Motif ID: Mbd2
Z-value: 1.250
Transcription factors associated with Mbd2:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Mbd2 | ENSMUSG00000024513.10 | Mbd2 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Mbd2 | mm10_v2_chr18_+_70568189_70568398 | -0.23 | 4.3e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.1 | 18.5 | GO:0021773 | striatal medium spiny neuron differentiation(GO:0021773) |
| 3.0 | 9.0 | GO:0035604 | fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow(GO:0035602) fibroblast growth factor receptor signaling pathway involved in hemopoiesis(GO:0035603) fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow(GO:0035604) coronal suture morphogenesis(GO:0060365) squamous basal epithelial stem cell differentiation involved in prostate gland acinus development(GO:0060529) |
| 2.9 | 8.8 | GO:1900133 | renin secretion into blood stream(GO:0002001) regulation of renin secretion into blood stream(GO:1900133) |
| 2.9 | 8.7 | GO:0060596 | mammary placode formation(GO:0060596) |
| 2.3 | 9.1 | GO:0014846 | esophagus smooth muscle contraction(GO:0014846) |
| 1.9 | 7.5 | GO:0032227 | negative regulation of synaptic transmission, dopaminergic(GO:0032227) |
| 1.7 | 15.4 | GO:1900034 | regulation of cellular response to heat(GO:1900034) |
| 1.5 | 7.4 | GO:0071692 | protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) |
| 1.4 | 4.1 | GO:0061537 | glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537) |
| 1.4 | 5.4 | GO:2000313 | fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313) |
| 1.3 | 13.0 | GO:0030322 | stabilization of membrane potential(GO:0030322) |
| 1.3 | 3.9 | GO:0045110 | intermediate filament bundle assembly(GO:0045110) |
| 1.2 | 6.1 | GO:0036324 | vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324) |
| 1.1 | 3.3 | GO:0001193 | maintenance of transcriptional fidelity during DNA-templated transcription elongation(GO:0001192) maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter(GO:0001193) |
| 1.0 | 2.9 | GO:2000744 | anterior head development(GO:0097065) regulation of anterior head development(GO:2000742) positive regulation of anterior head development(GO:2000744) |
| 0.9 | 3.6 | GO:0072344 | rescue of stalled ribosome(GO:0072344) |
| 0.8 | 2.5 | GO:0016332 | establishment or maintenance of polarity of embryonic epithelium(GO:0016332) trachea cartilage morphogenesis(GO:0060535) |
| 0.8 | 2.5 | GO:0046022 | regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022) |
| 0.8 | 2.5 | GO:0098928 | presynaptic signal transduction(GO:0098928) presynapse to nucleus signaling pathway(GO:0099526) |
| 0.8 | 2.4 | GO:0018103 | protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406) |
| 0.8 | 3.2 | GO:0060709 | glycogen cell differentiation involved in embryonic placenta development(GO:0060709) |
| 0.8 | 3.1 | GO:0021586 | pons maturation(GO:0021586) |
| 0.7 | 2.1 | GO:0019401 | alditol biosynthetic process(GO:0019401) |
| 0.7 | 3.3 | GO:0010968 | regulation of microtubule nucleation(GO:0010968) |
| 0.7 | 2.6 | GO:0009405 | pathogenesis(GO:0009405) |
| 0.6 | 1.9 | GO:0031117 | positive regulation of microtubule depolymerization(GO:0031117) |
| 0.6 | 3.8 | GO:0016266 | O-glycan processing(GO:0016266) |
| 0.6 | 3.0 | GO:2001025 | positive regulation of response to drug(GO:2001025) |
| 0.6 | 1.2 | GO:1904192 | cholangiocyte apoptotic process(GO:1902488) regulation of cholangiocyte apoptotic process(GO:1904192) negative regulation of cholangiocyte apoptotic process(GO:1904193) |
| 0.6 | 10.8 | GO:0031340 | positive regulation of vesicle fusion(GO:0031340) |
| 0.6 | 4.2 | GO:0016480 | negative regulation of transcription from RNA polymerase III promoter(GO:0016480) |
| 0.5 | 2.7 | GO:1902683 | regulation of receptor localization to synapse(GO:1902683) |
| 0.5 | 6.3 | GO:0007190 | activation of adenylate cyclase activity(GO:0007190) |
| 0.5 | 2.1 | GO:0042822 | pyridoxal phosphate metabolic process(GO:0042822) |
| 0.5 | 2.6 | GO:2000551 | regulation of T-helper 2 cell cytokine production(GO:2000551) positive regulation of T-helper 2 cell cytokine production(GO:2000553) |
| 0.5 | 1.5 | GO:0015886 | heme transport(GO:0015886) |
| 0.5 | 2.0 | GO:0070459 | prolactin secretion(GO:0070459) |
| 0.5 | 1.5 | GO:0038003 | opioid receptor signaling pathway(GO:0038003) cellular response to isoquinoline alkaloid(GO:0071317) regulation of opioid receptor signaling pathway(GO:2000474) |
| 0.5 | 6.9 | GO:0032486 | Rap protein signal transduction(GO:0032486) |
| 0.5 | 1.4 | GO:0015772 | disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772) |
| 0.5 | 2.3 | GO:0010626 | negative regulation of Schwann cell proliferation(GO:0010626) |
| 0.5 | 1.4 | GO:1902174 | positive regulation of keratinocyte apoptotic process(GO:1902174) |
| 0.5 | 3.6 | GO:0044027 | hypermethylation of CpG island(GO:0044027) |
| 0.5 | 9.0 | GO:0050650 | chondroitin sulfate proteoglycan biosynthetic process(GO:0050650) |
| 0.4 | 2.2 | GO:0072675 | osteoclast fusion(GO:0072675) |
| 0.4 | 6.3 | GO:1900454 | positive regulation of long term synaptic depression(GO:1900454) |
| 0.4 | 1.8 | GO:0046898 | response to cycloheximide(GO:0046898) |
| 0.4 | 2.2 | GO:0071896 | protein localization to adherens junction(GO:0071896) |
| 0.4 | 2.5 | GO:0071955 | recycling endosome to Golgi transport(GO:0071955) |
| 0.4 | 1.9 | GO:0010668 | ectodermal cell differentiation(GO:0010668) |
| 0.4 | 1.5 | GO:0046726 | positive regulation by virus of viral protein levels in host cell(GO:0046726) |
| 0.4 | 1.5 | GO:0050812 | regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) regulation of acyl-CoA biosynthetic process(GO:0050812) |
| 0.4 | 1.8 | GO:0090666 | scaRNA localization to Cajal body(GO:0090666) |
| 0.4 | 2.9 | GO:0001922 | B-1 B cell homeostasis(GO:0001922) |
| 0.4 | 1.8 | GO:0021993 | initiation of neural tube closure(GO:0021993) |
| 0.4 | 2.1 | GO:0035435 | phosphate ion transmembrane transport(GO:0035435) |
| 0.3 | 4.5 | GO:0043252 | sodium-independent organic anion transport(GO:0043252) |
| 0.3 | 1.7 | GO:0003376 | sphingosine-1-phosphate signaling pathway(GO:0003376) sphingolipid mediated signaling pathway(GO:0090520) |
| 0.3 | 1.3 | GO:0060576 | intestinal epithelial cell development(GO:0060576) |
| 0.3 | 1.5 | GO:0070535 | histone H2A K63-linked ubiquitination(GO:0070535) |
| 0.3 | 0.3 | GO:0045896 | regulation of transcription during mitosis(GO:0045896) positive regulation of transcription during mitosis(GO:0045897) |
| 0.3 | 2.4 | GO:0033564 | anterior/posterior axon guidance(GO:0033564) |
| 0.3 | 8.1 | GO:2000311 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311) |
| 0.3 | 0.3 | GO:0055009 | atrial cardiac muscle tissue development(GO:0003228) atrial cardiac muscle tissue morphogenesis(GO:0055009) |
| 0.3 | 1.5 | GO:1903378 | positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378) |
| 0.3 | 1.1 | GO:2001137 | positive regulation of endocytic recycling(GO:2001137) |
| 0.3 | 0.8 | GO:0015882 | L-ascorbic acid transport(GO:0015882) transepithelial L-ascorbic acid transport(GO:0070904) |
| 0.3 | 0.8 | GO:0014738 | regulation of muscle hyperplasia(GO:0014738) muscle hyperplasia(GO:0014900) |
| 0.3 | 1.3 | GO:1901097 | negative regulation of autophagosome maturation(GO:1901097) |
| 0.3 | 3.6 | GO:2001256 | regulation of store-operated calcium entry(GO:2001256) |
| 0.3 | 1.8 | GO:0005981 | regulation of glycogen catabolic process(GO:0005981) |
| 0.3 | 2.8 | GO:0006610 | ribosomal protein import into nucleus(GO:0006610) |
| 0.2 | 2.2 | GO:0051014 | actin filament severing(GO:0051014) |
| 0.2 | 0.7 | GO:2001016 | heparan sulfate proteoglycan catabolic process(GO:0030200) positive regulation of skeletal muscle cell differentiation(GO:2001016) |
| 0.2 | 4.4 | GO:0070262 | peptidyl-serine dephosphorylation(GO:0070262) |
| 0.2 | 0.6 | GO:2001184 | regulation of interleukin-12 secretion(GO:2001182) positive regulation of interleukin-12 secretion(GO:2001184) |
| 0.2 | 5.5 | GO:0055012 | ventricular cardiac muscle cell differentiation(GO:0055012) |
| 0.2 | 0.8 | GO:0001887 | selenium compound metabolic process(GO:0001887) selenocysteine metabolic process(GO:0016259) |
| 0.2 | 1.7 | GO:0019673 | GDP-mannose metabolic process(GO:0019673) |
| 0.2 | 0.4 | GO:0010360 | negative regulation of anion channel activity(GO:0010360) |
| 0.2 | 0.6 | GO:1905051 | regulation of base-excision repair(GO:1905051) positive regulation of base-excision repair(GO:1905053) |
| 0.2 | 1.8 | GO:0014824 | artery smooth muscle contraction(GO:0014824) |
| 0.2 | 5.0 | GO:0095500 | acetylcholine receptor signaling pathway(GO:0095500) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145) |
| 0.2 | 0.5 | GO:0060399 | positive regulation of growth hormone receptor signaling pathway(GO:0060399) |
| 0.2 | 1.4 | GO:0021684 | cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707) |
| 0.2 | 5.0 | GO:0016578 | histone deubiquitination(GO:0016578) |
| 0.2 | 1.2 | GO:0018026 | peptidyl-lysine monomethylation(GO:0018026) |
| 0.2 | 5.8 | GO:0071353 | cellular response to interleukin-4(GO:0071353) |
| 0.2 | 2.8 | GO:1903861 | positive regulation of dendrite extension(GO:1903861) |
| 0.2 | 1.2 | GO:0035269 | protein O-linked mannosylation(GO:0035269) |
| 0.2 | 1.4 | GO:0046541 | saliva secretion(GO:0046541) |
| 0.2 | 2.4 | GO:0033574 | response to testosterone(GO:0033574) |
| 0.2 | 0.9 | GO:0035405 | histone-threonine phosphorylation(GO:0035405) |
| 0.2 | 0.8 | GO:1900186 | negative regulation of clathrin-mediated endocytosis(GO:1900186) regulation of caveolin-mediated endocytosis(GO:2001286) |
| 0.2 | 6.9 | GO:0010830 | regulation of myotube differentiation(GO:0010830) |
| 0.2 | 0.9 | GO:0051534 | negative regulation of NFAT protein import into nucleus(GO:0051534) |
| 0.2 | 3.8 | GO:0043496 | regulation of protein homodimerization activity(GO:0043496) |
| 0.1 | 1.5 | GO:0035873 | lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879) |
| 0.1 | 2.6 | GO:0001516 | prostaglandin biosynthetic process(GO:0001516) prostanoid biosynthetic process(GO:0046457) |
| 0.1 | 1.3 | GO:0033210 | leptin-mediated signaling pathway(GO:0033210) |
| 0.1 | 1.2 | GO:0033631 | cell-cell adhesion mediated by integrin(GO:0033631) |
| 0.1 | 0.8 | GO:0019695 | choline metabolic process(GO:0019695) |
| 0.1 | 0.3 | GO:0035359 | cardiac neural crest cell migration involved in outflow tract morphogenesis(GO:0003253) negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359) |
| 0.1 | 0.5 | GO:0006121 | mitochondrial electron transport, succinate to ubiquinone(GO:0006121) |
| 0.1 | 1.0 | GO:0061084 | negative regulation of protein refolding(GO:0061084) |
| 0.1 | 1.2 | GO:0006362 | transcription elongation from RNA polymerase I promoter(GO:0006362) |
| 0.1 | 1.4 | GO:2000480 | negative regulation of cAMP-dependent protein kinase activity(GO:2000480) |
| 0.1 | 1.1 | GO:0001574 | ganglioside biosynthetic process(GO:0001574) |
| 0.1 | 2.5 | GO:0044804 | nucleophagy(GO:0044804) |
| 0.1 | 1.7 | GO:0048172 | regulation of short-term neuronal synaptic plasticity(GO:0048172) |
| 0.1 | 2.0 | GO:0042347 | negative regulation of NF-kappaB import into nucleus(GO:0042347) |
| 0.1 | 2.8 | GO:0051764 | actin crosslink formation(GO:0051764) |
| 0.1 | 0.8 | GO:0098703 | calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035) |
| 0.1 | 0.5 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 0.1 | 1.0 | GO:0018095 | protein polyglutamylation(GO:0018095) |
| 0.1 | 2.7 | GO:2000052 | protein localization to Golgi apparatus(GO:0034067) positive regulation of non-canonical Wnt signaling pathway(GO:2000052) |
| 0.1 | 1.4 | GO:0043248 | proteasome assembly(GO:0043248) |
| 0.1 | 0.3 | GO:0035574 | histone H4-K20 demethylation(GO:0035574) |
| 0.1 | 2.2 | GO:0097286 | iron ion import(GO:0097286) |
| 0.1 | 0.9 | GO:0071599 | otic vesicle development(GO:0071599) |
| 0.1 | 1.5 | GO:0045717 | negative regulation of fatty acid biosynthetic process(GO:0045717) |
| 0.1 | 2.8 | GO:0035335 | peptidyl-tyrosine dephosphorylation(GO:0035335) |
| 0.1 | 2.2 | GO:2000398 | regulation of T cell differentiation in thymus(GO:0033081) regulation of thymocyte aggregation(GO:2000398) |
| 0.1 | 0.7 | GO:0007296 | vitellogenesis(GO:0007296) |
| 0.1 | 0.3 | GO:0006049 | UDP-N-acetylglucosamine catabolic process(GO:0006049) |
| 0.1 | 0.5 | GO:0050862 | behavioral response to ethanol(GO:0048149) positive regulation of T cell receptor signaling pathway(GO:0050862) |
| 0.1 | 5.1 | GO:0055013 | cardiac muscle cell development(GO:0055013) |
| 0.1 | 1.5 | GO:0046069 | cGMP catabolic process(GO:0046069) |
| 0.1 | 0.6 | GO:0034393 | positive regulation of smooth muscle cell apoptotic process(GO:0034393) |
| 0.1 | 4.2 | GO:0010718 | positive regulation of epithelial to mesenchymal transition(GO:0010718) |
| 0.1 | 0.8 | GO:0045723 | positive regulation of fatty acid biosynthetic process(GO:0045723) |
| 0.1 | 1.2 | GO:2000035 | regulation of stem cell division(GO:2000035) |
| 0.1 | 0.8 | GO:0048096 | chromatin-mediated maintenance of transcription(GO:0048096) |
| 0.1 | 1.3 | GO:0071577 | zinc II ion transmembrane transport(GO:0071577) |
| 0.1 | 3.0 | GO:0045453 | bone resorption(GO:0045453) |
| 0.1 | 0.6 | GO:0042048 | olfactory behavior(GO:0042048) |
| 0.1 | 0.2 | GO:2001160 | negative regulation of urine volume(GO:0035811) regulation of histone H3-K79 methylation(GO:2001160) |
| 0.1 | 0.5 | GO:0097094 | craniofacial suture morphogenesis(GO:0097094) |
| 0.1 | 1.2 | GO:0035767 | endothelial cell chemotaxis(GO:0035767) |
| 0.1 | 2.3 | GO:1901385 | regulation of voltage-gated calcium channel activity(GO:1901385) |
| 0.1 | 3.7 | GO:0046626 | regulation of insulin receptor signaling pathway(GO:0046626) |
| 0.1 | 1.5 | GO:0021895 | cerebral cortex neuron differentiation(GO:0021895) |
| 0.1 | 0.6 | GO:0071479 | cellular response to ionizing radiation(GO:0071479) |
| 0.1 | 1.1 | GO:0043536 | positive regulation of blood vessel endothelial cell migration(GO:0043536) |
| 0.1 | 0.2 | GO:0072498 | embryonic skeletal joint development(GO:0072498) |
| 0.0 | 2.8 | GO:0045921 | positive regulation of exocytosis(GO:0045921) |
| 0.0 | 0.6 | GO:0036010 | protein localization to endosome(GO:0036010) |
| 0.0 | 0.1 | GO:1904814 | regulation of protein localization to chromosome, telomeric region(GO:1904814) |
| 0.0 | 1.3 | GO:0007257 | activation of JUN kinase activity(GO:0007257) |
| 0.0 | 0.9 | GO:0021535 | cell migration in hindbrain(GO:0021535) |
| 0.0 | 0.5 | GO:2000580 | positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582) |
| 0.0 | 0.6 | GO:0045793 | positive regulation of cell size(GO:0045793) |
| 0.0 | 0.6 | GO:0070200 | establishment of protein localization to telomere(GO:0070200) |
| 0.0 | 0.3 | GO:0060050 | positive regulation of protein glycosylation(GO:0060050) |
| 0.0 | 5.9 | GO:0035023 | regulation of Rho protein signal transduction(GO:0035023) |
| 0.0 | 0.8 | GO:0035774 | positive regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0035774) |
| 0.0 | 2.9 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
| 0.0 | 1.3 | GO:0008333 | endosome to lysosome transport(GO:0008333) |
| 0.0 | 0.6 | GO:0007184 | SMAD protein import into nucleus(GO:0007184) |
| 0.0 | 0.3 | GO:0019511 | peptidyl-proline hydroxylation(GO:0019511) |
| 0.0 | 1.6 | GO:0016925 | protein sumoylation(GO:0016925) |
| 0.0 | 1.3 | GO:0007059 | chromosome segregation(GO:0007059) |
| 0.0 | 2.9 | GO:0006633 | fatty acid biosynthetic process(GO:0006633) |
| 0.0 | 0.4 | GO:0090141 | positive regulation of mitochondrial fission(GO:0090141) |
| 0.0 | 0.3 | GO:0033148 | positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148) |
| 0.0 | 0.6 | GO:0048268 | clathrin coat assembly(GO:0048268) |
| 0.0 | 6.6 | GO:0050890 | cognition(GO:0050890) |
| 0.0 | 4.3 | GO:0071804 | cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805) |
| 0.0 | 0.8 | GO:0014003 | oligodendrocyte development(GO:0014003) |
| 0.0 | 1.0 | GO:0016575 | histone deacetylation(GO:0016575) |
| 0.0 | 0.1 | GO:0000395 | mRNA 5'-splice site recognition(GO:0000395) |
| 0.0 | 0.8 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 0.0 | 0.1 | GO:1902951 | negative regulation of dendritic spine maintenance(GO:1902951) |
| 0.0 | 1.6 | GO:0006487 | protein N-linked glycosylation(GO:0006487) |
| 0.0 | 0.2 | GO:0006370 | 7-methylguanosine mRNA capping(GO:0006370) |
| 0.0 | 1.2 | GO:0070936 | protein K48-linked ubiquitination(GO:0070936) |
| 0.0 | 0.3 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
| 0.0 | 2.2 | GO:0051028 | mRNA transport(GO:0051028) |
| 0.0 | 0.1 | GO:0045075 | interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075) |
| 0.0 | 0.9 | GO:0051298 | centrosome duplication(GO:0051298) |
| 0.0 | 2.6 | GO:0008654 | phospholipid biosynthetic process(GO:0008654) |
| 0.0 | 0.5 | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER(GO:0006890) |
| 0.0 | 0.0 | GO:0021849 | neuroblast division in subventricular zone(GO:0021849) |
| 0.0 | 0.2 | GO:0010762 | regulation of fibroblast migration(GO:0010762) |
| 0.0 | 1.6 | GO:0030041 | actin filament polymerization(GO:0030041) |
| 0.0 | 0.4 | GO:0000462 | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 15.4 | GO:0045298 | tubulin complex(GO:0045298) |
| 1.5 | 6.1 | GO:1990032 | parallel fiber(GO:1990032) |
| 1.0 | 3.1 | GO:0016533 | cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533) |
| 0.8 | 2.5 | GO:1990257 | piccolo-bassoon transport vesicle(GO:1990257) |
| 0.7 | 3.6 | GO:0030314 | junctional membrane complex(GO:0030314) |
| 0.6 | 7.4 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.5 | 13.0 | GO:0071565 | nBAF complex(GO:0071565) |
| 0.5 | 1.0 | GO:0000125 | PCAF complex(GO:0000125) |
| 0.5 | 1.5 | GO:0005967 | mitochondrial pyruvate dehydrogenase complex(GO:0005967) |
| 0.4 | 2.6 | GO:0045179 | apical cortex(GO:0045179) |
| 0.4 | 3.9 | GO:0005883 | neurofilament(GO:0005883) |
| 0.4 | 1.1 | GO:0020018 | ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018) |
| 0.3 | 6.3 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.3 | 3.3 | GO:0097136 | Bcl-2 family protein complex(GO:0097136) |
| 0.3 | 5.9 | GO:0032279 | asymmetric synapse(GO:0032279) |
| 0.3 | 0.8 | GO:0098592 | cytoplasmic side of apical plasma membrane(GO:0098592) |
| 0.3 | 1.8 | GO:0072357 | PTW/PP1 phosphatase complex(GO:0072357) |
| 0.3 | 1.5 | GO:0032591 | dendritic spine membrane(GO:0032591) |
| 0.2 | 1.2 | GO:0035867 | alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867) |
| 0.2 | 2.4 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
| 0.2 | 4.0 | GO:0000124 | SAGA complex(GO:0000124) |
| 0.2 | 3.1 | GO:0031105 | septin complex(GO:0031105) |
| 0.2 | 4.4 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.2 | 10.8 | GO:0031201 | SNARE complex(GO:0031201) |
| 0.2 | 4.6 | GO:0001741 | XY body(GO:0001741) |
| 0.2 | 3.0 | GO:1990635 | proximal dendrite(GO:1990635) |
| 0.2 | 15.2 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.2 | 3.3 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
| 0.2 | 1.1 | GO:0005638 | lamin filament(GO:0005638) |
| 0.2 | 6.6 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.2 | 1.3 | GO:0045261 | mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261) |
| 0.2 | 1.8 | GO:0005832 | chaperonin-containing T-complex(GO:0005832) |
| 0.1 | 2.1 | GO:0070938 | contractile ring(GO:0070938) |
| 0.1 | 2.2 | GO:0044754 | autolysosome(GO:0044754) |
| 0.1 | 1.2 | GO:0000813 | ESCRT I complex(GO:0000813) |
| 0.1 | 0.6 | GO:0070876 | SOSS complex(GO:0070876) |
| 0.1 | 1.9 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
| 0.1 | 1.4 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.1 | 0.8 | GO:0005664 | origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664) |
| 0.1 | 2.4 | GO:0032809 | neuronal cell body membrane(GO:0032809) |
| 0.1 | 0.6 | GO:0097550 | transcriptional preinitiation complex(GO:0097550) |
| 0.1 | 1.6 | GO:0035102 | PRC1 complex(GO:0035102) |
| 0.1 | 0.4 | GO:0030689 | Noc complex(GO:0030689) |
| 0.1 | 2.7 | GO:0051233 | spindle midzone(GO:0051233) |
| 0.1 | 2.5 | GO:0000407 | pre-autophagosomal structure(GO:0000407) |
| 0.1 | 2.1 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.1 | 5.3 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.1 | 3.8 | GO:0005776 | autophagosome(GO:0005776) |
| 0.1 | 1.2 | GO:0008305 | integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636) |
| 0.1 | 0.9 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.1 | 21.9 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.1 | 1.4 | GO:0043034 | costamere(GO:0043034) |
| 0.1 | 0.8 | GO:0043083 | synaptic cleft(GO:0043083) |
| 0.1 | 1.5 | GO:0097038 | perinuclear endoplasmic reticulum(GO:0097038) |
| 0.1 | 6.9 | GO:0005814 | centriole(GO:0005814) |
| 0.1 | 1.5 | GO:0043204 | perikaryon(GO:0043204) |
| 0.1 | 2.4 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.1 | 7.2 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.1 | 2.2 | GO:0002102 | podosome(GO:0002102) |
| 0.1 | 0.2 | GO:0031533 | mRNA cap methyltransferase complex(GO:0031533) |
| 0.1 | 0.5 | GO:0016461 | unconventional myosin complex(GO:0016461) |
| 0.1 | 6.8 | GO:0034399 | nuclear periphery(GO:0034399) |
| 0.1 | 3.3 | GO:0072686 | mitotic spindle(GO:0072686) |
| 0.0 | 1.7 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.0 | 0.5 | GO:0008541 | proteasome regulatory particle, lid subcomplex(GO:0008541) |
| 0.0 | 1.9 | GO:0044450 | microtubule organizing center part(GO:0044450) |
| 0.0 | 0.2 | GO:0016012 | dystroglycan complex(GO:0016011) sarcoglycan complex(GO:0016012) |
| 0.0 | 1.4 | GO:0005790 | smooth endoplasmic reticulum(GO:0005790) |
| 0.0 | 3.9 | GO:0036064 | ciliary basal body(GO:0036064) |
| 0.0 | 2.2 | GO:0045335 | phagocytic vesicle(GO:0045335) |
| 0.0 | 2.9 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.0 | 11.5 | GO:0060076 | excitatory synapse(GO:0060076) |
| 0.0 | 7.1 | GO:0005769 | early endosome(GO:0005769) |
| 0.0 | 0.1 | GO:1990730 | VCP-NSFL1C complex(GO:1990730) |
| 0.0 | 39.4 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 0.9 | GO:0097610 | cell division site(GO:0032153) cleavage furrow(GO:0032154) cell division site part(GO:0032155) cell surface furrow(GO:0097610) |
| 0.0 | 1.1 | GO:0005876 | spindle microtubule(GO:0005876) |
| 0.0 | 6.0 | GO:0019898 | extrinsic component of membrane(GO:0019898) |
| 0.0 | 2.1 | GO:0010008 | endosome membrane(GO:0010008) |
| 0.0 | 4.4 | GO:0098793 | presynapse(GO:0098793) |
| 0.0 | 0.3 | GO:0044666 | MLL3/4 complex(GO:0044666) |
| 0.0 | 0.6 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
| 0.0 | 1.4 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.0 | 2.6 | GO:0097060 | synaptic membrane(GO:0097060) |
| 0.0 | 2.2 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 0.7 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 0.0 | 1.2 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.0 | 1.9 | GO:0030027 | lamellipodium(GO:0030027) |
| 0.0 | 1.0 | GO:0016234 | inclusion body(GO:0016234) |
| 0.0 | 0.3 | GO:0016580 | Sin3 complex(GO:0016580) |
| 0.0 | 0.1 | GO:0001740 | Barr body(GO:0001740) |
| 0.0 | 0.2 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.0 | 1.5 | GO:0000781 | chromosome, telomeric region(GO:0000781) |
| 0.0 | 0.2 | GO:0005719 | nuclear euchromatin(GO:0005719) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.9 | 8.8 | GO:0051379 | epinephrine binding(GO:0051379) |
| 2.2 | 15.4 | GO:0099609 | microtubule lateral binding(GO:0099609) |
| 1.8 | 9.1 | GO:0008449 | N-acetylglucosamine-6-sulfatase activity(GO:0008449) |
| 1.3 | 8.0 | GO:0015018 | galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018) |
| 1.2 | 13.0 | GO:0022841 | potassium ion leak channel activity(GO:0022841) |
| 1.0 | 6.3 | GO:0008294 | calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294) |
| 1.0 | 9.0 | GO:0005007 | fibroblast growth factor-activated receptor activity(GO:0005007) |
| 0.9 | 6.1 | GO:0035662 | Toll-like receptor 4 binding(GO:0035662) |
| 0.7 | 6.4 | GO:0030550 | acetylcholine receptor inhibitor activity(GO:0030550) |
| 0.7 | 4.2 | GO:0098519 | nucleotide phosphatase activity, acting on free nucleotides(GO:0098519) |
| 0.7 | 5.5 | GO:0030375 | thyroid hormone receptor coactivator activity(GO:0030375) |
| 0.6 | 4.5 | GO:0015198 | oligopeptide transporter activity(GO:0015198) |
| 0.6 | 2.6 | GO:0050220 | prostaglandin-E synthase activity(GO:0050220) |
| 0.6 | 2.5 | GO:1902379 | chemoattractant activity involved in axon guidance(GO:1902379) |
| 0.6 | 10.0 | GO:0045499 | chemorepellent activity(GO:0045499) |
| 0.6 | 2.9 | GO:0008269 | JAK pathway signal transduction adaptor activity(GO:0008269) |
| 0.5 | 2.1 | GO:0005315 | inorganic phosphate transmembrane transporter activity(GO:0005315) |
| 0.5 | 1.5 | GO:0015232 | heme transporter activity(GO:0015232) |
| 0.5 | 1.4 | GO:0008515 | sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157) |
| 0.5 | 1.8 | GO:0008332 | low voltage-gated calcium channel activity(GO:0008332) |
| 0.5 | 3.6 | GO:0003886 | DNA (cytosine-5-)-methyltransferase activity(GO:0003886) |
| 0.4 | 2.2 | GO:0004322 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
| 0.4 | 7.7 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
| 0.4 | 4.1 | GO:0015187 | glycine transmembrane transporter activity(GO:0015187) |
| 0.4 | 2.4 | GO:0005042 | netrin receptor activity(GO:0005042) |
| 0.4 | 1.5 | GO:0047389 | glycerophosphocholine phosphodiesterase activity(GO:0047389) |
| 0.4 | 6.9 | GO:0043008 | ATP-dependent protein binding(GO:0043008) |
| 0.4 | 1.5 | GO:0004706 | JUN kinase kinase kinase activity(GO:0004706) |
| 0.4 | 2.2 | GO:0016176 | superoxide-generating NADPH oxidase activator activity(GO:0016176) |
| 0.4 | 1.5 | GO:0004740 | pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740) |
| 0.4 | 3.3 | GO:0051434 | BH3 domain binding(GO:0051434) |
| 0.3 | 4.7 | GO:0008331 | high voltage-gated calcium channel activity(GO:0008331) |
| 0.3 | 1.0 | GO:0050510 | N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510) |
| 0.3 | 5.9 | GO:0050811 | GABA receptor binding(GO:0050811) |
| 0.3 | 1.3 | GO:0097003 | adipokinetic hormone receptor activity(GO:0097003) |
| 0.3 | 2.8 | GO:0035374 | chondroitin sulfate binding(GO:0035374) |
| 0.3 | 3.9 | GO:0015643 | toxic substance binding(GO:0015643) |
| 0.3 | 0.9 | GO:0035402 | histone kinase activity (H3-T11 specific)(GO:0035402) |
| 0.3 | 0.8 | GO:0022833 | mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833) |
| 0.3 | 0.8 | GO:0070890 | L-ascorbate:sodium symporter activity(GO:0008520) L-ascorbic acid transporter activity(GO:0015229) sodium-dependent L-ascorbate transmembrane transporter activity(GO:0070890) |
| 0.3 | 1.3 | GO:0043532 | angiostatin binding(GO:0043532) |
| 0.2 | 2.0 | GO:0043559 | insulin binding(GO:0043559) |
| 0.2 | 0.7 | GO:0070052 | collagen V binding(GO:0070052) |
| 0.2 | 10.8 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.2 | 1.2 | GO:0001165 | RNA polymerase I upstream control element sequence-specific DNA binding(GO:0001165) |
| 0.2 | 8.2 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.2 | 4.6 | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) |
| 0.2 | 1.7 | GO:0038036 | sphingosine-1-phosphate receptor activity(GO:0038036) |
| 0.2 | 6.3 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.2 | 3.8 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.2 | 1.5 | GO:0015129 | lactate transmembrane transporter activity(GO:0015129) |
| 0.2 | 1.5 | GO:0004118 | cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) |
| 0.2 | 1.2 | GO:0046975 | histone methyltransferase activity (H3-K36 specific)(GO:0046975) |
| 0.2 | 0.8 | GO:0004104 | cholinesterase activity(GO:0004104) choline binding(GO:0033265) |
| 0.2 | 1.4 | GO:0061665 | SUMO ligase activity(GO:0061665) |
| 0.2 | 0.8 | GO:0070279 | vitamin B6 binding(GO:0070279) |
| 0.2 | 3.2 | GO:0030235 | nitric-oxide synthase regulator activity(GO:0030235) |
| 0.2 | 1.1 | GO:0003828 | alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828) |
| 0.2 | 2.8 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.2 | 1.2 | GO:0008568 | microtubule-severing ATPase activity(GO:0008568) |
| 0.2 | 1.4 | GO:0070679 | inositol 1,4,5 trisphosphate binding(GO:0070679) |
| 0.2 | 0.8 | GO:0001010 | transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010) |
| 0.2 | 2.9 | GO:0050321 | tau-protein kinase activity(GO:0050321) |
| 0.2 | 1.5 | GO:0031749 | D2 dopamine receptor binding(GO:0031749) |
| 0.1 | 1.9 | GO:0004576 | oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579) |
| 0.1 | 1.4 | GO:0008603 | cAMP-dependent protein kinase regulator activity(GO:0008603) |
| 0.1 | 1.8 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 0.1 | 2.7 | GO:0000030 | mannosyltransferase activity(GO:0000030) |
| 0.1 | 2.6 | GO:0004697 | protein kinase C activity(GO:0004697) |
| 0.1 | 2.6 | GO:0008432 | JUN kinase binding(GO:0008432) |
| 0.1 | 1.2 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.1 | 2.4 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.1 | 9.7 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
| 0.1 | 0.7 | GO:0090599 | alpha-glucosidase activity(GO:0090599) |
| 0.1 | 0.3 | GO:0035575 | histone demethylase activity (H4-K20 specific)(GO:0035575) |
| 0.1 | 2.5 | GO:0045503 | dynein light chain binding(GO:0045503) |
| 0.1 | 2.2 | GO:0005245 | voltage-gated calcium channel activity(GO:0005245) |
| 0.1 | 0.3 | GO:0003827 | alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827) |
| 0.1 | 2.6 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.1 | 4.0 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
| 0.1 | 1.7 | GO:0032183 | SUMO binding(GO:0032183) |
| 0.1 | 0.3 | GO:0034739 | histone deacetylase activity (H4-K16 specific)(GO:0034739) |
| 0.1 | 3.3 | GO:0003899 | DNA-directed RNA polymerase activity(GO:0003899) |
| 0.1 | 4.1 | GO:0005249 | voltage-gated potassium channel activity(GO:0005249) |
| 0.1 | 4.6 | GO:0019003 | GDP binding(GO:0019003) |
| 0.1 | 5.7 | GO:0019955 | cytokine binding(GO:0019955) |
| 0.1 | 1.8 | GO:0097602 | cullin family protein binding(GO:0097602) |
| 0.1 | 1.8 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
| 0.1 | 5.9 | GO:0051087 | chaperone binding(GO:0051087) |
| 0.1 | 1.7 | GO:0043539 | protein serine/threonine kinase activator activity(GO:0043539) |
| 0.1 | 0.5 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
| 0.1 | 1.7 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.1 | 0.8 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 0.1 | 0.6 | GO:0098505 | G-rich strand telomeric DNA binding(GO:0098505) |
| 0.1 | 1.1 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.1 | 0.2 | GO:0004482 | mRNA (guanine-N7-)-methyltransferase activity(GO:0004482) |
| 0.1 | 0.9 | GO:0051864 | histone demethylase activity (H3-K36 specific)(GO:0051864) |
| 0.1 | 4.6 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.0 | 1.3 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.0 | 2.9 | GO:0019894 | kinesin binding(GO:0019894) |
| 0.0 | 4.1 | GO:0005496 | steroid binding(GO:0005496) |
| 0.0 | 0.6 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
| 0.0 | 3.6 | GO:0019888 | protein phosphatase regulator activity(GO:0019888) |
| 0.0 | 0.5 | GO:0045505 | dynein intermediate chain binding(GO:0045505) |
| 0.0 | 3.1 | GO:0035254 | glutamate receptor binding(GO:0035254) |
| 0.0 | 2.1 | GO:0048365 | Rac GTPase binding(GO:0048365) |
| 0.0 | 0.5 | GO:0005537 | mannose binding(GO:0005537) |
| 0.0 | 0.3 | GO:0001222 | transcription corepressor binding(GO:0001222) |
| 0.0 | 0.6 | GO:0004707 | MAP kinase activity(GO:0004707) |
| 0.0 | 1.7 | GO:0016836 | hydro-lyase activity(GO:0016836) |
| 0.0 | 0.5 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.0 | 0.2 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.0 | 1.0 | GO:0004407 | histone deacetylase activity(GO:0004407) protein deacetylase activity(GO:0033558) |
| 0.0 | 2.4 | GO:0008013 | beta-catenin binding(GO:0008013) |
| 0.0 | 0.1 | GO:0008440 | inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) |
| 0.0 | 0.9 | GO:0070063 | RNA polymerase binding(GO:0070063) |
| 0.0 | 0.3 | GO:0008266 | poly(U) RNA binding(GO:0008266) |
| 0.0 | 0.1 | GO:0010385 | double-stranded methylated DNA binding(GO:0010385) |
| 0.0 | 0.6 | GO:0004712 | protein serine/threonine/tyrosine kinase activity(GO:0004712) |
| 0.0 | 3.4 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.0 | 0.5 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 15.3 | PID_P38_GAMMA_DELTA_PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.7 | 10.0 | PID_ERBB_NETWORK_PATHWAY | ErbB receptor signaling network |
| 0.4 | 6.3 | PID_LPA4_PATHWAY | LPA4-mediated signaling events |
| 0.3 | 11.9 | ST_MYOCYTE_AD_PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.2 | 8.7 | PID_RAS_PATHWAY | Regulation of Ras family activation |
| 0.1 | 5.5 | PID_RXR_VDR_PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.1 | 7.4 | PID_FGF_PATHWAY | FGF signaling pathway |
| 0.1 | 1.5 | PID_P38_MKK3_6PATHWAY | p38 MAPK signaling pathway |
| 0.1 | 1.9 | PID_LYMPH_ANGIOGENESIS_PATHWAY | VEGFR3 signaling in lymphatic endothelium |
| 0.1 | 6.9 | PID_AVB3_INTEGRIN_PATHWAY | Integrins in angiogenesis |
| 0.1 | 1.8 | SA_PROGRAMMED_CELL_DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.1 | 2.9 | ST_GAQ_PATHWAY | G alpha q Pathway |
| 0.1 | 2.5 | PID_WNT_SIGNALING_PATHWAY | Wnt signaling network |
| 0.1 | 5.6 | PID_MYC_REPRESS_PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 3.1 | PID_LIS1_PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.1 | 2.6 | PID_IFNG_PATHWAY | IFN-gamma pathway |
| 0.1 | 5.1 | PID_RHOA_REG_PATHWAY | Regulation of RhoA activity |
| 0.1 | 3.0 | PID_DELTA_NP63_PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.1 | 3.9 | PID_LKB1_PATHWAY | LKB1 signaling events |
| 0.1 | 1.5 | PID_IL6_7_PATHWAY | IL6-mediated signaling events |
| 0.1 | 7.4 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 1.1 | PID_ATM_PATHWAY | ATM pathway |
| 0.0 | 2.0 | PID_ATR_PATHWAY | ATR signaling pathway |
| 0.0 | 0.8 | PID_MYC_PATHWAY | C-MYC pathway |
| 0.0 | 2.4 | PID_P53_REGULATION_PATHWAY | p53 pathway |
| 0.0 | 4.4 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 0.4 | PID_CXCR4_PATHWAY | CXCR4-mediated signaling events |
| 0.0 | 0.7 | PID_CDC42_REG_PATHWAY | Regulation of CDC42 activity |
| 0.0 | 0.3 | PID_S1P_S1P2_PATHWAY | S1P2 pathway |
| 0.0 | 0.5 | PID_TCPTP_PATHWAY | Signaling events mediated by TCPTP |
| 0.0 | 0.3 | PID_HDAC_CLASSIII_PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 1.6 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 13.0 | REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS | Genes involved in Tandem pore domain potassium channels |
| 0.8 | 9.0 | REACTOME_FGFR2C_LIGAND_BINDING_AND_ACTIVATION | Genes involved in FGFR2c ligand binding and activation |
| 0.7 | 8.8 | REACTOME_AMINE_LIGAND_BINDING_RECEPTORS | Genes involved in Amine ligand-binding receptors |
| 0.7 | 15.4 | REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.6 | 4.5 | REACTOME_TRANSPORT_OF_ORGANIC_ANIONS | Genes involved in Transport of organic anions |
| 0.5 | 6.3 | REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY | Genes involved in Adenylate cyclase activating pathway |
| 0.4 | 4.1 | REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.4 | 15.2 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.3 | 8.8 | REACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS | Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis |
| 0.2 | 3.1 | REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |
| 0.2 | 2.4 | REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
| 0.2 | 3.3 | REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS | Genes involved in Viral Messenger RNA Synthesis |
| 0.2 | 2.8 | REACTOME_ERKS_ARE_INACTIVATED | Genes involved in ERKs are inactivated |
| 0.2 | 0.8 | REACTOME_ACYL_CHAIN_REMODELLING_OF_PG | Genes involved in Acyl chain remodelling of PG |
| 0.2 | 1.5 | REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.1 | 2.9 | REACTOME_CRMPS_IN_SEMA3A_SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.1 | 4.6 | REACTOME_SYNTHESIS_OF_PA | Genes involved in Synthesis of PA |
| 0.1 | 6.2 | REACTOME_NCAM1_INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.1 | 1.8 | REACTOME_INFLAMMASOMES | Genes involved in Inflammasomes |
| 0.1 | 3.7 | REACTOME_CA_DEPENDENT_EVENTS | Genes involved in Ca-dependent events |
| 0.1 | 1.5 | REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.1 | 1.2 | REACTOME_MEMBRANE_BINDING_AND_TARGETTING_OF_GAG_PROTEINS | Genes involved in Membrane binding and targetting of GAG proteins |
| 0.1 | 4.3 | REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.1 | 1.8 | REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.1 | 1.2 | REACTOME_RNA_POL_I_TRANSCRIPTION_TERMINATION | Genes involved in RNA Polymerase I Transcription Termination |
| 0.1 | 1.0 | REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.1 | 1.8 | REACTOME_FORMATION_OF_TUBULIN_FOLDING_INTERMEDIATES_BY_CCT_TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 0.1 | 0.8 | REACTOME_E2F_ENABLED_INHIBITION_OF_PRE_REPLICATION_COMPLEX_FORMATION | Genes involved in E2F-enabled inhibition of pre-replication complex formation |
| 0.1 | 5.5 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 1.3 | REACTOME_ZINC_TRANSPORTERS | Genes involved in Zinc transporters |
| 0.1 | 2.3 | REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA | Genes involved in G beta:gamma signalling through PLC beta |
| 0.1 | 1.3 | REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
| 0.1 | 1.5 | REACTOME_CGMP_EFFECTS | Genes involved in cGMP effects |
| 0.1 | 2.2 | REACTOME_IRON_UPTAKE_AND_TRANSPORT | Genes involved in Iron uptake and transport |
| 0.1 | 0.6 | REACTOME_DSCAM_INTERACTIONS | Genes involved in DSCAM interactions |
| 0.1 | 4.2 | REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK | Genes involved in NRAGE signals death through JNK |
| 0.1 | 1.6 | REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 0.0 | 0.8 | REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.0 | 0.6 | REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.0 | 2.7 | REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.0 | 2.4 | REACTOME_AUTODEGRADATION_OF_CDH1_BY_CDH1_APC_C | Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C |
| 0.0 | 0.5 | REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.0 | 3.0 | REACTOME_ASPARAGINE_N_LINKED_GLYCOSYLATION | Genes involved in Asparagine N-linked glycosylation |
| 0.0 | 1.2 | REACTOME_SIGNAL_TRANSDUCTION_BY_L1 | Genes involved in Signal transduction by L1 |
| 0.0 | 1.2 | REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.0 | 2.4 | REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.0 | 1.7 | REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS | Genes involved in Class A/1 (Rhodopsin-like receptors) |
| 0.0 | 0.8 | REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 0.8 | REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.0 | 0.5 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
