Motif ID: Mafb

Z-value: 0.558


Transcription factors associated with Mafb:

Gene SymbolEntrez IDGene Name
Mafb ENSMUSG00000074622.3 Mafb

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mafbmm10_v2_chr2_-_160367057_1603670730.019.5e-01Click!


Activity profile for motif Mafb.

activity profile for motif Mafb


Sorted Z-values histogram for motif Mafb

Sorted Z-values for motif Mafb



Network of associatons between targets according to the STRING database.



First level regulatory network of Mafb

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_120202104 6.816 ENSMUST00000033198.5
 Crym
crystallin, mu
chr4_-_136886187 6.240 ENSMUST00000046384.8
 C1qb
complement component 1, q subcomponent, beta polypeptide
chr2_+_170731807 5.204 ENSMUST00000029075.4
 Dok5
docking protein 5
chr7_+_130936172 4.558 ENSMUST00000006367.7
 Htra1
HtrA serine peptidase 1
chr9_-_77347816 4.463 ENSMUST00000184138.1
ENSMUST00000184006.1
ENSMUST00000185144.1
ENSMUST00000034910.9
 Mlip



muscular LMNA-interacting protein



chr18_+_65873478 4.408 ENSMUST00000025395.8
ENSMUST00000173530.1
 Grp

gastrin releasing peptide

chr9_-_77347787 3.627 ENSMUST00000184848.1
ENSMUST00000184415.1
 Mlip

muscular LMNA-interacting protein

chr7_-_110862944 2.834 ENSMUST00000033050.3
 Lyve1
lymphatic vessel endothelial hyaluronan receptor 1
chr9_-_77347889 2.680 ENSMUST00000185039.1
 Mlip
muscular LMNA-interacting protein
chr3_+_65109343 2.609 ENSMUST00000159525.1
ENSMUST00000049230.8
 Kcnab1

potassium voltage-gated channel, shaker-related subfamily, beta member 1

chr1_-_136260873 2.542 ENSMUST00000086395.5
 Gpr25
G protein-coupled receptor 25
chr17_+_3532554 2.492 ENSMUST00000168560.1
 Cldn20
claudin 20
chr7_-_141010759 2.447 ENSMUST00000026565.6
 Ifitm3
interferon induced transmembrane protein 3
chr8_+_25532125 2.368 ENSMUST00000167764.1
 Fgfr1
fibroblast growth factor receptor 1
chr4_+_102421518 2.313 ENSMUST00000106904.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr11_-_70229677 2.260 ENSMUST00000153449.1
ENSMUST00000000326.5
 Bcl6b

B cell CLL/lymphoma 6, member B

chr19_-_5510467 2.246 ENSMUST00000070172.4
 Snx32
sorting nexin 32
chr14_+_80000292 2.216 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr13_-_23710714 2.209 ENSMUST00000091707.6
ENSMUST00000006787.7
ENSMUST00000091706.6
 Hfe


hemochromatosis


chr5_+_112255813 2.166 ENSMUST00000031286.6
ENSMUST00000131673.1
ENSMUST00000112375.1
 Crybb1


crystallin, beta B1



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 117 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 11.3 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
1.4 6.8 GO:0070327 thyroid hormone transport(GO:0070327)
0.3 6.2 GO:0006958 complement activation, classical pathway(GO:0006958)
0.3 5.2 GO:0051386 regulation of neurotrophin TRK receptor signaling pathway(GO:0051386)
0.8 4.6 GO:0060718 chorionic trophoblast cell differentiation(GO:0060718)
1.5 4.4 GO:0061744 motor behavior(GO:0061744) positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738)
0.3 2.8 GO:0006027 glycosaminoglycan catabolic process(GO:0006027)
0.2 2.6 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260)
0.8 2.4 GO:0021837 motogenic signaling involved in postnatal olfactory bulb interneuron migration(GO:0021837) positive regulation of mitotic cell cycle DNA replication(GO:1903465)
0.1 2.4 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.2 2.3 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.7 2.2 GO:0002725 negative regulation of antigen processing and presentation(GO:0002578) negative regulation of T cell cytokine production(GO:0002725)
0.0 2.2 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0 2.2 GO:0007601 visual perception(GO:0007601)
0.0 2.2 GO:0006334 nucleosome assembly(GO:0006334)
0.2 2.1 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.1 2.1 GO:0042092 type 2 immune response(GO:0042092)
0.1 2.1 GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902230)
0.5 2.0 GO:0006409 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.0 2.0 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.8 GO:0016605 PML body(GO:0016605)
0.1 6.2 GO:0005581 collagen trimer(GO:0005581)
0.0 5.0 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0 4.2 GO:0031012 extracellular matrix(GO:0031012)
0.2 2.6 GO:1990635 proximal dendrite(GO:1990635)
0.1 2.5 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 2.4 GO:0005912 adherens junction(GO:0005912)
0.1 2.3 GO:0097228 sperm principal piece(GO:0097228)
0.1 2.3 GO:0000930 gamma-tubulin complex(GO:0000930)
0.4 2.2 GO:1990357 terminal web(GO:1990357)
0.2 2.2 GO:0042581 specific granule(GO:0042581)
0.1 2.0 GO:0032040 small-subunit processome(GO:0032040)
0.6 1.8 GO:0045160 myosin I complex(GO:0045160)
0.0 1.8 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 1.7 GO:0009925 basal plasma membrane(GO:0009925)
0.0 1.6 GO:0030315 T-tubule(GO:0030315)
0.1 1.4 GO:0071564 npBAF complex(GO:0071564)
0.0 1.4 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 1.4 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 1.4 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 91 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 12.9 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.8 6.8 GO:0070324 thyroid hormone binding(GO:0070324)
0.1 5.0 GO:0005158 insulin receptor binding(GO:0005158)
0.0 4.7 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.2 4.6 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.2 4.4 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 3.3 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.7 3.0 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.2 2.8 GO:0005540 hyaluronic acid binding(GO:0005540)
0.2 2.6 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)
0.0 2.5 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.3 2.4 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.1 2.3 GO:0043015 gamma-tubulin binding(GO:0043015)
0.2 2.2 GO:0039706 co-receptor binding(GO:0039706)
0.2 2.2 GO:0005212 structural constituent of eye lens(GO:0005212)
0.4 1.8 GO:0034481 chondroitin sulfotransferase activity(GO:0034481)
0.1 1.8 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 1.8 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 1.8 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.3 1.7 GO:0008865 fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)

Gene overrepresentation in C2:CP category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.2 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 5.3 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 3.0 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 2.7 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.0 2.4 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 2.1 PID_E2F_PATHWAY E2F transcription factor network
0.1 1.8 PID_ARF_3PATHWAY Arf1 pathway
0.0 1.3 PID_MTOR_4PATHWAY mTOR signaling pathway
0.0 1.1 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 1.1 PID_CDC42_PATHWAY CDC42 signaling events
0.0 0.9 PID_LKB1_PATHWAY LKB1 signaling events
0.1 0.8 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 0.8 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.7 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.6 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 0.3 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 0.2 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.2 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 6.2 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.2 4.4 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.3 2.8 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.1 2.6 REACTOME_GLUCOSE_TRANSPORT Genes involved in Glucose transport
0.1 2.5 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta
0.2 2.4 REACTOME_SIGNALING_BY_ACTIVATED_POINT_MUTANTS_OF_FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.1 2.4 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 2.3 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 2.1 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 2.0 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.1 1.8 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.1 1.8 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 1.6 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 1.2 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 1.1 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 1.1 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.1 1.0 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 1.0 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 1.0 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 0.9 REACTOME_SIGNALING_BY_NOTCH4 Genes involved in Signaling by NOTCH4