Motif ID: Myb

Z-value: 1.885


Transcription factors associated with Myb:

Gene SymbolEntrez IDGene Name
Myb ENSMUSG00000019982.8 Myb

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mybmm10_v2_chr10_-_21160925_211609840.792.5e-17Click!


Activity profile for motif Myb.

activity profile for motif Myb


Sorted Z-values histogram for motif Myb

Sorted Z-values for motif Myb



Network of associatons between targets according to the STRING database.



First level regulatory network of Myb

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_118437331 26.446 ENSMUST00000006565.6
 Cdc20
cell division cycle 20
chr5_+_123749696 25.962 ENSMUST00000031366.7
 Kntc1
kinetochore associated 1
chr2_-_127831817 23.856 ENSMUST00000028858.7
 Bub1
budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae)
chr2_+_118814237 23.460 ENSMUST00000028803.7
ENSMUST00000126045.1
 Knstrn

kinetochore-localized astrin/SPAG5 binding

chr2_+_118814195 21.827 ENSMUST00000110842.1
 Knstrn
kinetochore-localized astrin/SPAG5 binding
chr2_+_118813995 21.427 ENSMUST00000134661.1
 Knstrn
kinetochore-localized astrin/SPAG5 binding
chrX_+_58030999 19.306 ENSMUST00000088631.4
ENSMUST00000088629.3
 Zic3

zinc finger protein of the cerebellum 3

chr6_+_124829540 17.893 ENSMUST00000150120.1
 Cdca3
cell division cycle associated 3
chr18_+_5591860 17.229 ENSMUST00000025081.5
ENSMUST00000159390.1
 Zeb1

zinc finger E-box binding homeobox 1

chr9_+_72438534 16.651 ENSMUST00000034746.8
 Mns1
meiosis-specific nuclear structural protein 1
chr9_+_72438519 16.192 ENSMUST00000184604.1
 Mns1
meiosis-specific nuclear structural protein 1
chr6_+_124829582 16.156 ENSMUST00000024270.7
 Cdca3
cell division cycle associated 3
chr2_+_119047116 15.182 ENSMUST00000152380.1
ENSMUST00000099542.2
 Casc5

cancer susceptibility candidate 5

chr1_+_57995971 15.175 ENSMUST00000027202.8
 Sgol2
shugoshin-like 2 (S. pombe)
chr11_+_23665615 15.037 ENSMUST00000109525.1
ENSMUST00000020520.4
 Pus10

pseudouridylate synthase 10

chr9_-_96889381 14.622 ENSMUST00000112951.2
ENSMUST00000126411.1
ENSMUST00000078478.1
ENSMUST00000119141.1
ENSMUST00000120101.1
 Acpl2




acid phosphatase-like 2




chr17_-_33890584 14.218 ENSMUST00000114361.2
ENSMUST00000173492.1
 Kifc1

kinesin family member C1

chr8_-_110168204 13.822 ENSMUST00000003754.6
 Calb2
calbindin 2
chrX_+_58030622 13.755 ENSMUST00000088627.4
 Zic3
zinc finger protein of the cerebellum 3
chr15_+_57912199 13.595 ENSMUST00000022992.6
 Tbc1d31
TBC1 domain family, member 31

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 159 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.2 75.7 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.1 44.8 GO:0051301 cell division(GO:0051301)
5.5 33.1 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
2.1 32.8 GO:0070986 left/right axis specification(GO:0070986)
1.9 32.3 GO:0030953 astral microtubule organization(GO:0030953)
2.8 27.8 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
8.9 26.7 GO:0072382 minus-end-directed vesicle transport along microtubule(GO:0072382)
3.8 26.4 GO:0000279 M phase(GO:0000279)
0.2 24.2 GO:0007093 mitotic cell cycle checkpoint(GO:0007093)
8.0 23.9 GO:0051754 meiotic sister chromatid cohesion, centromeric(GO:0051754)
2.9 20.1 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.7 19.7 GO:0007099 centriole replication(GO:0007099)
0.1 19.3 GO:0008360 regulation of cell shape(GO:0008360)
1.9 17.2 GO:0048752 semicircular canal morphogenesis(GO:0048752)
3.3 16.6 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
0.5 16.1 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.8 14.7 GO:0000920 cell separation after cytokinesis(GO:0000920)
1.8 14.5 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
3.3 13.3 GO:0035609 C-terminal protein deglutamylation(GO:0035609)
0.3 13.2 GO:0033120 positive regulation of RNA splicing(GO:0033120)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 96 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.8 66.7 GO:0035371 microtubule plus-end(GO:0035371)
0.2 61.4 GO:0005813 centrosome(GO:0005813)
0.4 42.8 GO:0005814 centriole(GO:0005814)
0.5 32.1 GO:0005882 intermediate filament(GO:0005882)
0.3 30.4 GO:0005913 cell-cell adherens junction(GO:0005913)
0.3 28.4 GO:0000776 kinetochore(GO:0000776)
1.5 26.7 GO:0031616 spindle pole centrosome(GO:0031616)
8.7 26.0 GO:1990423 RZZ complex(GO:1990423)
1.0 25.5 GO:0005680 anaphase-promoting complex(GO:0005680)
0.5 24.3 GO:0005871 kinesin complex(GO:0005871)
6.0 23.9 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
0.8 23.3 GO:0034451 centriolar satellite(GO:0034451)
0.4 17.4 GO:0005801 cis-Golgi network(GO:0005801)
0.3 17.2 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.6 15.2 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.7 14.1 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.5 13.6 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.1 13.1 GO:0031965 nuclear membrane(GO:0031965)
4.3 12.9 GO:0042585 germinal vesicle(GO:0042585)
1.9 11.5 GO:0098536 deuterosome(GO:0098536)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 104 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 38.4 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
2.6 37.0 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
1.6 27.8 GO:0009982 pseudouridine synthase activity(GO:0009982)
4.4 26.4 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.4 24.3 GO:0003777 microtubule motor activity(GO:0003777)
0.7 18.2 GO:0008432 JUN kinase binding(GO:0008432)
0.1 15.4 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.3 15.2 GO:0070888 E-box binding(GO:0070888)
3.5 14.1 GO:0097100 supercoiled DNA binding(GO:0097100)
2.3 13.6 GO:0008494 translation activator activity(GO:0008494)
1.7 13.6 GO:0003964 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.7 13.3 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
2.6 12.9 GO:0035174 histone serine kinase activity(GO:0035174)
0.0 12.7 GO:0019904 protein domain specific binding(GO:0019904)
0.3 12.1 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.7 11.5 GO:1990226 histone methyltransferase binding(GO:1990226)
0.5 11.1 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 11.1 GO:0005509 calcium ion binding(GO:0005509)
2.5 9.9 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.1 9.8 GO:0004386 helicase activity(GO:0004386)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 88.8 PID_PLK1_PATHWAY PLK1 signaling events
0.9 32.3 PID_AURORA_A_PATHWAY Aurora A signaling
0.6 21.6 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.3 14.2 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.2 12.8 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.1 11.8 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.2 11.1 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.4 8.7 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.3 8.3 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.2 8.0 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.1 7.9 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.2 6.2 PID_ATR_PATHWAY ATR signaling pathway
0.4 5.6 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.1 4.9 ST_GA13_PATHWAY G alpha 13 Pathway
0.1 4.6 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 4.5 PID_AURORA_B_PATHWAY Aurora B signaling
0.3 3.9 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.1 3.9 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.1 3.6 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.3 3.2 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 115.1 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
1.5 41.3 REACTOME_KINESINS Genes involved in Kinesins
1.4 34.5 REACTOME_APC_CDC20_MEDIATED_DEGRADATION_OF_NEK2A Genes involved in APC-Cdc20 mediated degradation of Nek2A
0.6 22.8 REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS Genes involved in Activation of ATR in response to replication stress
0.6 15.6 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
1.8 14.1 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.2 12.0 REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.5 11.5 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.2 11.1 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.3 10.7 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 9.0 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.3 8.7 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.1 8.0 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.3 7.8 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.3 5.6 REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.4 5.3 REACTOME_COMPLEMENT_CASCADE Genes involved in Complement cascade
0.3 5.0 REACTOME_ACYL_CHAIN_REMODELLING_OF_PC Genes involved in Acyl chain remodelling of PC
0.1 5.0 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.4 4.9 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1
0.1 4.6 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis