Motif ID: Mef2d_Mef2a

Z-value: 1.578

Transcription factors associated with Mef2d_Mef2a:

Gene SymbolEntrez IDGene Name
Mef2a ENSMUSG00000030557.10 Mef2a
Mef2d ENSMUSG00000001419.11 Mef2d

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mef2dmm10_v2_chr3_+_88142328_881424830.438.6e-05Click!
Mef2amm10_v2_chr7_-_67372846_673728580.361.2e-03Click!


Activity profile for motif Mef2d_Mef2a.

activity profile for motif Mef2d_Mef2a


Sorted Z-values histogram for motif Mef2d_Mef2a

Sorted Z-values for motif Mef2d_Mef2a



Network of associatons between targets according to the STRING database.



First level regulatory network of Mef2d_Mef2a

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_+_83573577 47.597 ENSMUST00000185052.1
 Mef2c
myocyte enhancer factor 2C
chr13_-_113663670 39.352 ENSMUST00000054650.4
 Hspb3
heat shock protein 3
chr13_+_5861489 33.229 ENSMUST00000000080.6
 Klf6
Kruppel-like factor 6
chr5_+_24985840 31.051 ENSMUST00000075081.6
 1500035N22Rik
RIKEN cDNA 1500035N22 gene
chr11_-_83649349 28.102 ENSMUST00000001008.5
 Ccl3
chemokine (C-C motif) ligand 3
chr9_-_112232449 27.766 ENSMUST00000035085.5
 Arpp21
cyclic AMP-regulated phosphoprotein, 21
chr9_+_34904913 25.791 ENSMUST00000045091.6
 Kirrel3
kin of IRRE like 3 (Drosophila)
chr5_-_128953303 25.685 ENSMUST00000111346.1
 Rimbp2
RIMS binding protein 2
chr6_-_136171722 22.507 ENSMUST00000053880.6
 Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr19_+_38264761 22.090 ENSMUST00000087252.5
 Lgi1
leucine-rich repeat LGI family, member 1
chr11_+_111066154 21.622 ENSMUST00000042970.2
 Kcnj2
potassium inwardly-rectifying channel, subfamily J, member 2
chr1_+_75375271 19.118 ENSMUST00000087122.5
 Speg
SPEG complex locus
chr1_-_134234492 18.718 ENSMUST00000169927.1
 Adora1
adenosine A1 receptor
chr7_+_91090697 17.467 ENSMUST00000107196.2
 Dlg2
discs, large homolog 2 (Drosophila)
chr7_+_91090728 17.184 ENSMUST00000074273.3
 Dlg2
discs, large homolog 2 (Drosophila)
chr3_-_20155069 16.260 ENSMUST00000184552.1
ENSMUST00000178328.1
 Gyg

glycogenin

chr10_+_90576872 15.001 ENSMUST00000182550.1
ENSMUST00000099364.5
 Anks1b

ankyrin repeat and sterile alpha motif domain containing 1B

chr14_-_66280949 14.981 ENSMUST00000111121.1
ENSMUST00000022622.7
ENSMUST00000089250.2
 Ptk2b


PTK2 protein tyrosine kinase 2 beta


chrX_-_51681703 14.222 ENSMUST00000088172.5
 Hs6st2
heparan sulfate 6-O-sulfotransferase 2
chrX_-_51681856 13.797 ENSMUST00000114871.1
 Hs6st2
heparan sulfate 6-O-sulfotransferase 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 136 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 49.3 GO:0034605 cellular response to heat(GO:0034605)
15.9 47.6 GO:0007521 muscle cell fate determination(GO:0007521) cellular response to parathyroid hormone stimulus(GO:0071374) positive regulation of macrophage apoptotic process(GO:2000111)
2.5 34.7 GO:0045161 neuronal ion channel clustering(GO:0045161)
0.1 29.9 GO:0019221 cytokine-mediated signaling pathway(GO:0019221)
3.1 28.1 GO:0043615 astrocyte cell migration(GO:0043615)
4.7 28.0 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
5.2 25.8 GO:0042636 negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279)
5.2 25.8 GO:0002121 inter-male aggressive behavior(GO:0002121)
0.6 23.6 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
7.6 22.8 GO:0001928 regulation of exocyst assembly(GO:0001928)
5.6 22.5 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.3 22.0 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
2.9 20.5 GO:0071376 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.1 19.2 GO:0060541 respiratory system development(GO:0060541)
6.2 18.7 GO:0032241 positive regulation of nucleobase-containing compound transport(GO:0032241) regulation of nucleoside transport(GO:0032242) negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256)
2.6 18.4 GO:0014819 regulation of skeletal muscle contraction(GO:0014819)
0.1 15.4 GO:0060271 cilium morphogenesis(GO:0060271)
5.0 15.0 GO:0010752 signal complex assembly(GO:0007172) regulation of cGMP-mediated signaling(GO:0010752)
1.3 15.0 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.2 14.9 GO:0005978 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 77 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 63.0 GO:0016607 nuclear speck(GO:0016607)
0.2 57.3 GO:0016324 apical plasma membrane(GO:0016324)
0.3 48.9 GO:0001650 fibrillar center(GO:0001650)
2.2 37.5 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
1.7 34.7 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.4 34.2 GO:0016328 lateral plasma membrane(GO:0016328)
0.3 28.4 GO:0016605 PML body(GO:0016605)
8.6 25.8 GO:0043512 inhibin A complex(GO:0043512)
1.1 23.2 GO:0032279 asymmetric synapse(GO:0032279)
1.2 23.0 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.3 21.6 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.2 19.1 GO:0043198 dendritic shaft(GO:0043198)
0.1 17.5 GO:0030426 growth cone(GO:0030426)
0.1 16.2 GO:0005814 centriole(GO:0005814)
0.1 15.2 GO:0045211 postsynaptic membrane(GO:0045211)
4.1 12.2 GO:0045160 myosin I complex(GO:0045160)
2.9 11.6 GO:0090537 CERF complex(GO:0090537)
0.2 10.5 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 9.9 GO:0015630 microtubule cytoskeleton(GO:0015630)
1.8 8.9 GO:0044316 cone cell pedicle(GO:0044316)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 91 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.5 47.6 GO:0035198 miRNA binding(GO:0035198)
3.7 37.5 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
1.4 34.7 GO:0004385 guanylate kinase activity(GO:0004385)
5.2 31.3 GO:0070699 type II activin receptor binding(GO:0070699)
0.2 30.9 GO:0005516 calmodulin binding(GO:0005516)
0.2 30.2 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
1.0 28.1 GO:0048020 CCR chemokine receptor binding(GO:0048020)
7.0 28.0 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.8 26.2 GO:0035259 glucocorticoid receptor binding(GO:0035259)
1.2 23.4 GO:0030275 LRR domain binding(GO:0030275)
2.7 21.6 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008)
0.8 19.9 GO:0042805 actinin binding(GO:0042805)
2.7 18.7 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609) heterotrimeric G-protein binding(GO:0032795)
0.2 17.4 GO:0030165 PDZ domain binding(GO:0030165)
0.0 17.2 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
1.8 16.3 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.1 15.7 GO:0008017 microtubule binding(GO:0008017)
0.9 15.6 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.3 14.9 GO:0042562 hormone binding(GO:0042562)
0.4 13.4 GO:0017147 Wnt-protein binding(GO:0017147)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 57.3 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.7 43.4 PID_FGF_PATHWAY FGF signaling pathway
0.8 32.3 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.2 30.5 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.6 27.1 PID_IL12_2PATHWAY IL12-mediated signaling events
0.8 25.8 PID_ALK1_PATHWAY ALK1 signaling events
0.5 23.1 PID_REELIN_PATHWAY Reelin signaling pathway
0.3 12.6 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.4 12.3 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.3 9.0 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.4 8.9 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.3 8.5 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.6 7.8 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.3 5.7 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.1 5.5 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 5.2 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.1 4.8 PID_IL4_2PATHWAY IL4-mediated signaling events
0.1 4.6 PID_AP1_PATHWAY AP-1 transcription factor network
0.1 4.5 PID_MTOR_4PATHWAY mTOR signaling pathway
0.1 4.1 PID_ARF6_PATHWAY Arf6 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 47.2 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
1.1 31.2 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
1.1 28.1 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
1.1 28.1 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.7 28.0 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
6.5 25.8 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.5 24.2 REACTOME_INWARDLY_RECTIFYING_K_CHANNELS Genes involved in Inwardly rectifying K+ channels
0.6 22.8 REACTOME_INTERFERON_GAMMA_SIGNALING Genes involved in Interferon gamma signaling
1.4 18.4 REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
1.0 16.4 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.2 16.3 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.9 12.3 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.3 12.0 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1 11.3 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.3 11.2 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.3 10.8 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.7 8.5 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.1 8.4 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.3 8.0 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.5 6.7 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins