Motif ID: Mef2d_Mef2a
Z-value: 1.578
Transcription factors associated with Mef2d_Mef2a:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Mef2a | ENSMUSG00000030557.10 | Mef2a |
| Mef2d | ENSMUSG00000001419.11 | Mef2d |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Mef2d | mm10_v2_chr3_+_88142328_88142483 | 0.43 | 8.6e-05 | Click! |
| Mef2a | mm10_v2_chr7_-_67372846_67372858 | 0.36 | 1.2e-03 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 15.9 | 47.6 | GO:0007521 | muscle cell fate determination(GO:0007521) cellular response to parathyroid hormone stimulus(GO:0071374) positive regulation of macrophage apoptotic process(GO:2000111) |
| 7.6 | 22.8 | GO:0001928 | regulation of exocyst assembly(GO:0001928) |
| 6.2 | 18.7 | GO:0032241 | positive regulation of nucleobase-containing compound transport(GO:0032241) regulation of nucleoside transport(GO:0032242) negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256) |
| 5.6 | 22.5 | GO:0099566 | regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566) |
| 5.2 | 25.8 | GO:0042636 | negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279) |
| 5.2 | 25.8 | GO:0002121 | inter-male aggressive behavior(GO:0002121) |
| 5.0 | 15.0 | GO:0010752 | signal complex assembly(GO:0007172) regulation of cGMP-mediated signaling(GO:0010752) |
| 4.7 | 28.0 | GO:0015015 | heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015) |
| 3.1 | 28.1 | GO:0043615 | astrocyte cell migration(GO:0043615) |
| 2.9 | 20.5 | GO:0071376 | response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376) |
| 2.8 | 8.5 | GO:1903538 | meiotic cell cycle process involved in oocyte maturation(GO:1903537) regulation of meiotic cell cycle process involved in oocyte maturation(GO:1903538) |
| 2.6 | 18.4 | GO:0014819 | regulation of skeletal muscle contraction(GO:0014819) |
| 2.6 | 7.8 | GO:0007525 | somatic muscle development(GO:0007525) |
| 2.6 | 7.8 | GO:0035790 | platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790) |
| 2.5 | 12.7 | GO:0003105 | negative regulation of glomerular filtration(GO:0003105) |
| 2.5 | 34.7 | GO:0045161 | neuronal ion channel clustering(GO:0045161) |
| 2.4 | 12.2 | GO:1900748 | positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748) |
| 2.4 | 9.7 | GO:1904425 | negative regulation of GTP binding(GO:1904425) |
| 2.4 | 7.2 | GO:0002182 | cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248) |
| 2.3 | 6.9 | GO:1903279 | regulation of calcium:sodium antiporter activity(GO:1903279) |
| 2.2 | 8.9 | GO:1904457 | positive regulation of neuronal action potential(GO:1904457) |
| 1.9 | 7.4 | GO:0007066 | female meiosis sister chromatid cohesion(GO:0007066) |
| 1.8 | 12.9 | GO:0098909 | establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200) regulation of cardiac muscle cell action potential involved in regulation of contraction(GO:0098909) |
| 1.7 | 12.0 | GO:0015862 | uridine transport(GO:0015862) |
| 1.7 | 6.7 | GO:1904048 | negative regulation of synaptic vesicle recycling(GO:1903422) regulation of spontaneous neurotransmitter secretion(GO:1904048) |
| 1.5 | 4.6 | GO:0042264 | peptidyl-aspartic acid hydroxylation(GO:0042264) |
| 1.4 | 5.6 | GO:2000182 | regulation of progesterone biosynthetic process(GO:2000182) |
| 1.3 | 8.0 | GO:0046103 | ADP biosynthetic process(GO:0006172) inosine biosynthetic process(GO:0046103) |
| 1.3 | 15.0 | GO:1900383 | regulation of synaptic plasticity by receptor localization to synapse(GO:1900383) |
| 1.2 | 7.4 | GO:0098964 | dendritic transport of ribonucleoprotein complex(GO:0098961) dendritic transport of messenger ribonucleoprotein complex(GO:0098963) anterograde dendritic transport of messenger ribonucleoprotein complex(GO:0098964) |
| 1.1 | 3.4 | GO:0006059 | hexitol metabolic process(GO:0006059) alditol biosynthetic process(GO:0019401) |
| 1.1 | 3.2 | GO:2000987 | positive regulation of fear response(GO:1903367) positive regulation of behavioral fear response(GO:2000987) |
| 1.1 | 3.2 | GO:0003345 | proepicardium cell migration involved in pericardium morphogenesis(GO:0003345) |
| 1.0 | 8.4 | GO:2000766 | negative regulation of cytoplasmic translation(GO:2000766) |
| 1.0 | 5.1 | GO:0051365 | cellular response to potassium ion starvation(GO:0051365) |
| 1.0 | 3.0 | GO:0070375 | ERK5 cascade(GO:0070375) |
| 1.0 | 4.8 | GO:0045347 | negative regulation of MHC class II biosynthetic process(GO:0045347) |
| 1.0 | 3.8 | GO:1903984 | positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984) |
| 0.9 | 49.3 | GO:0034605 | cellular response to heat(GO:0034605) |
| 0.9 | 7.4 | GO:0031666 | positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666) |
| 0.9 | 5.2 | GO:1902998 | macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998) |
| 0.9 | 1.7 | GO:0061300 | cerebellum vasculature development(GO:0061300) |
| 0.8 | 12.1 | GO:0006706 | steroid catabolic process(GO:0006706) |
| 0.8 | 2.4 | GO:0046900 | tetrahydrofolylpolyglutamate metabolic process(GO:0046900) |
| 0.8 | 3.9 | GO:0032485 | regulation of Ral protein signal transduction(GO:0032485) |
| 0.8 | 3.9 | GO:0046684 | response to insecticide(GO:0017085) response to pyrethroid(GO:0046684) |
| 0.8 | 10.1 | GO:0001553 | luteinization(GO:0001553) |
| 0.8 | 2.3 | GO:2000224 | testosterone biosynthetic process(GO:0061370) regulation of testosterone biosynthetic process(GO:2000224) |
| 0.7 | 0.7 | GO:0003219 | cardiac right ventricle formation(GO:0003219) |
| 0.7 | 2.8 | GO:0051643 | endoplasmic reticulum localization(GO:0051643) |
| 0.7 | 5.5 | GO:0060120 | auditory receptor cell fate commitment(GO:0009912) inner ear receptor cell fate commitment(GO:0060120) |
| 0.7 | 6.2 | GO:0046543 | development of secondary female sexual characteristics(GO:0046543) |
| 0.7 | 8.9 | GO:0070842 | aggresome assembly(GO:0070842) |
| 0.7 | 5.4 | GO:0097118 | neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118) |
| 0.6 | 7.7 | GO:0060732 | positive regulation of inositol phosphate biosynthetic process(GO:0060732) |
| 0.6 | 7.0 | GO:0031274 | positive regulation of pseudopodium assembly(GO:0031274) |
| 0.6 | 23.6 | GO:0010614 | negative regulation of cardiac muscle hypertrophy(GO:0010614) |
| 0.6 | 4.5 | GO:2000074 | regulation of type B pancreatic cell development(GO:2000074) |
| 0.6 | 3.4 | GO:0099525 | presynaptic dense core granule exocytosis(GO:0099525) |
| 0.5 | 7.3 | GO:0006883 | cellular sodium ion homeostasis(GO:0006883) |
| 0.5 | 4.7 | GO:1903025 | regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903025) |
| 0.5 | 1.5 | GO:0035523 | protein K29-linked deubiquitination(GO:0035523) protein K6-linked deubiquitination(GO:0044313) |
| 0.5 | 5.6 | GO:0098989 | NMDA selective glutamate receptor signaling pathway(GO:0098989) |
| 0.4 | 2.7 | GO:1902261 | positive regulation of delayed rectifier potassium channel activity(GO:1902261) |
| 0.4 | 3.1 | GO:0019388 | galactose catabolic process(GO:0019388) |
| 0.4 | 10.5 | GO:0032011 | ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012) |
| 0.4 | 4.0 | GO:0046512 | sphingosine biosynthetic process(GO:0046512) sphingoid biosynthetic process(GO:0046520) |
| 0.4 | 2.0 | GO:2000255 | negative regulation of male germ cell proliferation(GO:2000255) |
| 0.4 | 8.3 | GO:0070536 | protein K63-linked deubiquitination(GO:0070536) |
| 0.4 | 2.2 | GO:0035093 | spermatogenesis, exchange of chromosomal proteins(GO:0035093) |
| 0.3 | 2.4 | GO:0061092 | involuntary skeletal muscle contraction(GO:0003011) regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092) |
| 0.3 | 0.3 | GO:0046878 | positive regulation of saliva secretion(GO:0046878) |
| 0.3 | 2.6 | GO:0048170 | positive regulation of long-term neuronal synaptic plasticity(GO:0048170) |
| 0.3 | 1.5 | GO:0010961 | cellular magnesium ion homeostasis(GO:0010961) |
| 0.3 | 22.0 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
| 0.3 | 2.5 | GO:0006013 | mannose metabolic process(GO:0006013) |
| 0.3 | 1.0 | GO:0014874 | response to stimulus involved in regulation of muscle adaptation(GO:0014874) |
| 0.3 | 4.6 | GO:2001014 | regulation of skeletal muscle cell differentiation(GO:2001014) |
| 0.3 | 2.3 | GO:0035428 | hexose transmembrane transport(GO:0035428) |
| 0.2 | 0.7 | GO:0014834 | skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration(GO:0014834) |
| 0.2 | 0.7 | GO:1902109 | ADP transport(GO:0015866) negative regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902109) |
| 0.2 | 11.6 | GO:0043044 | ATP-dependent chromatin remodeling(GO:0043044) |
| 0.2 | 14.9 | GO:0005978 | glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250) |
| 0.2 | 0.5 | GO:0016340 | calcium-dependent cell-matrix adhesion(GO:0016340) |
| 0.2 | 5.2 | GO:0070296 | sarcoplasmic reticulum calcium ion transport(GO:0070296) |
| 0.2 | 1.9 | GO:0010650 | positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827) |
| 0.2 | 4.5 | GO:0045745 | positive regulation of G-protein coupled receptor protein signaling pathway(GO:0045745) |
| 0.2 | 2.9 | GO:0048172 | regulation of short-term neuronal synaptic plasticity(GO:0048172) |
| 0.2 | 1.5 | GO:0090073 | positive regulation of protein homodimerization activity(GO:0090073) |
| 0.2 | 2.5 | GO:0060394 | negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394) |
| 0.1 | 1.5 | GO:1902866 | regulation of retina development in camera-type eye(GO:1902866) |
| 0.1 | 13.0 | GO:0001578 | microtubule bundle formation(GO:0001578) |
| 0.1 | 8.4 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
| 0.1 | 2.1 | GO:0006047 | UDP-N-acetylglucosamine metabolic process(GO:0006047) |
| 0.1 | 0.6 | GO:0010735 | positive regulation of transcription via serum response element binding(GO:0010735) |
| 0.1 | 2.6 | GO:0010107 | potassium ion import(GO:0010107) |
| 0.1 | 0.9 | GO:1902416 | positive regulation of mRNA binding(GO:1902416) |
| 0.1 | 5.6 | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER(GO:0006890) |
| 0.1 | 12.3 | GO:0007613 | memory(GO:0007613) |
| 0.1 | 3.5 | GO:0007416 | synapse assembly(GO:0007416) |
| 0.1 | 2.7 | GO:0008090 | retrograde axonal transport(GO:0008090) |
| 0.1 | 12.8 | GO:0050806 | positive regulation of synaptic transmission(GO:0050806) |
| 0.1 | 12.2 | GO:0043149 | contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149) |
| 0.1 | 29.9 | GO:0019221 | cytokine-mediated signaling pathway(GO:0019221) |
| 0.1 | 0.6 | GO:0007258 | JUN phosphorylation(GO:0007258) |
| 0.1 | 0.9 | GO:0005980 | polysaccharide catabolic process(GO:0000272) glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247) |
| 0.1 | 9.5 | GO:0006342 | chromatin silencing(GO:0006342) |
| 0.1 | 1.9 | GO:0035414 | negative regulation of catenin import into nucleus(GO:0035414) |
| 0.1 | 4.3 | GO:0006911 | phagocytosis, engulfment(GO:0006911) |
| 0.1 | 2.3 | GO:0031032 | actomyosin structure organization(GO:0031032) |
| 0.1 | 7.4 | GO:0010811 | positive regulation of cell-substrate adhesion(GO:0010811) |
| 0.1 | 0.2 | GO:0006556 | S-adenosylmethionine biosynthetic process(GO:0006556) |
| 0.1 | 19.2 | GO:0060541 | respiratory system development(GO:0060541) |
| 0.1 | 4.7 | GO:0021766 | hippocampus development(GO:0021766) |
| 0.1 | 6.8 | GO:0006892 | post-Golgi vesicle-mediated transport(GO:0006892) |
| 0.1 | 0.5 | GO:0046688 | response to copper ion(GO:0046688) |
| 0.1 | 3.6 | GO:0045600 | positive regulation of fat cell differentiation(GO:0045600) |
| 0.1 | 8.4 | GO:0006836 | neurotransmitter transport(GO:0006836) |
| 0.1 | 1.6 | GO:0045214 | sarcomere organization(GO:0045214) |
| 0.1 | 0.3 | GO:0010796 | regulation of multivesicular body size(GO:0010796) protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328) |
| 0.1 | 15.4 | GO:0060271 | cilium morphogenesis(GO:0060271) |
| 0.1 | 2.5 | GO:0070373 | negative regulation of ERK1 and ERK2 cascade(GO:0070373) |
| 0.0 | 4.5 | GO:0071805 | potassium ion transmembrane transport(GO:0071805) |
| 0.0 | 3.5 | GO:0006865 | amino acid transport(GO:0006865) |
| 0.0 | 3.1 | GO:0072332 | intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332) |
| 0.0 | 0.8 | GO:0061045 | negative regulation of wound healing(GO:0061045) |
| 0.0 | 0.2 | GO:0019227 | neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870) |
| 0.0 | 0.4 | GO:0002227 | innate immune response in mucosa(GO:0002227) organ or tissue specific immune response(GO:0002251) mucosal immune response(GO:0002385) |
| 0.0 | 0.8 | GO:0095500 | acetylcholine receptor signaling pathway(GO:0095500) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145) |
| 0.0 | 2.5 | GO:0007098 | centrosome cycle(GO:0007098) |
| 0.0 | 3.0 | GO:0007568 | aging(GO:0007568) |
| 0.0 | 0.9 | GO:0019933 | cAMP-mediated signaling(GO:0019933) |
| 0.0 | 0.5 | GO:0051591 | response to cAMP(GO:0051591) |
| 0.0 | 4.6 | GO:0018105 | peptidyl-serine phosphorylation(GO:0018105) |
| 0.0 | 0.1 | GO:2001214 | positive regulation of vasculogenesis(GO:2001214) |
| 0.0 | 0.3 | GO:0006607 | NLS-bearing protein import into nucleus(GO:0006607) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.6 | 25.8 | GO:0043512 | inhibin A complex(GO:0043512) |
| 4.1 | 12.2 | GO:0045160 | myosin I complex(GO:0045160) |
| 2.9 | 11.6 | GO:0090537 | CERF complex(GO:0090537) |
| 2.5 | 7.4 | GO:0000802 | transverse filament(GO:0000802) |
| 2.2 | 37.5 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
| 1.9 | 5.6 | GO:0099573 | glutamatergic postsynaptic density(GO:0099573) |
| 1.8 | 8.9 | GO:0044316 | cone cell pedicle(GO:0044316) |
| 1.7 | 34.7 | GO:0044224 | juxtaparanode region of axon(GO:0044224) |
| 1.2 | 5.0 | GO:0008282 | ATP-sensitive potassium channel complex(GO:0008282) |
| 1.2 | 3.7 | GO:0005927 | muscle tendon junction(GO:0005927) |
| 1.2 | 23.0 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 1.1 | 23.2 | GO:0032279 | asymmetric synapse(GO:0032279) |
| 1.1 | 3.2 | GO:0032280 | symmetric synapse(GO:0032280) |
| 1.0 | 8.0 | GO:0001520 | outer dense fiber(GO:0001520) |
| 1.0 | 6.9 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.9 | 2.8 | GO:0042642 | actomyosin, myosin complex part(GO:0042642) |
| 0.8 | 3.4 | GO:0097454 | Schwann cell microvillus(GO:0097454) |
| 0.8 | 5.1 | GO:0035976 | AP1 complex(GO:0035976) |
| 0.8 | 3.4 | GO:0098831 | presynaptic active zone cytoplasmic component(GO:0098831) |
| 0.7 | 5.2 | GO:0034366 | spherical high-density lipoprotein particle(GO:0034366) |
| 0.7 | 2.7 | GO:0031673 | H zone(GO:0031673) |
| 0.7 | 6.7 | GO:0048787 | presynaptic active zone membrane(GO:0048787) |
| 0.7 | 3.9 | GO:0005859 | muscle myosin complex(GO:0005859) |
| 0.6 | 5.4 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
| 0.6 | 1.7 | GO:0042720 | mitochondrial inner membrane peptidase complex(GO:0042720) |
| 0.5 | 4.6 | GO:0032541 | cortical endoplasmic reticulum(GO:0032541) |
| 0.4 | 34.2 | GO:0016328 | lateral plasma membrane(GO:0016328) |
| 0.4 | 3.7 | GO:0097197 | tetraspanin-enriched microdomain(GO:0097197) |
| 0.4 | 7.8 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.3 | 5.5 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.3 | 21.6 | GO:0034705 | voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705) |
| 0.3 | 48.9 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.3 | 2.9 | GO:0031091 | platelet alpha granule(GO:0031091) |
| 0.3 | 28.4 | GO:0016605 | PML body(GO:0016605) |
| 0.3 | 3.9 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.3 | 8.2 | GO:0097440 | apical dendrite(GO:0097440) |
| 0.3 | 2.3 | GO:0005922 | connexon complex(GO:0005922) |
| 0.2 | 57.3 | GO:0016324 | apical plasma membrane(GO:0016324) |
| 0.2 | 19.1 | GO:0043198 | dendritic shaft(GO:0043198) |
| 0.2 | 0.6 | GO:0044302 | dentate gyrus mossy fiber(GO:0044302) |
| 0.2 | 2.9 | GO:0032045 | guanyl-nucleotide exchange factor complex(GO:0032045) |
| 0.2 | 10.5 | GO:0097610 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.2 | 0.5 | GO:0097450 | astrocyte end-foot(GO:0097450) |
| 0.2 | 63.0 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.1 | 16.2 | GO:0005814 | centriole(GO:0005814) |
| 0.1 | 0.9 | GO:0046696 | lipopolysaccharide receptor complex(GO:0046696) |
| 0.1 | 5.2 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.1 | 3.1 | GO:0032420 | stereocilium(GO:0032420) |
| 0.1 | 6.6 | GO:0005902 | microvillus(GO:0005902) |
| 0.1 | 2.5 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.1 | 0.5 | GO:0033268 | node of Ranvier(GO:0033268) |
| 0.1 | 2.9 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.1 | 17.5 | GO:0030426 | growth cone(GO:0030426) |
| 0.1 | 4.7 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.1 | 2.7 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.1 | 0.3 | GO:0000814 | ESCRT II complex(GO:0000814) |
| 0.1 | 0.2 | GO:0048269 | methionine adenosyltransferase complex(GO:0048269) |
| 0.1 | 15.2 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.1 | 6.2 | GO:0043204 | perikaryon(GO:0043204) |
| 0.1 | 6.0 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.1 | 2.1 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.0 | 0.9 | GO:0045120 | pronucleus(GO:0045120) |
| 0.0 | 0.7 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.0 | 2.0 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.0 | 4.7 | GO:0008021 | synaptic vesicle(GO:0008021) |
| 0.0 | 2.3 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.0 | 0.7 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.0 | 9.9 | GO:0015630 | microtubule cytoskeleton(GO:0015630) |
| 0.0 | 3.5 | GO:0043235 | receptor complex(GO:0043235) |
| 0.0 | 4.3 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
| 0.0 | 1.5 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.0 | 0.2 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.0 | 0.1 | GO:0031466 | Cul5-RING ubiquitin ligase complex(GO:0031466) |
| 0.0 | 6.0 | GO:0005773 | vacuole(GO:0005773) |
| 0.0 | 2.2 | GO:0019897 | extrinsic component of plasma membrane(GO:0019897) |
| 0.0 | 2.5 | GO:0005769 | early endosome(GO:0005769) |
| 0.0 | 2.6 | GO:0031965 | nuclear membrane(GO:0031965) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.0 | 28.0 | GO:0017095 | heparan sulfate 6-O-sulfotransferase activity(GO:0017095) |
| 5.2 | 31.3 | GO:0070699 | type II activin receptor binding(GO:0070699) |
| 3.9 | 11.6 | GO:0070615 | nucleosome-dependent ATPase activity(GO:0070615) |
| 3.7 | 37.5 | GO:0004972 | NMDA glutamate receptor activity(GO:0004972) |
| 3.2 | 9.7 | GO:0008113 | peptide-methionine (S)-S-oxide reductase activity(GO:0008113) |
| 2.8 | 8.4 | GO:0005332 | gamma-aminobutyric acid:sodium symporter activity(GO:0005332) |
| 2.7 | 21.6 | GO:0086008 | voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008) |
| 2.7 | 18.7 | GO:0001609 | G-protein coupled adenosine receptor activity(GO:0001609) heterotrimeric G-protein binding(GO:0032795) |
| 2.5 | 47.6 | GO:0035198 | miRNA binding(GO:0035198) |
| 2.0 | 12.3 | GO:0008321 | Ral guanyl-nucleotide exchange factor activity(GO:0008321) |
| 1.8 | 16.3 | GO:0035251 | UDP-glucosyltransferase activity(GO:0035251) |
| 1.6 | 7.8 | GO:0038085 | vascular endothelial growth factor binding(GO:0038085) |
| 1.5 | 10.2 | GO:0001515 | opioid peptide activity(GO:0001515) |
| 1.4 | 34.7 | GO:0004385 | guanylate kinase activity(GO:0004385) |
| 1.2 | 23.4 | GO:0030275 | LRR domain binding(GO:0030275) |
| 1.0 | 4.0 | GO:0017050 | sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050) |
| 1.0 | 28.1 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
| 0.9 | 15.6 | GO:0000900 | translation repressor activity, nucleic acid binding(GO:0000900) |
| 0.8 | 26.2 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
| 0.8 | 12.2 | GO:0030898 | actin-dependent ATPase activity(GO:0030898) |
| 0.8 | 3.9 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 0.8 | 6.9 | GO:1990239 | steroid hormone binding(GO:1990239) |
| 0.8 | 19.9 | GO:0042805 | actinin binding(GO:0042805) |
| 0.7 | 8.0 | GO:0004017 | adenylate kinase activity(GO:0004017) |
| 0.7 | 3.4 | GO:0004032 | alditol:NADP+ 1-oxidoreductase activity(GO:0004032) |
| 0.6 | 2.3 | GO:0004692 | cGMP-dependent protein kinase activity(GO:0004692) |
| 0.6 | 2.8 | GO:0000146 | microfilament motor activity(GO:0000146) |
| 0.5 | 2.0 | GO:0004667 | prostaglandin-D synthase activity(GO:0004667) |
| 0.5 | 12.7 | GO:0005337 | nucleoside transmembrane transporter activity(GO:0005337) |
| 0.5 | 5.6 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) |
| 0.4 | 12.2 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.4 | 2.1 | GO:0008761 | UDP-N-acetylglucosamine 2-epimerase activity(GO:0008761) |
| 0.4 | 13.4 | GO:0017147 | Wnt-protein binding(GO:0017147) |
| 0.4 | 2.3 | GO:0051525 | NFAT protein binding(GO:0051525) |
| 0.4 | 7.6 | GO:0016208 | AMP binding(GO:0016208) |
| 0.3 | 10.5 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.3 | 8.0 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
| 0.3 | 9.9 | GO:0005112 | Notch binding(GO:0005112) |
| 0.3 | 12.3 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.3 | 3.4 | GO:0019992 | diacylglycerol binding(GO:0019992) |
| 0.3 | 1.5 | GO:1904288 | BAT3 complex binding(GO:1904288) |
| 0.3 | 0.9 | GO:0001875 | lipopolysaccharide receptor activity(GO:0001875) |
| 0.3 | 4.5 | GO:0030955 | potassium ion binding(GO:0030955) |
| 0.3 | 6.5 | GO:0016709 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709) |
| 0.3 | 5.1 | GO:0035497 | cAMP response element binding(GO:0035497) |
| 0.3 | 14.9 | GO:0042562 | hormone binding(GO:0042562) |
| 0.3 | 3.9 | GO:0005248 | voltage-gated sodium channel activity(GO:0005248) |
| 0.2 | 2.5 | GO:0015924 | mannosyl-oligosaccharide mannosidase activity(GO:0015924) |
| 0.2 | 3.2 | GO:0045499 | chemorepellent activity(GO:0045499) |
| 0.2 | 30.2 | GO:0001191 | transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191) |
| 0.2 | 5.2 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.2 | 2.0 | GO:0070097 | delta-catenin binding(GO:0070097) |
| 0.2 | 8.9 | GO:0030552 | cAMP binding(GO:0030552) |
| 0.2 | 8.5 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.2 | 0.9 | GO:1990715 | mRNA CDS binding(GO:1990715) |
| 0.2 | 5.5 | GO:0001968 | fibronectin binding(GO:0001968) |
| 0.2 | 9.4 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.2 | 5.6 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
| 0.2 | 30.9 | GO:0005516 | calmodulin binding(GO:0005516) |
| 0.2 | 5.2 | GO:0005245 | voltage-gated calcium channel activity(GO:0005245) |
| 0.2 | 12.3 | GO:0048365 | Rac GTPase binding(GO:0048365) |
| 0.2 | 17.4 | GO:0030165 | PDZ domain binding(GO:0030165) |
| 0.2 | 2.5 | GO:0034713 | type I transforming growth factor beta receptor binding(GO:0034713) |
| 0.2 | 6.7 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.1 | 8.0 | GO:0043022 | ribosome binding(GO:0043022) |
| 0.1 | 4.7 | GO:0051018 | protein kinase A binding(GO:0051018) |
| 0.1 | 1.5 | GO:0005078 | MAP-kinase scaffold activity(GO:0005078) |
| 0.1 | 2.6 | GO:0045182 | translation regulator activity(GO:0045182) |
| 0.1 | 0.5 | GO:0004322 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
| 0.1 | 5.0 | GO:0015459 | potassium channel regulator activity(GO:0015459) |
| 0.1 | 1.5 | GO:0015491 | cation:cation antiporter activity(GO:0015491) |
| 0.1 | 9.7 | GO:0030674 | protein binding, bridging(GO:0030674) |
| 0.1 | 9.8 | GO:0008201 | heparin binding(GO:0008201) |
| 0.1 | 0.8 | GO:0030550 | acetylcholine receptor inhibitor activity(GO:0030550) |
| 0.1 | 2.4 | GO:0016881 | acid-amino acid ligase activity(GO:0016881) |
| 0.1 | 4.6 | GO:0016706 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706) |
| 0.1 | 15.7 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.1 | 13.1 | GO:0044822 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.1 | 0.4 | GO:0004614 | phosphoglucomutase activity(GO:0004614) |
| 0.0 | 2.6 | GO:0019003 | GDP binding(GO:0019003) |
| 0.0 | 1.4 | GO:0045309 | protein phosphorylated amino acid binding(GO:0045309) |
| 0.0 | 3.6 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.0 | 17.2 | GO:0004674 | protein serine/threonine kinase activity(GO:0004674) |
| 0.0 | 2.2 | GO:0002039 | p53 binding(GO:0002039) |
| 0.0 | 6.5 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.0 | 0.7 | GO:0016922 | ligand-dependent nuclear receptor binding(GO:0016922) |
| 0.0 | 0.8 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 0.2 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 0.0 | 2.9 | GO:0005085 | guanyl-nucleotide exchange factor activity(GO:0005085) |
| 0.0 | 3.7 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.0 | 0.3 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 57.3 | PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.8 | 32.3 | ST_ERK1_ERK2_MAPK_PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.8 | 25.8 | PID_ALK1_PATHWAY | ALK1 signaling events |
| 0.7 | 43.4 | PID_FGF_PATHWAY | FGF signaling pathway |
| 0.6 | 7.8 | PID_PDGFRA_PATHWAY | PDGFR-alpha signaling pathway |
| 0.6 | 27.1 | PID_IL12_2PATHWAY | IL12-mediated signaling events |
| 0.5 | 23.1 | PID_REELIN_PATHWAY | Reelin signaling pathway |
| 0.4 | 8.9 | ST_WNT_CA2_CYCLIC_GMP_PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.4 | 12.3 | ST_T_CELL_SIGNAL_TRANSDUCTION | T Cell Signal Transduction |
| 0.3 | 12.6 | PID_KIT_PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.3 | 8.5 | PID_ANGIOPOIETIN_RECEPTOR_PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.3 | 5.7 | PID_PI3K_PLC_TRK_PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
| 0.3 | 4.0 | PID_S1P_S1P1_PATHWAY | S1P1 pathway |
| 0.3 | 9.0 | PID_RXR_VDR_PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.2 | 30.5 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 4.8 | PID_IL4_2PATHWAY | IL4-mediated signaling events |
| 0.1 | 2.9 | PID_IL8_CXCR2_PATHWAY | IL8- and CXCR2-mediated signaling events |
| 0.1 | 4.1 | PID_ARF6_PATHWAY | Arf6 signaling events |
| 0.1 | 2.8 | PID_EPHRINB_REV_PATHWAY | Ephrin B reverse signaling |
| 0.1 | 4.6 | PID_AP1_PATHWAY | AP-1 transcription factor network |
| 0.1 | 5.2 | PID_MYC_REPRESS_PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 2.2 | PID_FOXM1_PATHWAY | FOXM1 transcription factor network |
| 0.1 | 4.5 | PID_MTOR_4PATHWAY | mTOR signaling pathway |
| 0.1 | 2.3 | PID_TXA2PATHWAY | Thromboxane A2 receptor signaling |
| 0.1 | 5.5 | PID_NOTCH_PATHWAY | Notch signaling pathway |
| 0.1 | 0.7 | PID_SYNDECAN_4_PATHWAY | Syndecan-4-mediated signaling events |
| 0.0 | 0.5 | PID_TCR_CALCIUM_PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 0.9 | PID_TOLL_ENDOGENOUS_PATHWAY | Endogenous TLR signaling |
| 0.0 | 0.9 | PID_CERAMIDE_PATHWAY | Ceramide signaling pathway |
| 0.0 | 0.7 | PID_LKB1_PATHWAY | LKB1 signaling events |
| 0.0 | 0.6 | PID_RHOA_PATHWAY | RhoA signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.5 | 25.8 | REACTOME_GLYCOPROTEIN_HORMONES | Genes involved in Glycoprotein hormones |
| 1.5 | 47.2 | REACTOME_ERK_MAPK_TARGETS | Genes involved in ERK/MAPK targets |
| 1.4 | 18.4 | REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS | Genes involved in Nucleotide-like (purinergic) receptors |
| 1.1 | 28.1 | REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII | Genes involved in CREB phosphorylation through the activation of CaMKII |
| 1.1 | 28.1 | REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 1.1 | 31.2 | REACTOME_NEPHRIN_INTERACTIONS | Genes involved in Nephrin interactions |
| 1.0 | 16.4 | REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.9 | 12.3 | REACTOME_ACTIVATION_OF_RAC | Genes involved in Activation of Rac |
| 0.9 | 6.5 | REACTOME_ENDOGENOUS_STEROLS | Genes involved in Endogenous sterols |
| 0.7 | 28.0 | REACTOME_HS_GAG_BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.7 | 8.5 | REACTOME_TIE2_SIGNALING | Genes involved in Tie2 Signaling |
| 0.6 | 22.8 | REACTOME_INTERFERON_GAMMA_SIGNALING | Genes involved in Interferon gamma signaling |
| 0.5 | 24.2 | REACTOME_INWARDLY_RECTIFYING_K_CHANNELS | Genes involved in Inwardly rectifying K+ channels |
| 0.5 | 6.7 | REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.5 | 5.1 | REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.4 | 5.5 | REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |
| 0.3 | 4.5 | REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK | Genes involved in Regulation of Rheb GTPase activity by AMPK |
| 0.3 | 11.2 | REACTOME_RAP1_SIGNALLING | Genes involved in Rap1 signalling |
| 0.3 | 2.3 | REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 0.3 | 8.0 | REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.3 | 6.3 | REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.3 | 2.9 | REACTOME_SIGNALING_BY_PDGF | Genes involved in Signaling by PDGF |
| 0.3 | 12.0 | REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.3 | 10.8 | REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.2 | 16.3 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.2 | 2.3 | REACTOME_GAP_JUNCTION_ASSEMBLY | Genes involved in Gap junction assembly |
| 0.2 | 4.4 | REACTOME_PERK_REGULATED_GENE_EXPRESSION | Genes involved in PERK regulated gene expression |
| 0.1 | 8.4 | REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.1 | 2.8 | REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.1 | 4.5 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.1 | 2.9 | REACTOME_THE_ROLE_OF_NEF_IN_HIV1_REPLICATION_AND_DISEASE_PATHOGENESIS | Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis |
| 0.1 | 0.9 | REACTOME_TRAF6_MEDIATED_INDUCTION_OF_TAK1_COMPLEX | Genes involved in TRAF6 mediated induction of TAK1 complex |
| 0.1 | 3.5 | REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.1 | 4.0 | REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.1 | 6.5 | REACTOME_TOLL_RECEPTOR_CASCADES | Genes involved in Toll Receptor Cascades |
| 0.1 | 4.7 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.1 | 2.0 | REACTOME_METAL_ION_SLC_TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.1 | 4.7 | REACTOME_MEIOTIC_SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.1 | 11.3 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 1.9 | REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.1 | 5.1 | REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION | Genes involved in Downstream signal transduction |
| 0.0 | 0.7 | REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.0 | 0.3 | REACTOME_REGULATION_OF_WATER_BALANCE_BY_RENAL_AQUAPORINS | Genes involved in Regulation of Water Balance by Renal Aquaporins |
| 0.0 | 0.7 | REACTOME_INTERACTIONS_OF_VPR_WITH_HOST_CELLULAR_PROTEINS | Genes involved in Interactions of Vpr with host cellular proteins |
| 0.0 | 0.3 | REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
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