Motif ID: Meox2

Z-value: 0.812


Transcription factors associated with Meox2:

Gene SymbolEntrez IDGene Name
Meox2 ENSMUSG00000036144.5 Meox2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Meox2mm10_v2_chr12_+_37108533_371085460.243.8e-02Click!


Activity profile for motif Meox2.

activity profile for motif Meox2


Sorted Z-values histogram for motif Meox2

Sorted Z-values for motif Meox2



Network of associatons between targets according to the STRING database.



First level regulatory network of Meox2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr14_+_26119811 10.475 ENSMUST00000173617.1
Duxbl2
doubl homeobox B-like 2
chr16_+_42907563 10.084 ENSMUST00000151244.1
ENSMUST00000114694.2
Zbtb20

zinc finger and BTB domain containing 20

chr14_+_25980039 10.057 ENSMUST00000173155.1
Duxbl1
double homeobox B-like 1
chr14_+_26259109 8.682 ENSMUST00000174494.1
Duxbl3
double homeobox B-like 3
chr13_+_104229366 8.248 ENSMUST00000022227.6
Cenpk
centromere protein K
chr17_+_75005523 6.224 ENSMUST00000001927.5
Ltbp1
latent transforming growth factor beta binding protein 1
chr19_+_59458372 5.121 ENSMUST00000062216.3
Emx2
empty spiracles homeobox 2
chr9_-_36726374 5.022 ENSMUST00000172702.2
ENSMUST00000172742.1
ENSMUST00000034625.5
Chek1


checkpoint kinase 1


chr8_-_4779513 4.898 ENSMUST00000022945.7
Shcbp1
Shc SH2-domain binding protein 1
chr15_-_99651580 4.790 ENSMUST00000171908.1
ENSMUST00000171702.1
ENSMUST00000109581.2
ENSMUST00000169810.1
ENSMUST00000023756.5
Racgap1




Rac GTPase-activating protein 1




chr6_+_34598500 4.789 ENSMUST00000079391.3
ENSMUST00000142512.1
Cald1

caldesmon 1

chrM_+_10167 4.141 ENSMUST00000082414.1
mt-Nd4
mitochondrially encoded NADH dehydrogenase 4
chrM_-_14060 4.095 ENSMUST00000082419.1
mt-Nd6
mitochondrially encoded NADH dehydrogenase 6
chr14_+_25979401 3.848 ENSMUST00000173580.1
Duxbl1
double homeobox B-like 1
chr14_-_118132763 3.804 ENSMUST00000022727.8
Tgds
TDP-glucose 4,6-dehydratase
chr4_+_110397661 3.788 ENSMUST00000106589.2
ENSMUST00000106587.2
ENSMUST00000106591.1
ENSMUST00000106592.1
Agbl4



ATP/GTP binding protein-like 4



chr4_+_43058939 3.710 ENSMUST00000079978.6
Unc13b
unc-13 homolog B (C. elegans)
chr7_+_82611777 3.642 ENSMUST00000172784.1
Adamtsl3
ADAMTS-like 3
chr3_+_14533788 3.585 ENSMUST00000108370.2
Lrrcc1
leucine rich repeat and coiled-coil domain containing 1
chr3_+_127553462 3.560 ENSMUST00000043108.4
4930422G04Rik
RIKEN cDNA 4930422G04 gene
chr5_-_62766153 3.555 ENSMUST00000076623.4
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr16_-_26989974 3.483 ENSMUST00000089832.4
Gmnc
geminin coiled-coil domain containing
chr3_+_66219909 3.477 ENSMUST00000029421.5
Ptx3
pentraxin related gene
chr2_+_120629113 3.373 ENSMUST00000150912.1
ENSMUST00000180041.1
Stard9

START domain containing 9

chr7_-_5413145 3.288 ENSMUST00000108569.2
Vmn1r58
vomeronasal 1 receptor 58
chr14_-_20496780 3.229 ENSMUST00000022353.3
Mss51
MSS51 mitochondrial translational activator
chr8_+_12395287 3.206 ENSMUST00000180353.1
Sox1
SRY-box containing gene 1
chr1_-_24612700 3.180 ENSMUST00000088336.1
Gm10222
predicted gene 10222
chr1_+_10056922 3.162 ENSMUST00000149214.1
Cspp1
centrosome and spindle pole associated protein 1
chr10_-_128804353 3.065 ENSMUST00000051011.7
Tmem198b
transmembrane protein 198b
chr14_+_26119173 2.990 ENSMUST00000174564.1
Duxbl2
doubl homeobox B-like 2
chr14_+_26258786 2.990 ENSMUST00000172517.1
Duxbl3
double homeobox B-like 3
chr3_-_54714353 2.972 ENSMUST00000178832.1
Gm21958
predicted gene, 21958
chr13_-_77131276 2.925 ENSMUST00000159300.1
Ankrd32
ankyrin repeat domain 32
chr4_+_110397764 2.845 ENSMUST00000097920.2
ENSMUST00000080744.6
Agbl4

ATP/GTP binding protein-like 4

chr12_-_54986363 2.831 ENSMUST00000173433.1
ENSMUST00000173803.1
Baz1a
Gm20403
bromodomain adjacent to zinc finger domain 1A
predicted gene 20403
chr18_+_12972225 2.662 ENSMUST00000025290.5
Impact
imprinted and ancient
chrM_+_9870 2.639 ENSMUST00000084013.1
mt-Nd4l
mitochondrially encoded NADH dehydrogenase 4L
chr2_+_158768083 2.608 ENSMUST00000029183.2
Fam83d
family with sequence similarity 83, member D
chrM_+_7759 2.445 ENSMUST00000082407.1
ENSMUST00000082408.1
mt-Atp8
mt-Atp6
mitochondrially encoded ATP synthase 8
mitochondrially encoded ATP synthase 6
chr10_+_58394361 2.441 ENSMUST00000020077.4
Lims1
LIM and senescent cell antigen-like domains 1
chr8_+_4625840 2.409 ENSMUST00000073201.5
Zfp958
zinc finger protein 958
chr15_+_102296256 2.404 ENSMUST00000064924.4
Espl1
extra spindle poles-like 1 (S. cerevisiae)
chr16_+_44943737 2.366 ENSMUST00000114622.3
ENSMUST00000166731.1
Cd200r3

CD200 receptor 3

chr11_+_60699718 2.366 ENSMUST00000052346.3
Llgl1
lethal giant larvae homolog 1 (Drosophila)
chr17_-_15564322 2.346 ENSMUST00000147532.1
Prdm9
PR domain containing 9
chr10_-_116972609 2.309 ENSMUST00000092165.4
Gm10271
predicted gene 10271
chr8_-_41041828 2.304 ENSMUST00000051379.7
Mtus1
mitochondrial tumor suppressor 1
chr12_+_80790532 2.281 ENSMUST00000068519.5
4933426M11Rik
RIKEN cDNA 4933426M11 gene
chr15_-_74752963 2.280 ENSMUST00000023259.8
Lynx1
Ly6/neurotoxin 1
chr12_-_111813834 2.272 ENSMUST00000021715.5
Xrcc3
X-ray repair complementing defective repair in Chinese hamster cells 3
chrM_+_14138 2.259 ENSMUST00000082421.1
mt-Cytb
mitochondrially encoded cytochrome b
chr10_+_75037066 2.250 ENSMUST00000147802.1
ENSMUST00000020391.5
Rab36

RAB36, member RAS oncogene family

chr10_-_88683021 2.129 ENSMUST00000004473.8
Spic
Spi-C transcription factor (Spi-1/PU.1 related)
chr5_-_138619751 2.121 ENSMUST00000085852.4
ENSMUST00000110905.2
Zfp68

zinc finger protein 68

chr4_+_98546919 2.106 ENSMUST00000030290.7
Inadl
InaD-like (Drosophila)
chr3_+_107291215 2.050 ENSMUST00000029502.7
Slc16a4
solute carrier family 16 (monocarboxylic acid transporters), member 4
chr4_+_82065855 2.040 ENSMUST00000151038.1
Gm5860
predicted gene 5860
chr8_-_123754138 2.010 ENSMUST00000181805.1
4732419C18Rik
RIKEN cDNA 4732419C18 gene
chr19_-_43912392 1.994 ENSMUST00000026209.4
Dnmbp
dynamin binding protein
chr16_-_57292845 1.973 ENSMUST00000023434.8
ENSMUST00000120112.1
ENSMUST00000119407.1
Tmem30c


transmembrane protein 30C


chr14_-_16575456 1.967 ENSMUST00000063750.6
Rarb
retinoic acid receptor, beta
chr17_+_86963077 1.938 ENSMUST00000024956.8
Rhoq
ras homolog gene family, member Q
chrM_+_11734 1.908 ENSMUST00000082418.1
mt-Nd5
mitochondrially encoded NADH dehydrogenase 5
chr7_+_19508712 1.887 ENSMUST00000002112.8
ENSMUST00000108455.1
Trappc6a

trafficking protein particle complex 6A

chr3_+_53845086 1.854 ENSMUST00000108014.1
Gm10985
predicted gene 10985
chr8_-_56550791 1.847 ENSMUST00000134162.1
ENSMUST00000140107.1
ENSMUST00000040330.8
ENSMUST00000135337.1
Cep44



centrosomal protein 44



chr8_-_41016749 1.832 ENSMUST00000117735.1
Mtus1
mitochondrial tumor suppressor 1
chr2_-_165388245 1.782 ENSMUST00000103084.3
Zfp334
zinc finger protein 334
chr4_+_127077374 1.780 ENSMUST00000046751.6
ENSMUST00000094713.3
Zmym6

zinc finger, MYM-type 6

chr3_+_103739366 1.752 ENSMUST00000106852.1
Gm10964
predicted gene 10964
chr7_+_27927592 1.741 ENSMUST00000181644.1
Gm26891
predicted gene, 26891
chr2_+_19371636 1.722 ENSMUST00000023856.8
Msrb2
methionine sulfoxide reductase B2
chr2_-_160619971 1.718 ENSMUST00000109473.1
Gm14221
predicted gene 14221
chr19_-_9559204 1.675 ENSMUST00000090527.3
Stxbp3b
syntaxin-binding protein 3B
chr2_+_176711933 1.673 ENSMUST00000108983.2
Gm14305
predicted gene 14305
chr5_+_138187485 1.654 ENSMUST00000110934.2
Cnpy4
canopy 4 homolog (zebrafish)
chr4_-_129227883 1.636 ENSMUST00000106051.1
C77080
expressed sequence C77080
chr1_-_156034800 1.598 ENSMUST00000169241.1
Tor1aip1
torsin A interacting protein 1
chr4_+_98546710 1.562 ENSMUST00000102792.3
Inadl
InaD-like (Drosophila)
chr10_-_53647080 1.547 ENSMUST00000169866.1
Fam184a
family with sequence similarity 184, member A
chr6_+_47920476 1.537 ENSMUST00000009411.8
Zfp212
Zinc finger protein 212
chr10_-_127522428 1.513 ENSMUST00000026470.4
Shmt2
serine hydroxymethyltransferase 2 (mitochondrial)
chrM_+_3906 1.487 ENSMUST00000082396.1
mt-Nd2
mitochondrially encoded NADH dehydrogenase 2
chr16_+_14906622 1.448 ENSMUST00000090277.1
Efcab1
EF hand calcium binding domain 1
chr1_+_178405881 1.443 ENSMUST00000027775.7
Efcab2
EF-hand calcium binding domain 2
chr4_+_43059028 1.431 ENSMUST00000163653.1
ENSMUST00000107952.2
ENSMUST00000107953.2
Unc13b


unc-13 homolog B (C. elegans)


chr7_-_6730412 1.426 ENSMUST00000051209.4
Peg3
paternally expressed 3
chr7_+_7171330 1.358 ENSMUST00000051435.7
Zfp418
zinc finger protein 418
chr5_+_110330697 1.354 ENSMUST00000112481.1
Pole
polymerase (DNA directed), epsilon
chr16_+_4639941 1.342 ENSMUST00000038770.3
Vasn
vasorin
chr7_-_141443989 1.286 ENSMUST00000026580.5
Lrdd
leucine-rich and death domain containing
chr4_-_129641060 1.268 ENSMUST00000046425.9
ENSMUST00000133803.1
Txlna

taxilin alpha

chr13_-_104228833 1.257 ENSMUST00000022226.4
Ppwd1
peptidylprolyl isomerase domain and WD repeat containing 1
chrX_+_42068398 1.219 ENSMUST00000115095.2
Xiap
X-linked inhibitor of apoptosis
chr17_-_24220738 1.218 ENSMUST00000024930.7
1600002H07Rik
RIKEN cDNA 1600002H07 gene
chr4_+_116558056 1.181 ENSMUST00000106475.1
Gpbp1l1
GC-rich promoter binding protein 1-like 1
chr8_+_56551090 1.085 ENSMUST00000040218.5
ENSMUST00000110322.3
Fbxo8

F-box protein 8

chr4_+_146654927 1.082 ENSMUST00000070932.3
Gm13248
predicted gene 13248
chr7_-_42706369 1.053 ENSMUST00000180131.1
Gm17067
predicted gene 17067
chr13_-_29855630 1.045 ENSMUST00000091674.5
ENSMUST00000006353.7
Cdkal1

CDK5 regulatory subunit associated protein 1-like 1

chr14_+_73138755 1.044 ENSMUST00000171070.1
Rcbtb2
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
chr8_+_71922810 1.042 ENSMUST00000119003.1
Zfp617
zinc finger protein 617
chr15_-_100599983 1.030 ENSMUST00000073837.6
Pou6f1
POU domain, class 6, transcription factor 1
chr9_-_22208546 1.002 ENSMUST00000167359.1
1810064F22Rik
RIKEN cDNA 1810064F22 gene
chr11_-_20741580 0.945 ENSMUST00000035350.5
Aftph
aftiphilin
chr15_+_76343504 0.906 ENSMUST00000023210.6
Cyc1
cytochrome c-1
chr8_-_125492710 0.856 ENSMUST00000108775.1
Sipa1l2
signal-induced proliferation-associated 1 like 2
chr9_-_73968901 0.789 ENSMUST00000184666.1
Unc13c
unc-13 homolog C (C. elegans)
chr13_+_23531044 0.781 ENSMUST00000102972.3
Hist1h4h
histone cluster 1, H4h
chr17_+_45506825 0.779 ENSMUST00000024733.7
Aars2
alanyl-tRNA synthetase 2, mitochondrial (putative)
chr13_-_67306412 0.779 ENSMUST00000049705.7
Zfp457
zinc finger protein 457
chr5_-_138187177 0.771 ENSMUST00000110937.1
ENSMUST00000139276.1
ENSMUST00000048698.7
ENSMUST00000123415.1
Taf6



TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor



chr5_-_147894804 0.769 ENSMUST00000118527.1
ENSMUST00000031655.3
ENSMUST00000138244.1
Slc46a3


solute carrier family 46, member 3


chrX_-_75578188 0.759 ENSMUST00000033545.5
Rab39b
RAB39B, member RAS oncogene family
chr2_+_4718145 0.750 ENSMUST00000056914.6
Bend7
BEN domain containing 7
chr2_+_148681023 0.739 ENSMUST00000028928.7
Gzf1
GDNF-inducible zinc finger protein 1
chr16_+_65520503 0.695 ENSMUST00000176330.1
ENSMUST00000004964.8
ENSMUST00000176038.1
Pou1f1


POU domain, class 1, transcription factor 1


chr10_-_95673451 0.680 ENSMUST00000099328.1
Anapc15-ps
anaphase prompoting complex C subunit 15, pseudogene
chrX_+_101640056 0.665 ENSMUST00000119299.1
ENSMUST00000044475.4
Ogt

O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)

chrM_+_9452 0.630 ENSMUST00000082411.1
mt-Nd3
mitochondrially encoded NADH dehydrogenase 3
chr7_-_27985796 0.615 ENSMUST00000099111.3
Zfp850
zinc finger protein 850
chr11_-_80377975 0.597 ENSMUST00000179332.1
ENSMUST00000103225.4
ENSMUST00000134274.1
5730455P16Rik


RIKEN cDNA 5730455P16 gene


chr11_-_58168467 0.584 ENSMUST00000172035.1
ENSMUST00000035604.6
ENSMUST00000102711.2
Gemin5


gem (nuclear organelle) associated protein 5


chr4_+_63215402 0.570 ENSMUST00000036300.6
Col27a1
collagen, type XXVII, alpha 1
chr1_+_132477361 0.568 ENSMUST00000027700.8
Rbbp5
retinoblastoma binding protein 5
chr2_+_103957976 0.561 ENSMUST00000156813.1
ENSMUST00000170926.1
Lmo2

LIM domain only 2

chr12_+_117843489 0.554 ENSMUST00000021592.9
Cdca7l
cell division cycle associated 7 like
chr1_+_189728264 0.502 ENSMUST00000097442.2
Ptpn14
protein tyrosine phosphatase, non-receptor type 14
chr12_-_81485073 0.472 ENSMUST00000166723.1
ENSMUST00000110340.2
ENSMUST00000168463.1
ENSMUST00000169124.1
ENSMUST00000002757.4
Cox16




cytochrome c oxidase assembly protein 16




chr7_-_128298081 0.463 ENSMUST00000033044.9
BC017158
cDNA sequence BC017158
chr12_-_115964196 0.436 ENSMUST00000103550.2
Ighv1-83
immunoglobulin heavy variable 1-83
chr14_-_77036081 0.403 ENSMUST00000142300.1
Lacc1
laccase (multicopper oxidoreductase) domain containing 1
chr2_+_148681199 0.401 ENSMUST00000131292.1
Gzf1
GDNF-inducible zinc finger protein 1
chr16_-_36874806 0.400 ENSMUST00000075946.5
Eaf2
ELL associated factor 2
chr6_+_124304646 0.321 ENSMUST00000112541.2
ENSMUST00000032234.2
Cd163

CD163 antigen

chrX_+_74424632 0.303 ENSMUST00000114129.2
ENSMUST00000132749.1
Ikbkg

inhibitor of kappaB kinase gamma

chr3_-_98339921 0.285 ENSMUST00000065793.5
Phgdh
3-phosphoglycerate dehydrogenase
chr15_-_100599864 0.272 ENSMUST00000177247.2
ENSMUST00000177505.2
Pou6f1

POU domain, class 6, transcription factor 1

chr1_+_156040909 0.248 ENSMUST00000065648.8
ENSMUST00000097526.2
Tor1aip2

torsin A interacting protein 2

chr4_+_103143052 0.234 ENSMUST00000106855.1
Mier1
mesoderm induction early response 1 homolog (Xenopus laevis
chr13_+_65512678 0.234 ENSMUST00000081471.2
Gm10139
predicted gene 10139
chr11_-_116024489 0.221 ENSMUST00000016703.7
H3f3b
H3 histone, family 3B
chr12_+_76417598 0.220 ENSMUST00000063977.7
Ppp1r36
protein phosphatase 1, regulatory subunit 36
chr2_+_91237110 0.198 ENSMUST00000181191.1
A330069E16Rik
RIKEN cDNA A330069E16 gene
chrX_-_94212638 0.196 ENSMUST00000113922.1
Eif2s3x
eukaryotic translation initiation factor 2, subunit 3, structural gene X-linked
chr1_-_9748376 0.188 ENSMUST00000057438.6
Vcpip1
valosin containing protein (p97)/p47 complex interacting protein 1
chr13_+_23544052 0.182 ENSMUST00000075558.2
Hist1h3f
histone cluster 1, H3f
chrX_-_95956890 0.170 ENSMUST00000079987.6
ENSMUST00000113864.2
Las1l

LAS1-like (S. cerevisiae)

chr1_+_164275559 0.143 ENSMUST00000027867.6
Ccdc181
coiled-coil domain containing 181
chr17_-_10320229 0.134 ENSMUST00000053066.6
Qk
quaking
chr7_-_126396715 0.084 ENSMUST00000075671.4
Nfatc2ip
nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 interacting protein
chr11_-_83645621 0.077 ENSMUST00000182502.1
Rpl9-ps1
ribosomal protein L9, pseudogene 1
chr16_+_16870736 0.065 ENSMUST00000139740.1
ENSMUST00000119787.2
ENSMUST00000130650.1
ENSMUST00000156502.1
ENSMUST00000023465.7
ENSMUST00000124960.1
ENSMUST00000144513.1
Top3b






topoisomerase (DNA) III beta






chr13_-_119738394 0.048 ENSMUST00000178973.1
Nim1
serine/threonine-protein kinase NIM1
chr12_+_84069325 0.028 ENSMUST00000046422.4
ENSMUST00000072505.4
Acot5

acyl-CoA thioesterase 5


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 6.6 GO:0035609 C-terminal protein deglutamylation(GO:0035609)
1.6 4.8 GO:0044837 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837)
1.3 5.1 GO:0010808 positive regulation of synaptic vesicle priming(GO:0010808)
0.9 2.7 GO:0032058 positive regulation of translational initiation in response to stress(GO:0032058)
0.8 2.3 GO:0010845 positive regulation of reciprocal meiotic recombination(GO:0010845)
0.7 3.5 GO:0052428 modulation of molecular function in other organism(GO:0044359) negative regulation of molecular function in other organism(GO:0044362) negative regulation of molecular function in other organism involved in symbiotic interaction(GO:0052204) modulation of molecular function in other organism involved in symbiotic interaction(GO:0052205) negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428)
0.6 3.2 GO:0033762 response to glucagon(GO:0033762)
0.6 5.0 GO:0006975 DNA damage induced protein phosphorylation(GO:0006975)
0.5 2.4 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)
0.5 1.4 GO:0045004 DNA replication proofreading(GO:0045004)
0.4 1.7 GO:0030091 protein repair(GO:0030091)
0.4 1.2 GO:1902528 regulation of protein linear polyubiquitination(GO:1902528) positive regulation of protein linear polyubiquitination(GO:1902530)
0.4 2.3 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
0.4 1.5 GO:0006545 glycine biosynthetic process(GO:0006545)
0.4 1.9 GO:1903232 melanosome assembly(GO:1903232)
0.3 5.6 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.3 2.0 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.3 5.1 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.3 0.8 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.2 3.2 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.2 10.1 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.2 6.2 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.2 0.7 GO:0060126 somatotropin secreting cell differentiation(GO:0060126)
0.2 0.7 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.2 1.3 GO:0051775 response to redox state(GO:0051775)
0.2 0.6 GO:0003431 growth plate cartilage chondrocyte development(GO:0003431)
0.2 4.1 GO:0010758 regulation of macrophage chemotaxis(GO:0010758)
0.2 2.4 GO:0035090 maintenance of apical/basal cell polarity(GO:0035090)
0.2 1.6 GO:0071763 nuclear membrane organization(GO:0071763)
0.2 2.4 GO:0000212 meiotic spindle organization(GO:0000212)
0.1 0.3 GO:0006566 threonine metabolic process(GO:0006566)
0.1 0.8 GO:0032196 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529) transposition(GO:0032196)
0.1 13.4 GO:0045580 regulation of T cell differentiation(GO:0045580)
0.1 0.8 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.1 4.5 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.1 3.2 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.1 3.5 GO:0006270 DNA replication initiation(GO:0006270)
0.1 4.8 GO:0006940 regulation of smooth muscle contraction(GO:0006940)
0.1 1.9 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.1 1.6 GO:0007271 synaptic transmission, cholinergic(GO:0007271)
0.1 0.4 GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.1 1.8 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.1 2.6 GO:0072698 protein localization to microtubule cytoskeleton(GO:0072698)
0.1 4.9 GO:0008543 fibroblast growth factor receptor signaling pathway(GO:0008543)
0.1 0.2 GO:1902340 telomeric heterochromatin assembly(GO:0031509) negative regulation of chromosome condensation(GO:1902340)
0.1 3.2 GO:0007606 sensory perception of chemical stimulus(GO:0007606)
0.1 0.6 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.0 1.3 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 1.1 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.8 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.0 3.4 GO:0051225 spindle assembly(GO:0051225)
0.0 0.2 GO:0090168 Golgi reassembly(GO:0090168)
0.0 2.8 GO:0006261 DNA-dependent DNA replication(GO:0006261)
0.0 0.3 GO:0006953 acute-phase response(GO:0006953)
0.0 0.3 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.0 1.1 GO:0001658 branching involved in ureteric bud morphogenesis(GO:0001658)
0.0 0.5 GO:0001946 lymphangiogenesis(GO:0001946)
0.0 0.4 GO:0006958 complement activation, classical pathway(GO:0006958)
0.0 0.2 GO:0090435 protein localization to nuclear envelope(GO:0090435)
0.0 0.6 GO:0071384 cellular response to corticosteroid stimulus(GO:0071384) cellular response to glucocorticoid stimulus(GO:0071385)
0.0 0.2 GO:0031937 positive regulation of chromatin silencing(GO:0031937)
0.0 0.1 GO:0061158 3'-UTR-mediated mRNA destabilization(GO:0061158)
0.0 2.0 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.0 2.0 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 0.2 GO:0000478 endonucleolytic cleavage involved in rRNA processing(GO:0000478)
0.0 0.6 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.0 0.8 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.0 1.1 GO:0001824 blastocyst development(GO:0001824)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 6.2 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
1.0 5.9 GO:0044305 calyx of Held(GO:0044305)
1.0 4.8 GO:0097149 centralspindlin complex(GO:0097149)
0.7 2.8 GO:0008623 CHRAC(GO:0008623)
0.5 4.8 GO:0030478 actin cap(GO:0030478)
0.5 2.3 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.4 1.5 GO:0070552 BRISC complex(GO:0070552)
0.3 3.2 GO:0045275 respiratory chain complex III(GO:0045275)
0.3 1.4 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.2 0.9 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.2 2.4 GO:0000137 Golgi cis cisterna(GO:0000137)
0.2 14.9 GO:0070469 respiratory chain(GO:0070469)
0.1 2.6 GO:0097431 mitotic spindle pole(GO:0097431)
0.1 1.8 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 1.9 GO:0030008 TRAPP complex(GO:0030008)
0.1 8.0 GO:0005814 centriole(GO:0005814)
0.1 2.4 GO:0072686 mitotic spindle(GO:0072686)
0.1 4.3 GO:0005657 replication fork(GO:0005657)
0.1 5.3 GO:0000922 spindle pole(GO:0000922)
0.1 7.3 GO:0000776 kinetochore(GO:0000776)
0.1 0.8 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.0 0.6 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.6 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 0.6 GO:0032797 SMN complex(GO:0032797)
0.0 0.4 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 0.7 GO:0042588 zymogen granule(GO:0042588)
0.0 1.0 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.2 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0 0.1 GO:0002177 manchette(GO:0002177)
0.0 1.4 GO:0005776 autophagosome(GO:0005776)
0.0 1.2 GO:0005844 polysome(GO:0005844)
0.0 1.0 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 1.9 GO:0005884 actin filament(GO:0005884)
0.0 1.0 GO:0001669 acrosomal vesicle(GO:0001669)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 5.9 GO:0001565 phorbol ester receptor activity(GO:0001565) non-kinase phorbol ester receptor activity(GO:0001566)
1.7 5.0 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
1.6 6.2 GO:0050436 microfibril binding(GO:0050436)
0.5 14.9 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.5 1.5 GO:0008732 threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.5 3.5 GO:0001849 complement component C1q binding(GO:0001849)
0.5 1.4 GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.4 6.6 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.3 2.3 GO:0000150 recombinase activity(GO:0000150)
0.3 1.7 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.3 2.3 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.3 0.8 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.2 0.7 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.2 8.3 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.2 2.9 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.1 0.6 GO:0030621 U4 snRNA binding(GO:0030621)
0.1 1.1 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.1 0.3 GO:1990450 linear polyubiquitin binding(GO:1990450)
0.1 2.0 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.1 3.8 GO:0042169 SH2 domain binding(GO:0042169)
0.1 0.8 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.1 1.6 GO:0005521 lamin binding(GO:0005521)
0.1 3.8 GO:0016836 hydro-lyase activity(GO:0016836)
0.1 1.3 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.1 2.3 GO:0008200 ion channel inhibitor activity(GO:0008200)
0.0 2.0 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.0 8.2 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 1.1 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 3.4 GO:0003777 microtubule motor activity(GO:0003777)
0.0 2.4 GO:0043022 ribosome binding(GO:0043022)
0.0 1.0 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 0.8 GO:0031489 myosin V binding(GO:0031489)
0.0 2.3 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 1.3 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0 1.2 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.4 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 1.3 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 2.8 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.0 1.3 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 2.0 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 1.3 GO:0019905 syntaxin binding(GO:0019905)
0.0 0.3 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.6 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 4.4 GO:0003924 GTPase activity(GO:0003924)
0.0 0.9 GO:0020037 heme binding(GO:0020037)
0.0 13.0 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.0 1.2 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.0 2.4 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 2.8 GO:0008017 microtubule binding(GO:0008017)
0.0 0.4 GO:0005507 copper ion binding(GO:0005507)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 5.0 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 6.8 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.1 4.6 PID_ARF6_PATHWAY Arf6 signaling events
0.1 3.5 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.1 1.9 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.1 2.0 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 1.2 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 2.4 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 2.3 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.0 6.1 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 2.8 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.3 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 5.0 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.2 5.1 REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.2 8.7 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 4.8 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 3.7 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.1 2.4 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 1.4 REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.1 2.6 REACTOME_MEIOTIC_RECOMBINATION Genes involved in Meiotic Recombination
0.1 1.7 REACTOME_KINESINS Genes involved in Kinesins
0.0 0.8 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 5.5 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.3 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 1.2 REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.0 0.9 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.8 REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.3 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.6 REACTOME_METABOLISM_OF_NON_CODING_RNA Genes involved in Metabolism of non-coding RNA