Motif ID: Mef2c
Z-value: 0.706
Transcription factors associated with Mef2c:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Mef2c | ENSMUSG00000005583.10 | Mef2c |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Mef2c | mm10_v2_chr13_+_83504032_83504050 | -0.21 | 6.2e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 18.7 | GO:0042572 | retinol metabolic process(GO:0042572) |
| 1.5 | 15.3 | GO:0034983 | peptidyl-lysine deacetylation(GO:0034983) |
| 1.0 | 5.2 | GO:0035063 | nuclear speck organization(GO:0035063) |
| 0.9 | 5.2 | GO:0042535 | positive regulation of tumor necrosis factor biosynthetic process(GO:0042535) |
| 0.9 | 5.2 | GO:0015015 | heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015) |
| 0.7 | 8.0 | GO:0010650 | positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827) |
| 0.6 | 2.6 | GO:0015793 | glycerol transport(GO:0015793) |
| 0.6 | 7.1 | GO:0070886 | positive regulation of calcineurin-NFAT signaling cascade(GO:0070886) |
| 0.6 | 1.3 | GO:1901420 | negative regulation of response to alcohol(GO:1901420) |
| 0.6 | 1.8 | GO:0070375 | ERK5 cascade(GO:0070375) |
| 0.6 | 1.8 | GO:0045414 | regulation of muscle hyperplasia(GO:0014738) muscle hyperplasia(GO:0014900) regulation of interleukin-8 biosynthetic process(GO:0045414) |
| 0.6 | 1.7 | GO:0014834 | skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration(GO:0014834) |
| 0.6 | 5.2 | GO:0042760 | very long-chain fatty acid catabolic process(GO:0042760) |
| 0.5 | 1.6 | GO:0060399 | positive regulation of growth hormone receptor signaling pathway(GO:0060399) |
| 0.5 | 1.5 | GO:2000334 | response to linoleic acid(GO:0070543) blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334) |
| 0.5 | 5.3 | GO:2000741 | positive regulation of mesenchymal stem cell differentiation(GO:2000741) |
| 0.5 | 2.4 | GO:0071688 | striated muscle myosin thick filament assembly(GO:0071688) |
| 0.5 | 2.4 | GO:0042636 | negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279) |
| 0.5 | 2.3 | GO:0002024 | diet induced thermogenesis(GO:0002024) |
| 0.4 | 2.2 | GO:0098914 | membrane repolarization during atrial cardiac muscle cell action potential(GO:0098914) |
| 0.4 | 2.6 | GO:0034773 | histone H4-K20 trimethylation(GO:0034773) establishment of Sertoli cell barrier(GO:0097368) |
| 0.4 | 1.3 | GO:0014809 | regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809) |
| 0.4 | 4.3 | GO:0014883 | transition between fast and slow fiber(GO:0014883) |
| 0.4 | 1.8 | GO:0042045 | epithelial fluid transport(GO:0042045) |
| 0.3 | 1.7 | GO:0010701 | positive regulation of norepinephrine secretion(GO:0010701) positive regulation of inositol trisphosphate biosynthetic process(GO:0032962) |
| 0.3 | 2.1 | GO:0010747 | positive regulation of plasma membrane long-chain fatty acid transport(GO:0010747) |
| 0.3 | 1.0 | GO:0007525 | somatic muscle development(GO:0007525) |
| 0.3 | 0.5 | GO:0071286 | cellular response to magnesium ion(GO:0071286) |
| 0.3 | 0.8 | GO:1901509 | regulation of endothelial tube morphogenesis(GO:1901509) |
| 0.3 | 1.0 | GO:0007262 | STAT protein import into nucleus(GO:0007262) |
| 0.2 | 5.7 | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis(GO:0051044) |
| 0.2 | 1.6 | GO:0043569 | negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569) |
| 0.2 | 2.2 | GO:0019227 | neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870) |
| 0.2 | 8.5 | GO:0003301 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.2 | 4.0 | GO:0008209 | androgen metabolic process(GO:0008209) |
| 0.2 | 0.5 | GO:0003345 | proepicardium cell migration involved in pericardium morphogenesis(GO:0003345) |
| 0.2 | 1.2 | GO:0015862 | uridine transport(GO:0015862) |
| 0.2 | 0.5 | GO:0046900 | tetrahydrofolylpolyglutamate metabolic process(GO:0046900) |
| 0.2 | 0.5 | GO:1903644 | regulation of chaperone-mediated protein folding(GO:1903644) |
| 0.1 | 1.0 | GO:0043553 | negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553) |
| 0.1 | 0.7 | GO:0051365 | cellular response to potassium ion starvation(GO:0051365) |
| 0.1 | 1.4 | GO:1901409 | positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409) |
| 0.1 | 1.4 | GO:1902083 | negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083) |
| 0.1 | 2.5 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
| 0.1 | 1.1 | GO:0097118 | neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118) |
| 0.1 | 0.5 | GO:0031133 | cellular magnesium ion homeostasis(GO:0010961) regulation of axon diameter(GO:0031133) |
| 0.1 | 2.7 | GO:0007614 | short-term memory(GO:0007614) |
| 0.1 | 1.3 | GO:2000291 | regulation of myoblast proliferation(GO:2000291) |
| 0.1 | 0.4 | GO:0006447 | regulation of translational initiation by iron(GO:0006447) positive regulation of translational initiation by iron(GO:0045994) |
| 0.1 | 1.2 | GO:0061469 | regulation of type B pancreatic cell proliferation(GO:0061469) |
| 0.1 | 1.0 | GO:0051574 | positive regulation of histone H3-K9 methylation(GO:0051574) |
| 0.1 | 0.7 | GO:1990001 | inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001) |
| 0.1 | 3.1 | GO:0045604 | regulation of epidermal cell differentiation(GO:0045604) |
| 0.1 | 1.6 | GO:0044381 | glucose import in response to insulin stimulus(GO:0044381) |
| 0.1 | 0.3 | GO:1904425 | negative regulation of GTP binding(GO:1904425) |
| 0.1 | 1.7 | GO:0010758 | regulation of macrophage chemotaxis(GO:0010758) |
| 0.1 | 0.6 | GO:0033601 | positive regulation of mammary gland epithelial cell proliferation(GO:0033601) regulation of wound healing, spreading of epidermal cells(GO:1903689) positive regulation of lamellipodium morphogenesis(GO:2000394) |
| 0.1 | 2.1 | GO:0015804 | neutral amino acid transport(GO:0015804) |
| 0.1 | 0.3 | GO:0099525 | presynaptic dense core granule exocytosis(GO:0099525) |
| 0.1 | 1.5 | GO:0007097 | nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023) |
| 0.0 | 2.6 | GO:0030514 | negative regulation of BMP signaling pathway(GO:0030514) |
| 0.0 | 0.6 | GO:0035988 | chondrocyte proliferation(GO:0035988) |
| 0.0 | 0.6 | GO:0090129 | positive regulation of synapse maturation(GO:0090129) |
| 0.0 | 1.3 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 0.0 | 0.4 | GO:0010960 | magnesium ion homeostasis(GO:0010960) |
| 0.0 | 2.0 | GO:0031338 | regulation of vesicle fusion(GO:0031338) |
| 0.0 | 0.1 | GO:0010814 | substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959) |
| 0.0 | 0.7 | GO:0007274 | neuromuscular synaptic transmission(GO:0007274) |
| 0.0 | 0.3 | GO:1900383 | regulation of synaptic plasticity by receptor localization to synapse(GO:1900383) |
| 0.0 | 0.7 | GO:0051084 | 'de novo' posttranslational protein folding(GO:0051084) |
| 0.0 | 2.8 | GO:0072332 | intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332) |
| 0.0 | 1.0 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 0.0 | 1.5 | GO:0050885 | neuromuscular process controlling balance(GO:0050885) |
| 0.0 | 1.0 | GO:0061077 | chaperone-mediated protein folding(GO:0061077) |
| 0.0 | 0.9 | GO:0043044 | ATP-dependent chromatin remodeling(GO:0043044) |
| 0.0 | 0.4 | GO:0035235 | ionotropic glutamate receptor signaling pathway(GO:0035235) |
| 0.0 | 2.7 | GO:0048813 | dendrite morphogenesis(GO:0048813) |
| 0.0 | 0.2 | GO:0090557 | establishment of endothelial intestinal barrier(GO:0090557) |
| 0.0 | 0.1 | GO:0035609 | C-terminal protein deglutamylation(GO:0035609) |
| 0.0 | 0.4 | GO:0021799 | cerebral cortex radially oriented cell migration(GO:0021799) |
| 0.0 | 1.0 | GO:0010811 | positive regulation of cell-substrate adhesion(GO:0010811) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 4.3 | GO:0071148 | TEAD-1-YAP complex(GO:0071148) |
| 0.9 | 5.2 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.8 | 2.4 | GO:0043512 | inhibin A complex(GO:0043512) |
| 0.6 | 1.8 | GO:0031088 | platelet dense granule membrane(GO:0031088) |
| 0.4 | 8.0 | GO:0014731 | spectrin-associated cytoskeleton(GO:0014731) |
| 0.4 | 1.5 | GO:0032127 | dense core granule membrane(GO:0032127) |
| 0.3 | 2.8 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
| 0.3 | 1.3 | GO:0014802 | terminal cisterna(GO:0014802) |
| 0.3 | 1.1 | GO:0090537 | CERF complex(GO:0090537) |
| 0.2 | 0.8 | GO:0008282 | ATP-sensitive potassium channel complex(GO:0008282) |
| 0.2 | 16.3 | GO:0035097 | histone methyltransferase complex(GO:0035097) |
| 0.1 | 1.2 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
| 0.1 | 1.0 | GO:0005664 | origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664) |
| 0.1 | 0.7 | GO:0035976 | AP1 complex(GO:0035976) |
| 0.1 | 2.1 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.1 | 4.3 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.1 | 2.4 | GO:0005865 | striated muscle thin filament(GO:0005865) |
| 0.1 | 1.6 | GO:0032593 | insulin-responsive compartment(GO:0032593) |
| 0.1 | 1.6 | GO:0010369 | chromocenter(GO:0010369) |
| 0.1 | 0.3 | GO:0098831 | presynaptic active zone cytoplasmic component(GO:0098831) |
| 0.1 | 0.6 | GO:0097197 | tetraspanin-enriched microdomain(GO:0097197) |
| 0.1 | 1.0 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.1 | 0.4 | GO:0005964 | phosphorylase kinase complex(GO:0005964) |
| 0.1 | 2.2 | GO:0005790 | smooth endoplasmic reticulum(GO:0005790) |
| 0.0 | 1.7 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.0 | 1.0 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.0 | 3.5 | GO:0005778 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 0.0 | 4.8 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.0 | 1.6 | GO:0031941 | filamentous actin(GO:0031941) |
| 0.0 | 0.5 | GO:0008305 | integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636) |
| 0.0 | 2.6 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.0 | 6.7 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.0 | 1.4 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
| 0.0 | 0.7 | GO:0005719 | nuclear euchromatin(GO:0005719) |
| 0.0 | 2.1 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.0 | 7.2 | GO:0014069 | postsynaptic density(GO:0014069) |
| 0.0 | 1.5 | GO:0005901 | caveola(GO:0005901) |
| 0.0 | 3.1 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 0.0 | 0.1 | GO:0033093 | Weibel-Palade body(GO:0033093) |
| 0.0 | 0.6 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.0 | 0.2 | GO:0031091 | platelet alpha granule(GO:0031091) |
| 0.0 | 2.4 | GO:0045121 | membrane raft(GO:0045121) membrane microdomain(GO:0098857) |
| 0.0 | 1.6 | GO:0030027 | lamellipodium(GO:0030027) |
| 0.0 | 4.7 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.0 | 2.7 | GO:0000139 | Golgi membrane(GO:0000139) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.7 | 18.7 | GO:0052650 | NADP-retinol dehydrogenase activity(GO:0052650) |
| 1.3 | 5.2 | GO:0017095 | heparan sulfate 6-O-sulfotransferase activity(GO:0017095) |
| 0.6 | 14.5 | GO:0031078 | histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) |
| 0.6 | 1.8 | GO:0005220 | inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220) |
| 0.6 | 3.4 | GO:0070699 | type II activin receptor binding(GO:0070699) |
| 0.5 | 2.2 | GO:0016286 | small conductance calcium-activated potassium channel activity(GO:0016286) |
| 0.5 | 2.6 | GO:0015166 | polyol transmembrane transporter activity(GO:0015166) glycerol transmembrane transporter activity(GO:0015168) |
| 0.5 | 1.5 | GO:0070892 | lipoteichoic acid receptor activity(GO:0070892) |
| 0.5 | 5.7 | GO:0019855 | calcium channel inhibitor activity(GO:0019855) |
| 0.4 | 1.6 | GO:0055056 | D-glucose transmembrane transporter activity(GO:0055056) |
| 0.4 | 1.1 | GO:0070615 | nucleosome-dependent ATPase activity(GO:0070615) |
| 0.4 | 1.8 | GO:0001010 | transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010) |
| 0.3 | 1.0 | GO:0036313 | phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313) |
| 0.3 | 2.8 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
| 0.3 | 4.3 | GO:0001134 | transcription factor activity, transcription factor recruiting(GO:0001134) |
| 0.3 | 0.8 | GO:0008113 | peptide-methionine (S)-S-oxide reductase activity(GO:0008113) |
| 0.3 | 2.4 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.2 | 2.1 | GO:0019534 | toxin transporter activity(GO:0019534) |
| 0.2 | 1.0 | GO:0004095 | carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416) |
| 0.2 | 6.5 | GO:0042805 | actinin binding(GO:0042805) |
| 0.2 | 1.7 | GO:0070679 | inositol 1,4,5 trisphosphate binding(GO:0070679) |
| 0.2 | 2.2 | GO:0005225 | volume-sensitive anion channel activity(GO:0005225) |
| 0.2 | 0.5 | GO:0098639 | collagen binding involved in cell-matrix adhesion(GO:0098639) |
| 0.2 | 1.6 | GO:0004445 | inositol-polyphosphate 5-phosphatase activity(GO:0004445) inositol trisphosphate phosphatase activity(GO:0046030) |
| 0.2 | 4.0 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
| 0.2 | 5.2 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
| 0.2 | 2.2 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 0.1 | 0.7 | GO:0004382 | guanosine-diphosphatase activity(GO:0004382) |
| 0.1 | 8.3 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.1 | 2.6 | GO:0070410 | co-SMAD binding(GO:0070410) |
| 0.1 | 2.1 | GO:0102391 | decanoate--CoA ligase activity(GO:0102391) |
| 0.1 | 1.7 | GO:0016290 | palmitoyl-CoA hydrolase activity(GO:0016290) |
| 0.1 | 2.2 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.1 | 1.0 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 0.1 | 0.8 | GO:0044548 | S100 protein binding(GO:0044548) |
| 0.1 | 0.4 | GO:0070644 | vitamin D response element binding(GO:0070644) |
| 0.1 | 0.4 | GO:0004689 | phosphorylase kinase activity(GO:0004689) |
| 0.1 | 0.4 | GO:0009019 | tRNA (guanine-N1-)-methyltransferase activity(GO:0009019) |
| 0.1 | 0.8 | GO:0043495 | protein anchor(GO:0043495) |
| 0.0 | 1.2 | GO:0005337 | nucleoside transmembrane transporter activity(GO:0005337) |
| 0.0 | 1.8 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 0.0 | 1.4 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.0 | 2.1 | GO:0005254 | chloride channel activity(GO:0005254) |
| 0.0 | 0.7 | GO:0035497 | cAMP response element binding(GO:0035497) |
| 0.0 | 1.0 | GO:0001968 | fibronectin binding(GO:0001968) |
| 0.0 | 4.3 | GO:0042626 | ATPase activity, coupled to transmembrane movement of substances(GO:0042626) |
| 0.0 | 0.5 | GO:0045499 | chemorepellent activity(GO:0045499) |
| 0.0 | 1.3 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.0 | 6.4 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.0 | 0.5 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
| 0.0 | 1.0 | GO:0032452 | histone demethylase activity(GO:0032452) |
| 0.0 | 1.0 | GO:0051879 | Hsp90 protein binding(GO:0051879) |
| 0.0 | 1.8 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 0.6 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
| 0.0 | 0.9 | GO:0051018 | protein kinase A binding(GO:0051018) |
| 0.0 | 0.5 | GO:0016881 | acid-amino acid ligase activity(GO:0016881) |
| 0.0 | 0.6 | GO:0005246 | calcium channel regulator activity(GO:0005246) |
| 0.0 | 0.5 | GO:0070888 | E-box binding(GO:0070888) |
| 0.0 | 0.5 | GO:0001671 | ATPase activator activity(GO:0001671) |
| 0.0 | 2.5 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.0 | 0.5 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.0 | 2.0 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.0 | 2.8 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.0 | 0.3 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
| 0.0 | 4.3 | GO:0005509 | calcium ion binding(GO:0005509) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 18.2 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.2 | 14.9 | PID_HDAC_CLASSI_PATHWAY | Signaling events mediated by HDAC Class I |
| 0.1 | 3.9 | PID_P38_MK2_PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.1 | 2.9 | PID_INSULIN_GLUCOSE_PATHWAY | Insulin-mediated glucose transport |
| 0.1 | 5.6 | PID_PI3KCI_PATHWAY | Class I PI3K signaling events |
| 0.1 | 1.8 | ST_WNT_CA2_CYCLIC_GMP_PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.1 | 2.4 | PID_ALK1_PATHWAY | ALK1 signaling events |
| 0.1 | 1.7 | PID_SYNDECAN_4_PATHWAY | Syndecan-4-mediated signaling events |
| 0.1 | 0.7 | PID_TCR_JNK_PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.0 | 1.6 | PID_RXR_VDR_PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 0.5 | PID_ERBB_NETWORK_PATHWAY | ErbB receptor signaling network |
| 0.0 | 3.0 | PID_BETA_CATENIN_NUC_PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 2.6 | PID_AP1_PATHWAY | AP-1 transcription factor network |
| 0.0 | 0.5 | PID_INTEGRIN_CS_PATHWAY | Integrin family cell surface interactions |
| 0.0 | 0.7 | SA_CASPASE_CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.0 | 1.0 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 0.6 | PID_ARF6_PATHWAY | Arf6 signaling events |
| 0.0 | 1.5 | PID_CDC42_PATHWAY | CDC42 signaling events |
| 0.0 | 0.5 | PID_DELTA_NP63_PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 0.8 | PID_FGF_PATHWAY | FGF signaling pathway |
| 0.0 | 0.2 | PID_INTEGRIN2_PATHWAY | Beta2 integrin cell surface interactions |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 2.4 | REACTOME_GLYCOPROTEIN_HORMONES | Genes involved in Glycoprotein hormones |
| 0.3 | 2.6 | REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.2 | 8.0 | REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.2 | 15.0 | REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.2 | 4.7 | REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.2 | 3.5 | REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.1 | 1.6 | REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 0.1 | 5.2 | REACTOME_HS_GAG_BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.1 | 2.6 | REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.1 | 1.8 | REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.1 | 1.0 | REACTOME_E2F_ENABLED_INHIBITION_OF_PRE_REPLICATION_COMPLEX_FORMATION | Genes involved in E2F-enabled inhibition of pre-replication complex formation |
| 0.1 | 0.8 | REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION | Genes involved in FGFR4 ligand binding and activation |
| 0.1 | 2.4 | REACTOME_STRIATED_MUSCLE_CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.1 | 5.2 | REACTOME_DESTABILIZATION_OF_MRNA_BY_AUF1_HNRNP_D0 | Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0) |
| 0.1 | 0.8 | REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT | Genes involved in ABC-family proteins mediated transport |
| 0.1 | 2.1 | REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.1 | 1.5 | REACTOME_ANTIGEN_PROCESSING_CROSS_PRESENTATION | Genes involved in Antigen processing-Cross presentation |
| 0.1 | 2.1 | REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.1 | 1.0 | REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE | Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle |
| 0.1 | 1.6 | REACTOME_IL_RECEPTOR_SHC_SIGNALING | Genes involved in Interleukin receptor SHC signaling |
| 0.0 | 0.7 | REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |
| 0.0 | 0.5 | REACTOME_SIGNALING_BY_CONSTITUTIVELY_ACTIVE_EGFR | Genes involved in Signaling by constitutively active EGFR |
| 0.0 | 1.2 | REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.0 | 1.2 | REACTOME_PIP3_ACTIVATES_AKT_SIGNALING | Genes involved in PIP3 activates AKT signaling |
| 0.0 | 0.5 | REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.0 | 3.1 | REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.0 | 0.7 | REACTOME_NOD1_2_SIGNALING_PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.0 | 0.5 | REACTOME_METAL_ION_SLC_TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.0 | 1.1 | REACTOME_POTASSIUM_CHANNELS | Genes involved in Potassium Channels |
