Motif ID: Meis1

Z-value: 0.723


Transcription factors associated with Meis1:

Gene SymbolEntrez IDGene Name
Meis1 ENSMUSG00000020160.12 Meis1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Meis1mm10_v2_chr11_-_19018714_190188280.722.1e-13Click!


Activity profile for motif Meis1.

activity profile for motif Meis1


Sorted Z-values histogram for motif Meis1

Sorted Z-values for motif Meis1



Network of associatons between targets according to the STRING database.



First level regulatory network of Meis1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_139543889 16.740 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr14_-_47411666 7.528 ENSMUST00000111778.3
 Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr14_-_98169542 6.816 ENSMUST00000069334.7
ENSMUST00000071533.6
 Dach1

dachshund 1 (Drosophila)

chr1_-_138842429 6.057 ENSMUST00000112026.2
ENSMUST00000019374.7
 Lhx9

LIM homeobox protein 9

chr11_+_44617310 5.867 ENSMUST00000081265.5
ENSMUST00000101326.3
ENSMUST00000109268.1
 Ebf1


early B cell factor 1


chr3_+_109123104 5.294 ENSMUST00000029477.6
 Slc25a24
solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 24
chr11_-_64436653 4.878 ENSMUST00000177999.1
 F930015N05Rik
RIKEN cDNA F930015N05 gene
chr8_+_127064022 4.815 ENSMUST00000160272.1
ENSMUST00000079777.5
ENSMUST00000162907.1
 Pard3


par-3 (partitioning defective 3) homolog (C. elegans)


chr8_+_127064107 4.749 ENSMUST00000162536.1
ENSMUST00000026921.6
ENSMUST00000162665.1
ENSMUST00000160766.1
ENSMUST00000162602.1
ENSMUST00000162531.1
ENSMUST00000160581.1
ENSMUST00000161355.1
ENSMUST00000159537.1
 Pard3








par-3 (partitioning defective 3) homolog (C. elegans)








chr6_+_4747306 4.525 ENSMUST00000175823.1
ENSMUST00000176204.1
ENSMUST00000166678.1
 Peg10


paternally expressed 10


chr9_+_87022014 4.398 ENSMUST00000168529.2
ENSMUST00000174724.1
ENSMUST00000173126.1
 Cyb5r4


cytochrome b5 reductase 4


chrX_-_23365044 4.296 ENSMUST00000115313.1
 Klhl13
kelch-like 13
chr7_+_51621830 4.118 ENSMUST00000032710.5
 Slc17a6
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
chr3_+_125404292 4.078 ENSMUST00000144344.1
 Ndst4
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chr8_+_108714644 3.889 ENSMUST00000043896.8
 Zfhx3
zinc finger homeobox 3
chr7_+_70388305 3.866 ENSMUST00000080024.5
 B130024G19Rik
RIKEN cDNA B130024G19 gene
chr14_+_13284774 3.764 ENSMUST00000070323.5
 Synpr
synaptoporin
chr16_-_50732707 3.672 ENSMUST00000169791.2
 5330426P16Rik
RIKEN cDNA 5330426P16 gene
chr1_+_136467958 3.554 ENSMUST00000047817.6
 Kif14
kinesin family member 14
chr13_+_108316395 3.421 ENSMUST00000171178.1
 Depdc1b
DEP domain containing 1B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 102 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.1 16.7 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
1.6 9.6 GO:0003383 apical constriction(GO:0003383)
2.3 6.8 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
1.2 6.1 GO:0035262 gonad morphogenesis(GO:0035262)
1.1 5.3 GO:0015867 ATP transport(GO:0015867)
0.1 4.4 GO:0046677 response to antibiotic(GO:0046677)
0.1 4.4 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512)
0.5 4.1 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
1.3 3.9 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.0 3.9 GO:0000910 cytokinesis(GO:0000910)
1.2 3.6 GO:0003349 epicardium-derived cardiac endothelial cell differentiation(GO:0003349)
0.9 3.6 GO:0021698 cerebellar cortex structural organization(GO:0021698)
0.4 3.3 GO:0070474 positive regulation of uterine smooth muscle contraction(GO:0070474)
0.3 2.9 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.2 2.8 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.8 2.5 GO:0046671 negative regulation of retinal cell programmed cell death(GO:0046671)
0.0 2.4 GO:0007050 cell cycle arrest(GO:0007050)
0.1 2.3 GO:0060009 Sertoli cell development(GO:0060009)
0.1 2.3 GO:0050982 detection of mechanical stimulus(GO:0050982)
0.1 2.0 GO:0006182 cGMP biosynthetic process(GO:0006182)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 14.1 GO:0005667 transcription factor complex(GO:0005667)
1.2 9.6 GO:0033269 internode region of axon(GO:0033269)
0.3 7.9 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.4 7.5 GO:0031616 spindle pole centrosome(GO:0031616)
0.1 3.7 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 3.6 GO:0051233 spindle midzone(GO:0051233)
0.1 3.6 GO:0090544 BAF-type complex(GO:0090544)
0.1 2.8 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 2.7 GO:0001669 acrosomal vesicle(GO:0001669)
0.2 2.6 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 2.4 GO:0097546 ciliary base(GO:0097546)
0.0 2.3 GO:0000775 chromosome, centromeric region(GO:0000775)
0.5 2.0 GO:0008537 proteasome activator complex(GO:0008537)
0.1 2.0 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 2.0 GO:0032590 dendrite membrane(GO:0032590)
0.1 1.7 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.3 1.6 GO:0098536 deuterosome(GO:0098536)
0.5 1.5 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
0.1 1.5 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.1 1.2 GO:0005652 nuclear lamina(GO:0005652)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 72 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 21.9 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.0 14.8 GO:0003677 DNA binding(GO:0003677)
0.2 9.6 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 7.6 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.9 6.8 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.5 5.9 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.5 5.2 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.0 4.6 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.6 4.1 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.4 3.9 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.2 3.9 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)
0.1 3.6 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1 3.6 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 3.6 GO:0005096 GTPase activator activity(GO:0005096)
0.2 3.3 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.0 2.8 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.4 2.6 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.2 2.0 GO:0061133 endopeptidase activator activity(GO:0061133)
0.1 2.0 GO:0004383 guanylate cyclase activity(GO:0004383)
0.3 1.8 GO:0047276 N-acetyllactosaminide 3-alpha-galactosyltransferase activity(GO:0047276)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.2 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.2 7.5 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 5.2 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 4.3 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 4.2 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.2 3.6 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 3.4 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 3.2 PID_CMYB_PATHWAY C-MYB transcription factor network
0.0 2.7 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.1 1.5 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.1 1.0 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 1.0 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 0.9 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 0.8 PID_IL27_PATHWAY IL27-mediated signaling events
0.0 0.8 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.7 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.5 PID_ATM_PATHWAY ATM pathway
0.0 0.4 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 0.4 PID_ATR_PATHWAY ATR signaling pathway
0.0 0.3 PID_TRAIL_PATHWAY TRAIL signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 7.2 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1 5.6 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 4.8 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 4.3 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 4.1 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 4.1 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 3.3 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 3.3 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 2.8 REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES Genes involved in Generation of second messenger molecules
0.1 2.4 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 2.1 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 1.9 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.1 1.7 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.1 1.6 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.1 1.5 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 1.3 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 1.2 REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.1 1.1 REACTOME_REGULATION_OF_AMPK_ACTIVITY_VIA_LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.1 1.0 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.1 1.0 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport