Motif ID: Mnt

Z-value: 0.735


Transcription factors associated with Mnt:

Gene SymbolEntrez IDGene Name
Mnt ENSMUSG00000000282.6 Mnt

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mntmm10_v2_chr11_+_74830920_74831005-0.291.1e-02Click!


Activity profile for motif Mnt.

activity profile for motif Mnt


Sorted Z-values histogram for motif Mnt

Sorted Z-values for motif Mnt



Network of associatons between targets according to the STRING database.



First level regulatory network of Mnt

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_-_25570678 5.740 ENSMUST00000025003.3
ENSMUST00000173447.1
 Sox8

SRY-box containing gene 8

chrX_-_51681703 4.715 ENSMUST00000088172.5
 Hs6st2
heparan sulfate 6-O-sulfotransferase 2
chr6_+_17463749 4.642 ENSMUST00000115443.1
 Met
met proto-oncogene
chr16_-_43979050 4.441 ENSMUST00000165648.1
ENSMUST00000036321.7
 Zdhhc23

zinc finger, DHHC domain containing 23

chr6_+_17463927 4.304 ENSMUST00000115442.1
 Met
met proto-oncogene
chr15_+_81811414 4.288 ENSMUST00000023024.7
 Tef
thyrotroph embryonic factor
chr12_+_24651346 4.210 ENSMUST00000020982.5
 Klf11
Kruppel-like factor 11
chr3_-_89773221 4.150 ENSMUST00000038450.1
 4632404H12Rik
RIKEN cDNA 4632404H12 gene
chr12_+_70825492 4.126 ENSMUST00000057859.7
 Frmd6
FERM domain containing 6
chr17_-_66077022 4.121 ENSMUST00000150766.1
ENSMUST00000038116.5
 Ankrd12

ankyrin repeat domain 12

chr1_-_186705980 4.096 ENSMUST00000045288.8
 Tgfb2
transforming growth factor, beta 2
chr2_+_4300462 3.819 ENSMUST00000175669.1
 Frmd4a
FERM domain containing 4A
chr9_-_121495678 3.769 ENSMUST00000035120.4
 Cck
cholecystokinin
chr8_+_84990585 3.555 ENSMUST00000064495.6
 Hook2
hook homolog 2 (Drosophila)
chr11_-_101785252 3.404 ENSMUST00000164750.1
ENSMUST00000107176.1
ENSMUST00000017868.6
 Etv4


ets variant gene 4 (E1A enhancer binding protein, E1AF)


chr8_-_29219338 3.209 ENSMUST00000168630.2
 Unc5d
unc-5 homolog D (C. elegans)
chr1_+_59684949 3.204 ENSMUST00000027174.3
 Nop58
NOP58 ribonucleoprotein
chr12_-_90738438 3.178 ENSMUST00000082432.3
 Dio2
deiodinase, iodothyronine, type II
chr6_+_17463826 3.128 ENSMUST00000140070.1
 Met
met proto-oncogene
chr4_+_21848039 3.054 ENSMUST00000098238.2
ENSMUST00000108229.1
 Sfrs18

serine/arginine-rich splicing factor 18


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 263 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.8 12.3 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.0 6.9 GO:0008643 carbohydrate transport(GO:0008643)
1.9 5.7 GO:0072034 renal vesicle induction(GO:0072034)
0.3 5.7 GO:2001014 regulation of skeletal muscle cell differentiation(GO:2001014)
1.8 5.4 GO:1904049 negative regulation of spontaneous neurotransmitter secretion(GO:1904049)
0.2 5.0 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
1.6 4.8 GO:1902256 apoptotic process involved in outflow tract morphogenesis(GO:0003275) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256)
0.8 4.7 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.2 4.6 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.9 4.4 GO:0070460 thyroid-stimulating hormone secretion(GO:0070460)
0.7 4.1 GO:0003383 apical constriction(GO:0003383)
1.3 3.9 GO:0003349 epicardium-derived cardiac endothelial cell differentiation(GO:0003349)
0.4 3.8 GO:0051901 positive regulation of mitochondrial depolarization(GO:0051901)
0.1 3.7 GO:0051703 social behavior(GO:0035176) intraspecies interaction between organisms(GO:0051703)
0.9 3.6 GO:0007066 female meiosis sister chromatid cohesion(GO:0007066)
0.1 3.6 GO:0045022 early endosome to late endosome transport(GO:0045022)
0.9 3.5 GO:0002101 tRNA wobble cytosine modification(GO:0002101)
0.7 3.5 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.1 3.5 GO:0061157 mRNA destabilization(GO:0061157)
0.6 3.4 GO:0033600 negative regulation of mammary gland epithelial cell proliferation(GO:0033600)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 132 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 12.3 GO:0009925 basal plasma membrane(GO:0009925)
0.4 7.1 GO:1990635 proximal dendrite(GO:1990635)
0.3 5.7 GO:0071004 U2-type prespliceosome(GO:0071004)
1.1 5.4 GO:1990761 growth cone lamellipodium(GO:1990761)
1.3 5.3 GO:0034991 nuclear meiotic cohesin complex(GO:0034991)
0.0 4.6 GO:0097060 synaptic membrane(GO:0097060)
0.0 4.5 GO:0005604 basement membrane(GO:0005604)
0.0 4.2 GO:0000922 spindle pole(GO:0000922)
0.1 4.1 GO:0090544 BAF-type complex(GO:0090544)
0.0 3.9 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 3.9 GO:0000139 Golgi membrane(GO:0000139)
0.4 3.8 GO:0071141 SMAD protein complex(GO:0071141)
0.3 3.8 GO:0043203 axon hillock(GO:0043203)
0.1 3.7 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.5 3.6 GO:0070695 FHF complex(GO:0070695)
0.0 3.4 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.6 2.9 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.3 2.8 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 2.8 GO:0014704 intercalated disc(GO:0014704)
0.0 2.6 GO:0016459 myosin complex(GO:0016459)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 183 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.0 12.1 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.3 7.4 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.1 6.5 GO:0015485 cholesterol binding(GO:0015485)
0.9 5.6 GO:0034186 apolipoprotein A-I binding(GO:0034186)
0.3 5.4 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.3 5.4 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.2 5.4 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.2 5.2 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 5.1 GO:0008565 protein transporter activity(GO:0008565)
1.2 4.7 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.5 4.5 GO:0050308 sugar-phosphatase activity(GO:0050308)
0.2 4.4 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
1.0 4.1 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.7 4.1 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.1 4.0 GO:0051018 protein kinase A binding(GO:0051018)
0.6 3.9 GO:0043426 MRF binding(GO:0043426)
0.1 3.8 GO:0035064 methylated histone binding(GO:0035064)
0.0 3.8 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 3.6 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.1 3.6 GO:0017134 fibroblast growth factor binding(GO:0017134)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 12.6 PID_ARF6_PATHWAY Arf6 signaling events
0.1 6.9 PID_FOXO_PATHWAY FoxO family signaling
0.0 5.8 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.3 5.2 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.2 5.0 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.4 4.1 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 4.0 PID_LKB1_PATHWAY LKB1 signaling events
0.2 3.5 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 3.5 PID_MET_PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.1 2.9 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.1 2.7 PID_RAS_PATHWAY Regulation of Ras family activation
0.1 2.4 PID_BMP_PATHWAY BMP receptor signaling
0.1 1.9 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.0 1.8 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.8 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.7 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 1.6 PID_E2F_PATHWAY E2F transcription factor network
0.4 1.4 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 1.4 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.0 1.4 PID_INSULIN_PATHWAY Insulin Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 12.1 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.1 6.4 REACTOME_HEPARAN_SULFATE_HEPARIN_HS_GAG_METABOLISM Genes involved in Heparan sulfate/heparin (HS-GAG) metabolism
0.1 5.6 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.3 5.5 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.2 5.5 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.1 4.4 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.2 3.6 REACTOME_FORMATION_OF_INCISION_COMPLEX_IN_GG_NER Genes involved in Formation of incision complex in GG-NER
0.3 3.2 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.1 3.2 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.1 3.0 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.2 2.7 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.1 2.7 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.1 2.6 REACTOME_TRANSFERRIN_ENDOCYTOSIS_AND_RECYCLING Genes involved in Transferrin endocytosis and recycling
0.0 2.6 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
0.1 2.5 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.1 2.4 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.6 2.2 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.2 2.2 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 2.2 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.1 2.1 REACTOME_CA_DEPENDENT_EVENTS Genes involved in Ca-dependent events