Motif ID: Mecp2

Z-value: 2.742


Transcription factors associated with Mecp2:

Gene SymbolEntrez IDGene Name
Mecp2 ENSMUSG00000031393.10 Mecp2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mecp2mm10_v2_chrX_-_74085586_740856520.199.7e-02Click!


Activity profile for motif Mecp2.

activity profile for motif Mecp2


Sorted Z-values histogram for motif Mecp2

Sorted Z-values for motif Mecp2



Network of associatons between targets according to the STRING database.



First level regulatory network of Mecp2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_86033777 40.310 ENSMUST00000016172.7
 Celsr1
cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)
chr19_+_7268296 34.767 ENSMUST00000066646.4
 Rcor2
REST corepressor 2
chr16_+_33684460 33.309 ENSMUST00000152782.1
ENSMUST00000179453.1
 Heg1

HEG homolog 1 (zebrafish)

chr5_+_64803513 26.692 ENSMUST00000165536.1
 Klf3
Kruppel-like factor 3 (basic)
chr2_+_38339258 25.862 ENSMUST00000143783.2
 Lhx2
LIM homeobox protein 2
chr18_+_64340225 24.539 ENSMUST00000175965.2
ENSMUST00000115145.3
 Onecut2

one cut domain, family member 2

chr4_+_8690399 23.680 ENSMUST00000127476.1
 Chd7
chromodomain helicase DNA binding protein 7
chr16_+_33684538 23.277 ENSMUST00000126532.1
 Heg1
HEG homolog 1 (zebrafish)
chr6_+_128362919 22.052 ENSMUST00000073316.6
 Foxm1
forkhead box M1
chr6_+_120666388 21.667 ENSMUST00000112686.1
 Cecr2
cat eye syndrome chromosome region, candidate 2
chr14_-_67715585 21.654 ENSMUST00000163100.1
ENSMUST00000132705.1
ENSMUST00000124045.1
 Cdca2


cell division cycle associated 2


chr13_-_56252163 21.602 ENSMUST00000058475.4
 Neurog1
neurogenin 1
chr2_-_34372004 20.241 ENSMUST00000113132.2
ENSMUST00000040638.8
 Pbx3

pre B cell leukemia homeobox 3

chr2_+_52857844 19.837 ENSMUST00000090952.4
ENSMUST00000049483.6
ENSMUST00000050719.6
 Fmnl2


formin-like 2


chr5_-_98030727 19.203 ENSMUST00000031281.9
 Antxr2
anthrax toxin receptor 2
chr4_-_59549314 18.698 ENSMUST00000148331.2
ENSMUST00000030076.5
 Ptbp3

polypyrimidine tract binding protein 3

chr17_-_6782775 18.680 ENSMUST00000064234.6
 Ezr
ezrin
chr9_-_94538075 18.478 ENSMUST00000113028.1
 1190002N15Rik
RIKEN cDNA 1190002N15 gene
chr2_+_135659625 18.463 ENSMUST00000134310.1
 Plcb4
phospholipase C, beta 4
chr4_+_116877376 18.404 ENSMUST00000044823.3
 Zswim5
zinc finger SWIM-type containing 5

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 1,063 entries
Log-likelihood per target Total log-likelihoodTermDescription
18.9 56.8 GO:0090271 positive regulation of fibroblast growth factor production(GO:0090271)
1.5 55.0 GO:0035329 hippo signaling(GO:0035329)
17.1 51.4 GO:0060489 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
7.4 44.2 GO:0003383 apical constriction(GO:0003383)
2.1 41.6 GO:0021978 telencephalon regionalization(GO:0021978)
13.6 40.8 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
2.0 40.5 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
2.4 39.1 GO:0048617 embryonic foregut morphogenesis(GO:0048617)
3.9 38.6 GO:0060059 embryonic retina morphogenesis in camera-type eye(GO:0060059)
7.4 37.1 GO:0060849 regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
1.1 37.1 GO:0021591 ventricular system development(GO:0021591)
1.4 35.4 GO:0035411 catenin import into nucleus(GO:0035411)
8.5 34.0 GO:1902724 positive regulation of skeletal muscle satellite cell proliferation(GO:1902724) positive regulation of growth factor dependent skeletal muscle satellite cell proliferation(GO:1902728)
2.4 34.0 GO:0022027 interkinetic nuclear migration(GO:0022027)
2.8 33.9 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
5.4 32.5 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
8.1 32.3 GO:0021603 cranial nerve formation(GO:0021603)
3.1 31.5 GO:2000781 positive regulation of double-strand break repair(GO:2000781)
3.9 31.0 GO:0010032 meiotic chromosome condensation(GO:0010032)
6.2 30.9 GO:0035262 gonad morphogenesis(GO:0035262)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 334 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 427.6 GO:0005654 nucleoplasm(GO:0005654)
0.1 318.8 GO:0005634 nucleus(GO:0005634)
1.1 148.4 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
1.3 116.3 GO:0017053 transcriptional repressor complex(GO:0017053)
0.5 105.4 GO:0005667 transcription factor complex(GO:0005667)
0.4 74.9 GO:0009897 external side of plasma membrane(GO:0009897)
0.6 53.1 GO:0001669 acrosomal vesicle(GO:0001669)
0.7 50.2 GO:0005844 polysome(GO:0005844)
4.4 44.3 GO:0000796 condensin complex(GO:0000796)
5.3 42.6 GO:0033269 internode region of axon(GO:0033269)
7.4 37.1 GO:0097149 centralspindlin complex(GO:0097149)
0.9 34.9 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.4 34.8 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
1.2 32.3 GO:0016363 nuclear matrix(GO:0016363)
1.5 31.0 GO:0016514 SWI/SNF complex(GO:0016514)
1.4 28.6 GO:0016580 Sin3 complex(GO:0016580)
0.1 28.1 GO:0005813 centrosome(GO:0005813)
1.6 28.0 GO:0031616 spindle pole centrosome(GO:0031616)
2.5 27.8 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.4 27.5 GO:0030175 filopodium(GO:0030175)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 551 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 295.0 GO:0003677 DNA binding(GO:0003677)
0.9 276.2 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.7 96.7 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.6 87.4 GO:0042393 histone binding(GO:0042393)
0.6 76.5 GO:0003714 transcription corepressor activity(GO:0003714)
1.4 61.1 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.8 57.8 GO:0003777 microtubule motor activity(GO:0003777)
1.4 47.3 GO:0071837 HMG box domain binding(GO:0071837)
3.8 45.9 GO:0050693 LBD domain binding(GO:0050693)
1.3 42.6 GO:1990841 promoter-specific chromatin binding(GO:1990841)
4.4 40.0 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.3 39.0 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.3 35.7 GO:0004386 helicase activity(GO:0004386)
1.5 35.5 GO:0008266 poly(U) RNA binding(GO:0008266)
3.8 33.9 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.9 33.6 GO:0030332 cyclin binding(GO:0030332)
0.6 32.0 GO:0001047 core promoter binding(GO:0001047)
1.7 31.9 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
3.9 31.1 GO:0046790 virion binding(GO:0046790)
2.5 29.4 GO:0038191 neuropilin binding(GO:0038191)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 92 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.5 151.9 PID_PLK1_PATHWAY PLK1 signaling events
2.1 84.6 PID_AURORA_B_PATHWAY Aurora B signaling
0.9 63.5 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
1.0 52.4 PID_ILK_PATHWAY Integrin-linked kinase signaling
1.0 51.9 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
1.4 50.7 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.8 50.3 PID_E2F_PATHWAY E2F transcription factor network
3.5 48.3 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
1.4 45.4 PID_FOXM1_PATHWAY FOXM1 transcription factor network
1.5 44.7 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
1.0 44.3 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.8 43.8 PID_INTEGRIN1_PATHWAY Beta1 integrin cell surface interactions
2.4 43.3 ST_STAT3_PATHWAY STAT3 Pathway
1.1 37.0 ST_G_ALPHA_I_PATHWAY G alpha i Pathway
1.3 32.0 PID_FAS_PATHWAY FAS (CD95) signaling pathway
3.5 31.9 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
1.1 31.0 PID_CD40_PATHWAY CD40/CD40L signaling
0.6 31.0 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.6 28.0 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.9 26.7 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 144 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 115.0 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
2.3 72.5 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
1.8 57.2 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
2.5 54.9 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
1.5 54.3 REACTOME_MYOGENESIS Genes involved in Myogenesis
1.4 46.3 REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT Genes involved in Regulation of beta-cell development
1.7 45.5 REACTOME_KINESINS Genes involved in Kinesins
3.6 43.6 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
2.7 42.5 REACTOME_ASSOCIATION_OF_LICENSING_FACTORS_WITH_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
2.1 41.3 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
1.3 38.2 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
3.5 34.6 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.6 33.5 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
1.8 33.1 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
3.3 32.9 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.2 32.8 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.6 30.6 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
1.3 27.4 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
1.0 26.6 REACTOME_G1_PHASE Genes involved in G1 Phase
0.9 26.3 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse