ISMARA results: Mef2b

Motif ID: Mef2b

Z-value: 0.798

Transcription factors associated with Mef2b:

Gene Symbol	Entrez ID	Gene Name
Mef2b	ENSMUSG00000079033.3	Mef2b

Activity-expression correlation:

Gene Symbol	Promoter	Pearson corr. coef.	P-value	Plot
Mef2b	mm10_v2_chr8_+_70152754_70152781	0.06	6.1e-01	Click!

View svg image
View png image

Top targets:

Search:

Show entries

Showing 1 to 20 of 177 entries

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr6_-_23248264	8.847	ENSMUST00000031709.5	Fezf1	Fez family zinc finger 1
chr5_+_24985840	7.975	ENSMUST00000075081.6	1500035N22Rik	RIKEN cDNA 1500035N22 gene
chr6_+_137410721	7.344	ENSMUST00000167002.1	Ptpro	protein tyrosine phosphatase, receptor type, O
chr5_-_128953303	7.147	ENSMUST00000111346.1	Rimbp2	RIMS binding protein 2
chr13_+_5861489	6.670	ENSMUST00000000080.6	Klf6	Kruppel-like factor 6
chr3_+_146852359	6.485	ENSMUST00000038090.5 ENSMUST00000170055.1	Ttll7	tubulin tyrosine ligase-like family, member 7
chr9_+_34904913	6.270	ENSMUST00000045091.6	Kirrel3	kin of IRRE like 3 (Drosophila)
chr2_-_172043466	5.695	ENSMUST00000087950.3	Cbln4	cerebellin 4 precursor protein
chr18_+_60963517	5.668	ENSMUST00000115295.2 ENSMUST00000039904.6	Camk2a	calcium/calmodulin-dependent protein kinase II alpha
chrY_-_1286563	5.010	ENSMUST00000091190.5	Ddx3y	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
chr3_-_158562199	4.569	ENSMUST00000106044.1	Lrrc7	leucine rich repeat containing 7
chr3_+_96596628	4.412	ENSMUST00000058943.7	Ankrd34a	ankyrin repeat domain 34A
chr13_-_113663670	4.238	ENSMUST00000054650.4	Hspb3	heat shock protein 3
chr2_-_79908428	4.218	ENSMUST00000102652.3 ENSMUST00000102651.3	Pde1a	phosphodiesterase 1A, calmodulin-dependent
chr2_-_57124003	4.050	ENSMUST00000112629.1	Nr4a2	nuclear receptor subfamily 4, group A, member 2
chr7_-_142899985	3.637	ENSMUST00000000219.3	Th	tyrosine hydroxylase
chr2_+_118663235	3.619	ENSMUST00000099557.3	Pak6	p21 protein (Cdc42/Rac)-activated kinase 6
chr9_-_110742577	3.496	ENSMUST00000006005.7	Pth1r	parathyroid hormone 1 receptor
chr3_-_113574758	3.396	ENSMUST00000106540.1	Amy1	amylase 1, salivary
chr18_+_76059458	3.137	ENSMUST00000167921.1	Zbtb7c	zinc finger and BTB domain containing 7C

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Search:

Show entries

Showing 1 to 20 of 93 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.5	9.5	GO:0046069	cGMP catabolic process(GO:0046069)
1.5	8.8	GO:0021797	forebrain anterior/posterior pattern specification(GO:0021797)
1.5	7.3	GO:0003105	negative regulation of glomerular filtration(GO:0003105)
0.1	7.1	GO:0010923	negative regulation of phosphatase activity(GO:0010923)
0.7	6.5	GO:0018095	protein polyglutamylation(GO:0018095)
1.3	6.3	GO:0002121	inter-male aggressive behavior(GO:0002121)
0.5	5.7	GO:0098989	NMDA selective glutamate receptor signaling pathway(GO:0098989)
0.1	5.0	GO:0010501	RNA secondary structure unwinding(GO:0010501)
1.0	4.1	GO:0051866	general adaptation syndrome(GO:0051866)
0.0	4.1	GO:0019221	cytokine-mediated signaling pathway(GO:0019221)
0.7	3.9	GO:1901164	negative regulation of trophoblast cell migration(GO:1901164)
0.0	3.8	GO:0010976	positive regulation of neuron projection development(GO:0010976)
0.9	3.6	GO:0042414	epinephrine metabolic process(GO:0042414)
0.0	3.6	GO:0007613	memory(GO:0007613)
0.3	3.5	GO:0060732	positive regulation of inositol phosphate biosynthetic process(GO:0060732)
0.0	3.5	GO:0048813	dendrite morphogenesis(GO:0048813)
0.0	3.4	GO:0060271	cilium morphogenesis(GO:0060271)
0.7	3.3	GO:0090669	snoRNA guided rRNA pseudouridine synthesis(GO:0000454) telomerase RNA stabilization(GO:0090669)
0.3	3.1	GO:1903025	regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903025)
0.7	3.0	GO:0099566	regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)

Gene overrepresentation in cellular_component category:

Search:

Show entries

Showing 1 to 20 of 50 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	12.4	GO:0045202	synapse(GO:0045202)
0.0	10.4	GO:0043025	neuronal cell body(GO:0043025)
0.1	10.3	GO:0001650	fibrillar center(GO:0001650)
0.1	7.6	GO:0016328	lateral plasma membrane(GO:0016328)
0.1	6.9	GO:0043198	dendritic shaft(GO:0043198)
0.0	6.3	GO:0005874	microtubule(GO:0005874)
1.9	5.7	GO:0099573	glutamatergic postsynaptic density(GO:0099573)
0.0	5.0	GO:0036464	cytoplasmic ribonucleoprotein granule(GO:0036464)
0.0	4.8	GO:0045211	postsynaptic membrane(GO:0045211)
0.1	4.6	GO:0043194	axon initial segment(GO:0043194)
1.2	3.6	GO:0045009	melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.1	3.5	GO:0031526	brush border membrane(GO:0031526)
0.8	3.3	GO:0090661	box H/ACA telomerase RNP complex(GO:0090661)
0.4	3.0	GO:0005833	hemoglobin complex(GO:0005833)
0.2	3.0	GO:0043083	synaptic cleft(GO:0043083)
0.2	3.0	GO:0044224	juxtaparanode region of axon(GO:0044224)
0.0	3.0	GO:0098852	lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.2	2.8	GO:0002178	palmitoyltransferase complex(GO:0002178)
0.0	2.8	GO:0005814	centriole(GO:0005814)
0.6	2.4	GO:0070032	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)

Gene overrepresentation in molecular_function category:

Search:

Show entries

Showing 1 to 20 of 72 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	11.3	GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
1.4	9.5	GO:0048101	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.2	7.3	GO:0017147	Wnt-protein binding(GO:0017147)
1.6	6.5	GO:0070740	tubulin-glutamic acid ligase activity(GO:0070740)
0.1	6.2	GO:0030165	PDZ domain binding(GO:0030165)
0.5	5.7	GO:0009931	calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1	5.0	GO:0004004	RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.6	3.9	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.7	3.6	GO:0035240	dopamine binding(GO:0035240)
0.1	3.5	GO:0017046	peptide hormone binding(GO:0017046)
1.1	3.4	GO:0016160	alpha-amylase activity(GO:0004556) amylase activity(GO:0016160)
0.5	3.3	GO:0034513	box H/ACA snoRNA binding(GO:0034513)
0.8	3.0	GO:0031721	hemoglobin alpha binding(GO:0031721)
0.4	3.0	GO:0099583	neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.1	3.0	GO:0004385	guanylate kinase activity(GO:0004385)
0.7	2.9	GO:0004111	creatine kinase activity(GO:0004111)
0.1	2.9	GO:0036002	pre-mRNA binding(GO:0036002)
0.1	2.8	GO:0003708	retinoic acid receptor activity(GO:0003708)
0.1	2.8	GO:0019707	protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.1	2.5	GO:0035259	glucocorticoid receptor binding(GO:0035259)

Gene overrepresentation in C2:CP category:

Search:

Show entries

Showing 1 to 15 of 15 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	7.8	ST_ERK1_ERK2_MAPK_PATHWAY	ERK1/ERK2 MAPK Pathway
0.1	7.3	PID_KIT_PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)
0.3	5.9	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
0.0	5.6	NABA_SECRETED_FACTORS	Genes encoding secreted soluble factors
0.1	4.1	PID_P38_MK2_PATHWAY	p38 signaling mediated by MAPKAP kinases
0.1	3.9	PID_CASPASE_PATHWAY	Caspase cascade in apoptosis
0.1	3.6	ST_T_CELL_SIGNAL_TRANSDUCTION	T Cell Signal Transduction
0.1	3.0	PID_REELIN_PATHWAY	Reelin signaling pathway
0.1	1.9	ST_G_ALPHA_I_PATHWAY	G alpha i Pathway
0.1	1.8	PID_NETRIN_PATHWAY	Netrin-mediated signaling events
0.0	1.5	PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY	Signaling mediated by p38-alpha and p38-beta
0.0	1.1	PID_FOXM1_PATHWAY	FOXM1 transcription factor network
0.0	0.7	PID_TCR_CALCIUM_PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.0	0.4	PID_NFAT_TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0	0.2	PID_INTEGRIN_CS_PATHWAY	Integrin family cell surface interactions

Gene overrepresentation in C2:CP:REACTOME category:

Search:

Show entries

Showing 1 to 20 of 32 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.4	9.5	REACTOME_CGMP_EFFECTS	Genes involved in cGMP effects
0.3	8.7	REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII	Genes involved in CREB phosphorylation through the activation of CaMKII
0.2	5.5	REACTOME_NEPHRIN_INTERACTIONS	Genes involved in Nephrin interactions
0.3	3.6	REACTOME_AMINE_DERIVED_HORMONES	Genes involved in Amine-derived hormones
0.2	3.6	REACTOME_ACTIVATION_OF_RAC	Genes involved in Activation of Rac
0.1	3.6	REACTOME_EXTENSION_OF_TELOMERES	Genes involved in Extension of Telomeres
0.1	3.5	REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS	Genes involved in Class B/2 (Secretin family receptors)
0.1	3.4	REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.0	2.5	REACTOME_SIGNALING_BY_RHO_GTPASES	Genes involved in Signaling by Rho GTPases
0.2	2.4	REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE	Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.1	2.1	REACTOME_COLLAGEN_FORMATION	Genes involved in Collagen formation
0.1	1.9	REACTOME_ERK_MAPK_TARGETS	Genes involved in ERK/MAPK targets
0.0	1.9	REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS	Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1	1.8	REACTOME_THE_ROLE_OF_NEF_IN_HIV1_REPLICATION_AND_DISEASE_PATHOGENESIS	Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0	1.8	REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY	Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1	1.7	REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS	Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0	1.6	REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives
0.1	1.4	REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.0	0.7	REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.0	0.7	REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES	Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)