Motif ID: Mybl1

Z-value: 0.868


Transcription factors associated with Mybl1:

Gene SymbolEntrez IDGene Name
Mybl1 ENSMUSG00000025912.10 Mybl1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mybl1mm10_v2_chr1_-_9700209_9700329-0.066.3e-01Click!


Activity profile for motif Mybl1.

activity profile for motif Mybl1


Sorted Z-values histogram for motif Mybl1

Sorted Z-values for motif Mybl1



Network of associatons between targets according to the STRING database.



First level regulatory network of Mybl1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_+_29093763 5.669 ENSMUST00000023829.6
 Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr12_+_112146187 4.731 ENSMUST00000128402.2
 Kif26a
kinesin family member 26A
chr4_-_118437331 4.508 ENSMUST00000006565.6
 Cdc20
cell division cycle 20
chr2_+_118814237 4.504 ENSMUST00000028803.7
ENSMUST00000126045.1
 Knstrn

kinetochore-localized astrin/SPAG5 binding

chr2_+_118814195 4.107 ENSMUST00000110842.1
 Knstrn
kinetochore-localized astrin/SPAG5 binding
chr4_-_41695442 3.685 ENSMUST00000102961.3
ENSMUST00000064443.6
 Cntfr

ciliary neurotrophic factor receptor

chr11_-_106999369 3.682 ENSMUST00000106768.1
ENSMUST00000144834.1
 Kpna2

karyopherin (importin) alpha 2

chr2_+_118813995 3.657 ENSMUST00000134661.1
 Knstrn
kinetochore-localized astrin/SPAG5 binding
chr14_+_46760526 3.574 ENSMUST00000067426.4
 Cdkn3
cyclin-dependent kinase inhibitor 3
chr11_-_69921190 3.478 ENSMUST00000108607.1
 Eif5a
eukaryotic translation initiation factor 5A
chr9_+_78191966 3.370 ENSMUST00000034903.5
 Gsta4
glutathione S-transferase, alpha 4
chr14_+_65806066 3.192 ENSMUST00000139644.1
 Pbk
PDZ binding kinase
chr6_+_124829540 3.162 ENSMUST00000150120.1
 Cdca3
cell division cycle associated 3
chr6_+_124829582 2.954 ENSMUST00000024270.7
 Cdca3
cell division cycle associated 3
chr11_-_84068554 2.914 ENSMUST00000164891.1
 Dusp14
dual specificity phosphatase 14
chr4_-_43499608 2.899 ENSMUST00000136005.1
ENSMUST00000054538.6
 Arhgef39

Rho guanine nucleotide exchange factor (GEF) 39

chr4_-_117182623 2.897 ENSMUST00000065896.2
 Kif2c
kinesin family member 2C
chr11_-_106999482 2.878 ENSMUST00000018506.6
 Kpna2
karyopherin (importin) alpha 2
chr8_+_83715504 2.798 ENSMUST00000109810.1
 Ddx39
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39
chr3_-_95995835 2.501 ENSMUST00000143485.1
 Plekho1
pleckstrin homology domain containing, family O member 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 264 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 12.3 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
1.6 9.9 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.4 9.3 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
1.5 6.2 GO:0003360 brainstem development(GO:0003360)
0.2 6.1 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.6 5.6 GO:0071493 cellular response to UV-B(GO:0071493)
0.1 5.2 GO:0070303 negative regulation of stress-activated MAPK cascade(GO:0032873) negative regulation of stress-activated protein kinase signaling cascade(GO:0070303)
0.1 4.8 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.4 4.7 GO:0048484 enteric nervous system development(GO:0048484)
0.6 4.5 GO:0000279 M phase(GO:0000279)
0.6 4.5 GO:1902255 positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator(GO:1902255)
0.1 4.2 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.5 3.2 GO:0035701 hematopoietic stem cell migration(GO:0035701)
0.2 3.2 GO:0043248 proteasome assembly(GO:0043248)
0.2 3.1 GO:0051451 myoblast migration(GO:0051451)
0.0 3.1 GO:0006342 chromatin silencing(GO:0006342)
0.6 2.9 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.6 2.8 GO:0032901 positive regulation of neurotrophin production(GO:0032901)
0.2 2.7 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.1 2.6 GO:0070979 protein K11-linked ubiquitination(GO:0070979)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 139 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 15.2 GO:0035371 microtubule plus-end(GO:0035371)
0.8 9.0 GO:0005642 annulate lamellae(GO:0005642)
0.1 7.5 GO:0005643 nuclear pore(GO:0005643)
0.3 6.7 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 6.6 GO:0016607 nuclear speck(GO:0016607)
2.1 6.2 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
1.9 5.7 GO:0070557 PCNA-p21 complex(GO:0070557)
0.1 5.6 GO:0005871 kinesin complex(GO:0005871)
0.1 5.3 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 5.1 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 4.6 GO:0016234 inclusion body(GO:0016234)
0.1 3.6 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 3.5 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.1 2.8 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 2.8 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 2.6 GO:0009897 external side of plasma membrane(GO:0009897)
0.4 2.5 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.1 2.5 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 2.5 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 2.5 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 166 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.5 GO:0003735 structural constituent of ribosome(GO:0003735)
0.6 10.0 GO:0017070 U6 snRNA binding(GO:0017070)
0.3 8.7 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.1 6.8 GO:0004004 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
1.0 6.2 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
1.9 5.7 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.4 5.3 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.8 4.5 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.1 4.5 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 4.3 GO:0003777 microtubule motor activity(GO:0003777)
0.1 4.2 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.1 3.4 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.1 2.9 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.3 2.8 GO:0048403 brain-derived neurotrophic factor binding(GO:0048403)
0.1 2.8 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 2.8 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 2.7 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 2.6 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.8 2.5 GO:0030156 benzodiazepine receptor binding(GO:0030156)
0.1 2.5 GO:0051010 microtubule plus-end binding(GO:0051010)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 7.8 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1 7.5 PID_PLK1_PATHWAY PLK1 signaling events
0.6 5.7 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 3.9 PID_TRAIL_PATHWAY TRAIL signaling pathway
0.1 3.4 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.1 2.9 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 2.0 PID_RAS_PATHWAY Regulation of Ras family activation
0.1 1.9 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 1.8 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 1.7 PID_E2F_PATHWAY E2F transcription factor network
0.0 1.7 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.1 1.4 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 1.4 PID_MET_PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.1 1.3 PID_MYC_PATHWAY C-MYC pathway
0.0 1.3 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.1 1.2 PID_ALK2_PATHWAY ALK2 signaling events
0.0 1.1 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 1.1 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 1.1 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 1.0 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 66 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 9.9 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.3 8.6 REACTOME_KINESINS Genes involved in Kinesins
0.1 7.6 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.1 7.6 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.2 5.9 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.1 5.2 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.0 5.0 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 4.8 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.2 4.5 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.2 4.2 REACTOME_FORMATION_OF_TUBULIN_FOLDING_INTERMEDIATES_BY_CCT_TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.3 4.1 REACTOME_ASSOCIATION_OF_LICENSING_FACTORS_WITH_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.1 4.1 REACTOME_AUTODEGRADATION_OF_CDH1_BY_CDH1_APC_C Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C
0.1 3.3 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.0 3.2 REACTOME_INFLUENZA_VIRAL_RNA_TRANSCRIPTION_AND_REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication
0.1 3.1 REACTOME_EXTENSION_OF_TELOMERES Genes involved in Extension of Telomeres
0.1 2.8 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 2.7 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 2.6 REACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE Genes involved in Cell death signalling via NRAGE, NRIF and NADE
0.1 2.3 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.1 2.2 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis