Motif ID: Maz_Zfp281
Z-value: 1.335
Transcription factors associated with Maz_Zfp281:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Maz | ENSMUSG00000030678.6 | Maz |
| Zfp281 | ENSMUSG00000041483.8 | Zfp281 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Zfp281 | mm10_v2_chr1_+_136624901_136624949 | 0.48 | 1.2e-05 | Click! |
| Maz | mm10_v2_chr7_-_127026479_127026496 | -0.24 | 3.3e-02 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 1,115 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 11.4 | 56.9 | GO:0035262 | gonad morphogenesis(GO:0035262) |
| 1.7 | 39.2 | GO:0006978 | DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:0006978) |
| 2.0 | 35.5 | GO:0010715 | regulation of extracellular matrix disassembly(GO:0010715) |
| 11.5 | 34.4 | GO:0002302 | CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302) |
| 2.2 | 32.6 | GO:0072189 | ureter development(GO:0072189) |
| 2.1 | 30.0 | GO:0070102 | interleukin-6-mediated signaling pathway(GO:0070102) |
| 2.8 | 27.9 | GO:0048386 | positive regulation of retinoic acid receptor signaling pathway(GO:0048386) |
| 1.7 | 27.8 | GO:0048385 | regulation of retinoic acid receptor signaling pathway(GO:0048385) |
| 4.5 | 26.8 | GO:0070094 | positive regulation of glucagon secretion(GO:0070094) |
| 3.0 | 23.9 | GO:0021796 | cerebral cortex regionalization(GO:0021796) |
| 7.8 | 23.4 | GO:0030421 | defecation(GO:0030421) |
| 7.7 | 23.2 | GO:0003221 | right ventricular cardiac muscle tissue morphogenesis(GO:0003221) |
| 3.6 | 21.9 | GO:0021965 | spinal cord ventral commissure morphogenesis(GO:0021965) |
| 1.9 | 21.3 | GO:0060539 | diaphragm development(GO:0060539) |
| 2.0 | 19.6 | GO:0060235 | lens induction in camera-type eye(GO:0060235) |
| 0.1 | 19.5 | GO:0006397 | mRNA processing(GO:0006397) |
| 2.1 | 18.8 | GO:0021521 | ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573) |
| 2.3 | 18.4 | GO:2001198 | regulation of dendritic cell differentiation(GO:2001198) |
| 1.5 | 17.8 | GO:0048617 | embryonic foregut morphogenesis(GO:0048617) |
| 0.6 | 17.3 | GO:0008608 | attachment of spindle microtubules to kinetochore(GO:0008608) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 329 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 243.8 | GO:0005654 | nucleoplasm(GO:0005654) |
| 0.1 | 232.0 | GO:0005634 | nucleus(GO:0005634) |
| 0.8 | 59.3 | GO:0005844 | polysome(GO:0005844) |
| 0.4 | 44.9 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.3 | 35.9 | GO:0000775 | chromosome, centromeric region(GO:0000775) |
| 0.2 | 34.6 | GO:0005681 | spliceosomal complex(GO:0005681) |
| 0.3 | 32.7 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 1.6 | 31.1 | GO:0010369 | chromocenter(GO:0010369) |
| 0.5 | 25.7 | GO:0005876 | spindle microtubule(GO:0005876) |
| 0.3 | 25.4 | GO:0000228 | nuclear chromosome(GO:0000228) |
| 1.3 | 24.9 | GO:0097470 | ribbon synapse(GO:0097470) |
| 2.2 | 24.0 | GO:1990907 | beta-catenin-TCF complex(GO:1990907) |
| 0.2 | 22.2 | GO:0005813 | centrosome(GO:0005813) |
| 0.2 | 21.8 | GO:0001650 | fibrillar center(GO:0001650) |
| 1.5 | 19.0 | GO:0043219 | lateral loop(GO:0043219) |
| 1.6 | 18.9 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 0.8 | 18.2 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 0.4 | 18.1 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.2 | 17.7 | GO:0005694 | chromosome(GO:0005694) |
| 0.4 | 16.2 | GO:1990391 | DNA repair complex(GO:1990391) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 537 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 144.6 | GO:0003677 | DNA binding(GO:0003677) |
| 0.6 | 133.2 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.7 | 64.0 | GO:0001158 | enhancer sequence-specific DNA binding(GO:0001158) |
| 0.5 | 52.2 | GO:0001047 | core promoter binding(GO:0001047) |
| 0.3 | 49.8 | GO:0042393 | histone binding(GO:0042393) |
| 0.3 | 45.8 | GO:0000987 | core promoter proximal region sequence-specific DNA binding(GO:0000987) |
| 0.8 | 39.0 | GO:0001102 | RNA polymerase II activating transcription factor binding(GO:0001102) |
| 0.2 | 35.8 | GO:0061659 | ubiquitin-like protein ligase activity(GO:0061659) |
| 0.8 | 34.2 | GO:0001103 | RNA polymerase II repressing transcription factor binding(GO:0001103) |
| 1.4 | 34.0 | GO:0008266 | poly(U) RNA binding(GO:0008266) |
| 0.7 | 33.3 | GO:0001085 | RNA polymerase II transcription factor binding(GO:0001085) |
| 3.5 | 28.1 | GO:0016618 | hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267) |
| 1.7 | 26.9 | GO:0003680 | AT DNA binding(GO:0003680) |
| 0.7 | 24.8 | GO:0070888 | E-box binding(GO:0070888) |
| 2.7 | 23.9 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
| 0.9 | 20.8 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 0.2 | 20.7 | GO:0004386 | helicase activity(GO:0004386) |
| 0.8 | 19.4 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
| 1.0 | 18.4 | GO:0004435 | phosphatidylinositol phospholipase C activity(GO:0004435) |
| 0.7 | 18.4 | GO:0070064 | proline-rich region binding(GO:0070064) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 93 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 65.3 | PID_BETA_CATENIN_NUC_PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 1.1 | 55.8 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
| 1.1 | 52.6 | PID_AURORA_B_PATHWAY | Aurora B signaling |
| 0.8 | 46.6 | PID_HES_HEY_PATHWAY | Notch-mediated HES/HEY network |
| 0.9 | 45.8 | PID_PLK1_PATHWAY | PLK1 signaling events |
| 0.5 | 35.5 | PID_AR_PATHWAY | Coregulation of Androgen receptor activity |
| 2.3 | 32.5 | SA_REG_CASCADE_OF_CYCLIN_EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.6 | 30.9 | PID_HEDGEHOG_GLI_PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 1.0 | 29.9 | PID_WNT_SIGNALING_PATHWAY | Wnt signaling network |
| 0.7 | 28.8 | PID_INTEGRIN_A4B1_PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.6 | 28.5 | PID_IL12_2PATHWAY | IL12-mediated signaling events |
| 0.7 | 25.7 | PID_WNT_NONCANONICAL_PATHWAY | Noncanonical Wnt signaling pathway |
| 0.5 | 24.1 | WNT_SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.4 | 18.7 | PID_E2F_PATHWAY | E2F transcription factor network |
| 0.5 | 17.9 | PID_ILK_PATHWAY | Integrin-linked kinase signaling |
| 0.8 | 17.7 | PID_P38_MK2_PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.9 | 16.0 | PID_RANBP2_PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.4 | 14.7 | ST_JNK_MAPK_PATHWAY | JNK MAPK Pathway |
| 0.4 | 13.1 | PID_HDAC_CLASSII_PATHWAY | Signaling events mediated by HDAC Class II |
| 0.6 | 12.9 | PID_PS1_PATHWAY | Presenilin action in Notch and Wnt signaling |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 155 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 72.8 | REACTOME_MITOTIC_PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.2 | 44.9 | REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 1.2 | 41.7 | REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 1.0 | 29.7 | REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.8 | 27.2 | REACTOME_G1_PHASE | Genes involved in G1 Phase |
| 1.0 | 21.7 | REACTOME_SIGNAL_ATTENUATION | Genes involved in Signal attenuation |
| 1.7 | 20.1 | REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX | Genes involved in CDC6 association with the ORC:origin complex |
| 0.9 | 17.8 | REACTOME_G0_AND_EARLY_G1 | Genes involved in G0 and Early G1 |
| 0.2 | 16.7 | REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.6 | 16.4 | REACTOME_STRIATED_MUSCLE_CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.3 | 16.0 | REACTOME_RECYCLING_PATHWAY_OF_L1 | Genes involved in Recycling pathway of L1 |
| 0.5 | 15.9 | REACTOME_DOWNSTREAM_SIGNALING_EVENTS_OF_B_CELL_RECEPTOR_BCR | Genes involved in Downstream Signaling Events Of B Cell Receptor (BCR) |
| 1.1 | 15.0 | REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
| 1.8 | 14.7 | REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
| 1.4 | 14.5 | REACTOME_INTRINSIC_PATHWAY | Genes involved in Intrinsic Pathway |
| 0.9 | 14.0 | REACTOME_DSCAM_INTERACTIONS | Genes involved in DSCAM interactions |
| 0.4 | 13.2 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |
| 0.3 | 13.1 | REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.1 | 12.6 | REACTOME_G_ALPHA1213_SIGNALLING_EVENTS | Genes involved in G alpha (12/13) signalling events |
| 1.1 | 12.4 | REACTOME_PROLACTIN_RECEPTOR_SIGNALING | Genes involved in Prolactin receptor signaling |
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