Motif ID: Mecom

Z-value: 0.765


Transcription factors associated with Mecom:

Gene SymbolEntrez IDGene Name
Mecom ENSMUSG00000027684.10 Mecom



Activity profile for motif Mecom.

activity profile for motif Mecom


Sorted Z-values histogram for motif Mecom

Sorted Z-values for motif Mecom



Network of associatons between targets according to the STRING database.



First level regulatory network of Mecom

PNG image of the network

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Top targets:


Showing 1 to 20 of 54 entries
PromoterScoreRefseqGene SymbolGene Name
chrY_+_897782 28.239 ENSMUST00000055032.7
 Kdm5d
lysine (K)-specific demethylase 5D
chr1_+_185454803 11.241 ENSMUST00000061093.6
 Slc30a10
solute carrier family 30, member 10
chr14_-_52020698 10.772 ENSMUST00000067549.7
 Zfp219
zinc finger protein 219
chr6_+_138140298 8.969 ENSMUST00000008684.4
 Mgst1
microsomal glutathione S-transferase 1
chrX_-_145505136 7.543 ENSMUST00000112835.1
 Amot
angiomotin
chrX_-_145505175 6.516 ENSMUST00000143610.1
 Amot
angiomotin
chr7_-_103853199 6.364 ENSMUST00000033229.3
 Hbb-y
hemoglobin Y, beta-like embryonic chain
chr9_+_65890237 5.760 ENSMUST00000045802.6
 2810417H13Rik
RIKEN cDNA 2810417H13 gene
chr5_-_120467296 4.852 ENSMUST00000132916.1
 Sdsl
serine dehydratase-like
chr4_+_128846163 4.209 ENSMUST00000138291.1
 Gm12968
predicted gene 12968
chr4_+_11704439 3.947 ENSMUST00000108304.2
 Gem
GTP binding protein (gene overexpressed in skeletal muscle)
chr1_+_120006980 3.887 ENSMUST00000072886.4
 Sctr
secretin receptor
chr1_+_107511489 3.848 ENSMUST00000064916.2
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr1_+_107511416 3.819 ENSMUST00000009356.4
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr10_-_6980376 3.749 ENSMUST00000105617.1
 Ipcef1
interaction protein for cytohesin exchange factors 1
chr3_+_41742615 3.588 ENSMUST00000146165.1
ENSMUST00000119572.1
ENSMUST00000108065.2
ENSMUST00000120167.1
ENSMUST00000026867.7
ENSMUST00000026868.7
 D3Ertd751e





DNA segment, Chr 3, ERATO Doi 751, expressed





chr11_-_115367667 3.474 ENSMUST00000123428.1
ENSMUST00000044152.6
ENSMUST00000106542.2
 Hid1


HID1 domain containing


chr4_-_110292719 3.299 ENSMUST00000106601.1
 Elavl4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr13_+_104287855 2.980 ENSMUST00000065766.6
 Adamts6
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 6
chr14_+_55854115 2.845 ENSMUST00000168479.1
 Nynrin
NYN domain and retroviral integrase containing

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.6 28.2 GO:0002457 T cell antigen processing and presentation(GO:0002457)
3.5 14.1 GO:0003365 establishment of cell polarity involved in ameboidal cell migration(GO:0003365)
3.7 11.2 GO:0071579 regulation of zinc ion transport(GO:0071579)
2.2 9.0 GO:0006982 response to lipid hydroperoxide(GO:0006982) cellular response to lipid hydroperoxide(GO:0071449)
0.0 7.7 GO:0010466 negative regulation of peptidase activity(GO:0010466)
1.3 6.4 GO:0015671 oxygen transport(GO:0015671)
0.7 5.6 GO:0015074 DNA integration(GO:0015074)
0.3 4.3 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.4 3.9 GO:1901386 negative regulation of voltage-gated calcium channel activity(GO:1901386)
0.1 3.9 GO:0030819 positive regulation of cAMP biosynthetic process(GO:0030819)
0.1 3.5 GO:0046677 response to antibiotic(GO:0046677)
0.0 3.0 GO:0060976 coronary vasculature development(GO:0060976)
0.1 2.8 GO:0048864 stem cell development(GO:0048864)
0.1 2.6 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 2.1 GO:0043488 regulation of mRNA stability(GO:0043488)
0.0 1.6 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.3 1.3 GO:0070171 negative regulation of tooth mineralization(GO:0070171)
0.2 1.3 GO:0035878 nail development(GO:0035878)
0.0 1.3 GO:0007519 skeletal muscle tissue development(GO:0007519)
0.3 1.2 GO:1902340 telomeric heterochromatin assembly(GO:0031509) negative regulation of chromosome condensation(GO:1902340)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 14.1 GO:0008180 COP9 signalosome(GO:0008180)
0.1 11.2 GO:0055037 recycling endosome(GO:0055037)
0.8 6.4 GO:0005833 hemoglobin complex(GO:0005833)
0.1 6.1 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.1 4.9 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 4.7 GO:0005667 transcription factor complex(GO:0005667)
0.1 3.9 GO:0051233 spindle midzone(GO:0051233)
0.7 3.5 GO:0090498 extrinsic component of Golgi membrane(GO:0090498)
0.2 3.3 GO:0042788 polysomal ribosome(GO:0042788)
0.0 2.8 GO:0005844 polysome(GO:0005844)
0.0 2.6 GO:0070382 exocytic vesicle(GO:0070382)
0.0 2.2 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 1.3 GO:0030056 hemidesmosome(GO:0030056)
0.0 1.3 GO:0043034 costamere(GO:0043034)
0.0 1.2 GO:0000788 nuclear nucleosome(GO:0000788)
0.2 1.1 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.1 0.7 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.3 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 0.1 GO:0031415 NatA complex(GO:0031415)
0.0 0.1 GO:0005663 DNA replication factor C complex(GO:0005663)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.0 28.2 GO:0032453 histone demethylase activity (H3-K4 specific)(GO:0032453)
2.8 14.1 GO:0043532 angiostatin binding(GO:0043532)
0.4 11.2 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 10.8 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.4 9.0 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.2 7.7 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
1.6 6.4 GO:0031721 hemoglobin alpha binding(GO:0031721)
1.2 4.9 GO:0003941 L-serine ammonia-lyase activity(GO:0003941)
0.1 4.3 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.1 3.9 GO:0019003 GDP binding(GO:0019003)
0.0 3.9 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.1 2.8 GO:0008266 poly(U) RNA binding(GO:0008266)
0.1 2.6 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 2.4 GO:0017091 AU-rich element binding(GO:0017091)
0.3 1.3 GO:0038132 neuregulin binding(GO:0038132)
0.0 1.3 GO:0005518 collagen binding(GO:0005518)
0.0 1.2 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 1.1 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.9 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 0.7 GO:0051434 BH3 domain binding(GO:0051434)

Gene overrepresentation in C2:CP category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 13.5 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 3.7 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.1 2.2 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 2.0 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 1.3 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.0 1.3 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 0.7 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.6 PID_GLYPICAN_1PATHWAY Glypican 1 network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 14.1 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.3 9.0 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.0 8.5 REACTOME_HEMOSTASIS Genes involved in Hemostasis
0.1 3.9 REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS Genes involved in Glucagon-type ligand receptors
0.0 1.2 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.7 REACTOME_INFLAMMASOMES Genes involved in Inflammasomes
0.0 0.3 REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease