Motif ID: Msx1_Lhx9_Barx1_Rax_Dlx6

Z-value: 0.878

Transcription factors associated with Msx1_Lhx9_Barx1_Rax_Dlx6:

Gene SymbolEntrez IDGene Name
Barx1 ENSMUSG00000021381.4 Barx1
Dlx6 ENSMUSG00000029754.7 Dlx6
Lhx9 ENSMUSG00000019230.8 Lhx9
Msx1 ENSMUSG00000048450.10 Msx1
Rax ENSMUSG00000024518.3 Rax

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Lhx9mm10_v2_chr1_-_138848576_138848603-0.561.2e-07Click!
Msx1mm10_v2_chr5_-_37824580_378245840.352.0e-03Click!
Raxmm10_v2_chr18_-_65939048_65939089-0.161.7e-01Click!
Dlx6mm10_v2_chr6_+_6863269_68633340.066.3e-01Click!


Activity profile for motif Msx1_Lhx9_Barx1_Rax_Dlx6.

activity profile for motif Msx1_Lhx9_Barx1_Rax_Dlx6


Sorted Z-values histogram for motif Msx1_Lhx9_Barx1_Rax_Dlx6

Sorted Z-values for motif Msx1_Lhx9_Barx1_Rax_Dlx6



Network of associatons between targets according to the STRING database.



First level regulatory network of Msx1_Lhx9_Barx1_Rax_Dlx6

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_134747241 24.194 ENSMUST00000015138.9
 Eln
elastin
chr3_-_49757257 15.308 ENSMUST00000035931.7
 Pcdh18
protocadherin 18
chr2_+_116067213 11.949 ENSMUST00000152412.1
 G630016G05Rik
RIKEN cDNA G630016G05 gene
chr14_-_118052235 11.760 ENSMUST00000022725.2
 Dct
dopachrome tautomerase
chr16_+_42907563 10.842 ENSMUST00000151244.1
ENSMUST00000114694.2
 Zbtb20

zinc finger and BTB domain containing 20

chr11_-_98053415 10.717 ENSMUST00000017544.2
 Stac2
SH3 and cysteine rich domain 2
chr19_+_26749726 9.827 ENSMUST00000175842.1
 Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr5_-_62766153 9.367 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr2_-_116067391 9.143 ENSMUST00000140185.1
 2700033N17Rik
RIKEN cDNA 2700033N17 gene
chr12_-_83487708 9.065 ENSMUST00000177959.1
ENSMUST00000178756.1
 Dpf3

D4, zinc and double PHD fingers, family 3

chr2_-_77703252 8.830 ENSMUST00000171063.1
 Zfp385b
zinc finger protein 385B
chr9_-_40346290 8.480 ENSMUST00000121357.1
 Gramd1b
GRAM domain containing 1B
chr10_+_99263224 8.043 ENSMUST00000020118.4
 Dusp6
dual specificity phosphatase 6
chr3_+_66219909 6.895 ENSMUST00000029421.5
 Ptx3
pentraxin related gene
chr16_-_37384915 6.549 ENSMUST00000114787.1
ENSMUST00000114782.1
ENSMUST00000023526.2
ENSMUST00000114775.1
 Stxbp5l



syntaxin binding protein 5-like



chr1_+_104768510 6.504 ENSMUST00000062528.8
 Cdh20
cadherin 20
chr3_+_68572245 5.774 ENSMUST00000170788.2
 Schip1
schwannomin interacting protein 1
chr3_+_86070915 5.382 ENSMUST00000182666.1
 Sh3d19
SH3 domain protein D19
chr6_+_125552948 5.351 ENSMUST00000112254.1
ENSMUST00000112253.1
ENSMUST00000001995.7
 Vwf


Von Willebrand factor homolog


chr13_+_44121167 4.731 ENSMUST00000163056.1
ENSMUST00000159595.1
 Gm5083

predicted gene 5083


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 88 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 25.6 GO:0043149 contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)
0.6 14.7 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
1.4 12.3 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
1.7 11.8 GO:0021847 ventricular zone neuroblast division(GO:0021847)
0.2 11.3 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.3 10.8 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.1 8.8 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
2.7 8.0 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.4 7.8 GO:0001553 luteinization(GO:0001553)
1.3 7.7 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) phosphate ion transmembrane transport(GO:0035435) cellular trivalent inorganic anion homeostasis(GO:0072502)
1.4 6.9 GO:0052428 modulation of molecular function in other organism(GO:0044359) negative regulation of molecular function in other organism(GO:0044362) negative regulation of molecular function in other organism involved in symbiotic interaction(GO:0052204) modulation of molecular function in other organism involved in symbiotic interaction(GO:0052205) negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428)
1.3 6.3 GO:0038032 termination of G-protein coupled receptor signaling pathway(GO:0038032)
2.1 6.2 GO:0090425 hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.0 6.2 GO:0016569 covalent chromatin modification(GO:0016569)
1.5 6.1 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.9 6.1 GO:0019532 oxalate transport(GO:0019532)
0.2 6.0 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.2 5.4 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.1 5.1 GO:0030168 platelet activation(GO:0030168)
0.0 4.7 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
8.1 24.2 GO:0071953 elastic fiber(GO:0071953)
0.9 21.3 GO:0071565 nBAF complex(GO:0071565)
0.0 10.2 GO:0016323 basolateral plasma membrane(GO:0016323)
0.3 9.1 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 7.9 GO:0001650 fibrillar center(GO:0001650)
0.2 6.6 GO:0097440 apical dendrite(GO:0097440)
1.1 5.4 GO:0033093 Weibel-Palade body(GO:0033093)
0.3 4.7 GO:0005614 interstitial matrix(GO:0005614)
0.0 4.2 GO:0031594 neuromuscular junction(GO:0031594)
0.0 3.6 GO:0009986 cell surface(GO:0009986)
0.2 3.2 GO:0043083 synaptic cleft(GO:0043083)
0.2 3.0 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.8 2.5 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.0 2.5 GO:0045211 postsynaptic membrane(GO:0045211)
0.3 2.4 GO:0097433 dense body(GO:0097433)
0.0 2.3 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 2.3 GO:0016459 myosin complex(GO:0016459)
0.0 2.2 GO:0016328 lateral plasma membrane(GO:0016328)
0.7 2.0 GO:0043512 inhibin A complex(GO:0043512)
0.2 1.5 GO:0033588 Elongator holoenzyme complex(GO:0033588)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 71 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 23.0 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.2 12.3 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.2 12.1 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.9 11.8 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.1 11.3 GO:0019905 syntaxin binding(GO:0019905)
0.1 8.1 GO:0002039 p53 binding(GO:0002039)
0.8 7.8 GO:0019865 immunoglobulin binding(GO:0019865)
2.6 7.7 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
1.0 6.9 GO:0001849 complement component C1q binding(GO:0001849)
0.5 6.2 GO:0050693 LBD domain binding(GO:0050693)
1.0 6.1 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.6 6.1 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.1 5.8 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.4 5.5 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.2 5.4 GO:0070064 proline-rich region binding(GO:0070064)
0.2 4.7 GO:0001968 fibronectin binding(GO:0001968)
0.0 4.5 GO:0017048 Rho GTPase binding(GO:0017048)
1.1 4.2 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.4 3.2 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.1 3.0 GO:0017080 sodium channel regulator activity(GO:0017080)

Gene overrepresentation in C2:CP category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 32.6 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.2 12.8 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.3 11.7 PID_ARF6_PATHWAY Arf6 signaling events
0.1 7.1 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.2 6.9 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 4.5 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 3.1 PID_REELIN_PATHWAY Reelin signaling pathway
0.0 2.6 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 2.3 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.1 2.0 PID_ALK1_PATHWAY ALK1 signaling events
0.0 2.0 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 1.5 ST_INTERFERON_GAMMA_PATHWAY Interferon gamma pathway.
0.0 1.3 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.1 1.1 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.1 1.1 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.9 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.0 0.8 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 0.2 PID_HNF3A_PATHWAY FOXA1 transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 13.1 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 12.5 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 8.8 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.5 5.4 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.1 5.4 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.4 5.3 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.4 4.2 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.1 3.2 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.0 2.3 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.5 2.0 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.0 1.5 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.1 1.3 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 1.2 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.1 1.2 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.1 1.1 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 1.1 REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.1 1.0 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.9 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.0 0.8 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.1 0.6 REACTOME_ACYL_CHAIN_REMODELLING_OF_PG Genes involved in Acyl chain remodelling of PG