
5.9 17.6 GO:0034437 very-low-density lipoprotein particle binding(GO:0034189) glycoprotein transporter activity(GO:0034437)
0.4 14.4 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 13.5 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.1 12.5 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
0.3 8.7 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.2 8.5 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.8 7.3 GO:0008046 axon guidance receptor activity(GO:0008046)
1.2 6.9 GO:0004065 arylsulfatase activity(GO:0004065)
2.1 6.4 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.0 6.0 GO:0005543 phospholipid binding(GO:0005543)
0.3 5.6 GO:0005540 hyaluronic acid binding(GO:0005540)
0.9 5.2 GO:0051429 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.5 5.0 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 5.0 GO:0017137 Rab GTPase binding(GO:0017137)
0.7 4.2 GO:0033691 sialic acid binding(GO:0033691)
0.7 3.9 GO:0098519 nucleotide phosphatase activity, acting on free nucleotides(GO:0098519)
0.1 3.9 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)

Gene overrepresentation in C2:CP category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 13.9 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.5 8.7 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 8.2 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.5 6.4 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.3 5.2 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.1 4.2 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.0 0.9 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.1 0.8 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 41.2 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.6 23.5 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.2 14.4 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events
0.1 8.7 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.2 7.3 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.3 6.4 REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
1.7 5.2 REACTOME_G_PROTEIN_ACTIVATION Genes involved in G-protein activation
0.0 4.5 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 4.2 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.3 3.8 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.1 3.6 REACTOME_KINESINS Genes involved in Kinesins
0.3 3.0 REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR Genes involved in Trafficking and processing of endosomal TLR
0.3 2.5 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 2.4 REACTOME_GLYCEROPHOSPHOLIPID_BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.0 2.2 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 1.0 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 0.8 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.0 0.6 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins