Motif ID: Meis2

Z-value: 1.107


Transcription factors associated with Meis2:

Gene SymbolEntrez IDGene Name
Meis2 ENSMUSG00000027210.14 Meis2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Meis2mm10_v2_chr2_-_116065047_116065133-0.378.4e-04Click!


Activity profile for motif Meis2.

activity profile for motif Meis2


Sorted Z-values histogram for motif Meis2

Sorted Z-values for motif Meis2



Network of associatons between targets according to the STRING database.



First level regulatory network of Meis2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_49822710 19.948 ENSMUST00000031843.6
Npy
neuropeptide Y
chr3_-_82074639 16.026 ENSMUST00000029635.8
Gucy1b3
guanylate cyclase 1, soluble, beta 3
chr19_-_57197556 14.166 ENSMUST00000099294.2
Ablim1
actin-binding LIM protein 1
chr19_-_57197496 14.030 ENSMUST00000111544.1
Ablim1
actin-binding LIM protein 1
chr19_-_57197435 13.857 ENSMUST00000111550.1
Ablim1
actin-binding LIM protein 1
chr19_-_57197377 13.809 ENSMUST00000111546.1
Ablim1
actin-binding LIM protein 1
chr4_+_42922253 10.273 ENSMUST00000139100.1
N28178
expressed sequence N28178
chr9_+_120539801 9.169 ENSMUST00000047687.7
Entpd3
ectonucleoside triphosphate diphosphohydrolase 3
chr9_+_53771499 9.130 ENSMUST00000048670.8
Slc35f2
solute carrier family 35, member F2
chr5_-_100159261 8.653 ENSMUST00000139520.1
Tmem150c
transmembrane protein 150C
chr9_-_63711969 8.639 ENSMUST00000154323.1
Smad3
SMAD family member 3
chr2_+_158667119 8.500 ENSMUST00000045503.4
Ppp1r16b
protein phosphatase 1, regulatory (inhibitor) subunit 16B
chr7_+_48959089 8.135 ENSMUST00000183659.1
Nav2
neuron navigator 2
chr2_+_158666690 7.852 ENSMUST00000103116.3
Ppp1r16b
protein phosphatase 1, regulatory (inhibitor) subunit 16B
chr18_+_36939178 7.798 ENSMUST00000115662.2
Pcdha2
protocadherin alpha 2
chr2_+_71981184 7.660 ENSMUST00000090826.5
ENSMUST00000102698.3
Rapgef4

Rap guanine nucleotide exchange factor (GEF) 4

chr4_+_128058962 7.320 ENSMUST00000184063.1
Csmd2
CUB and Sushi multiple domains 2
chr19_+_42247544 6.930 ENSMUST00000122375.1
Golga7b
golgi autoantigen, golgin subfamily a, 7B
chr13_-_41079628 6.778 ENSMUST00000165087.1
ENSMUST00000070193.6
Mak

male germ cell-associated kinase

chr19_-_19001099 6.606 ENSMUST00000040153.8
ENSMUST00000112828.1
Rorb

RAR-related orphan receptor beta


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 158 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 48.5 GO:0030032 lamellipodium assembly(GO:0030032)
1.6 24.5 GO:0032098 regulation of appetite(GO:0032098)
3.3 16.4 GO:1903587 negative regulation of peptidyl-serine dephosphorylation(GO:1902309) regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903587)
5.3 16.0 GO:0099548 trans-synaptic signaling by nitric oxide(GO:0099548)
0.3 13.6 GO:0006376 mRNA splice site selection(GO:0006376)
3.1 9.4 GO:0046168 glycerol-3-phosphate catabolic process(GO:0046168)
0.7 9.2 GO:0009143 nucleoside triphosphate catabolic process(GO:0009143)
2.9 8.6 GO:0044413 regulation of lung blood pressure(GO:0014916) evasion or tolerance of host defenses by virus(GO:0019049) positive regulation of transforming growth factor beta3 production(GO:0032916) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
2.0 8.1 GO:0021564 glossopharyngeal nerve development(GO:0021563) vagus nerve development(GO:0021564)
0.1 8.0 GO:0008643 carbohydrate transport(GO:0008643)
1.9 7.7 GO:1904457 positive regulation of neuronal action potential(GO:1904457)
0.3 7.6 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.6 6.9 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
1.0 6.8 GO:1902856 negative regulation of nonmotile primary cilium assembly(GO:1902856)
0.9 6.6 GO:0046549 retinal cone cell development(GO:0046549)
0.6 6.6 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.4 6.5 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
1.0 6.3 GO:0010747 positive regulation of plasma membrane long-chain fatty acid transport(GO:0010747)
0.7 5.9 GO:0070474 positive regulation of uterine smooth muscle contraction(GO:0070474)
0.3 5.9 GO:0046069 cGMP catabolic process(GO:0046069)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 93 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 51.8 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.2 23.8 GO:0043204 perikaryon(GO:0043204)
0.0 12.4 GO:0000139 Golgi membrane(GO:0000139)
0.0 12.1 GO:0016607 nuclear speck(GO:0016607)
1.9 9.5 GO:0044316 cone cell pedicle(GO:0044316)
1.9 9.4 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
1.7 8.6 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.4 8.5 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.6 8.1 GO:0097542 ciliary tip(GO:0097542)
0.0 8.0 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.2 7.2 GO:0032809 neuronal cell body membrane(GO:0032809)
0.6 6.9 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.0 6.8 GO:0009897 external side of plasma membrane(GO:0009897)
0.5 6.6 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.4 6.5 GO:0044292 dendrite terminus(GO:0044292)
0.4 6.2 GO:0005614 interstitial matrix(GO:0005614)
0.0 5.8 GO:0001650 fibrillar center(GO:0001650)
0.2 5.5 GO:0031430 M band(GO:0031430)
0.2 4.9 GO:0000242 pericentriolar material(GO:0000242)
0.5 4.8 GO:0005883 neurofilament(GO:0005883)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 127 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 46.8 GO:0003779 actin binding(GO:0003779)
1.1 22.8 GO:0005184 neuropeptide hormone activity(GO:0005184)
1.3 16.0 GO:0004016 adenylate cyclase activity(GO:0004016)
0.2 14.9 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.2 11.5 GO:0036002 pre-mRNA binding(GO:0036002)
0.4 11.1 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.1 10.5 GO:0008201 heparin binding(GO:0008201)
1.9 9.4 GO:0004367 glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.6 9.2 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.3 8.9 GO:0030552 cAMP binding(GO:0030552)
0.2 8.8 GO:0030507 spectrin binding(GO:0030507)
1.7 8.6 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.4 8.6 GO:0005351 sugar:proton symporter activity(GO:0005351)
1.9 7.6 GO:0004441 inositol-1,4-bisphosphate 1-phosphatase activity(GO:0004441)
0.1 6.7 GO:0005125 cytokine activity(GO:0005125)
2.2 6.6 GO:0008502 melatonin receptor activity(GO:0008502)
0.9 6.5 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.3 6.3 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.8 5.9 GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118)
0.3 5.9 GO:0008188 neuropeptide receptor activity(GO:0008188)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 8.6 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1 6.3 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.1 4.9 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.1 4.8 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 4.5 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.1 4.1 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.1 2.9 PID_IL3_PATHWAY IL3-mediated signaling events
0.1 2.8 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 2.7 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 2.4 SIG_CHEMOTAXIS Genes related to chemotaxis
0.0 2.0 PID_MTOR_4PATHWAY mTOR signaling pathway
0.0 1.7 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 1.6 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 1.4 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 1.1 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 1.1 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.2 1.0 ST_IL_13_PATHWAY Interleukin 13 (IL-13) Pathway
0.0 1.0 NABA_COLLAGENS Genes encoding collagen proteins
0.0 0.9 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.0 0.9 PID_AP1_PATHWAY AP-1 transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 54 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 50.8 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.4 29.5 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.7 21.9 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.3 10.5 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.3 9.4 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.4 8.6 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.1 6.5 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.2 6.3 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.2 5.0 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.5 4.9 REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.3 4.2 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.2 4.1 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.0 3.9 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 3.4 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 3.3 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 2.9 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.2 2.8 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.1 2.6 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.1 2.6 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 2.4 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels