Motif ID: Mnx1_Lhx6_Lmx1a
Z-value: 0.888
Transcription factors associated with Mnx1_Lhx6_Lmx1a:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Lhx6 | ENSMUSG00000026890.13 | Lhx6 |
| Lmx1a | ENSMUSG00000026686.8 | Lmx1a |
| Mnx1 | ENSMUSG00000001566.8 | Mnx1 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Lmx1a | mm10_v2_chr1_+_167689108_167689239 | 0.50 | 3.3e-06 | Click! |
| Lhx6 | mm10_v2_chr2_-_36105271_36105434 | -0.46 | 3.1e-05 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.8 | 23.3 | GO:0002302 | CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302) |
| 5.5 | 16.4 | GO:0060489 | orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490) |
| 3.6 | 14.3 | GO:0015889 | cobalamin transport(GO:0015889) |
| 2.5 | 9.8 | GO:0006982 | response to lipid hydroperoxide(GO:0006982) cellular response to lipid hydroperoxide(GO:0071449) |
| 2.4 | 7.1 | GO:0090271 | positive regulation of fibroblast growth factor production(GO:0090271) |
| 2.1 | 16.7 | GO:0035726 | common myeloid progenitor cell proliferation(GO:0035726) |
| 1.4 | 4.3 | GO:0016554 | cytidine to uridine editing(GO:0016554) |
| 1.4 | 5.7 | GO:0046552 | eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552) |
| 1.3 | 4.0 | GO:0035934 | corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852) |
| 1.3 | 3.8 | GO:1905000 | regulation of membrane repolarization during atrial cardiac muscle cell action potential(GO:1905000) |
| 1.2 | 23.7 | GO:0071803 | keratinocyte development(GO:0003334) positive regulation of podosome assembly(GO:0071803) |
| 1.2 | 19.7 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway(GO:0048387) |
| 1.0 | 3.0 | GO:0044028 | DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029) |
| 1.0 | 5.8 | GO:0006570 | tyrosine metabolic process(GO:0006570) |
| 0.9 | 2.6 | GO:0042320 | regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938) |
| 0.9 | 3.5 | GO:0035553 | oxidative single-stranded RNA demethylation(GO:0035553) |
| 0.8 | 2.4 | GO:0097155 | fasciculation of sensory neuron axon(GO:0097155) |
| 0.8 | 8.5 | GO:0060539 | diaphragm development(GO:0060539) |
| 0.8 | 2.3 | GO:0019343 | cysteine biosynthetic process via cystathionine(GO:0019343) cysteine biosynthetic process(GO:0019344) |
| 0.7 | 7.8 | GO:0048934 | peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935) |
| 0.7 | 4.9 | GO:0032596 | protein transport into membrane raft(GO:0032596) dsRNA transport(GO:0033227) |
| 0.7 | 5.9 | GO:1900194 | negative regulation of oocyte maturation(GO:1900194) |
| 0.6 | 3.8 | GO:0060648 | mammary gland bud morphogenesis(GO:0060648) |
| 0.6 | 4.3 | GO:0043569 | negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569) |
| 0.6 | 1.7 | GO:0032918 | polyamine acetylation(GO:0032917) spermidine acetylation(GO:0032918) |
| 0.5 | 5.9 | GO:2000741 | positive regulation of mesenchymal stem cell differentiation(GO:2000741) |
| 0.5 | 1.6 | GO:1902498 | regulation of protein autoubiquitination(GO:1902498) |
| 0.5 | 1.0 | GO:2001187 | positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187) |
| 0.5 | 3.2 | GO:0060501 | positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501) |
| 0.5 | 5.9 | GO:0021521 | ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573) |
| 0.5 | 21.3 | GO:0003301 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.4 | 3.3 | GO:0072615 | interleukin-17 secretion(GO:0072615) |
| 0.4 | 2.0 | GO:0021856 | cerebral cortex tangential migration using cell-axon interactions(GO:0021824) gonadotrophin-releasing hormone neuronal migration to the hypothalamus(GO:0021828) hypothalamic tangential migration using cell-axon interactions(GO:0021856) facioacoustic ganglion development(GO:1903375) |
| 0.4 | 3.3 | GO:0009396 | folic acid-containing compound biosynthetic process(GO:0009396) |
| 0.4 | 2.9 | GO:0030242 | pexophagy(GO:0030242) |
| 0.4 | 1.2 | GO:0035790 | platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790) |
| 0.4 | 2.8 | GO:0098535 | positive regulation of centriole replication(GO:0046601) de novo centriole assembly(GO:0098535) |
| 0.4 | 5.0 | GO:0072189 | ureter development(GO:0072189) |
| 0.3 | 4.5 | GO:0021796 | cerebral cortex regionalization(GO:0021796) |
| 0.3 | 1.4 | GO:0071596 | ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596) |
| 0.3 | 1.3 | GO:1900377 | negative regulation of melanin biosynthetic process(GO:0048022) negative regulation of secondary metabolite biosynthetic process(GO:1900377) |
| 0.3 | 2.3 | GO:0051611 | negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 0.3 | 1.9 | GO:0000707 | meiotic DNA recombinase assembly(GO:0000707) |
| 0.3 | 1.5 | GO:0006538 | glutamate catabolic process(GO:0006538) |
| 0.3 | 11.8 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 0.3 | 6.5 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
| 0.3 | 2.0 | GO:0045213 | neurotransmitter receptor metabolic process(GO:0045213) |
| 0.3 | 0.9 | GO:1904245 | regulation of polynucleotide adenylyltransferase activity(GO:1904245) |
| 0.3 | 2.3 | GO:0034454 | microtubule anchoring at centrosome(GO:0034454) |
| 0.3 | 0.8 | GO:0061357 | Wnt protein secretion(GO:0061355) regulation of Wnt protein secretion(GO:0061356) positive regulation of Wnt protein secretion(GO:0061357) |
| 0.2 | 1.4 | GO:0051987 | positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987) |
| 0.2 | 0.7 | GO:0090324 | negative regulation of oxidative phosphorylation(GO:0090324) |
| 0.2 | 2.4 | GO:0071763 | nuclear membrane organization(GO:0071763) |
| 0.2 | 1.2 | GO:0038032 | termination of G-protein coupled receptor signaling pathway(GO:0038032) |
| 0.2 | 1.1 | GO:0015788 | UDP-N-acetylglucosamine transport(GO:0015788) |
| 0.2 | 3.8 | GO:0001833 | inner cell mass cell proliferation(GO:0001833) |
| 0.2 | 3.3 | GO:0050860 | negative regulation of T cell receptor signaling pathway(GO:0050860) |
| 0.2 | 1.8 | GO:0071372 | cellular response to follicle-stimulating hormone stimulus(GO:0071372) |
| 0.2 | 0.2 | GO:0060364 | frontal suture morphogenesis(GO:0060364) |
| 0.2 | 0.8 | GO:0007352 | zygotic specification of dorsal/ventral axis(GO:0007352) |
| 0.2 | 3.6 | GO:0007530 | sex determination(GO:0007530) |
| 0.2 | 1.4 | GO:0048625 | myoblast fate commitment(GO:0048625) |
| 0.2 | 10.1 | GO:0042773 | ATP synthesis coupled electron transport(GO:0042773) |
| 0.2 | 3.4 | GO:0060218 | hematopoietic stem cell differentiation(GO:0060218) |
| 0.2 | 9.6 | GO:0002066 | columnar/cuboidal epithelial cell development(GO:0002066) |
| 0.2 | 2.0 | GO:0090435 | protein localization to nuclear envelope(GO:0090435) |
| 0.2 | 0.6 | GO:0019614 | catechol-containing compound catabolic process(GO:0019614) dopamine catabolic process(GO:0042420) catecholamine catabolic process(GO:0042424) |
| 0.2 | 3.4 | GO:0033194 | response to hydroperoxide(GO:0033194) |
| 0.1 | 9.0 | GO:0051489 | regulation of filopodium assembly(GO:0051489) |
| 0.1 | 1.4 | GO:0033148 | positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148) |
| 0.1 | 0.5 | GO:0046619 | optic placode formation involved in camera-type eye formation(GO:0046619) |
| 0.1 | 0.6 | GO:0042256 | mature ribosome assembly(GO:0042256) |
| 0.1 | 0.7 | GO:0051096 | positive regulation of helicase activity(GO:0051096) |
| 0.1 | 3.8 | GO:0034508 | centromere complex assembly(GO:0034508) |
| 0.1 | 0.6 | GO:0070562 | regulation of vitamin D receptor signaling pathway(GO:0070562) |
| 0.1 | 0.9 | GO:0030853 | negative regulation of granulocyte differentiation(GO:0030853) positive regulation of brown fat cell differentiation(GO:0090336) |
| 0.1 | 0.7 | GO:0021869 | forebrain ventricular zone progenitor cell division(GO:0021869) |
| 0.1 | 4.5 | GO:0030901 | midbrain development(GO:0030901) |
| 0.1 | 0.3 | GO:0036233 | glycine import(GO:0036233) |
| 0.1 | 0.5 | GO:0006564 | L-serine biosynthetic process(GO:0006564) |
| 0.1 | 2.6 | GO:0051693 | actin filament capping(GO:0051693) |
| 0.1 | 0.3 | GO:1902605 | heterotrimeric G-protein complex assembly(GO:1902605) |
| 0.1 | 0.6 | GO:0046292 | formaldehyde metabolic process(GO:0046292) |
| 0.1 | 2.2 | GO:0032011 | ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012) |
| 0.1 | 0.3 | GO:2000324 | positive regulation of glucocorticoid receptor signaling pathway(GO:2000324) |
| 0.1 | 7.3 | GO:0043488 | regulation of mRNA stability(GO:0043488) |
| 0.1 | 2.0 | GO:0009954 | proximal/distal pattern formation(GO:0009954) |
| 0.1 | 2.3 | GO:0007588 | excretion(GO:0007588) |
| 0.1 | 4.0 | GO:0006940 | regulation of smooth muscle contraction(GO:0006940) |
| 0.1 | 4.7 | GO:0071774 | response to fibroblast growth factor(GO:0071774) |
| 0.1 | 0.4 | GO:0051461 | regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461) |
| 0.1 | 1.9 | GO:0032330 | regulation of chondrocyte differentiation(GO:0032330) |
| 0.1 | 0.6 | GO:0035372 | protein localization to microtubule(GO:0035372) |
| 0.1 | 2.1 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 0.1 | 1.4 | GO:0060749 | mammary gland alveolus development(GO:0060749) mammary gland lobule development(GO:0061377) |
| 0.1 | 1.5 | GO:0071384 | cellular response to corticosteroid stimulus(GO:0071384) cellular response to glucocorticoid stimulus(GO:0071385) |
| 0.1 | 1.1 | GO:0010172 | embryonic body morphogenesis(GO:0010172) |
| 0.0 | 3.6 | GO:0001824 | blastocyst development(GO:0001824) |
| 0.0 | 0.9 | GO:0051457 | maintenance of protein location in nucleus(GO:0051457) |
| 0.0 | 1.3 | GO:0034723 | DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723) |
| 0.0 | 1.5 | GO:0031365 | N-terminal protein amino acid modification(GO:0031365) |
| 0.0 | 0.5 | GO:0010603 | regulation of cytoplasmic mRNA processing body assembly(GO:0010603) |
| 0.0 | 0.4 | GO:0030322 | stabilization of membrane potential(GO:0030322) |
| 0.0 | 0.4 | GO:0034219 | carbohydrate transmembrane transport(GO:0034219) |
| 0.0 | 0.4 | GO:0046339 | diacylglycerol metabolic process(GO:0046339) |
| 0.0 | 0.1 | GO:1904565 | response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566) |
| 0.0 | 1.1 | GO:0006303 | double-strand break repair via nonhomologous end joining(GO:0006303) |
| 0.0 | 0.1 | GO:1902268 | negative regulation of polyamine transmembrane transport(GO:1902268) |
| 0.0 | 1.0 | GO:0006284 | base-excision repair(GO:0006284) |
| 0.0 | 4.0 | GO:0006261 | DNA-dependent DNA replication(GO:0006261) |
| 0.0 | 0.6 | GO:0061014 | positive regulation of mRNA catabolic process(GO:0061014) |
| 0.0 | 2.4 | GO:0016055 | Wnt signaling pathway(GO:0016055) cell-cell signaling by wnt(GO:0198738) |
| 0.0 | 3.4 | GO:0046488 | phosphatidylinositol metabolic process(GO:0046488) |
| 0.0 | 1.0 | GO:0032007 | negative regulation of TOR signaling(GO:0032007) |
| 0.0 | 0.3 | GO:0061436 | establishment of skin barrier(GO:0061436) |
| 0.0 | 0.4 | GO:0043984 | histone H4-K16 acetylation(GO:0043984) |
| 0.0 | 0.2 | GO:0060837 | blood vessel endothelial cell differentiation(GO:0060837) |
| 0.0 | 0.5 | GO:0015985 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
| 0.0 | 1.6 | GO:0045580 | regulation of T cell differentiation(GO:0045580) |
| 0.0 | 0.4 | GO:1902236 | negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902236) |
| 0.0 | 0.5 | GO:0006730 | one-carbon metabolic process(GO:0006730) |
| 0.0 | 0.8 | GO:0010633 | negative regulation of epithelial cell migration(GO:0010633) |
| 0.0 | 2.1 | GO:0008360 | regulation of cell shape(GO:0008360) |
| 0.0 | 0.4 | GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184) |
| 0.0 | 2.6 | GO:0007059 | chromosome segregation(GO:0007059) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.1 | 16.4 | GO:0060187 | cell pole(GO:0060187) |
| 1.2 | 7.5 | GO:0000444 | MIS12/MIND type complex(GO:0000444) |
| 1.0 | 4.1 | GO:0008623 | CHRAC(GO:0008623) |
| 1.0 | 3.0 | GO:0005943 | phosphatidylinositol 3-kinase complex, class IA(GO:0005943) |
| 0.8 | 3.8 | GO:0031523 | Myb complex(GO:0031523) |
| 0.5 | 23.7 | GO:0002102 | podosome(GO:0002102) |
| 0.5 | 4.1 | GO:0030478 | actin cap(GO:0030478) |
| 0.5 | 7.3 | GO:0042788 | polysomal ribosome(GO:0042788) |
| 0.5 | 2.8 | GO:0098536 | deuterosome(GO:0098536) |
| 0.4 | 1.9 | GO:0033063 | Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063) |
| 0.3 | 2.3 | GO:0070695 | FHF complex(GO:0070695) |
| 0.3 | 5.8 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.2 | 14.5 | GO:0016459 | myosin complex(GO:0016459) |
| 0.2 | 16.9 | GO:0070469 | respiratory chain(GO:0070469) |
| 0.2 | 0.6 | GO:0042585 | germinal vesicle(GO:0042585) |
| 0.2 | 1.1 | GO:0032807 | DNA ligase IV complex(GO:0032807) |
| 0.2 | 1.4 | GO:0070369 | beta-catenin-TCF7L2 complex(GO:0070369) |
| 0.1 | 0.9 | GO:0030914 | STAGA complex(GO:0030914) |
| 0.1 | 1.4 | GO:1990023 | mitotic spindle midzone(GO:1990023) |
| 0.1 | 8.9 | GO:0005778 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 0.1 | 0.6 | GO:0042406 | extrinsic component of endoplasmic reticulum membrane(GO:0042406) |
| 0.1 | 0.6 | GO:0005726 | perichromatin fibrils(GO:0005726) |
| 0.1 | 0.4 | GO:0072487 | MSL complex(GO:0072487) |
| 0.1 | 1.0 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.1 | 1.0 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.1 | 0.9 | GO:0036038 | MKS complex(GO:0036038) |
| 0.1 | 0.9 | GO:0042405 | nuclear inclusion body(GO:0042405) |
| 0.1 | 9.4 | GO:0043296 | apical junction complex(GO:0043296) |
| 0.1 | 9.0 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.1 | 5.9 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.1 | 0.9 | GO:0005640 | nuclear outer membrane(GO:0005640) |
| 0.0 | 0.6 | GO:0000177 | cytoplasmic exosome (RNase complex)(GO:0000177) |
| 0.0 | 1.3 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 0.0 | 1.5 | GO:0060077 | inhibitory synapse(GO:0060077) |
| 0.0 | 0.4 | GO:0031080 | nuclear pore outer ring(GO:0031080) |
| 0.0 | 0.6 | GO:0005852 | eukaryotic translation initiation factor 3 complex(GO:0005852) |
| 0.0 | 1.6 | GO:0097610 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.0 | 4.3 | GO:0000792 | heterochromatin(GO:0000792) |
| 0.0 | 0.5 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.0 | 0.8 | GO:0032590 | dendrite membrane(GO:0032590) |
| 0.0 | 0.5 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
| 0.0 | 0.4 | GO:0044322 | endoplasmic reticulum quality control compartment(GO:0044322) |
| 0.0 | 0.2 | GO:0032777 | Piccolo NuA4 histone acetyltransferase complex(GO:0032777) |
| 0.0 | 0.5 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.0 | 3.6 | GO:0000776 | kinetochore(GO:0000776) |
| 0.0 | 2.9 | GO:0070382 | exocytic vesicle(GO:0070382) |
| 0.0 | 2.4 | GO:0043198 | dendritic shaft(GO:0043198) |
| 0.0 | 0.9 | GO:0016235 | aggresome(GO:0016235) |
| 0.0 | 5.8 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 0.9 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
| 0.0 | 1.0 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.0 | 3.1 | GO:0005769 | early endosome(GO:0005769) |
| 0.0 | 2.4 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.0 | 0.3 | GO:0035253 | ciliary rootlet(GO:0035253) |
| 0.0 | 4.4 | GO:0045121 | membrane raft(GO:0045121) membrane microdomain(GO:0098857) |
| 0.0 | 0.8 | GO:0043679 | axon terminus(GO:0043679) |
| 0.0 | 0.5 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.0 | 79.1 | GO:0005634 | nucleus(GO:0005634) |
| 0.0 | 0.4 | GO:1990391 | DNA repair complex(GO:1990391) |
| 0.0 | 0.6 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 14.3 | GO:0031419 | cobalamin binding(GO:0031419) |
| 1.2 | 18.6 | GO:0044323 | retinoic acid-responsive element binding(GO:0044323) |
| 1.1 | 4.3 | GO:0004126 | cytidine deaminase activity(GO:0004126) |
| 1.0 | 3.8 | GO:0034988 | Fc-gamma receptor I complex binding(GO:0034988) |
| 0.9 | 3.5 | GO:0035515 | oxidative RNA demethylase activity(GO:0035515) |
| 0.8 | 3.3 | GO:0008142 | oxysterol binding(GO:0008142) |
| 0.8 | 0.8 | GO:0031852 | mu-type opioid receptor binding(GO:0031852) |
| 0.6 | 7.2 | GO:0043522 | leucine zipper domain binding(GO:0043522) |
| 0.6 | 1.7 | GO:0004145 | diamine N-acetyltransferase activity(GO:0004145) |
| 0.5 | 4.2 | GO:0005004 | GPI-linked ephrin receptor activity(GO:0005004) |
| 0.5 | 14.1 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.5 | 1.4 | GO:0031779 | melanocortin receptor binding(GO:0031779) type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782) |
| 0.5 | 3.8 | GO:0051428 | peptide hormone receptor binding(GO:0051428) |
| 0.5 | 23.3 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
| 0.4 | 5.8 | GO:0016863 | intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863) |
| 0.4 | 9.8 | GO:1900750 | glutathione peroxidase activity(GO:0004602) glutathione binding(GO:0043295) oligopeptide binding(GO:1900750) |
| 0.4 | 3.0 | GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813) |
| 0.4 | 2.3 | GO:0016846 | carbon-sulfur lyase activity(GO:0016846) |
| 0.4 | 23.3 | GO:0001102 | RNA polymerase II activating transcription factor binding(GO:0001102) |
| 0.3 | 1.0 | GO:0008311 | double-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008311) |
| 0.3 | 5.2 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
| 0.3 | 4.1 | GO:0045499 | chemorepellent activity(GO:0045499) |
| 0.3 | 1.9 | GO:0000150 | recombinase activity(GO:0000150) |
| 0.3 | 0.5 | GO:0005168 | neurotrophin TRK receptor binding(GO:0005167) neurotrophin TRKA receptor binding(GO:0005168) |
| 0.3 | 1.3 | GO:0008273 | calcium, potassium:sodium antiporter activity(GO:0008273) |
| 0.3 | 0.8 | GO:0047256 | beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity(GO:0008457) lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity(GO:0047256) |
| 0.2 | 1.5 | GO:0004351 | glutamate decarboxylase activity(GO:0004351) |
| 0.2 | 7.3 | GO:0017091 | AU-rich element binding(GO:0017091) |
| 0.2 | 4.0 | GO:0004435 | phosphatidylinositol phospholipase C activity(GO:0004435) |
| 0.2 | 3.3 | GO:0005542 | folic acid binding(GO:0005542) |
| 0.2 | 10.5 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.2 | 3.5 | GO:0070410 | co-SMAD binding(GO:0070410) |
| 0.2 | 1.1 | GO:0015016 | [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016) |
| 0.2 | 0.6 | GO:0004030 | aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030) |
| 0.2 | 0.6 | GO:0051378 | primary amine oxidase activity(GO:0008131) serotonin binding(GO:0051378) |
| 0.1 | 0.6 | GO:0034056 | estrogen response element binding(GO:0034056) |
| 0.1 | 13.8 | GO:0001158 | enhancer sequence-specific DNA binding(GO:0001158) |
| 0.1 | 21.6 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.1 | 1.0 | GO:0046703 | natural killer cell lectin-like receptor binding(GO:0046703) |
| 0.1 | 2.4 | GO:0005521 | lamin binding(GO:0005521) |
| 0.1 | 2.9 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
| 0.1 | 5.9 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
| 0.1 | 0.8 | GO:0008121 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
| 0.1 | 2.9 | GO:0000062 | fatty-acyl-CoA binding(GO:0000062) |
| 0.1 | 0.9 | GO:0043495 | protein anchor(GO:0043495) |
| 0.1 | 2.0 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.1 | 0.6 | GO:0033592 | RNA strand annealing activity(GO:0033592) |
| 0.1 | 0.4 | GO:0004427 | inorganic diphosphatase activity(GO:0004427) |
| 0.1 | 2.2 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.1 | 2.3 | GO:0051959 | dynein light intermediate chain binding(GO:0051959) |
| 0.1 | 0.3 | GO:0030375 | thyroid hormone receptor coactivator activity(GO:0030375) |
| 0.1 | 1.5 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.1 | 0.4 | GO:0005052 | peroxisome matrix targeting signal-1 binding(GO:0005052) |
| 0.1 | 30.8 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.1 | 0.5 | GO:0015129 | lactate transmembrane transporter activity(GO:0015129) |
| 0.1 | 12.5 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.1 | 18.0 | GO:0003779 | actin binding(GO:0003779) |
| 0.1 | 0.2 | GO:0000982 | transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982) |
| 0.1 | 2.0 | GO:0001671 | ATPase activator activity(GO:0001671) |
| 0.1 | 0.5 | GO:0050692 | DBD domain binding(GO:0050692) |
| 0.1 | 1.3 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.1 | 7.5 | GO:0016779 | nucleotidyltransferase activity(GO:0016779) |
| 0.1 | 3.3 | GO:0001046 | core promoter sequence-specific DNA binding(GO:0001046) |
| 0.1 | 0.3 | GO:0003857 | 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857) |
| 0.1 | 1.2 | GO:0005057 | receptor signaling protein activity(GO:0005057) |
| 0.0 | 1.1 | GO:0005351 | sugar:proton symporter activity(GO:0005351) |
| 0.0 | 2.3 | GO:0017022 | myosin binding(GO:0017022) |
| 0.0 | 2.1 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.0 | 1.3 | GO:0031435 | mitogen-activated protein kinase kinase kinase binding(GO:0031435) |
| 0.0 | 0.3 | GO:0008479 | queuine tRNA-ribosyltransferase activity(GO:0008479) |
| 0.0 | 1.8 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.0 | 0.4 | GO:0004143 | diacylglycerol kinase activity(GO:0004143) |
| 0.0 | 0.9 | GO:0005242 | inward rectifier potassium channel activity(GO:0005242) |
| 0.0 | 0.1 | GO:0071532 | ankyrin repeat binding(GO:0071532) |
| 0.0 | 0.9 | GO:0033613 | activating transcription factor binding(GO:0033613) |
| 0.0 | 0.9 | GO:0008143 | poly(A) binding(GO:0008143) |
| 0.0 | 0.4 | GO:0022841 | potassium ion leak channel activity(GO:0022841) |
| 0.0 | 0.3 | GO:0008440 | inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) |
| 0.0 | 0.5 | GO:0015197 | peptide transporter activity(GO:0015197) |
| 0.0 | 1.0 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.0 | 0.2 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.0 | 0.3 | GO:0015187 | glycine transmembrane transporter activity(GO:0015187) |
| 0.0 | 0.5 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.0 | 0.4 | GO:0045125 | bioactive lipid receptor activity(GO:0045125) |
| 0.0 | 0.9 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.0 | 0.1 | GO:0031628 | opioid receptor binding(GO:0031628) |
| 0.0 | 0.4 | GO:1904264 | ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264) |
| 0.0 | 6.4 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.0 | 0.5 | GO:0008483 | transaminase activity(GO:0008483) |
| 0.0 | 2.6 | GO:0004519 | endonuclease activity(GO:0004519) |
| 0.0 | 1.5 | GO:0008276 | protein methyltransferase activity(GO:0008276) |
| 0.0 | 1.0 | GO:0004402 | histone acetyltransferase activity(GO:0004402) |
| 0.0 | 2.0 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.0 | 1.1 | GO:0043566 | structure-specific DNA binding(GO:0043566) |
| 0.0 | 0.4 | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) |
| 0.0 | 0.5 | GO:0070491 | repressing transcription factor binding(GO:0070491) |
| 0.0 | 1.1 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 0.0 | 6.4 | GO:0043565 | sequence-specific DNA binding(GO:0043565) |
| 0.0 | 0.9 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.0 | 2.2 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.0 | 0.6 | GO:0051219 | phosphoprotein binding(GO:0051219) |
| 0.0 | 0.4 | GO:0030971 | receptor tyrosine kinase binding(GO:0030971) |
| 0.0 | 17.1 | GO:0003723 | RNA binding(GO:0003723) |
| 0.0 | 3.9 | GO:0005509 | calcium ion binding(GO:0005509) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 20.8 | PID_ARF6_PATHWAY | Arf6 signaling events |
| 0.4 | 23.3 | PID_IL12_2PATHWAY | IL12-mediated signaling events |
| 0.3 | 1.7 | PID_INTEGRIN_A9B1_PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.3 | 15.2 | PID_NETRIN_PATHWAY | Netrin-mediated signaling events |
| 0.3 | 5.9 | PID_PDGFRA_PATHWAY | PDGFR-alpha signaling pathway |
| 0.2 | 3.2 | PID_EPHA2_FWD_PATHWAY | EPHA2 forward signaling |
| 0.2 | 4.2 | PID_EPHA_FWDPATHWAY | EPHA forward signaling |
| 0.2 | 7.8 | PID_P38_MK2_PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.2 | 2.0 | PID_ERBB_NETWORK_PATHWAY | ErbB receptor signaling network |
| 0.1 | 3.8 | PID_HEDGEHOG_2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.1 | 3.3 | PID_IL2_STAT5_PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.1 | 3.8 | PID_WNT_NONCANONICAL_PATHWAY | Noncanonical Wnt signaling pathway |
| 0.1 | 1.4 | PID_SYNDECAN_3_PATHWAY | Syndecan-3-mediated signaling events |
| 0.1 | 2.3 | PID_NEPHRIN_NEPH1_PATHWAY | Nephrin/Neph1 signaling in the kidney podocyte |
| 0.1 | 2.2 | PID_MYC_PATHWAY | C-MYC pathway |
| 0.1 | 5.9 | PID_E2F_PATHWAY | E2F transcription factor network |
| 0.1 | 6.8 | PID_BETA_CATENIN_NUC_PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.1 | 3.5 | PID_SYNDECAN_1_PATHWAY | Syndecan-1-mediated signaling events |
| 0.0 | 0.3 | ST_PAC1_RECEPTOR_PATHWAY | PAC1 Receptor Pathway |
| 0.0 | 3.1 | PID_AR_PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 1.1 | PID_DNA_PK_PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.0 | 1.5 | PID_FAK_PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.0 | 1.6 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
| 0.0 | 1.9 | PID_FANCONI_PATHWAY | Fanconi anemia pathway |
| 0.0 | 2.0 | PID_PLK1_PATHWAY | PLK1 signaling events |
| 0.0 | 0.5 | PID_RET_PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.0 | 1.0 | PID_RAC1_REG_PATHWAY | Regulation of RAC1 activity |
| 0.0 | 0.4 | PID_NFAT_TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.0 | 0.2 | PID_P38_MKK3_6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 0.6 | PID_P75_NTR_PATHWAY | p75(NTR)-mediated signaling |
| 0.0 | 0.6 | PID_AR_TF_PATHWAY | Regulation of Androgen receptor activity |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 9.8 | REACTOME_GLUTATHIONE_CONJUGATION | Genes involved in Glutathione conjugation |
| 0.3 | 0.6 | REACTOME_NOREPINEPHRINE_NEUROTRANSMITTER_RELEASE_CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.3 | 1.4 | REACTOME_ANDROGEN_BIOSYNTHESIS | Genes involved in Androgen biosynthesis |
| 0.2 | 14.5 | REACTOME_NETRIN1_SIGNALING | Genes involved in Netrin-1 signaling |
| 0.2 | 7.4 | REACTOME_IL_RECEPTOR_SHC_SIGNALING | Genes involved in Interleukin receptor SHC signaling |
| 0.2 | 19.7 | REACTOME_MITOTIC_PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.2 | 2.0 | REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.1 | 1.7 | REACTOME_SULFUR_AMINO_ACID_METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.1 | 4.1 | REACTOME_SMOOTH_MUSCLE_CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.1 | 19.7 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 2.0 | REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING | Genes involved in SHC1 events in ERBB4 signaling |
| 0.1 | 1.7 | REACTOME_METABOLISM_OF_POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.1 | 1.2 | REACTOME_CS_DS_DEGRADATION | Genes involved in CS/DS degradation |
| 0.1 | 2.7 | REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.1 | 0.6 | REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
| 0.1 | 0.5 | REACTOME_PROLONGED_ERK_ACTIVATION_EVENTS | Genes involved in Prolonged ERK activation events |
| 0.1 | 4.5 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 1.5 | REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.1 | 0.4 | REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS | Genes involved in Tandem pore domain potassium channels |
| 0.1 | 3.5 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
| 0.1 | 0.9 | REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS | Genes involved in Processing of Intronless Pre-mRNAs |
| 0.0 | 4.2 | REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS | Genes involved in G alpha (q) signalling events |
| 0.0 | 3.6 | REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 0.3 | REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.0 | 2.8 | REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.0 | 1.4 | REACTOME_G1_PHASE | Genes involved in G1 Phase |
| 0.0 | 0.6 | REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
| 0.0 | 1.1 | REACTOME_HS_GAG_BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.0 | 1.1 | REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.0 | 1.3 | REACTOME_RNA_POL_I_PROMOTER_OPENING | Genes involved in RNA Polymerase I Promoter Opening |
| 0.0 | 0.8 | REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.0 | 0.1 | REACTOME_G_PROTEIN_ACTIVATION | Genes involved in G-protein activation |
| 0.0 | 0.3 | REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.0 | 0.5 | REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.0 | 0.4 | REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |
| 0.0 | 0.3 | REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.0 | 0.3 | REACTOME_KINESINS | Genes involved in Kinesins |
| 0.0 | 0.4 | REACTOME_SYNTHESIS_OF_PA | Genes involved in Synthesis of PA |
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