Motif ID: Mecom
Z-value: 0.765
Transcription factors associated with Mecom:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Mecom | ENSMUSG00000027684.10 | Mecom |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.6 | 28.2 | GO:0002457 | T cell antigen processing and presentation(GO:0002457) |
| 3.7 | 11.2 | GO:0071579 | regulation of zinc ion transport(GO:0071579) |
| 3.5 | 14.1 | GO:0003365 | establishment of cell polarity involved in ameboidal cell migration(GO:0003365) |
| 2.2 | 9.0 | GO:0006982 | response to lipid hydroperoxide(GO:0006982) cellular response to lipid hydroperoxide(GO:0071449) |
| 1.3 | 6.4 | GO:0015671 | oxygen transport(GO:0015671) |
| 0.7 | 5.6 | GO:0015074 | DNA integration(GO:0015074) |
| 0.4 | 3.9 | GO:1901386 | negative regulation of voltage-gated calcium channel activity(GO:1901386) |
| 0.3 | 4.3 | GO:0097067 | cellular response to thyroid hormone stimulus(GO:0097067) |
| 0.3 | 1.2 | GO:1902340 | telomeric heterochromatin assembly(GO:0031509) negative regulation of chromosome condensation(GO:1902340) |
| 0.3 | 1.3 | GO:0070171 | negative regulation of tooth mineralization(GO:0070171) |
| 0.2 | 1.3 | GO:0035878 | nail development(GO:0035878) |
| 0.2 | 0.6 | GO:0003032 | detection of oxygen(GO:0003032) |
| 0.2 | 0.7 | GO:0046898 | response to cycloheximide(GO:0046898) |
| 0.1 | 1.1 | GO:0018344 | protein geranylgeranylation(GO:0018344) |
| 0.1 | 0.3 | GO:0060126 | hypophysis morphogenesis(GO:0048850) somatotropin secreting cell differentiation(GO:0060126) |
| 0.1 | 1.0 | GO:0035372 | protein localization to microtubule(GO:0035372) |
| 0.1 | 0.3 | GO:0034473 | U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476) |
| 0.1 | 3.5 | GO:0046677 | response to antibiotic(GO:0046677) |
| 0.1 | 2.6 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 0.1 | 0.2 | GO:0048014 | Tie signaling pathway(GO:0048014) |
| 0.1 | 2.8 | GO:0048864 | stem cell development(GO:0048864) |
| 0.1 | 3.9 | GO:0030819 | positive regulation of cAMP biosynthetic process(GO:0030819) |
| 0.0 | 7.7 | GO:0010466 | negative regulation of peptidase activity(GO:0010466) |
| 0.0 | 0.1 | GO:0018002 | N-terminal peptidyl-serine acetylation(GO:0017198) N-terminal peptidyl-glutamic acid acetylation(GO:0018002) peptidyl-serine acetylation(GO:0030920) |
| 0.0 | 3.0 | GO:0060976 | coronary vasculature development(GO:0060976) |
| 0.0 | 1.6 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 0.0 | 1.3 | GO:0007519 | skeletal muscle tissue development(GO:0007519) |
| 0.0 | 2.1 | GO:0043488 | regulation of mRNA stability(GO:0043488) |
| 0.0 | 0.2 | GO:0090051 | negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948) negative regulation of cell migration involved in sprouting angiogenesis(GO:0090051) |
| 0.0 | 0.1 | GO:1900262 | regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 6.4 | GO:0005833 | hemoglobin complex(GO:0005833) |
| 0.7 | 3.5 | GO:0090498 | extrinsic component of Golgi membrane(GO:0090498) |
| 0.3 | 14.1 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 0.2 | 3.3 | GO:0042788 | polysomal ribosome(GO:0042788) |
| 0.2 | 1.1 | GO:0005968 | Rab-protein geranylgeranyltransferase complex(GO:0005968) |
| 0.1 | 1.3 | GO:0030056 | hemidesmosome(GO:0030056) |
| 0.1 | 3.9 | GO:0051233 | spindle midzone(GO:0051233) |
| 0.1 | 4.9 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.1 | 6.1 | GO:0005778 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 0.1 | 11.2 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.1 | 0.7 | GO:0097136 | Bcl-2 family protein complex(GO:0097136) |
| 0.0 | 2.8 | GO:0005844 | polysome(GO:0005844) |
| 0.0 | 1.2 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 0.0 | 0.3 | GO:0000176 | nuclear exosome (RNase complex)(GO:0000176) |
| 0.0 | 1.3 | GO:0043034 | costamere(GO:0043034) |
| 0.0 | 2.2 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.0 | 0.1 | GO:0031415 | NatA complex(GO:0031415) |
| 0.0 | 2.6 | GO:0070382 | exocytic vesicle(GO:0070382) |
| 0.0 | 0.1 | GO:0005663 | DNA replication factor C complex(GO:0005663) |
| 0.0 | 4.7 | GO:0005667 | transcription factor complex(GO:0005667) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.0 | 28.2 | GO:0032453 | histone demethylase activity (H3-K4 specific)(GO:0032453) |
| 2.8 | 14.1 | GO:0043532 | angiostatin binding(GO:0043532) |
| 1.6 | 6.4 | GO:0031721 | hemoglobin alpha binding(GO:0031721) |
| 1.2 | 4.9 | GO:0003941 | L-serine ammonia-lyase activity(GO:0003941) |
| 0.4 | 11.2 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.4 | 9.0 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
| 0.3 | 1.3 | GO:0038132 | neuregulin binding(GO:0038132) |
| 0.2 | 7.7 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 0.6 | GO:0034714 | type III transforming growth factor beta receptor binding(GO:0034714) |
| 0.1 | 2.8 | GO:0008266 | poly(U) RNA binding(GO:0008266) |
| 0.1 | 4.3 | GO:0043425 | bHLH transcription factor binding(GO:0043425) |
| 0.1 | 0.7 | GO:0051434 | BH3 domain binding(GO:0051434) |
| 0.1 | 2.4 | GO:0017091 | AU-rich element binding(GO:0017091) |
| 0.1 | 3.9 | GO:0019003 | GDP binding(GO:0019003) |
| 0.1 | 2.6 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.1 | 10.8 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.0 | 0.3 | GO:0001206 | transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206) |
| 0.0 | 1.1 | GO:0005092 | GDP-dissociation inhibitor activity(GO:0005092) |
| 0.0 | 0.9 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.0 | 1.2 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.0 | 1.3 | GO:0005518 | collagen binding(GO:0005518) |
| 0.0 | 3.9 | GO:0004930 | G-protein coupled receptor activity(GO:0004930) |
| 0.0 | 0.2 | GO:0005172 | vascular endothelial growth factor receptor binding(GO:0005172) |
| 0.0 | 0.7 | GO:0016831 | carboxy-lyase activity(GO:0016831) |
| 0.0 | 0.1 | GO:0003689 | DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.7 | SA_PTEN_PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.1 | 13.5 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 1.3 | PID_INTEGRIN_CS_PATHWAY | Integrin family cell surface interactions |
| 0.1 | 2.2 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 0.7 | SA_PROGRAMMED_CELL_DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.0 | 0.6 | PID_GLYPICAN_1PATHWAY | Glypican 1 network |
| 0.0 | 2.0 | PID_MYC_ACTIV_PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 1.3 | PID_AR_PATHWAY | Coregulation of Androgen receptor activity |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 14.1 | REACTOME_SIGNALING_BY_HIPPO | Genes involved in Signaling by Hippo |
| 0.3 | 9.0 | REACTOME_GLUTATHIONE_CONJUGATION | Genes involved in Glutathione conjugation |
| 0.1 | 3.9 | REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS | Genes involved in Glucagon-type ligand receptors |
| 0.0 | 0.7 | REACTOME_INFLAMMASOMES | Genes involved in Inflammasomes |
| 0.0 | 0.3 | REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE | Genes involved in mRNA Decay by 3' to 5' Exoribonuclease |
| 0.0 | 1.2 | REACTOME_RNA_POL_I_PROMOTER_OPENING | Genes involved in RNA Polymerase I Promoter Opening |
| 0.0 | 8.5 | REACTOME_HEMOSTASIS | Genes involved in Hemostasis |
