Motif ID: Mafb
Z-value: 0.558
Transcription factors associated with Mafb:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Mafb | ENSMUSG00000074622.3 | Mafb |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Mafb | mm10_v2_chr2_-_160367057_160367073 | 0.01 | 9.5e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 4.4 | GO:0061744 | motor behavior(GO:0061744) positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738) |
| 1.4 | 6.8 | GO:0070327 | thyroid hormone transport(GO:0070327) |
| 0.8 | 2.4 | GO:0021837 | motogenic signaling involved in postnatal olfactory bulb interneuron migration(GO:0021837) positive regulation of mitotic cell cycle DNA replication(GO:1903465) |
| 0.8 | 4.6 | GO:0060718 | chorionic trophoblast cell differentiation(GO:0060718) |
| 0.7 | 2.2 | GO:0002725 | negative regulation of antigen processing and presentation(GO:0002578) negative regulation of T cell cytokine production(GO:0002725) |
| 0.6 | 1.9 | GO:2000501 | natural killer cell chemotaxis(GO:0035747) negative regulation of lymphocyte migration(GO:2000402) regulation of natural killer cell chemotaxis(GO:2000501) |
| 0.6 | 1.8 | GO:0030208 | dermatan sulfate biosynthetic process(GO:0030208) |
| 0.5 | 2.0 | GO:0006409 | tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431) |
| 0.5 | 1.4 | GO:0046900 | tetrahydrofolylpolyglutamate metabolic process(GO:0046900) |
| 0.4 | 1.8 | GO:1900748 | positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748) |
| 0.3 | 1.7 | GO:0051012 | microtubule sliding(GO:0051012) |
| 0.3 | 5.2 | GO:0051386 | regulation of neurotrophin TRK receptor signaling pathway(GO:0051386) |
| 0.3 | 0.9 | GO:0015712 | hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760) |
| 0.3 | 1.7 | GO:0032483 | regulation of Rab protein signal transduction(GO:0032483) |
| 0.3 | 0.9 | GO:1904139 | microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139) |
| 0.3 | 6.2 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.3 | 2.8 | GO:0006027 | glycosaminoglycan catabolic process(GO:0006027) |
| 0.3 | 11.3 | GO:0010614 | negative regulation of cardiac muscle hypertrophy(GO:0010614) |
| 0.3 | 0.8 | GO:1902219 | negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219) |
| 0.3 | 0.8 | GO:0002538 | arachidonic acid metabolite production involved in inflammatory response(GO:0002538) olefin metabolic process(GO:1900673) |
| 0.3 | 1.3 | GO:0072014 | proximal tubule development(GO:0072014) |
| 0.2 | 0.7 | GO:0016561 | protein import into peroxisome matrix, translocation(GO:0016561) |
| 0.2 | 1.7 | GO:0061718 | NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718) |
| 0.2 | 1.0 | GO:0070213 | protein auto-ADP-ribosylation(GO:0070213) |
| 0.2 | 0.2 | GO:0097116 | gephyrin clustering involved in postsynaptic density assembly(GO:0097116) |
| 0.2 | 2.1 | GO:0035887 | aortic smooth muscle cell differentiation(GO:0035887) |
| 0.2 | 0.9 | GO:0060332 | positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335) |
| 0.2 | 1.2 | GO:0010637 | diet induced thermogenesis(GO:0002024) negative regulation of mitochondrial fusion(GO:0010637) |
| 0.2 | 1.8 | GO:0035269 | protein O-linked mannosylation(GO:0035269) |
| 0.2 | 0.8 | GO:0032788 | saturated monocarboxylic acid metabolic process(GO:0032788) unsaturated monocarboxylic acid metabolic process(GO:0032789) |
| 0.2 | 1.5 | GO:0018916 | nitrobenzene metabolic process(GO:0018916) |
| 0.2 | 1.3 | GO:0019262 | N-acetylneuraminate catabolic process(GO:0019262) |
| 0.2 | 0.7 | GO:0038128 | ERBB2 signaling pathway(GO:0038128) |
| 0.2 | 1.1 | GO:0071442 | positive regulation of histone H3-K14 acetylation(GO:0071442) |
| 0.2 | 2.3 | GO:1901898 | negative regulation of relaxation of cardiac muscle(GO:1901898) |
| 0.2 | 2.6 | GO:1902260 | negative regulation of delayed rectifier potassium channel activity(GO:1902260) |
| 0.2 | 0.8 | GO:0051182 | coenzyme transport(GO:0051182) |
| 0.2 | 0.8 | GO:0035405 | histone-threonine phosphorylation(GO:0035405) |
| 0.2 | 1.0 | GO:0006172 | ADP biosynthetic process(GO:0006172) |
| 0.1 | 0.7 | GO:0046501 | protoporphyrinogen IX metabolic process(GO:0046501) |
| 0.1 | 0.6 | GO:0017183 | peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183) |
| 0.1 | 1.1 | GO:0071361 | cellular response to ethanol(GO:0071361) |
| 0.1 | 0.5 | GO:0046368 | GDP-L-fucose metabolic process(GO:0046368) |
| 0.1 | 2.4 | GO:0046597 | negative regulation of viral entry into host cell(GO:0046597) |
| 0.1 | 0.4 | GO:2000418 | positive regulation of eosinophil migration(GO:2000418) |
| 0.1 | 0.4 | GO:0030321 | transepithelial chloride transport(GO:0030321) |
| 0.1 | 1.0 | GO:0060087 | negative regulation of cholesterol biosynthetic process(GO:0045541) relaxation of vascular smooth muscle(GO:0060087) negative regulation of cholesterol metabolic process(GO:0090206) |
| 0.1 | 0.6 | GO:0071688 | striated muscle myosin thick filament assembly(GO:0071688) |
| 0.1 | 0.5 | GO:0070358 | actin polymerization-dependent cell motility(GO:0070358) |
| 0.1 | 0.6 | GO:0009405 | pathogenesis(GO:0009405) |
| 0.1 | 0.3 | GO:1900122 | positive regulation of receptor binding(GO:1900122) |
| 0.1 | 0.8 | GO:0016114 | terpenoid biosynthetic process(GO:0016114) |
| 0.1 | 0.5 | GO:0001923 | B-1 B cell differentiation(GO:0001923) |
| 0.1 | 0.3 | GO:1901052 | sarcosine metabolic process(GO:1901052) sarcosine catabolic process(GO:1901053) |
| 0.1 | 0.6 | GO:0001542 | ovulation from ovarian follicle(GO:0001542) positive regulation of hydrogen peroxide-mediated programmed cell death(GO:1901300) |
| 0.1 | 2.1 | GO:0042092 | type 2 immune response(GO:0042092) |
| 0.1 | 0.7 | GO:0015868 | purine ribonucleotide transport(GO:0015868) |
| 0.1 | 0.3 | GO:0006421 | asparaginyl-tRNA aminoacylation(GO:0006421) |
| 0.1 | 0.3 | GO:0034285 | response to sucrose(GO:0009744) response to disaccharide(GO:0034285) |
| 0.1 | 0.9 | GO:0043589 | skin morphogenesis(GO:0043589) |
| 0.1 | 0.5 | GO:0034983 | peptidyl-lysine deacetylation(GO:0034983) |
| 0.1 | 0.6 | GO:0044791 | modulation by host of viral release from host cell(GO:0044789) positive regulation by host of viral release from host cell(GO:0044791) |
| 0.1 | 0.9 | GO:0035635 | entry of bacterium into host cell(GO:0035635) regulation of entry of bacterium into host cell(GO:2000535) |
| 0.1 | 0.8 | GO:0007190 | activation of adenylate cyclase activity(GO:0007190) |
| 0.1 | 0.5 | GO:1901162 | serotonin biosynthetic process(GO:0042427) primary amino compound biosynthetic process(GO:1901162) |
| 0.1 | 0.6 | GO:1990253 | cellular response to leucine starvation(GO:1990253) |
| 0.1 | 0.5 | GO:0071420 | cellular response to histamine(GO:0071420) |
| 0.1 | 2.1 | GO:1902230 | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902230) |
| 0.1 | 0.4 | GO:0016185 | synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185) |
| 0.1 | 0.6 | GO:0000042 | protein targeting to Golgi(GO:0000042) |
| 0.1 | 0.2 | GO:0010499 | proteasomal ubiquitin-independent protein catabolic process(GO:0010499) |
| 0.1 | 0.7 | GO:1990440 | positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440) |
| 0.1 | 0.7 | GO:0008272 | sulfate transport(GO:0008272) |
| 0.1 | 0.7 | GO:0046339 | diacylglycerol metabolic process(GO:0046339) |
| 0.1 | 0.4 | GO:2000074 | regulation of type B pancreatic cell development(GO:2000074) |
| 0.1 | 0.4 | GO:0042590 | antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590) |
| 0.0 | 0.4 | GO:0010820 | positive regulation of T cell chemotaxis(GO:0010820) |
| 0.0 | 2.0 | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER(GO:0006890) |
| 0.0 | 1.1 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
| 0.0 | 1.6 | GO:1901385 | regulation of voltage-gated calcium channel activity(GO:1901385) |
| 0.0 | 0.2 | GO:1902990 | mitotic telomere maintenance via semi-conservative replication(GO:1902990) |
| 0.0 | 0.2 | GO:0006982 | response to lipid hydroperoxide(GO:0006982) cellular response to lipid hydroperoxide(GO:0071449) |
| 0.0 | 0.2 | GO:0035720 | intraciliary anterograde transport(GO:0035720) |
| 0.0 | 0.3 | GO:1901029 | negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901029) |
| 0.0 | 0.1 | GO:1903061 | establishment of protein localization to endoplasmic reticulum membrane(GO:0097051) regulation of protein lipidation(GO:1903059) positive regulation of protein lipidation(GO:1903061) |
| 0.0 | 0.9 | GO:0030033 | microvillus assembly(GO:0030033) |
| 0.0 | 2.2 | GO:0043124 | negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124) |
| 0.0 | 0.4 | GO:0045717 | negative regulation of fatty acid biosynthetic process(GO:0045717) |
| 0.0 | 0.2 | GO:0031022 | nuclear migration along microfilament(GO:0031022) |
| 0.0 | 1.5 | GO:0050729 | positive regulation of inflammatory response(GO:0050729) |
| 0.0 | 1.0 | GO:0000027 | ribosomal large subunit assembly(GO:0000027) |
| 0.0 | 1.0 | GO:0090280 | positive regulation of calcium ion import(GO:0090280) |
| 0.0 | 0.6 | GO:0030813 | positive regulation of nucleotide catabolic process(GO:0030813) positive regulation of glycolytic process(GO:0045821) positive regulation of cofactor metabolic process(GO:0051194) positive regulation of coenzyme metabolic process(GO:0051197) |
| 0.0 | 0.2 | GO:0038203 | TORC2 signaling(GO:0038203) |
| 0.0 | 0.2 | GO:0051014 | actin filament severing(GO:0051014) |
| 0.0 | 1.1 | GO:0001825 | blastocyst formation(GO:0001825) |
| 0.0 | 2.2 | GO:0007601 | visual perception(GO:0007601) |
| 0.0 | 0.5 | GO:0070200 | establishment of protein localization to telomere(GO:0070200) |
| 0.0 | 0.3 | GO:0060670 | branching involved in labyrinthine layer morphogenesis(GO:0060670) |
| 0.0 | 1.1 | GO:0051438 | regulation of ubiquitin-protein transferase activity(GO:0051438) |
| 0.0 | 0.1 | GO:0006538 | glutamate catabolic process(GO:0006538) |
| 0.0 | 0.1 | GO:0050435 | beta-amyloid metabolic process(GO:0050435) |
| 0.0 | 0.3 | GO:0005980 | polysaccharide catabolic process(GO:0000272) glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247) |
| 0.0 | 0.1 | GO:0042573 | retinoic acid metabolic process(GO:0042573) |
| 0.0 | 1.4 | GO:0072583 | clathrin-mediated endocytosis(GO:0072583) |
| 0.0 | 2.2 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 0.0 | 0.1 | GO:0046370 | fructose biosynthetic process(GO:0046370) |
| 0.0 | 1.9 | GO:0007605 | sensory perception of sound(GO:0007605) |
| 0.0 | 0.8 | GO:2000649 | regulation of sodium ion transmembrane transporter activity(GO:2000649) |
| 0.0 | 0.5 | GO:0008045 | motor neuron axon guidance(GO:0008045) |
| 0.0 | 0.6 | GO:0018279 | protein N-linked glycosylation via asparagine(GO:0018279) |
| 0.0 | 0.2 | GO:0019233 | sensory perception of pain(GO:0019233) |
| 0.0 | 0.6 | GO:0007032 | endosome organization(GO:0007032) |
| 0.0 | 0.4 | GO:0046460 | triglyceride biosynthetic process(GO:0019432) neutral lipid biosynthetic process(GO:0046460) acylglycerol biosynthetic process(GO:0046463) |
| 0.0 | 0.5 | GO:0042982 | amyloid precursor protein metabolic process(GO:0042982) |
| 0.0 | 1.0 | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) |
| 0.0 | 0.7 | GO:0055013 | cardiac muscle cell development(GO:0055013) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 1.8 | GO:0045160 | myosin I complex(GO:0045160) |
| 0.4 | 2.2 | GO:1990357 | terminal web(GO:1990357) |
| 0.2 | 0.7 | GO:1990415 | Pex17p-Pex14p docking complex(GO:1990415) peroxisomal importomer complex(GO:1990429) |
| 0.2 | 2.6 | GO:1990635 | proximal dendrite(GO:1990635) |
| 0.2 | 2.2 | GO:0042581 | specific granule(GO:0042581) |
| 0.1 | 0.6 | GO:1990131 | Gtr1-Gtr2 GTPase complex(GO:1990131) |
| 0.1 | 1.0 | GO:0001520 | outer dense fiber(GO:0001520) |
| 0.1 | 2.3 | GO:0097228 | sperm principal piece(GO:0097228) |
| 0.1 | 1.0 | GO:0002177 | manchette(GO:0002177) |
| 0.1 | 0.5 | GO:0070876 | SOSS complex(GO:0070876) |
| 0.1 | 0.6 | GO:0005859 | muscle myosin complex(GO:0005859) |
| 0.1 | 1.0 | GO:0030130 | clathrin coat of trans-Golgi network vesicle(GO:0030130) |
| 0.1 | 2.3 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
| 0.1 | 6.2 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.1 | 1.1 | GO:0031462 | Cul2-RING ubiquitin ligase complex(GO:0031462) |
| 0.1 | 8.8 | GO:0016605 | PML body(GO:0016605) |
| 0.1 | 0.3 | GO:0070436 | Grb2-EGFR complex(GO:0070436) |
| 0.1 | 1.4 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.1 | 0.9 | GO:0044754 | secondary lysosome(GO:0005767) autolysosome(GO:0044754) |
| 0.1 | 0.3 | GO:0031021 | interphase microtubule organizing center(GO:0031021) |
| 0.1 | 0.7 | GO:0001673 | male germ cell nucleus(GO:0001673) |
| 0.1 | 1.0 | GO:0031045 | dense core granule(GO:0031045) |
| 0.1 | 2.0 | GO:0032040 | small-subunit processome(GO:0032040) |
| 0.1 | 0.4 | GO:0032937 | SREBP-SCAP-Insig complex(GO:0032937) |
| 0.1 | 0.4 | GO:0042825 | TAP complex(GO:0042825) |
| 0.1 | 2.5 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.1 | 0.7 | GO:0005922 | connexon complex(GO:0005922) |
| 0.0 | 0.9 | GO:0000145 | exocyst(GO:0000145) |
| 0.0 | 0.8 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.0 | 0.2 | GO:0034993 | microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993) |
| 0.0 | 0.2 | GO:0097361 | CIA complex(GO:0097361) |
| 0.0 | 0.5 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 0.0 | 0.3 | GO:0071541 | eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541) |
| 0.0 | 1.1 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.0 | 1.4 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.0 | 0.5 | GO:0042101 | T cell receptor complex(GO:0042101) |
| 0.0 | 1.1 | GO:0032391 | photoreceptor connecting cilium(GO:0032391) |
| 0.0 | 1.4 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.0 | 0.4 | GO:0030122 | AP-2 adaptor complex(GO:0030122) |
| 0.0 | 1.7 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.0 | 0.3 | GO:0000243 | commitment complex(GO:0000243) |
| 0.0 | 0.5 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
| 0.0 | 0.5 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
| 0.0 | 1.6 | GO:0030315 | T-tubule(GO:0030315) |
| 0.0 | 0.2 | GO:0097470 | ribbon synapse(GO:0097470) |
| 0.0 | 1.1 | GO:0036126 | sperm flagellum(GO:0036126) |
| 0.0 | 0.8 | GO:0030667 | secretory granule membrane(GO:0030667) |
| 0.0 | 1.0 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.0 | 0.5 | GO:0030673 | axolemma(GO:0030673) |
| 0.0 | 0.2 | GO:0031932 | TORC2 complex(GO:0031932) |
| 0.0 | 1.0 | GO:0005905 | clathrin-coated pit(GO:0005905) |
| 0.0 | 1.4 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.0 | 0.6 | GO:0030136 | clathrin-coated vesicle(GO:0030136) |
| 0.0 | 0.4 | GO:0030119 | AP-type membrane coat adaptor complex(GO:0030119) |
| 0.0 | 5.0 | GO:0005764 | lytic vacuole(GO:0000323) lysosome(GO:0005764) |
| 0.0 | 4.2 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.0 | 0.2 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.0 | 0.3 | GO:0016529 | sarcoplasmic reticulum(GO:0016529) |
| 0.0 | 1.8 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.0 | 2.4 | GO:0005912 | adherens junction(GO:0005912) |
| 0.0 | 0.0 | GO:0005638 | lamin filament(GO:0005638) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 6.8 | GO:0070324 | thyroid hormone binding(GO:0070324) |
| 0.7 | 3.0 | GO:0031727 | CCR2 chemokine receptor binding(GO:0031727) |
| 0.4 | 1.8 | GO:0034481 | chondroitin sulfotransferase activity(GO:0034481) |
| 0.4 | 1.3 | GO:0045127 | N-acetylglucosamine kinase activity(GO:0045127) |
| 0.3 | 1.0 | GO:0004658 | propionyl-CoA carboxylase activity(GO:0004658) |
| 0.3 | 1.7 | GO:0008865 | fructokinase activity(GO:0008865) mannokinase activity(GO:0019158) |
| 0.3 | 0.8 | GO:0035402 | histone kinase activity (H3-T11 specific)(GO:0035402) |
| 0.3 | 0.8 | GO:0005128 | erythropoietin receptor binding(GO:0005128) |
| 0.3 | 2.4 | GO:0005007 | fibroblast growth factor-activated receptor activity(GO:0005007) |
| 0.2 | 0.7 | GO:0030350 | iron-responsive element binding(GO:0030350) |
| 0.2 | 1.0 | GO:0004784 | superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721) |
| 0.2 | 2.2 | GO:0039706 | co-receptor binding(GO:0039706) |
| 0.2 | 2.2 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.2 | 4.4 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.2 | 4.6 | GO:0005520 | insulin-like growth factor binding(GO:0005520) |
| 0.2 | 0.8 | GO:0004301 | epoxide hydrolase activity(GO:0004301) |
| 0.2 | 1.2 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 0.2 | 0.5 | GO:0004510 | tryptophan 5-monooxygenase activity(GO:0004510) |
| 0.2 | 2.6 | GO:0004033 | aldo-keto reductase (NADP) activity(GO:0004033) |
| 0.2 | 2.8 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.1 | 0.4 | GO:0035939 | microsatellite binding(GO:0035939) |
| 0.1 | 0.8 | GO:0004311 | farnesyltranstransferase activity(GO:0004311) |
| 0.1 | 0.8 | GO:0051185 | coenzyme transporter activity(GO:0051185) |
| 0.1 | 0.5 | GO:0005237 | inhibitory extracellular ligand-gated ion channel activity(GO:0005237) |
| 0.1 | 0.4 | GO:0008195 | phosphatidate phosphatase activity(GO:0008195) |
| 0.1 | 0.6 | GO:0043891 | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891) |
| 0.1 | 0.6 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 0.1 | 0.3 | GO:0004816 | asparagine-tRNA ligase activity(GO:0004816) |
| 0.1 | 0.9 | GO:0042500 | aspartic endopeptidase activity, intramembrane cleaving(GO:0042500) |
| 0.1 | 1.4 | GO:0032050 | clathrin heavy chain binding(GO:0032050) |
| 0.1 | 5.0 | GO:0005158 | insulin receptor binding(GO:0005158) |
| 0.1 | 12.9 | GO:0001191 | transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191) |
| 0.1 | 0.3 | GO:0046997 | sarcosine dehydrogenase activity(GO:0008480) oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor(GO:0046997) |
| 0.1 | 0.9 | GO:0015114 | phosphate ion transmembrane transporter activity(GO:0015114) |
| 0.1 | 0.9 | GO:0015250 | water channel activity(GO:0015250) |
| 0.1 | 1.0 | GO:0004017 | adenylate kinase activity(GO:0004017) |
| 0.1 | 0.3 | GO:0004022 | alcohol dehydrogenase (NAD) activity(GO:0004022) |
| 0.1 | 0.5 | GO:0035381 | extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381) |
| 0.1 | 0.3 | GO:0008184 | glycogen phosphorylase activity(GO:0008184) |
| 0.1 | 1.8 | GO:0017160 | Ral GTPase binding(GO:0017160) |
| 0.1 | 1.4 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.1 | 0.3 | GO:0005168 | neurotrophin TRKA receptor binding(GO:0005168) |
| 0.1 | 0.8 | GO:0004016 | adenylate cyclase activity(GO:0004016) |
| 0.1 | 3.3 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
| 0.1 | 1.7 | GO:1900750 | glutathione binding(GO:0043295) oligopeptide binding(GO:1900750) |
| 0.1 | 0.7 | GO:0019531 | secondary active sulfate transmembrane transporter activity(GO:0008271) sulfate transmembrane transporter activity(GO:0015116) oxalate transmembrane transporter activity(GO:0019531) |
| 0.1 | 0.7 | GO:0005243 | gap junction channel activity(GO:0005243) |
| 0.1 | 0.7 | GO:0004143 | diacylglycerol kinase activity(GO:0004143) |
| 0.1 | 0.3 | GO:0030144 | alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144) |
| 0.1 | 0.4 | GO:0046978 | TAP1 binding(GO:0046978) TAP2 binding(GO:0046979) |
| 0.1 | 2.3 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.1 | 1.1 | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) |
| 0.0 | 0.8 | GO:0016290 | palmitoyl-CoA hydrolase activity(GO:0016290) |
| 0.0 | 1.2 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
| 0.0 | 0.3 | GO:0042731 | PH domain binding(GO:0042731) |
| 0.0 | 1.0 | GO:0043539 | protein serine/threonine kinase activator activity(GO:0043539) |
| 0.0 | 0.3 | GO:0097642 | calcitonin family receptor activity(GO:0097642) |
| 0.0 | 1.8 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.0 | 0.7 | GO:0035497 | cAMP response element binding(GO:0035497) |
| 0.0 | 0.5 | GO:0098505 | single-stranded telomeric DNA binding(GO:0043047) G-rich strand telomeric DNA binding(GO:0098505) |
| 0.0 | 0.6 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.0 | 0.4 | GO:0015643 | toxic substance binding(GO:0015643) |
| 0.0 | 1.8 | GO:0008375 | acetylglucosaminyltransferase activity(GO:0008375) |
| 0.0 | 0.5 | GO:0070403 | NAD+ binding(GO:0070403) |
| 0.0 | 1.4 | GO:0005246 | calcium channel regulator activity(GO:0005246) |
| 0.0 | 0.4 | GO:0070742 | C2H2 zinc finger domain binding(GO:0070742) |
| 0.0 | 0.4 | GO:0048018 | receptor agonist activity(GO:0048018) |
| 0.0 | 0.6 | GO:0008373 | sialyltransferase activity(GO:0008373) |
| 0.0 | 0.2 | GO:0032184 | SUMO polymer binding(GO:0032184) |
| 0.0 | 0.8 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.0 | 0.9 | GO:0005507 | copper ion binding(GO:0005507) |
| 0.0 | 0.1 | GO:0004844 | uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506) |
| 0.0 | 4.7 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.0 | 0.3 | GO:0001968 | fibronectin binding(GO:0001968) |
| 0.0 | 0.7 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.0 | 0.1 | GO:0004351 | glutamate decarboxylase activity(GO:0004351) |
| 0.0 | 0.7 | GO:0017069 | snRNA binding(GO:0017069) |
| 0.0 | 0.4 | GO:0050750 | low-density lipoprotein particle receptor binding(GO:0050750) |
| 0.0 | 0.2 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.0 | 2.5 | GO:0004930 | G-protein coupled receptor activity(GO:0004930) |
| 0.0 | 0.2 | GO:0005314 | high-affinity glutamate transmembrane transporter activity(GO:0005314) |
| 0.0 | 0.4 | GO:0001104 | RNA polymerase II transcription cofactor activity(GO:0001104) |
| 0.0 | 1.0 | GO:0005262 | calcium channel activity(GO:0005262) |
| 0.0 | 0.2 | GO:0031681 | G-protein beta-subunit binding(GO:0031681) |
| 0.0 | 0.4 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.0 | 0.2 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.0 | 0.5 | GO:0019209 | kinase activator activity(GO:0019209) |
| 0.0 | 0.1 | GO:0070513 | death domain binding(GO:0070513) |
| 0.0 | 0.1 | GO:0004342 | glucosamine-6-phosphate deaminase activity(GO:0004342) |
| 0.0 | 0.4 | GO:0048487 | beta-tubulin binding(GO:0048487) |
| 0.0 | 0.1 | GO:0004190 | aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.7 | PID_SYNDECAN_4_PATHWAY | Syndecan-4-mediated signaling events |
| 0.1 | 5.3 | PID_RET_PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.1 | 1.8 | PID_ARF_3PATHWAY | Arf1 pathway |
| 0.1 | 0.8 | PID_LPA4_PATHWAY | LPA4-mediated signaling events |
| 0.1 | 6.2 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 0.8 | PID_P38_GAMMA_DELTA_PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.0 | 1.1 | PID_HDAC_CLASSIII_PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 3.0 | PID_HIF1_TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 0.2 | PID_TCR_JNK_PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.0 | 2.1 | PID_E2F_PATHWAY | E2F transcription factor network |
| 0.0 | 0.9 | PID_LKB1_PATHWAY | LKB1 signaling events |
| 0.0 | 2.4 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 0.3 | ST_G_ALPHA_S_PATHWAY | G alpha s Pathway |
| 0.0 | 0.2 | PID_THROMBIN_PAR4_PATHWAY | PAR4-mediated thrombin signaling events |
| 0.0 | 0.7 | PID_NFAT_TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.0 | 0.6 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
| 0.0 | 1.3 | PID_MTOR_4PATHWAY | mTOR signaling pathway |
| 0.0 | 1.1 | PID_CDC42_PATHWAY | CDC42 signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 6.2 | REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.3 | 2.8 | REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.2 | 2.4 | REACTOME_SIGNALING_BY_ACTIVATED_POINT_MUTANTS_OF_FGFR1 | Genes involved in Signaling by activated point mutants of FGFR1 |
| 0.2 | 4.4 | REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GLP1 | Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1) |
| 0.1 | 1.2 | REACTOME_P2Y_RECEPTORS | Genes involved in P2Y receptors |
| 0.1 | 1.8 | REACTOME_GAP_JUNCTION_DEGRADATION | Genes involved in Gap junction degradation |
| 0.1 | 1.8 | REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.1 | 2.5 | REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA | Genes involved in G beta:gamma signalling through PLC beta |
| 0.1 | 0.8 | REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY | Genes involved in Adenylate cyclase activating pathway |
| 0.1 | 0.7 | REACTOME_GAP_JUNCTION_TRAFFICKING | Genes involved in Gap junction trafficking |
| 0.1 | 1.0 | REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
| 0.1 | 2.4 | REACTOME_INTERFERON_ALPHA_BETA_SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 2.6 | REACTOME_GLUCOSE_TRANSPORT | Genes involved in Glucose transport |
| 0.1 | 0.9 | REACTOME_SIGNALING_BY_NOTCH4 | Genes involved in Signaling by NOTCH4 |
| 0.1 | 2.0 | REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.1 | 2.3 | REACTOME_DARPP_32_EVENTS | Genes involved in DARPP-32 events |
| 0.0 | 2.1 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.0 | 0.5 | REACTOME_AMINE_DERIVED_HORMONES | Genes involved in Amine-derived hormones |
| 0.0 | 1.1 | REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 0.7 | REACTOME_GABA_A_RECEPTOR_ACTIVATION | Genes involved in GABA A receptor activation |
| 0.0 | 1.0 | REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.0 | 0.8 | REACTOME_CHOLESTEROL_BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.0 | 0.7 | REACTOME_METABOLISM_OF_PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.0 | 0.4 | REACTOME_SYNTHESIS_OF_PE | Genes involved in Synthesis of PE |
| 0.0 | 1.1 | REACTOME_SYNTHESIS_OF_PA | Genes involved in Synthesis of PA |
| 0.0 | 0.8 | REACTOME_GLUTATHIONE_CONJUGATION | Genes involved in Glutathione conjugation |
| 0.0 | 0.4 | REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK | Genes involved in Regulation of Rheb GTPase activity by AMPK |
| 0.0 | 0.6 | REACTOME_SIGNALING_BY_NODAL | Genes involved in Signaling by NODAL |
| 0.0 | 0.6 | REACTOME_SIGNAL_ATTENUATION | Genes involved in Signal attenuation |
| 0.0 | 0.3 | REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.0 | 0.6 | REACTOME_STRIATED_MUSCLE_CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.0 | 0.3 | REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.0 | 0.7 | REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.0 | 1.6 | REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.0 | 0.6 | REACTOME_GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.0 | 0.5 | REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.0 | 0.4 | REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT | Genes involved in ABC-family proteins mediated transport |
| 0.0 | 1.0 | REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.0 | 0.7 | REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.0 | 0.3 | REACTOME_G0_AND_EARLY_G1 | Genes involved in G0 and Early G1 |
| 0.0 | 0.2 | REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
