Motif ID: Mnx1_Lhx6_Lmx1a

Z-value: 0.888

Transcription factors associated with Mnx1_Lhx6_Lmx1a:

Gene SymbolEntrez IDGene Name
Lhx6 ENSMUSG00000026890.13 Lhx6
Lmx1a ENSMUSG00000026686.8 Lmx1a
Mnx1 ENSMUSG00000001566.8 Mnx1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Lmx1amm10_v2_chr1_+_167689108_1676892390.503.3e-06Click!
Lhx6mm10_v2_chr2_-_36105271_36105434-0.463.1e-05Click!


Activity profile for motif Mnx1_Lhx6_Lmx1a.

activity profile for motif Mnx1_Lhx6_Lmx1a


Sorted Z-values histogram for motif Mnx1_Lhx6_Lmx1a

Sorted Z-values for motif Mnx1_Lhx6_Lmx1a



Network of associatons between targets according to the STRING database.



First level regulatory network of Mnx1_Lhx6_Lmx1a

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_-_61902669 23.727 ENSMUST00000121785.1
ENSMUST00000034057.7
 Palld

palladin, cytoskeletal associated protein

chr5_-_62766153 19.385 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr5_+_139543889 16.417 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr15_+_25773985 14.536 ENSMUST00000125667.1
 Myo10
myosin X
chr9_+_118478182 11.873 ENSMUST00000111763.1
 Eomes
eomesodermin homolog (Xenopus laevis)
chr9_+_118478344 11.389 ENSMUST00000035020.8
 Eomes
eomesodermin homolog (Xenopus laevis)
chr9_+_65890237 11.332 ENSMUST00000045802.6
 2810417H13Rik
RIKEN cDNA 2810417H13 gene
chr2_+_25372315 10.989 ENSMUST00000028329.6
ENSMUST00000114293.2
ENSMUST00000100323.2
 Sapcd2


suppressor APC domain containing 2


chr2_+_20737306 10.411 ENSMUST00000114606.1
ENSMUST00000114608.1
 Etl4

enhancer trap locus 4

chr1_-_172027269 9.682 ENSMUST00000027837.6
ENSMUST00000111264.1
 Vangl2

vang-like 2 (van gogh, Drosophila)

chr13_-_97747373 9.045 ENSMUST00000123535.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr9_+_96258697 9.044 ENSMUST00000179416.1
 Tfdp2
transcription factor Dp 2
chr18_+_57468478 9.016 ENSMUST00000091892.2
 Ctxn3
cortexin 3
chr2_+_116067213 8.727 ENSMUST00000152412.1
 G630016G05Rik
RIKEN cDNA G630016G05 gene
chr13_-_97747399 8.701 ENSMUST00000144993.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr3_+_55782500 8.610 ENSMUST00000075422.4
 Mab21l1
mab-21-like 1 (C. elegans)
chr8_+_45658666 8.563 ENSMUST00000134675.1
ENSMUST00000139869.1
ENSMUST00000126067.1
 Sorbs2


sorbin and SH3 domain containing 2


chr2_-_116067391 8.380 ENSMUST00000140185.1
 2700033N17Rik
RIKEN cDNA 2700033N17 gene
chr8_+_45658731 8.312 ENSMUST00000143820.1
ENSMUST00000132139.1
 Sorbs2

sorbin and SH3 domain containing 2

chr4_-_97778042 8.230 ENSMUST00000146447.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 125 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 23.7 GO:0071803 keratinocyte development(GO:0003334) positive regulation of podosome assembly(GO:0071803)
7.8 23.3 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.5 21.3 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
1.2 19.7 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
2.1 16.7 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
5.5 16.4 GO:0060489 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
3.6 14.3 GO:0015889 cobalamin transport(GO:0015889)
0.3 11.8 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.2 10.1 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
2.5 9.8 GO:0006982 response to lipid hydroperoxide(GO:0006982) cellular response to lipid hydroperoxide(GO:0071449)
0.2 9.6 GO:0002066 columnar/cuboidal epithelial cell development(GO:0002066)
0.1 9.0 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.8 8.5 GO:0060539 diaphragm development(GO:0060539)
0.7 7.8 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.1 7.3 GO:0043488 regulation of mRNA stability(GO:0043488)
2.4 7.1 GO:0090271 positive regulation of fibroblast growth factor production(GO:0090271)
0.3 6.5 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.7 5.9 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.5 5.9 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.5 5.9 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 79.1 GO:0005634 nucleus(GO:0005634)
0.5 23.7 GO:0002102 podosome(GO:0002102)
0.2 16.9 GO:0070469 respiratory chain(GO:0070469)
4.1 16.4 GO:0060187 cell pole(GO:0060187)
0.2 14.5 GO:0016459 myosin complex(GO:0016459)
0.1 9.4 GO:0043296 apical junction complex(GO:0043296)
0.1 9.0 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 8.9 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
1.2 7.5 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.5 7.3 GO:0042788 polysomal ribosome(GO:0042788)
0.1 5.9 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.3 5.8 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 5.8 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 4.4 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 4.3 GO:0000792 heterochromatin(GO:0000792)
1.0 4.1 GO:0008623 CHRAC(GO:0008623)
0.5 4.1 GO:0030478 actin cap(GO:0030478)
0.8 3.8 GO:0031523 Myb complex(GO:0031523)
0.0 3.6 GO:0000776 kinetochore(GO:0000776)
0.0 3.1 GO:0005769 early endosome(GO:0005769)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 104 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 30.8 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.5 23.3 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.4 23.3 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 21.6 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
1.2 18.6 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.1 18.0 GO:0003779 actin binding(GO:0003779)
0.0 17.1 GO:0003723 RNA binding(GO:0003723)
2.0 14.3 GO:0031419 cobalamin binding(GO:0031419)
0.5 14.1 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 13.8 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.1 12.5 GO:0051015 actin filament binding(GO:0051015)
0.2 10.5 GO:0030507 spectrin binding(GO:0030507)
0.4 9.8 GO:1900750 glutathione peroxidase activity(GO:0004602) glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.1 7.5 GO:0016779 nucleotidyltransferase activity(GO:0016779)
0.2 7.3 GO:0017091 AU-rich element binding(GO:0017091)
0.6 7.2 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 6.4 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 6.4 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.1 5.9 GO:0001784 phosphotyrosine binding(GO:0001784)
0.4 5.8 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 23.3 PID_IL12_2PATHWAY IL12-mediated signaling events
0.5 20.8 PID_ARF6_PATHWAY Arf6 signaling events
0.3 15.2 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.2 7.8 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 6.8 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.3 5.9 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.1 5.9 PID_E2F_PATHWAY E2F transcription factor network
0.2 4.2 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.1 3.8 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 3.8 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.1 3.5 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.1 3.3 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.2 3.2 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.0 3.1 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 2.3 PID_NEPHRIN_NEPH1_PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.1 2.2 PID_MYC_PATHWAY C-MYC pathway
0.2 2.0 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 2.0 PID_PLK1_PATHWAY PLK1 signaling events
0.0 1.9 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.3 1.7 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 19.7 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 19.7 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.2 14.5 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.4 9.8 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.2 7.4 REACTOME_IL_RECEPTOR_SHC_SIGNALING Genes involved in Interleukin receptor SHC signaling
0.1 4.5 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 4.2 REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS Genes involved in G alpha (q) signalling events
0.1 4.1 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 3.6 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 3.5 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 2.8 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 2.7 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.2 2.0 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 2.0 REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.1 1.7 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 1.7 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.1 1.5 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.3 1.4 REACTOME_ANDROGEN_BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.0 1.4 REACTOME_G1_PHASE Genes involved in G1 Phase
0.0 1.3 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening