Motif ID: Meis1
Z-value: 0.723
Transcription factors associated with Meis1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Meis1 | ENSMUSG00000020160.12 | Meis1 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Meis1 | mm10_v2_chr11_-_19018714_19018828 | 0.72 | 2.1e-13 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 6.8 | GO:0060244 | negative regulation of cell proliferation involved in contact inhibition(GO:0060244) |
| 2.1 | 16.7 | GO:0035726 | common myeloid progenitor cell proliferation(GO:0035726) |
| 1.6 | 9.6 | GO:0003383 | apical constriction(GO:0003383) |
| 1.3 | 3.9 | GO:1904059 | regulation of locomotor rhythm(GO:1904059) |
| 1.2 | 6.1 | GO:0035262 | gonad morphogenesis(GO:0035262) |
| 1.2 | 3.6 | GO:0003349 | epicardium-derived cardiac endothelial cell differentiation(GO:0003349) |
| 1.1 | 5.3 | GO:0015867 | ATP transport(GO:0015867) |
| 0.9 | 3.6 | GO:0021698 | cerebellar cortex structural organization(GO:0021698) |
| 0.8 | 2.5 | GO:0046671 | negative regulation of retinal cell programmed cell death(GO:0046671) |
| 0.6 | 1.8 | GO:0002191 | cap-dependent translational initiation(GO:0002191) |
| 0.5 | 4.1 | GO:0098700 | neurotransmitter loading into synaptic vesicle(GO:0098700) |
| 0.4 | 3.3 | GO:0070474 | positive regulation of uterine smooth muscle contraction(GO:0070474) |
| 0.3 | 1.0 | GO:0060821 | inactivation of X chromosome by DNA methylation(GO:0060821) |
| 0.3 | 1.0 | GO:0090649 | response to oxygen-glucose deprivation(GO:0090649) cellular response to oxygen-glucose deprivation(GO:0090650) |
| 0.3 | 1.7 | GO:0007197 | adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207) |
| 0.3 | 1.0 | GO:0072092 | ureteric bud invasion(GO:0072092) |
| 0.3 | 1.5 | GO:0018076 | N-terminal peptidyl-lysine acetylation(GO:0018076) |
| 0.3 | 0.8 | GO:0002430 | complement receptor mediated signaling pathway(GO:0002430) GPI anchor release(GO:0006507) |
| 0.3 | 0.8 | GO:0001951 | intestinal D-glucose absorption(GO:0001951) terminal web assembly(GO:1902896) |
| 0.3 | 0.8 | GO:0015712 | hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760) |
| 0.3 | 2.9 | GO:2000741 | positive regulation of mesenchymal stem cell differentiation(GO:2000741) |
| 0.3 | 0.8 | GO:0035973 | aggrephagy(GO:0035973) |
| 0.2 | 0.7 | GO:0031204 | posttranslational protein targeting to membrane, translocation(GO:0031204) |
| 0.2 | 0.7 | GO:0032058 | positive regulation of translational initiation in response to stress(GO:0032058) |
| 0.2 | 0.9 | GO:0051902 | negative regulation of mitochondrial depolarization(GO:0051902) negative regulation of membrane depolarization(GO:1904180) |
| 0.2 | 0.2 | GO:0072425 | signal transduction involved in G2 DNA damage checkpoint(GO:0072425) signal transduction involved in mitotic G2 DNA damage checkpoint(GO:0072434) |
| 0.2 | 0.9 | GO:0019287 | isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287) |
| 0.2 | 1.1 | GO:0090521 | glomerular visceral epithelial cell migration(GO:0090521) |
| 0.2 | 0.9 | GO:0044330 | canonical Wnt signaling pathway involved in positive regulation of wound healing(GO:0044330) lactic acid secretion(GO:0046722) regulation of metanephric cap mesenchymal cell proliferation(GO:0090095) positive regulation of metanephric cap mesenchymal cell proliferation(GO:0090096) |
| 0.2 | 0.6 | GO:0006667 | sphinganine metabolic process(GO:0006667) |
| 0.2 | 0.6 | GO:0002408 | myeloid dendritic cell chemotaxis(GO:0002408) |
| 0.2 | 1.0 | GO:0034196 | acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197) |
| 0.2 | 1.1 | GO:0045668 | negative regulation of osteoblast differentiation(GO:0045668) |
| 0.2 | 1.1 | GO:0042795 | snRNA transcription from RNA polymerase II promoter(GO:0042795) |
| 0.2 | 1.3 | GO:1902746 | regulation of lens fiber cell differentiation(GO:1902746) |
| 0.2 | 0.7 | GO:0060800 | regulation of cell differentiation involved in embryonic placenta development(GO:0060800) |
| 0.2 | 2.8 | GO:0001833 | inner cell mass cell proliferation(GO:0001833) |
| 0.2 | 0.8 | GO:1903756 | regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758) |
| 0.2 | 1.5 | GO:0000722 | telomere maintenance via recombination(GO:0000722) |
| 0.1 | 1.3 | GO:0030259 | lipid glycosylation(GO:0030259) |
| 0.1 | 0.1 | GO:0061373 | mammillary body development(GO:0021767) mammillary axonal complex development(GO:0061373) |
| 0.1 | 0.4 | GO:2000812 | response to rapamycin(GO:1901355) regulation of barbed-end actin filament capping(GO:2000812) |
| 0.1 | 0.8 | GO:1901164 | negative regulation of trophoblast cell migration(GO:1901164) |
| 0.1 | 0.7 | GO:0090168 | Golgi reassembly(GO:0090168) |
| 0.1 | 0.4 | GO:0060126 | somatotropin secreting cell differentiation(GO:0060126) |
| 0.1 | 0.3 | GO:0071963 | establishment or maintenance of cell polarity regulating cell shape(GO:0071963) |
| 0.1 | 0.9 | GO:0007296 | vitellogenesis(GO:0007296) |
| 0.1 | 4.4 | GO:0046677 | response to antibiotic(GO:0046677) |
| 0.1 | 0.7 | GO:0061732 | mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732) |
| 0.1 | 0.9 | GO:0070874 | negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874) |
| 0.1 | 0.9 | GO:0035845 | photoreceptor cell outer segment organization(GO:0035845) |
| 0.1 | 2.3 | GO:0060009 | Sertoli cell development(GO:0060009) |
| 0.1 | 0.4 | GO:0050651 | dermatan sulfate proteoglycan biosynthetic process(GO:0050651) |
| 0.1 | 0.7 | GO:2000301 | negative regulation of synaptic vesicle exocytosis(GO:2000301) |
| 0.1 | 1.2 | GO:1904262 | negative regulation of TORC1 signaling(GO:1904262) |
| 0.1 | 0.6 | GO:0032049 | cardiolipin biosynthetic process(GO:0032049) |
| 0.1 | 0.2 | GO:1904430 | negative regulation of t-circle formation(GO:1904430) |
| 0.1 | 1.4 | GO:0007064 | mitotic sister chromatid cohesion(GO:0007064) |
| 0.1 | 0.4 | GO:0048478 | replication fork protection(GO:0048478) |
| 0.1 | 4.4 | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) |
| 0.1 | 0.6 | GO:0045945 | positive regulation of transcription from RNA polymerase III promoter(GO:0045945) negative regulation of fibroblast apoptotic process(GO:2000270) |
| 0.1 | 0.3 | GO:0015868 | purine ribonucleotide transport(GO:0015868) |
| 0.1 | 0.5 | GO:0006104 | succinyl-CoA metabolic process(GO:0006104) |
| 0.1 | 2.0 | GO:0006182 | cGMP biosynthetic process(GO:0006182) |
| 0.1 | 0.4 | GO:0060050 | positive regulation of protein glycosylation(GO:0060050) spindle assembly involved in meiosis(GO:0090306) |
| 0.1 | 2.3 | GO:0050982 | detection of mechanical stimulus(GO:0050982) |
| 0.0 | 0.6 | GO:0006517 | protein deglycosylation(GO:0006517) |
| 0.0 | 1.6 | GO:0007099 | centriole replication(GO:0007099) |
| 0.0 | 0.3 | GO:0000056 | ribosomal small subunit export from nucleus(GO:0000056) |
| 0.0 | 0.9 | GO:0010758 | regulation of macrophage chemotaxis(GO:0010758) |
| 0.0 | 0.3 | GO:0071285 | cellular response to lithium ion(GO:0071285) |
| 0.0 | 1.6 | GO:0051310 | metaphase plate congression(GO:0051310) |
| 0.0 | 0.3 | GO:0000395 | mRNA 5'-splice site recognition(GO:0000395) |
| 0.0 | 0.2 | GO:0045059 | positive thymic T cell selection(GO:0045059) |
| 0.0 | 1.1 | GO:0010800 | positive regulation of peptidyl-threonine phosphorylation(GO:0010800) |
| 0.0 | 0.4 | GO:0045187 | regulation of circadian sleep/wake cycle, sleep(GO:0045187) |
| 0.0 | 0.3 | GO:0006398 | mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398) |
| 0.0 | 0.2 | GO:0015808 | L-alanine transport(GO:0015808) |
| 0.0 | 3.9 | GO:0000910 | cytokinesis(GO:0000910) |
| 0.0 | 0.2 | GO:0051967 | negative regulation of synaptic transmission, glutamatergic(GO:0051967) |
| 0.0 | 0.2 | GO:0042590 | antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590) |
| 0.0 | 0.8 | GO:0034723 | DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723) |
| 0.0 | 0.5 | GO:0008535 | respiratory chain complex IV assembly(GO:0008535) |
| 0.0 | 0.1 | GO:0052428 | modulation of molecular function in other organism(GO:0044359) negative regulation of molecular function in other organism(GO:0044362) negative regulation of molecular function in other organism involved in symbiotic interaction(GO:0052204) modulation of molecular function in other organism involved in symbiotic interaction(GO:0052205) negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428) |
| 0.0 | 1.1 | GO:0031122 | cytoplasmic microtubule organization(GO:0031122) |
| 0.0 | 0.3 | GO:1990403 | embryonic brain development(GO:1990403) |
| 0.0 | 0.3 | GO:0050909 | sensory perception of taste(GO:0050909) |
| 0.0 | 1.0 | GO:0005978 | glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250) |
| 0.0 | 1.3 | GO:0046847 | filopodium assembly(GO:0046847) |
| 0.0 | 0.3 | GO:0032463 | negative regulation of protein homooligomerization(GO:0032463) |
| 0.0 | 2.4 | GO:0007050 | cell cycle arrest(GO:0007050) |
| 0.0 | 1.2 | GO:0042147 | retrograde transport, endosome to Golgi(GO:0042147) |
| 0.0 | 0.4 | GO:2000637 | positive regulation of gene silencing by miRNA(GO:2000637) |
| 0.0 | 0.9 | GO:0006367 | transcription initiation from RNA polymerase II promoter(GO:0006367) |
| 0.0 | 0.0 | GO:0007621 | negative regulation of female receptivity(GO:0007621) female courtship behavior(GO:0008050) |
| 0.0 | 1.4 | GO:0030177 | positive regulation of Wnt signaling pathway(GO:0030177) |
| 0.0 | 0.1 | GO:0034316 | negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316) actin filament severing(GO:0051014) |
| 0.0 | 0.0 | GO:0033364 | mast cell secretory granule organization(GO:0033364) |
| 0.0 | 1.3 | GO:0010950 | positive regulation of endopeptidase activity(GO:0010950) |
| 0.0 | 0.1 | GO:0006654 | phosphatidic acid biosynthetic process(GO:0006654) |
| 0.0 | 0.4 | GO:0046676 | negative regulation of insulin secretion(GO:0046676) |
| 0.0 | 0.1 | GO:0060753 | regulation of mast cell chemotaxis(GO:0060753) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 9.6 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.5 | 2.0 | GO:0008537 | proteasome activator complex(GO:0008537) |
| 0.5 | 1.5 | GO:0031205 | endoplasmic reticulum Sec complex(GO:0031205) |
| 0.4 | 7.5 | GO:0031616 | spindle pole centrosome(GO:0031616) |
| 0.3 | 7.9 | GO:0030285 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 0.3 | 0.9 | GO:0005673 | transcription factor TFIIE complex(GO:0005673) |
| 0.3 | 0.8 | GO:0033186 | CAF-1 complex(GO:0033186) |
| 0.3 | 1.6 | GO:0098536 | deuterosome(GO:0098536) |
| 0.3 | 0.8 | GO:0034274 | Atg12-Atg5-Atg16 complex(GO:0034274) |
| 0.2 | 2.6 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.2 | 0.8 | GO:1990357 | terminal web(GO:1990357) |
| 0.1 | 1.0 | GO:0001740 | Barr body(GO:0001740) |
| 0.1 | 1.7 | GO:0032045 | guanyl-nucleotide exchange factor complex(GO:0032045) |
| 0.1 | 3.6 | GO:0051233 | spindle midzone(GO:0051233) |
| 0.1 | 0.7 | GO:0045254 | pyruvate dehydrogenase complex(GO:0045254) |
| 0.1 | 2.0 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.1 | 3.6 | GO:0090544 | BAF-type complex(GO:0090544) |
| 0.1 | 1.5 | GO:0005671 | Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671) |
| 0.1 | 2.8 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.1 | 0.3 | GO:0016939 | kinesin II complex(GO:0016939) |
| 0.1 | 1.2 | GO:0005652 | nuclear lamina(GO:0005652) |
| 0.1 | 0.2 | GO:0070939 | Dsl1p complex(GO:0070939) |
| 0.1 | 0.4 | GO:0030915 | Smc5-Smc6 complex(GO:0030915) |
| 0.1 | 0.4 | GO:0036195 | muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195) |
| 0.1 | 1.0 | GO:0031528 | microvillus membrane(GO:0031528) |
| 0.1 | 2.4 | GO:0097546 | ciliary base(GO:0097546) |
| 0.1 | 0.9 | GO:0036038 | MKS complex(GO:0036038) |
| 0.1 | 0.4 | GO:0031298 | replication fork protection complex(GO:0031298) |
| 0.1 | 3.7 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.0 | 0.2 | GO:0042105 | alpha-beta T cell receptor complex(GO:0042105) |
| 0.0 | 2.0 | GO:0032590 | dendrite membrane(GO:0032590) |
| 0.0 | 0.8 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.0 | 1.1 | GO:0005682 | U5 snRNP(GO:0005682) |
| 0.0 | 0.5 | GO:0031080 | nuclear pore outer ring(GO:0031080) |
| 0.0 | 1.1 | GO:0034451 | centriolar satellite(GO:0034451) |
| 0.0 | 0.1 | GO:0031510 | SUMO activating enzyme complex(GO:0031510) |
| 0.0 | 14.1 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.0 | 0.3 | GO:0000243 | commitment complex(GO:0000243) |
| 0.0 | 0.6 | GO:0035102 | PRC1 complex(GO:0035102) |
| 0.0 | 2.7 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.0 | 0.6 | GO:0071339 | MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339) |
| 0.0 | 0.3 | GO:0031464 | Cul4A-RING E3 ubiquitin ligase complex(GO:0031464) |
| 0.0 | 1.1 | GO:0016235 | aggresome(GO:0016235) |
| 0.0 | 0.1 | GO:0030121 | AP-1 adaptor complex(GO:0030121) |
| 0.0 | 0.4 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.0 | 0.7 | GO:0005719 | nuclear euchromatin(GO:0005719) |
| 0.0 | 0.9 | GO:0002102 | podosome(GO:0002102) |
| 0.0 | 0.3 | GO:0005922 | connexon complex(GO:0005922) |
| 0.0 | 1.0 | GO:0016234 | inclusion body(GO:0016234) |
| 0.0 | 0.4 | GO:0032156 | septin cytoskeleton(GO:0032156) |
| 0.0 | 1.0 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.0 | 1.2 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.0 | 0.3 | GO:0000242 | pericentriolar material(GO:0000242) |
| 0.0 | 0.9 | GO:0016459 | myosin complex(GO:0016459) |
| 0.0 | 0.3 | GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex(GO:0005847) |
| 0.0 | 2.3 | GO:0000775 | chromosome, centromeric region(GO:0000775) |
| 0.0 | 0.5 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.0 | 0.4 | GO:0005801 | cis-Golgi network(GO:0005801) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 6.8 | GO:0001075 | transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075) |
| 0.6 | 4.1 | GO:0015016 | [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016) |
| 0.6 | 1.7 | GO:0016934 | extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934) |
| 0.5 | 5.2 | GO:0015217 | ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217) |
| 0.5 | 5.9 | GO:0070742 | C2H2 zinc finger domain binding(GO:0070742) |
| 0.4 | 3.9 | GO:0004128 | cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128) |
| 0.4 | 2.6 | GO:0071074 | eukaryotic initiation factor eIF2 binding(GO:0071074) |
| 0.4 | 1.2 | GO:0000253 | 3-keto sterol reductase activity(GO:0000253) |
| 0.3 | 1.3 | GO:0004046 | aminoacylase activity(GO:0004046) |
| 0.3 | 1.8 | GO:0047276 | N-acetyllactosaminide 3-alpha-galactosyltransferase activity(GO:0047276) |
| 0.3 | 1.5 | GO:0004468 | lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468) |
| 0.3 | 1.0 | GO:0015254 | glycerol channel activity(GO:0015254) |
| 0.3 | 0.8 | GO:0019776 | Atg8 ligase activity(GO:0019776) |
| 0.2 | 2.0 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
| 0.2 | 0.6 | GO:0042284 | sphingolipid delta-4 desaturase activity(GO:0042284) |
| 0.2 | 3.9 | GO:0005313 | L-glutamate transmembrane transporter activity(GO:0005313) |
| 0.2 | 9.6 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
| 0.2 | 0.5 | GO:0003996 | acyl-CoA ligase activity(GO:0003996) |
| 0.2 | 0.5 | GO:0004774 | succinate-CoA ligase activity(GO:0004774) |
| 0.2 | 3.3 | GO:0008188 | neuropeptide receptor activity(GO:0008188) |
| 0.1 | 0.7 | GO:0034604 | pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604) |
| 0.1 | 0.9 | GO:0035326 | enhancer binding(GO:0035326) |
| 0.1 | 0.8 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
| 0.1 | 3.6 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.1 | 1.3 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) |
| 0.1 | 1.0 | GO:0035251 | UDP-glucosyltransferase activity(GO:0035251) |
| 0.1 | 1.1 | GO:0003964 | telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964) |
| 0.1 | 0.9 | GO:0071253 | connexin binding(GO:0071253) |
| 0.1 | 2.0 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
| 0.1 | 0.8 | GO:0070087 | chromo shadow domain binding(GO:0070087) |
| 0.1 | 0.7 | GO:0015450 | P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450) |
| 0.1 | 0.3 | GO:0008527 | taste receptor activity(GO:0008527) |
| 0.1 | 0.8 | GO:0004630 | phospholipase D activity(GO:0004630) |
| 0.1 | 0.4 | GO:0072542 | protein phosphatase activator activity(GO:0072542) |
| 0.1 | 0.8 | GO:0015114 | phosphate ion transmembrane transporter activity(GO:0015114) |
| 0.1 | 0.7 | GO:0017034 | Rap guanyl-nucleotide exchange factor activity(GO:0017034) |
| 0.1 | 3.6 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.1 | 0.6 | GO:0017169 | CDP-alcohol phosphatidyltransferase activity(GO:0017169) |
| 0.1 | 0.2 | GO:0015173 | hydrogen:amino acid symporter activity(GO:0005280) aromatic amino acid transmembrane transporter activity(GO:0015173) |
| 0.1 | 1.4 | GO:0004707 | MAP kinase activity(GO:0004707) |
| 0.1 | 1.7 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.1 | 0.4 | GO:0033592 | RNA strand annealing activity(GO:0033592) |
| 0.0 | 1.0 | GO:0034185 | apolipoprotein binding(GO:0034185) |
| 0.0 | 0.4 | GO:0061676 | importin-alpha family protein binding(GO:0061676) |
| 0.0 | 1.1 | GO:0043539 | protein serine/threonine kinase activator activity(GO:0043539) |
| 0.0 | 0.9 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
| 0.0 | 7.6 | GO:0004721 | phosphoprotein phosphatase activity(GO:0004721) |
| 0.0 | 2.8 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 0.3 | GO:0005243 | gap junction channel activity(GO:0005243) |
| 0.0 | 0.6 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.0 | 0.8 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 0.0 | 4.6 | GO:0001046 | core promoter sequence-specific DNA binding(GO:0001046) |
| 0.0 | 0.1 | GO:0001162 | RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162) |
| 0.0 | 0.1 | GO:0003986 | acetyl-CoA hydrolase activity(GO:0003986) |
| 0.0 | 0.5 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.0 | 1.3 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.0 | 0.4 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.0 | 0.4 | GO:0019789 | SUMO transferase activity(GO:0019789) |
| 0.0 | 0.5 | GO:0016864 | protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864) |
| 0.0 | 21.9 | GO:0043565 | sequence-specific DNA binding(GO:0043565) |
| 0.0 | 1.1 | GO:0020037 | heme binding(GO:0020037) |
| 0.0 | 0.1 | GO:0070728 | leucine binding(GO:0070728) |
| 0.0 | 1.0 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.0 | 0.3 | GO:0005092 | GDP-dissociation inhibitor activity(GO:0005092) |
| 0.0 | 0.9 | GO:0016776 | phosphotransferase activity, phosphate group as acceptor(GO:0016776) |
| 0.0 | 0.3 | GO:0008409 | 5'-3' exonuclease activity(GO:0008409) |
| 0.0 | 14.8 | GO:0003677 | DNA binding(GO:0003677) |
| 0.0 | 0.6 | GO:0016811 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811) |
| 0.0 | 3.6 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.0 | 0.1 | GO:0004143 | diacylglycerol kinase activity(GO:0004143) |
| 0.0 | 0.6 | GO:0005179 | hormone activity(GO:0005179) |
| 0.0 | 0.3 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 7.5 | PID_AURORA_A_PATHWAY | Aurora A signaling |
| 0.2 | 3.6 | PID_P38_MK2_PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.1 | 10.2 | SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES | Genes related to the insulin receptor pathway |
| 0.1 | 1.0 | PID_INSULIN_GLUCOSE_PATHWAY | Insulin-mediated glucose transport |
| 0.1 | 4.3 | PID_AURORA_B_PATHWAY | Aurora B signaling |
| 0.1 | 4.2 | PID_RET_PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.1 | 1.5 | PID_HDAC_CLASSIII_PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 5.2 | PID_MYC_ACTIV_PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 2.7 | PID_CASPASE_PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 3.4 | PID_BETA_CATENIN_NUC_PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 0.8 | PID_IL27_PATHWAY | IL27-mediated signaling events |
| 0.0 | 3.2 | PID_CMYB_PATHWAY | C-MYB transcription factor network |
| 0.0 | 0.8 | PID_UPA_UPAR_PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.0 | 1.0 | PID_NETRIN_PATHWAY | Netrin-mediated signaling events |
| 0.0 | 0.5 | PID_ATM_PATHWAY | ATM pathway |
| 0.0 | 0.3 | PID_TRAIL_PATHWAY | TRAIL signaling pathway |
| 0.0 | 0.7 | PID_ECADHERIN_STABILIZATION_PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.0 | 0.9 | PID_AR_PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 0.2 | PID_IL12_STAT4_PATHWAY | IL12 signaling mediated by STAT4 |
| 0.0 | 0.4 | PID_RAC1_PATHWAY | RAC1 signaling pathway |
| 0.0 | 0.4 | PID_ATR_PATHWAY | ATR signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 7.2 | REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.1 | 2.8 | REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.1 | 1.7 | REACTOME_AMINE_LIGAND_BINDING_RECEPTORS | Genes involved in Amine ligand-binding receptors |
| 0.1 | 1.0 | REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.1 | 1.6 | REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
| 0.1 | 4.1 | REACTOME_HS_GAG_BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.1 | 2.4 | REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.1 | 1.5 | REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.1 | 1.0 | REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.1 | 2.1 | REACTOME_CHOLESTEROL_BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.1 | 4.1 | REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.1 | 5.6 | REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.1 | 1.1 | REACTOME_REGULATION_OF_AMPK_ACTIVITY_VIA_LKB1 | Genes involved in Regulation of AMPK activity via LKB1 |
| 0.1 | 3.3 | REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.1 | 1.9 | REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN | Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein |
| 0.1 | 0.7 | REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.0 | 3.3 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.0 | 1.3 | REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.0 | 1.2 | REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.0 | 0.3 | REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.0 | 0.7 | REACTOME_DESTABILIZATION_OF_MRNA_BY_KSRP | Genes involved in Destabilization of mRNA by KSRP |
| 0.0 | 4.8 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 0.4 | REACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS | Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis |
| 0.0 | 0.9 | REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.0 | 0.3 | REACTOME_TRANSPORT_OF_MATURE_MRNA_DERIVED_FROM_AN_INTRONLESS_TRANSCRIPT | Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript |
| 0.0 | 0.3 | REACTOME_GAP_JUNCTION_ASSEMBLY | Genes involved in Gap junction assembly |
| 0.0 | 0.5 | REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.0 | 0.3 | REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.0 | 1.0 | REACTOME_NETRIN1_SIGNALING | Genes involved in Netrin-1 signaling |
| 0.0 | 0.9 | REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 0.0 | 4.3 | REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.0 | 0.6 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.0 | 0.4 | REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
