Motif ID: Msx3

Z-value: 0.511


Transcription factors associated with Msx3:

Gene SymbolEntrez IDGene Name
Msx3 ENSMUSG00000025469.9 Msx3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Msx3mm10_v2_chr7_-_140049083_1400490890.511.7e-06Click!


Activity profile for motif Msx3.

activity profile for motif Msx3


Sorted Z-values histogram for motif Msx3

Sorted Z-values for motif Msx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Msx3

PNG image of the network

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Top targets:


Showing 1 to 20 of 67 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_14621805 9.182 ENSMUST00000042221.7
Slc26a7
solute carrier family 26, member 7
chr15_+_44787746 5.725 ENSMUST00000181839.1
2310069G16Rik
RIKEN cDNA 2310069G16 gene
chr4_-_14621494 5.238 ENSMUST00000149633.1
Slc26a7
solute carrier family 26, member 7
chr4_+_102254739 5.016 ENSMUST00000106907.2
Pde4b
phosphodiesterase 4B, cAMP specific
chr4_-_14621669 4.639 ENSMUST00000143105.1
Slc26a7
solute carrier family 26, member 7
chr2_-_45117349 4.031 ENSMUST00000176438.2
Zeb2
zinc finger E-box binding homeobox 2
chr10_+_81257277 3.761 ENSMUST00000117488.1
ENSMUST00000105328.3
ENSMUST00000121205.1
Matk


megakaryocyte-associated tyrosine kinase


chr9_-_53975246 3.421 ENSMUST00000048409.7
Elmod1
ELMO/CED-12 domain containing 1
chr10_+_39612934 3.175 ENSMUST00000019987.6
Traf3ip2
TRAF3 interacting protein 2
chr2_-_33087169 3.076 ENSMUST00000102810.3
Garnl3
GTPase activating RANGAP domain-like 3
chr2_-_33086366 2.605 ENSMUST00000049618.2
Garnl3
GTPase activating RANGAP domain-like 3
chr10_+_88379217 2.528 ENSMUST00000130301.1
ENSMUST00000020251.8
Gnptab

N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits

chr10_+_88379127 2.169 ENSMUST00000127615.1
Gnptab
N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
chr15_+_82252397 2.125 ENSMUST00000136948.1
1500009C09Rik
RIKEN cDNA 1500009C09 gene
chr2_+_125136692 1.883 ENSMUST00000099452.2
Ctxn2
cortexin 2
chr1_-_52190901 1.697 ENSMUST00000156887.1
ENSMUST00000129107.1
Gls

glutaminase

chr3_-_116253467 1.668 ENSMUST00000090473.5
Gpr88
G-protein coupled receptor 88
chr7_-_127895578 1.603 ENSMUST00000033074.6
Vkorc1
vitamin K epoxide reductase complex, subunit 1
chr5_+_14514918 1.571 ENSMUST00000030691.10
ENSMUST00000182407.1
Pclo

piccolo (presynaptic cytomatrix protein)

chr13_+_83732438 1.333 ENSMUST00000182701.1
C130071C03Rik
RIKEN cDNA C130071C03 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.7 19.1 GO:0019532 oxalate transport(GO:0019532)
0.4 5.0 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
1.6 4.7 GO:0016256 N-glycan processing to lysosome(GO:0016256)
0.0 4.4 GO:0051056 regulation of small GTPase mediated signal transduction(GO:0051056)
0.7 4.0 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.1 3.8 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.0 3.4 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.2 3.2 GO:0002230 positive regulation of defense response to virus by host(GO:0002230)
0.2 2.4 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.2 2.2 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.1 2.0 GO:0046677 response to antibiotic(GO:0046677)
0.4 1.7 GO:0061743 motor learning(GO:0061743)
0.3 1.7 GO:0006543 glutamine catabolic process(GO:0006543)
0.5 1.6 GO:0018214 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.5 1.6 GO:0098928 presynaptic signal transduction(GO:0098928) presynapse to nucleus signaling pathway(GO:0099526)
0.0 1.2 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.1 1.1 GO:0097186 amelogenesis(GO:0097186)
0.2 1.0 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.1 1.0 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.1 0.9 GO:0099628 receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) neurotransmitter receptor diffusion trapping(GO:0099628)

Gene overrepresentation in cellular_component category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 17.3 GO:0016323 basolateral plasma membrane(GO:0016323)
0.2 5.0 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 4.7 GO:0000139 Golgi membrane(GO:0000139)
0.0 3.8 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.4 1.6 GO:0099569 presynaptic cytoskeleton(GO:0099569)
0.2 1.0 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.1 1.0 GO:0071437 invadopodium(GO:0071437)
0.1 0.8 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.1 0.7 GO:0090543 ESCRT III complex(GO:0000815) Flemming body(GO:0090543)
0.0 0.7 GO:0045335 phagocytic vesicle(GO:0045335)
0.0 0.6 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1 0.5 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.4 GO:0044292 dendrite terminus(GO:0044292)
0.0 0.3 GO:0071439 clathrin complex(GO:0071439)
0.0 0.2 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 0.2 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 0.1 GO:0034457 Mpp10 complex(GO:0034457)
0.0 0.1 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)

Gene overrepresentation in molecular_function category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.7 19.1 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.2 5.0 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
1.2 4.7 GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
0.0 4.2 GO:0005096 GTPase activator activity(GO:0005096)
0.1 4.0 GO:0070412 R-SMAD binding(GO:0070412)
0.1 3.8 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.3 1.7 GO:0004359 glutaminase activity(GO:0004359)
0.0 1.7 GO:0003774 motor activity(GO:0003774)
0.1 1.6 GO:0005522 profilin binding(GO:0005522)
0.1 1.6 GO:0048038 quinone binding(GO:0048038)
0.2 1.1 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.1 0.9 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.1 0.8 GO:0015114 phosphate ion transmembrane transporter activity(GO:0015114)
0.0 0.8 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.1 0.6 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.5 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.2 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.1 GO:0030519 snoRNP binding(GO:0030519)

Gene overrepresentation in C2:CP category:

Showing 1 to 3 of 3 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.8 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1 2.2 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.9 ST_GA12_PATHWAY G alpha 12 Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 20.1 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 5.0 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 3.8 REACTOME_SIGNALING_BY_ERBB2 Genes involved in Signaling by ERBB2
0.0 2.2 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.1 1.7 REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.2 1.6 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0 1.0 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.8 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.0 0.8 REACTOME_GLUCOSE_TRANSPORT Genes involved in Glucose transport
0.0 0.7 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.5 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.1 0.4 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling