Motif ID: Max_Mycn

Z-value: 1.831

Transcription factors associated with Max_Mycn:

Gene SymbolEntrez IDGene Name
Max ENSMUSG00000059436.6 Max
Mycn ENSMUSG00000037169.8 Mycn

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mycnmm10_v2_chr12_-_12941827_129419140.561.3e-07Click!
Maxmm10_v2_chr12_-_76962178_769622480.512.1e-06Click!


Activity profile for motif Max_Mycn.

activity profile for motif Max_Mycn


Sorted Z-values histogram for motif Max_Mycn

Sorted Z-values for motif Max_Mycn



Network of associatons between targets according to the STRING database.



First level regulatory network of Max_Mycn

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_44788016 21.675 ENSMUST00000090057.4
ENSMUST00000110269.1
 Sybu

syntabulin (syntaxin-interacting)

chr17_-_26201363 17.823 ENSMUST00000121959.1
 Arhgdig
Rho GDP dissociation inhibitor (GDI) gamma
chr4_+_148591482 16.187 ENSMUST00000006611.8
 Srm
spermidine synthase
chr8_+_48109949 16.050 ENSMUST00000170263.2
ENSMUST00000033966.6
 Dctd

dCMP deaminase

chr9_-_121495678 12.406 ENSMUST00000035120.4
 Cck
cholecystokinin
chr8_+_48110156 12.388 ENSMUST00000174379.1
 Dctd
dCMP deaminase
chr15_+_44787746 12.164 ENSMUST00000181839.1
 2310069G16Rik
RIKEN cDNA 2310069G16 gene
chr5_-_135251209 11.595 ENSMUST00000062572.2
 Fzd9
frizzled homolog 9 (Drosophila)
chr15_+_60822947 10.359 ENSMUST00000180730.1
 9930014A18Rik
RIKEN cDNA 9930014A18 gene
chr4_-_155992604 10.048 ENSMUST00000052185.3
 B3galt6
UDP-Gal:betaGal beta 1,3-galactosyltransferase, polypeptide 6
chr19_+_43440404 9.464 ENSMUST00000165311.1
 Cnnm1
cyclin M1
chr13_-_47014814 9.339 ENSMUST00000052747.2
 Nhlrc1
NHL repeat containing 1
chr3_+_104638658 9.141 ENSMUST00000046212.1
 Slc16a1
solute carrier family 16 (monocarboxylic acid transporters), member 1
chr8_-_105938384 8.772 ENSMUST00000034369.8
 Psmb10
proteasome (prosome, macropain) subunit, beta type 10
chr1_+_55088132 8.448 ENSMUST00000075242.6
 Hspe1
heat shock protein 1 (chaperonin 10)
chr11_-_6065737 8.309 ENSMUST00000002817.5
ENSMUST00000109813.2
ENSMUST00000090443.3
 Camk2b


calcium/calmodulin-dependent protein kinase II, beta


chr6_-_91473361 8.200 ENSMUST00000040835.7
 Chchd4
coiled-coil-helix-coiled-coil-helix domain containing 4
chr17_+_45563928 8.078 ENSMUST00000041353.6
 Slc35b2
solute carrier family 35, member B2
chr8_+_13159135 7.871 ENSMUST00000033824.6
 Lamp1
lysosomal-associated membrane protein 1
chr11_-_101785252 7.862 ENSMUST00000164750.1
ENSMUST00000107176.1
ENSMUST00000017868.6
 Etv4


ets variant gene 4 (E1A enhancer binding protein, E1AF)



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 661 entries
Log-likelihood per target Total log-likelihoodTermDescription
9.5 28.4 GO:0006226 dUMP biosynthetic process(GO:0006226)
3.9 23.2 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
1.5 21.0 GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000466)
0.7 19.1 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.4 17.7 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
4.0 16.2 GO:0008295 spermidine biosynthetic process(GO:0008295)
3.2 16.0 GO:0008355 olfactory learning(GO:0008355)
0.6 15.8 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991)
0.6 15.4 GO:0018345 protein palmitoylation(GO:0018345)
0.5 15.4 GO:0006024 glycosaminoglycan biosynthetic process(GO:0006024)
0.1 15.2 GO:0006626 protein targeting to mitochondrion(GO:0006626)
3.0 14.9 GO:0043987 histone H3-S10 phosphorylation(GO:0043987)
0.3 14.9 GO:0006414 translational elongation(GO:0006414)
1.3 14.7 GO:0034551 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.7 14.5 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
2.0 13.7 GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000447)
0.5 13.1 GO:0071353 cellular response to interleukin-4(GO:0071353)
0.2 12.9 GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178)
1.2 12.7 GO:0006228 UTP biosynthetic process(GO:0006228)
1.4 12.4 GO:0051901 positive regulation of mitochondrial depolarization(GO:0051901)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 295 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 45.0 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 40.8 GO:0070062 extracellular exosome(GO:0070062)
0.0 39.7 GO:0016021 integral component of membrane(GO:0016021)
0.7 35.4 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 30.2 GO:0005759 mitochondrial matrix(GO:0005759)
0.3 28.2 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
2.4 26.5 GO:0005642 annulate lamellae(GO:0005642)
2.9 22.9 GO:0097433 dense body(GO:0097433)
0.9 21.1 GO:0030686 90S preribosome(GO:0030686)
0.3 20.8 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 19.8 GO:0031965 nuclear membrane(GO:0031965)
0.4 18.6 GO:0044298 cell body membrane(GO:0044298)
1.3 18.4 GO:0043203 axon hillock(GO:0043203)
0.1 18.2 GO:0005903 brush border(GO:0005903)
1.6 15.8 GO:0070545 PeBoW complex(GO:0070545)
0.2 14.4 GO:0043198 dendritic shaft(GO:0043198)
0.7 14.0 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.2 13.7 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.9 13.3 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.3 13.2 GO:0031941 filamentous actin(GO:0031941)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 451 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 84.8 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 36.4 GO:0003924 GTPase activity(GO:0003924)
1.0 29.9 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
1.6 26.1 GO:0017070 U6 snRNA binding(GO:0017070)
3.6 25.5 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
1.1 21.3 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.8 20.6 GO:0017075 syntaxin-1 binding(GO:0017075)
1.1 20.4 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.3 18.3 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
2.2 17.7 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.5 15.9 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.2 14.7 GO:0051082 unfolded protein binding(GO:0051082)
0.9 14.1 GO:0005326 neurotransmitter transporter activity(GO:0005326)
0.7 14.1 GO:0043274 phospholipase binding(GO:0043274)
2.3 14.0 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
2.0 14.0 GO:0008499 UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499)
0.8 13.9 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.6 13.5 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.3 12.5 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.6 12.4 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 70 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 31.0 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.2 30.5 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.2 25.8 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.3 20.0 PID_MTOR_4PATHWAY mTOR signaling pathway
0.3 18.9 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.3 18.9 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.4 16.8 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.9 15.5 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.8 15.4 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.2 14.7 PID_P53_REGULATION_PATHWAY p53 pathway
0.3 12.7 PID_IL4_2PATHWAY IL4-mediated signaling events
0.5 12.5 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 12.1 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.3 11.3 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.1 9.5 PID_CMYB_PATHWAY C-MYB transcription factor network
0.5 9.1 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.3 9.0 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.3 8.9 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.3 7.9 PID_MYC_PATHWAY C-MYC pathway
0.3 6.8 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 155 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 49.1 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.7 45.1 REACTOME_3_UTR_MEDIATED_TRANSLATIONAL_REGULATION Genes involved in 3' -UTR-mediated translational regulation
1.6 35.5 REACTOME_PYRIMIDINE_METABOLISM Genes involved in Pyrimidine metabolism
0.2 31.1 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
1.0 25.8 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
1.6 25.2 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.8 21.5 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.4 19.3 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.3 17.9 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.5 17.4 REACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.7 16.3 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.4 15.9 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.6 15.4 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.3 14.8 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.2 14.4 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
1.2 14.0 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.8 13.9 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.5 13.6 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.3 13.4 REACTOME_TRANSLATION Genes involved in Translation
0.6 13.1 REACTOME_FORMATION_OF_TUBULIN_FOLDING_INTERMEDIATES_BY_CCT_TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC