Motif ID: Maff

Z-value: 1.052


Transcription factors associated with Maff:

Gene SymbolEntrez IDGene Name
Maff ENSMUSG00000042622.7 Maff

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Maffmm10_v2_chr15_+_79347534_793475560.412.0e-04Click!


Activity profile for motif Maff.

activity profile for motif Maff


Sorted Z-values histogram for motif Maff

Sorted Z-values for motif Maff



Network of associatons between targets according to the STRING database.



First level regulatory network of Maff

PNG image of the network

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Top targets:


Showing 1 to 20 of 74 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_136886187 24.643 ENSMUST00000046384.8
 C1qb
complement component 1, q subcomponent, beta polypeptide
chr7_-_110862944 23.073 ENSMUST00000033050.3
 Lyve1
lymphatic vessel endothelial hyaluronan receptor 1
chr15_+_3270767 20.094 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
 Sepp1



selenoprotein P, plasma, 1



chr19_-_57197556 15.398 ENSMUST00000099294.2
 Ablim1
actin-binding LIM protein 1
chr16_-_22439719 14.731 ENSMUST00000079601.6
 Etv5
ets variant gene 5
chr9_-_111690313 13.026 ENSMUST00000035083.7
 Stac
src homology three (SH3) and cysteine rich domain
chr13_-_23710714 12.051 ENSMUST00000091707.6
ENSMUST00000006787.7
ENSMUST00000091706.6
 Hfe


hemochromatosis


chr5_-_67815852 10.892 ENSMUST00000141443.1
 Atp8a1
ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
chr11_+_82101836 10.718 ENSMUST00000000194.3
 Ccl12
chemokine (C-C motif) ligand 12
chr1_-_136260873 9.597 ENSMUST00000086395.5
 Gpr25
G protein-coupled receptor 25
chr15_-_33687840 8.773 ENSMUST00000042021.3
 Tspyl5
testis-specific protein, Y-encoded-like 5
chr17_-_67950908 8.403 ENSMUST00000164647.1
 Arhgap28
Rho GTPase activating protein 28
chr16_+_72663143 7.803 ENSMUST00000023600.7
 Robo1
roundabout homolog 1 (Drosophila)
chr5_+_104435112 7.704 ENSMUST00000031243.8
ENSMUST00000086833.6
ENSMUST00000112748.1
ENSMUST00000112746.1
ENSMUST00000145084.1
ENSMUST00000132457.1
 Spp1





secreted phosphoprotein 1





chr3_-_59262825 7.160 ENSMUST00000050360.7
 P2ry12
purinergic receptor P2Y, G-protein coupled 12
chr4_+_102421518 7.087 ENSMUST00000106904.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr3_+_65109343 6.494 ENSMUST00000159525.1
ENSMUST00000049230.8
 Kcnab1

potassium voltage-gated channel, shaker-related subfamily, beta member 1

chr3_+_109573907 6.455 ENSMUST00000106576.2
 Vav3
vav 3 oncogene
chr19_+_26753588 6.129 ENSMUST00000177116.1
 Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr18_+_32377176 5.317 ENSMUST00000091967.5
ENSMUST00000025239.7
 Bin1

bridging integrator 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 24.6 GO:0006958 complement activation, classical pathway(GO:0006958)
2.3 23.1 GO:0006027 glycosaminoglycan catabolic process(GO:0006027)
0.1 15.4 GO:0007411 axon guidance(GO:0007411)
2.9 14.7 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.4 13.8 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
4.0 12.1 GO:0002725 negative regulation of antigen processing and presentation(GO:0002578) negative regulation of T cell cytokine production(GO:0002725)
1.6 10.9 GO:0061092 regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092)
3.6 10.7 GO:2000501 natural killer cell chemotaxis(GO:0035747) negative regulation of lymphocyte migration(GO:2000402) regulation of natural killer cell chemotaxis(GO:2000501)
0.1 8.8 GO:0051897 positive regulation of protein kinase B signaling(GO:0051897)
2.1 8.4 GO:1904425 negative regulation of GTP binding(GO:1904425)
2.6 7.8 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.0 7.8 GO:0007186 G-protein coupled receptor signaling pathway(GO:0007186)
1.9 7.7 GO:0035937 androgen catabolic process(GO:0006710) estrogen secretion(GO:0035937) estradiol secretion(GO:0035938) regulation of estrogen secretion(GO:2000861) regulation of estradiol secretion(GO:2000864)
2.4 7.2 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.5 7.1 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 7.0 GO:0017015 regulation of transforming growth factor beta receptor signaling pathway(GO:0017015)
0.4 6.5 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260)
0.3 6.5 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.7 6.1 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.4 5.3 GO:0048711 positive regulation of astrocyte differentiation(GO:0048711)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 36.7 GO:0016021 integral component of membrane(GO:0016021)
0.3 24.6 GO:0005581 collagen trimer(GO:0005581)
0.1 13.2 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 13.0 GO:0030315 T-tubule(GO:0030315)
0.0 12.2 GO:0045177 apical part of cell(GO:0045177)
2.4 12.1 GO:1990357 terminal web(GO:1990357)
0.0 11.9 GO:0005615 extracellular space(GO:0005615)
0.0 11.6 GO:0005802 trans-Golgi network(GO:0005802)
0.2 7.8 GO:0030673 axolemma(GO:0030673)
0.1 7.2 GO:0009925 basal plasma membrane(GO:0009925)
0.4 6.5 GO:1990635 proximal dendrite(GO:1990635)
0.0 6.5 GO:0005769 early endosome(GO:0005769)
0.3 6.1 GO:0071564 npBAF complex(GO:0071564)
0.0 6.1 GO:0005770 late endosome(GO:0005770)
0.3 5.3 GO:0043196 varicosity(GO:0043196)
0.2 5.2 GO:0000930 gamma-tubulin complex(GO:0000930)
1.5 4.5 GO:0045160 myosin I complex(GO:0045160)
0.0 4.5 GO:0044798 nuclear transcription factor complex(GO:0044798)
1.4 4.1 GO:0099573 glutamatergic postsynaptic density(GO:0099573)
0.0 3.8 GO:0001669 acrosomal vesicle(GO:0001669)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 23.1 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 19.5 GO:0042803 protein homodimerization activity(GO:0042803)
1.3 12.1 GO:0039706 co-receptor binding(GO:0039706)
1.7 11.6 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.4 10.9 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
2.7 10.7 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.1 9.6 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.1 8.6 GO:0051219 phosphoprotein binding(GO:0051219)
0.9 7.8 GO:0008046 axon guidance receptor activity(GO:0008046)
0.1 7.7 GO:0050840 extracellular matrix binding(GO:0050840)
0.2 7.1 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 6.9 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.4 6.5 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)
0.2 6.5 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.2 5.4 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.2 5.3 GO:0048156 tau protein binding(GO:0048156)
1.5 4.6 GO:0045127 N-acetylglucosamine kinase activity(GO:0045127)
1.1 4.6 GO:0034481 chondroitin sulfotransferase activity(GO:0034481)
0.0 4.6 GO:0005262 calcium channel activity(GO:0005262)
0.3 4.5 GO:0030898 actin-dependent ATPase activity(GO:0030898)

Gene overrepresentation in C2:CP category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 24.6 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.5 14.7 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.1 7.8 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.3 7.7 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.3 6.5 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.1 6.1 PID_E2F_PATHWAY E2F transcription factor network
0.1 5.3 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.1 4.3 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.2 4.1 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 2.2 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.1 1.5 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 0.8 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.0 0.8 PID_IL8_CXCR2_PATHWAY IL8- and CXCR2-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.1 24.6 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
2.3 23.1 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.6 15.4 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
1.3 11.6 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.3 10.9 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.6 7.8 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.1 7.7 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.2 7.2 REACTOME_GPVI_MEDIATED_ACTIVATION_CASCADE Genes involved in GPVI-mediated activation cascade
0.2 7.1 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.2 6.5 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.2 4.6 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.3 4.3 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.2 4.1 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.1 2.7 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.1 2.7 REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Activation of the pre-replicative complex
0.0 2.6 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 2.0 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.0 2.0 REACTOME_GLYCEROPHOSPHOLIPID_BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.0 1.5 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 1.5 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)