Motif ID: Mef2c

Z-value: 0.706


Transcription factors associated with Mef2c:

Gene SymbolEntrez IDGene Name
Mef2c ENSMUSG00000005583.10 Mef2c

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mef2cmm10_v2_chr13_+_83504032_83504050-0.216.2e-02Click!


Activity profile for motif Mef2c.

activity profile for motif Mef2c


Sorted Z-values histogram for motif Mef2c

Sorted Z-values for motif Mef2c



Network of associatons between targets according to the STRING database.



First level regulatory network of Mef2c

PNG image of the network

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Top targets:


Showing 1 to 20 of 186 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_-_34528844 15.346 ENSMUST00000110819.2
 Hdac9
histone deacetylase 9
chr4_+_144892813 7.396 ENSMUST00000105744.1
ENSMUST00000171001.1
 Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr6_+_112273758 6.358 ENSMUST00000032376.5
 Lmcd1
LIM and cysteine-rich domains 1
chr4_+_144893077 5.987 ENSMUST00000154208.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr3_-_85722474 5.728 ENSMUST00000119077.1
 Fam160a1
family with sequence similarity 160, member A1
chr4_+_144893127 5.320 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr19_-_5802640 5.228 ENSMUST00000173523.1
ENSMUST00000173499.1
ENSMUST00000172812.2
 Malat1


metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)


chr10_+_69785507 4.363 ENSMUST00000182993.1
 Ank3
ankyrin 3, epithelial
chr7_+_112742025 4.284 ENSMUST00000164363.1
 Tead1
TEA domain family member 1
chr15_-_91191733 3.479 ENSMUST00000069511.6
 Abcd2
ATP-binding cassette, sub-family D (ALD), member 2
chr5_+_66745835 3.465 ENSMUST00000101164.4
ENSMUST00000118242.1
ENSMUST00000119854.1
ENSMUST00000117601.1
 Limch1



LIM and calponin homology domains 1



chr2_+_91256144 3.314 ENSMUST00000154959.1
ENSMUST00000059566.4
 Pacsin3

protein kinase C and casein kinase substrate in neurons 3

chr14_+_101840602 3.025 ENSMUST00000159314.1
 Lmo7
LIM domain only 7
chr8_+_45658273 2.975 ENSMUST00000153798.1
 Sorbs2
sorbin and SH3 domain containing 2
chr5_-_111761697 2.933 ENSMUST00000129146.1
ENSMUST00000137398.1
ENSMUST00000129065.1
 E130006D01Rik


RIKEN cDNA E130006D01 gene


chr2_-_77703252 2.847 ENSMUST00000171063.1
 Zfp385b
zinc finger protein 385B
chr7_-_115846080 2.819 ENSMUST00000166207.1
 Sox6
SRY-box containing gene 6
chr5_+_135887988 2.726 ENSMUST00000111155.1
 Hspb1
heat shock protein 1
chr5_-_122002340 2.668 ENSMUST00000134326.1
 Cux2
cut-like homeobox 2
chr3_+_103279293 2.632 ENSMUST00000029444.6
ENSMUST00000106860.1
 Trim33

tripartite motif-containing 33


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 81 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.7 18.7 GO:0042572 retinol metabolic process(GO:0042572)
1.5 15.3 GO:0034983 peptidyl-lysine deacetylation(GO:0034983)
0.2 8.5 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.7 8.0 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.6 7.1 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.2 5.7 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.5 5.3 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
1.0 5.2 GO:0035063 nuclear speck organization(GO:0035063)
0.9 5.2 GO:0042535 positive regulation of tumor necrosis factor biosynthetic process(GO:0042535)
0.9 5.2 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.6 5.2 GO:0042760 very long-chain fatty acid catabolic process(GO:0042760)
0.4 4.3 GO:0014883 transition between fast and slow fiber(GO:0014883)
0.2 4.0 GO:0008209 androgen metabolic process(GO:0008209)
0.1 3.1 GO:0045604 regulation of epidermal cell differentiation(GO:0045604)
0.0 2.8 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.1 2.7 GO:0007614 short-term memory(GO:0007614)
0.0 2.7 GO:0048813 dendrite morphogenesis(GO:0048813)
0.6 2.6 GO:0015793 glycerol transport(GO:0015793)
0.4 2.6 GO:0034773 histone H4-K20 trimethylation(GO:0034773) establishment of Sertoli cell barrier(GO:0097368)
0.0 2.6 GO:0030514 negative regulation of BMP signaling pathway(GO:0030514)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 16.3 GO:0035097 histone methyltransferase complex(GO:0035097)
0.4 8.0 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 7.2 GO:0014069 postsynaptic density(GO:0014069)
0.0 6.7 GO:0005802 trans-Golgi network(GO:0005802)
0.9 5.2 GO:0097512 cardiac myofibril(GO:0097512)
0.0 4.8 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 4.7 GO:0031012 extracellular matrix(GO:0031012)
1.1 4.3 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.1 4.3 GO:0034707 chloride channel complex(GO:0034707)
0.0 3.5 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 3.1 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.3 2.8 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 2.7 GO:0000139 Golgi membrane(GO:0000139)
0.0 2.6 GO:0032587 ruffle membrane(GO:0032587)
0.8 2.4 GO:0043512 inhibin A complex(GO:0043512)
0.1 2.4 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 2.4 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.1 2.2 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.1 2.1 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 2.1 GO:0017053 transcriptional repressor complex(GO:0017053)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 65 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.7 18.7 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.6 14.5 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.1 8.3 GO:0030507 spectrin binding(GO:0030507)
0.2 6.5 GO:0042805 actinin binding(GO:0042805)
0.0 6.4 GO:0003714 transcription corepressor activity(GO:0003714)
0.5 5.7 GO:0019855 calcium channel inhibitor activity(GO:0019855)
1.3 5.2 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.2 5.2 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.3 4.3 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.0 4.3 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.0 4.3 GO:0005509 calcium ion binding(GO:0005509)
0.2 4.0 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.6 3.4 GO:0070699 type II activin receptor binding(GO:0070699)
0.3 2.8 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 2.8 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.5 2.6 GO:0015166 polyol transmembrane transporter activity(GO:0015166) glycerol transmembrane transporter activity(GO:0015168)
0.1 2.6 GO:0070410 co-SMAD binding(GO:0070410)
0.0 2.5 GO:0051015 actin filament binding(GO:0051015)
0.3 2.4 GO:0005523 tropomyosin binding(GO:0005523)
0.5 2.2 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 18.2 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.2 14.9 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.1 5.6 PID_PI3KCI_PATHWAY Class I PI3K signaling events
0.1 3.9 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 3.0 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 2.9 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 2.6 PID_AP1_PATHWAY AP-1 transcription factor network
0.1 2.4 PID_ALK1_PATHWAY ALK1 signaling events
0.1 1.8 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 1.7 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.0 1.6 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 1.5 PID_CDC42_PATHWAY CDC42 signaling events
0.0 1.0 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.8 PID_FGF_PATHWAY FGF signaling pathway
0.1 0.7 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.7 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 0.6 PID_ARF6_PATHWAY Arf6 signaling events
0.0 0.5 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 0.5 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.0 0.5 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 15.0 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.2 8.0 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 5.2 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 5.2 REACTOME_DESTABILIZATION_OF_MRNA_BY_AUF1_HNRNP_D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.2 4.7 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.2 3.5 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 3.1 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.3 2.6 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.1 2.6 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.6 2.4 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.1 2.4 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.1 2.1 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1 2.1 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 1.8 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.1 1.6 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.1 1.6 REACTOME_IL_RECEPTOR_SHC_SIGNALING Genes involved in Interleukin receptor SHC signaling
0.1 1.5 REACTOME_ANTIGEN_PROCESSING_CROSS_PRESENTATION Genes involved in Antigen processing-Cross presentation
0.0 1.2 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 1.2 REACTOME_PIP3_ACTIVATES_AKT_SIGNALING Genes involved in PIP3 activates AKT signaling
0.0 1.1 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels