Motif ID: Mybl2
Z-value: 2.116
Transcription factors associated with Mybl2:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Mybl2 | ENSMUSG00000017861.5 | Mybl2 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Mybl2 | mm10_v2_chr2_+_163054682_163054693 | 0.83 | 8.6e-21 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.4 | 21.8 | GO:0030997 | regulation of centriole-centriole cohesion(GO:0030997) |
| 4.7 | 42.7 | GO:0048752 | semicircular canal morphogenesis(GO:0048752) |
| 4.7 | 23.3 | GO:1900147 | Schwann cell migration(GO:0036135) regulation of Schwann cell migration(GO:1900147) |
| 3.4 | 20.5 | GO:0034080 | CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641) |
| 3.2 | 9.5 | GO:0042732 | D-xylose metabolic process(GO:0042732) |
| 2.7 | 8.1 | GO:0090526 | regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526) |
| 2.5 | 10.0 | GO:0046655 | glycine biosynthetic process(GO:0006545) folic acid metabolic process(GO:0046655) |
| 2.5 | 10.0 | GO:0003360 | brainstem development(GO:0003360) |
| 2.4 | 7.1 | GO:0035519 | protein K29-linked ubiquitination(GO:0035519) |
| 2.3 | 6.9 | GO:0070782 | phosphatidylserine exposure on apoptotic cell surface(GO:0070782) regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373) |
| 2.3 | 18.1 | GO:0071557 | histone H3-K27 demethylation(GO:0071557) |
| 2.2 | 15.7 | GO:2000348 | regulation of CD40 signaling pathway(GO:2000348) |
| 2.1 | 6.4 | GO:0097026 | dendritic cell dendrite assembly(GO:0097026) |
| 2.1 | 14.4 | GO:0016584 | nucleosome positioning(GO:0016584) |
| 1.9 | 5.8 | GO:1903048 | regulation of acetylcholine-gated cation channel activity(GO:1903048) |
| 1.9 | 1.9 | GO:1903978 | regulation of microglial cell activation(GO:1903978) |
| 1.8 | 5.5 | GO:0071707 | immunoglobulin heavy chain V-D-J recombination(GO:0071707) |
| 1.7 | 6.9 | GO:0015889 | cobalamin transport(GO:0015889) |
| 1.5 | 54.8 | GO:0008608 | attachment of spindle microtubules to kinetochore(GO:0008608) |
| 1.5 | 4.6 | GO:0060392 | negative regulation of SMAD protein import into nucleus(GO:0060392) |
| 1.5 | 4.5 | GO:0031660 | regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031660) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031662) positive regulation of calcium-transporting ATPase activity(GO:1901896) |
| 1.5 | 8.8 | GO:0098734 | protein depalmitoylation(GO:0002084) negative regulation of Golgi to plasma membrane protein transport(GO:0042997) negative regulation of establishment of protein localization to plasma membrane(GO:0090005) macromolecule depalmitoylation(GO:0098734) |
| 1.5 | 5.8 | GO:0010808 | positive regulation of synaptic vesicle priming(GO:0010808) |
| 1.4 | 2.9 | GO:1901668 | regulation of superoxide dismutase activity(GO:1901668) |
| 1.3 | 6.6 | GO:0034421 | post-translational protein acetylation(GO:0034421) |
| 1.3 | 33.9 | GO:0006336 | DNA replication-independent nucleosome assembly(GO:0006336) |
| 1.3 | 7.5 | GO:0071883 | activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883) |
| 1.2 | 5.0 | GO:2000562 | negative regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000562) |
| 1.2 | 21.6 | GO:0000920 | cell separation after cytokinesis(GO:0000920) |
| 1.2 | 4.7 | GO:0002188 | translation reinitiation(GO:0002188) |
| 1.2 | 4.7 | GO:0035521 | monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522) |
| 1.1 | 10.2 | GO:1904668 | mitotic spindle midzone assembly(GO:0051256) positive regulation of ubiquitin protein ligase activity(GO:1904668) |
| 1.1 | 3.3 | GO:0045819 | plasmacytoid dendritic cell activation(GO:0002270) positive regulation of glycogen catabolic process(GO:0045819) |
| 1.1 | 3.2 | GO:0007084 | mitotic nuclear envelope reassembly(GO:0007084) |
| 1.0 | 17.6 | GO:0007080 | mitotic metaphase plate congression(GO:0007080) |
| 1.0 | 14.4 | GO:0048199 | vesicle targeting, to, from or within Golgi(GO:0048199) |
| 1.0 | 3.0 | GO:2000402 | negative regulation of lymphocyte migration(GO:2000402) |
| 1.0 | 6.0 | GO:0032196 | regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529) transposition(GO:0032196) |
| 1.0 | 4.9 | GO:2001032 | regulation of double-strand break repair via nonhomologous end joining(GO:2001032) |
| 0.9 | 2.8 | GO:0044208 | 'de novo' AMP biosynthetic process(GO:0044208) |
| 0.9 | 10.3 | GO:0070836 | caveola assembly(GO:0070836) |
| 0.9 | 2.8 | GO:1990927 | negative regulation of membrane invagination(GO:1905154) calcium ion regulated lysosome exocytosis(GO:1990927) |
| 0.9 | 6.4 | GO:0021775 | smoothened signaling pathway involved in ventral spinal cord interneuron specification(GO:0021775) smoothened signaling pathway involved in spinal cord motor neuron cell fate specification(GO:0021776) |
| 0.9 | 5.5 | GO:0030263 | apoptotic chromosome condensation(GO:0030263) |
| 0.9 | 29.7 | GO:0007099 | centriole replication(GO:0007099) |
| 0.9 | 17.6 | GO:0060009 | Sertoli cell development(GO:0060009) |
| 0.8 | 5.9 | GO:0035735 | intraciliary transport involved in cilium morphogenesis(GO:0035735) |
| 0.8 | 5.8 | GO:0001880 | Mullerian duct regression(GO:0001880) |
| 0.8 | 5.0 | GO:0006072 | glycerol-3-phosphate metabolic process(GO:0006072) |
| 0.8 | 2.5 | GO:0009106 | lipoate metabolic process(GO:0009106) |
| 0.8 | 8.2 | GO:0071763 | nuclear membrane organization(GO:0071763) |
| 0.8 | 0.8 | GO:0071921 | establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922) |
| 0.8 | 7.4 | GO:0051409 | response to nitrosative stress(GO:0051409) |
| 0.8 | 2.4 | GO:1902310 | positive regulation of peptidyl-serine dephosphorylation(GO:1902310) |
| 0.8 | 14.4 | GO:2000574 | regulation of microtubule motor activity(GO:2000574) |
| 0.8 | 17.3 | GO:0006607 | NLS-bearing protein import into nucleus(GO:0006607) |
| 0.8 | 8.5 | GO:2000051 | negative regulation of non-canonical Wnt signaling pathway(GO:2000051) |
| 0.8 | 3.1 | GO:0043987 | histone-serine phosphorylation(GO:0035404) histone H3-S10 phosphorylation(GO:0043987) |
| 0.7 | 7.3 | GO:0031119 | tRNA pseudouridine synthesis(GO:0031119) |
| 0.7 | 2.2 | GO:0009298 | GDP-mannose biosynthetic process(GO:0009298) |
| 0.7 | 2.1 | GO:0035621 | ER to Golgi ceramide transport(GO:0035621) ceramide transport(GO:0035627) |
| 0.7 | 3.5 | GO:0036151 | phosphatidylcholine acyl-chain remodeling(GO:0036151) |
| 0.7 | 3.4 | GO:1903566 | positive regulation of protein localization to cilium(GO:1903566) |
| 0.7 | 4.1 | GO:0060903 | positive regulation of meiosis I(GO:0060903) |
| 0.7 | 2.0 | GO:0070944 | neutrophil mediated killing of bacterium(GO:0070944) |
| 0.6 | 11.7 | GO:0051451 | myoblast migration(GO:0051451) |
| 0.6 | 6.4 | GO:0043568 | positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568) |
| 0.6 | 4.8 | GO:0002862 | negative regulation of inflammatory response to antigenic stimulus(GO:0002862) protein oxidation(GO:0018158) |
| 0.6 | 4.8 | GO:0006590 | thyroid hormone generation(GO:0006590) |
| 0.5 | 27.1 | GO:0035307 | positive regulation of protein dephosphorylation(GO:0035307) |
| 0.5 | 2.1 | GO:0051643 | endoplasmic reticulum localization(GO:0051643) |
| 0.5 | 4.1 | GO:0044829 | positive regulation by host of viral genome replication(GO:0044829) |
| 0.5 | 2.6 | GO:2000680 | regulation of rubidium ion transport(GO:2000680) |
| 0.5 | 14.9 | GO:0016572 | histone phosphorylation(GO:0016572) |
| 0.5 | 1.5 | GO:0098501 | polynucleotide dephosphorylation(GO:0098501) |
| 0.5 | 2.5 | GO:0023021 | termination of signal transduction(GO:0023021) termination of G-protein coupled receptor signaling pathway(GO:0038032) |
| 0.5 | 7.5 | GO:0042407 | cristae formation(GO:0042407) |
| 0.5 | 1.0 | GO:0034184 | positive regulation of maintenance of sister chromatid cohesion(GO:0034093) positive regulation of maintenance of mitotic sister chromatid cohesion(GO:0034184) |
| 0.5 | 6.2 | GO:0019985 | translesion synthesis(GO:0019985) |
| 0.5 | 2.3 | GO:0002121 | inter-male aggressive behavior(GO:0002121) response to pheromone(GO:0019236) |
| 0.4 | 12.1 | GO:0048741 | skeletal muscle fiber development(GO:0048741) |
| 0.4 | 2.1 | GO:0031145 | anaphase-promoting complex-dependent catabolic process(GO:0031145) |
| 0.4 | 1.3 | GO:0048007 | antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007) |
| 0.4 | 5.7 | GO:0070914 | UV-damage excision repair(GO:0070914) |
| 0.4 | 2.3 | GO:0016266 | O-glycan processing(GO:0016266) |
| 0.4 | 1.2 | GO:1904211 | membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211) |
| 0.4 | 1.9 | GO:0001561 | fatty acid alpha-oxidation(GO:0001561) |
| 0.4 | 18.4 | GO:0045737 | positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) |
| 0.4 | 1.8 | GO:0030423 | targeting of mRNA for destruction involved in RNA interference(GO:0030423) |
| 0.4 | 6.8 | GO:0032467 | positive regulation of cytokinesis(GO:0032467) |
| 0.3 | 1.7 | GO:0031860 | telomeric 3' overhang formation(GO:0031860) |
| 0.3 | 3.9 | GO:0006012 | galactose metabolic process(GO:0006012) |
| 0.3 | 5.5 | GO:0090161 | Golgi ribbon formation(GO:0090161) |
| 0.3 | 0.9 | GO:0042275 | error-free postreplication DNA repair(GO:0042275) |
| 0.3 | 1.4 | GO:2000623 | regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623) |
| 0.3 | 3.0 | GO:0010650 | positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827) |
| 0.3 | 2.7 | GO:0006995 | cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562) |
| 0.3 | 2.8 | GO:0036159 | inner dynein arm assembly(GO:0036159) |
| 0.2 | 5.5 | GO:0016578 | histone deubiquitination(GO:0016578) |
| 0.2 | 2.4 | GO:0033148 | positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148) positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800) |
| 0.2 | 3.8 | GO:0048642 | negative regulation of skeletal muscle tissue development(GO:0048642) |
| 0.2 | 2.6 | GO:1903818 | positive regulation of voltage-gated potassium channel activity(GO:1903818) |
| 0.2 | 1.6 | GO:1903003 | positive regulation of protein deubiquitination(GO:1903003) |
| 0.2 | 5.0 | GO:2001273 | regulation of glucose import in response to insulin stimulus(GO:2001273) |
| 0.2 | 1.7 | GO:0000395 | mRNA 5'-splice site recognition(GO:0000395) |
| 0.2 | 4.6 | GO:2000001 | regulation of DNA damage checkpoint(GO:2000001) |
| 0.2 | 3.3 | GO:0000338 | protein deneddylation(GO:0000338) |
| 0.2 | 14.0 | GO:0000271 | polysaccharide biosynthetic process(GO:0000271) |
| 0.2 | 2.8 | GO:2000637 | positive regulation of gene silencing by miRNA(GO:2000637) |
| 0.2 | 0.8 | GO:0042360 | vitamin E metabolic process(GO:0042360) |
| 0.2 | 3.7 | GO:0006907 | pinocytosis(GO:0006907) |
| 0.2 | 8.7 | GO:0015914 | phospholipid transport(GO:0015914) |
| 0.2 | 0.9 | GO:0090669 | telomerase RNA stabilization(GO:0090669) |
| 0.2 | 1.3 | GO:0008635 | activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635) |
| 0.2 | 12.0 | GO:0001578 | microtubule bundle formation(GO:0001578) |
| 0.2 | 1.5 | GO:1900194 | receptor guanylyl cyclase signaling pathway(GO:0007168) negative regulation of oocyte development(GO:0060283) negative regulation of oocyte maturation(GO:1900194) |
| 0.2 | 4.9 | GO:1902042 | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902042) |
| 0.2 | 8.4 | GO:0010507 | negative regulation of autophagy(GO:0010507) |
| 0.2 | 3.3 | GO:0035036 | binding of sperm to zona pellucida(GO:0007339) sperm-egg recognition(GO:0035036) |
| 0.2 | 17.9 | GO:0006413 | translational initiation(GO:0006413) |
| 0.1 | 15.1 | GO:0006997 | nucleus organization(GO:0006997) |
| 0.1 | 2.0 | GO:0021924 | cell proliferation in external granule layer(GO:0021924) cerebellar granule cell precursor proliferation(GO:0021930) |
| 0.1 | 3.6 | GO:0006625 | protein targeting to peroxisome(GO:0006625) peroxisomal transport(GO:0043574) protein localization to peroxisome(GO:0072662) establishment of protein localization to peroxisome(GO:0072663) |
| 0.1 | 3.1 | GO:0051894 | positive regulation of focal adhesion assembly(GO:0051894) |
| 0.1 | 2.7 | GO:0043277 | apoptotic cell clearance(GO:0043277) |
| 0.1 | 1.4 | GO:0044872 | lipoprotein transport(GO:0042953) lipoprotein localization(GO:0044872) |
| 0.1 | 0.5 | GO:0090365 | regulation of mRNA modification(GO:0090365) |
| 0.1 | 0.8 | GO:0032926 | negative regulation of activin receptor signaling pathway(GO:0032926) |
| 0.1 | 0.6 | GO:0021910 | smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021910) |
| 0.1 | 6.2 | GO:0016574 | histone ubiquitination(GO:0016574) |
| 0.1 | 0.7 | GO:0019695 | choline metabolic process(GO:0019695) |
| 0.1 | 0.2 | GO:0006610 | ribosomal protein import into nucleus(GO:0006610) |
| 0.1 | 2.9 | GO:0045494 | photoreceptor cell maintenance(GO:0045494) |
| 0.1 | 3.5 | GO:0006891 | intra-Golgi vesicle-mediated transport(GO:0006891) |
| 0.1 | 2.8 | GO:0030520 | intracellular estrogen receptor signaling pathway(GO:0030520) |
| 0.1 | 1.5 | GO:0030150 | protein import into mitochondrial matrix(GO:0030150) mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034) |
| 0.1 | 0.5 | GO:0048859 | formation of anatomical boundary(GO:0048859) |
| 0.1 | 8.4 | GO:0007631 | feeding behavior(GO:0007631) |
| 0.1 | 7.0 | GO:0090263 | positive regulation of canonical Wnt signaling pathway(GO:0090263) |
| 0.1 | 1.1 | GO:0032460 | negative regulation of protein oligomerization(GO:0032460) negative regulation of protein homooligomerization(GO:0032463) |
| 0.1 | 4.8 | GO:0006367 | transcription initiation from RNA polymerase II promoter(GO:0006367) |
| 0.1 | 3.8 | GO:0016445 | somatic diversification of immunoglobulins(GO:0016445) |
| 0.1 | 3.1 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 0.1 | 2.8 | GO:2000134 | negative regulation of G1/S transition of mitotic cell cycle(GO:2000134) |
| 0.1 | 1.1 | GO:0046855 | inositol phosphate dephosphorylation(GO:0046855) |
| 0.1 | 3.2 | GO:0061003 | positive regulation of dendritic spine morphogenesis(GO:0061003) |
| 0.1 | 0.9 | GO:0070995 | NADPH oxidation(GO:0070995) |
| 0.1 | 3.4 | GO:0048635 | negative regulation of muscle organ development(GO:0048635) |
| 0.1 | 0.5 | GO:0046677 | response to antibiotic(GO:0046677) |
| 0.1 | 0.5 | GO:0000012 | single strand break repair(GO:0000012) |
| 0.1 | 6.0 | GO:0048706 | embryonic skeletal system development(GO:0048706) |
| 0.1 | 1.8 | GO:0031122 | cytoplasmic microtubule organization(GO:0031122) |
| 0.1 | 0.1 | GO:1900034 | regulation of cellular response to heat(GO:1900034) |
| 0.1 | 0.6 | GO:0002227 | innate immune response in mucosa(GO:0002227) |
| 0.1 | 0.2 | GO:0036515 | serotonergic neuron axon guidance(GO:0036515) |
| 0.1 | 0.2 | GO:0030214 | hyaluronan catabolic process(GO:0030214) |
| 0.1 | 1.6 | GO:0046827 | positive regulation of protein export from nucleus(GO:0046827) |
| 0.1 | 2.4 | GO:0050919 | negative chemotaxis(GO:0050919) |
| 0.0 | 1.8 | GO:0010501 | RNA secondary structure unwinding(GO:0010501) |
| 0.0 | 0.3 | GO:0045583 | regulation of cytotoxic T cell differentiation(GO:0045583) positive regulation of cytotoxic T cell differentiation(GO:0045585) |
| 0.0 | 2.7 | GO:0001935 | endothelial cell proliferation(GO:0001935) |
| 0.0 | 2.8 | GO:0001892 | embryonic placenta development(GO:0001892) |
| 0.0 | 1.2 | GO:0007212 | dopamine receptor signaling pathway(GO:0007212) |
| 0.0 | 2.0 | GO:0007368 | determination of left/right symmetry(GO:0007368) |
| 0.0 | 0.6 | GO:0000289 | nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289) |
| 0.0 | 0.1 | GO:1902775 | mitochondrial large ribosomal subunit assembly(GO:1902775) |
| 0.0 | 0.9 | GO:0006383 | transcription from RNA polymerase III promoter(GO:0006383) |
| 0.0 | 0.2 | GO:1902231 | positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231) |
| 0.0 | 0.4 | GO:0071392 | cellular response to estradiol stimulus(GO:0071392) |
| 0.0 | 0.8 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146) |
| 0.0 | 6.1 | GO:0070997 | neuron death(GO:0070997) |
| 0.0 | 0.3 | GO:0045776 | negative regulation of blood pressure(GO:0045776) |
| 0.0 | 1.3 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 10.3 | 61.7 | GO:0031262 | Ndc80 complex(GO:0031262) |
| 5.8 | 23.3 | GO:0045098 | type III intermediate filament(GO:0045098) |
| 3.3 | 10.0 | GO:0097059 | CNTFR-CLCF1 complex(GO:0097059) |
| 3.3 | 16.6 | GO:0032133 | chromosome passenger complex(GO:0032133) |
| 2.5 | 7.4 | GO:0017109 | glutamate-cysteine ligase complex(GO:0017109) |
| 2.3 | 16.1 | GO:0001940 | male pronucleus(GO:0001940) |
| 1.7 | 11.9 | GO:0031465 | Cul4B-RING E3 ubiquitin ligase complex(GO:0031465) |
| 1.7 | 11.7 | GO:0036195 | muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195) |
| 1.5 | 4.5 | GO:0036128 | CatSper complex(GO:0036128) |
| 1.3 | 14.4 | GO:0005677 | chromatin silencing complex(GO:0005677) |
| 1.0 | 14.4 | GO:0030126 | COPI vesicle coat(GO:0030126) |
| 1.0 | 5.8 | GO:0044305 | calyx of Held(GO:0044305) |
| 1.0 | 17.5 | GO:0031616 | spindle pole centrosome(GO:0031616) |
| 0.9 | 6.2 | GO:0033503 | HULC complex(GO:0033503) |
| 0.9 | 2.6 | GO:0071001 | U4/U6 snRNP(GO:0071001) |
| 0.7 | 5.2 | GO:0097422 | tubular endosome(GO:0097422) |
| 0.7 | 6.6 | GO:0031390 | Ctf18 RFC-like complex(GO:0031390) |
| 0.7 | 2.1 | GO:0042642 | actomyosin, myosin complex part(GO:0042642) |
| 0.7 | 6.2 | GO:0061617 | MICOS complex(GO:0061617) |
| 0.6 | 2.6 | GO:0097487 | multivesicular body, internal vesicle(GO:0097487) |
| 0.6 | 4.8 | GO:0097413 | Lewy body(GO:0097413) |
| 0.6 | 2.9 | GO:1990130 | Iml1 complex(GO:1990130) |
| 0.6 | 3.4 | GO:0098536 | deuterosome(GO:0098536) |
| 0.6 | 11.2 | GO:0033276 | transcription factor TFTC complex(GO:0033276) |
| 0.5 | 5.8 | GO:0005892 | acetylcholine-gated channel complex(GO:0005892) |
| 0.5 | 4.7 | GO:0071541 | eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541) |
| 0.5 | 17.5 | GO:0005876 | spindle microtubule(GO:0005876) |
| 0.4 | 3.1 | GO:0045254 | pyruvate dehydrogenase complex(GO:0045254) |
| 0.4 | 6.1 | GO:0045120 | pronucleus(GO:0045120) |
| 0.4 | 12.1 | GO:0000777 | condensed chromosome kinetochore(GO:0000777) |
| 0.4 | 21.6 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.4 | 9.2 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 0.4 | 12.3 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.4 | 4.0 | GO:0030130 | clathrin coat of trans-Golgi network vesicle(GO:0030130) |
| 0.4 | 39.7 | GO:0000922 | spindle pole(GO:0000922) |
| 0.4 | 11.8 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 0.3 | 2.8 | GO:0034750 | Scrib-APC-beta-catenin complex(GO:0034750) |
| 0.3 | 3.0 | GO:0061574 | ASAP complex(GO:0061574) |
| 0.3 | 1.7 | GO:0030870 | Mre11 complex(GO:0030870) |
| 0.3 | 1.9 | GO:0097443 | sorting endosome(GO:0097443) |
| 0.3 | 6.4 | GO:0016514 | SWI/SNF complex(GO:0016514) |
| 0.3 | 1.8 | GO:0000214 | tRNA-intron endonuclease complex(GO:0000214) |
| 0.3 | 23.7 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.3 | 4.6 | GO:0042588 | zymogen granule(GO:0042588) |
| 0.3 | 10.3 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.3 | 0.9 | GO:0031372 | UBC13-MMS2 complex(GO:0031372) |
| 0.3 | 15.3 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.3 | 2.4 | GO:0071141 | SMAD protein complex(GO:0071141) |
| 0.3 | 6.9 | GO:0070971 | endoplasmic reticulum exit site(GO:0070971) |
| 0.3 | 2.8 | GO:0048787 | presynaptic active zone membrane(GO:0048787) |
| 0.2 | 18.8 | GO:0005814 | centriole(GO:0005814) |
| 0.2 | 3.1 | GO:0036038 | MKS complex(GO:0036038) |
| 0.2 | 1.4 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.2 | 0.7 | GO:0071595 | Nem1-Spo7 phosphatase complex(GO:0071595) |
| 0.2 | 1.2 | GO:0071556 | integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553) |
| 0.2 | 3.3 | GO:0097228 | sperm principal piece(GO:0097228) |
| 0.2 | 2.8 | GO:0016589 | NURF complex(GO:0016589) |
| 0.2 | 3.2 | GO:0017119 | Golgi transport complex(GO:0017119) |
| 0.2 | 2.7 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.2 | 2.7 | GO:0097225 | sperm midpiece(GO:0097225) |
| 0.2 | 1.5 | GO:0005744 | mitochondrial inner membrane presequence translocase complex(GO:0005744) |
| 0.2 | 9.3 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.2 | 4.0 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.2 | 14.4 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.2 | 3.0 | GO:0035327 | transcriptionally active chromatin(GO:0035327) |
| 0.2 | 3.0 | GO:0014731 | spectrin-associated cytoskeleton(GO:0014731) |
| 0.1 | 1.0 | GO:0030915 | Smc5-Smc6 complex(GO:0030915) |
| 0.1 | 6.8 | GO:0097610 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.1 | 3.5 | GO:0097038 | perinuclear endoplasmic reticulum(GO:0097038) |
| 0.1 | 45.1 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.1 | 2.8 | GO:0097223 | sperm part(GO:0097223) |
| 0.1 | 1.4 | GO:0000974 | Prp19 complex(GO:0000974) |
| 0.1 | 2.4 | GO:0005697 | telomerase holoenzyme complex(GO:0005697) |
| 0.1 | 3.3 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 0.1 | 1.3 | GO:0035631 | CD40 receptor complex(GO:0035631) |
| 0.1 | 1.7 | GO:0034451 | centriolar satellite(GO:0034451) |
| 0.1 | 2.6 | GO:0030673 | axolemma(GO:0030673) |
| 0.1 | 4.1 | GO:0016459 | myosin complex(GO:0016459) |
| 0.1 | 9.5 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.1 | 1.5 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.1 | 9.0 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.1 | 0.9 | GO:0030061 | mitochondrial crista(GO:0030061) |
| 0.1 | 0.3 | GO:0097524 | sperm plasma membrane(GO:0097524) |
| 0.1 | 2.5 | GO:0097440 | apical dendrite(GO:0097440) |
| 0.1 | 8.2 | GO:0005884 | actin filament(GO:0005884) |
| 0.1 | 1.7 | GO:0035145 | exon-exon junction complex(GO:0035145) |
| 0.1 | 1.9 | GO:0005779 | integral component of peroxisomal membrane(GO:0005779) |
| 0.1 | 41.1 | GO:0005694 | chromosome(GO:0005694) |
| 0.0 | 2.8 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.0 | 3.2 | GO:0043198 | dendritic shaft(GO:0043198) |
| 0.0 | 3.1 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.0 | 7.0 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.0 | 2.8 | GO:0005844 | polysome(GO:0005844) |
| 0.0 | 2.3 | GO:0005902 | microvillus(GO:0005902) |
| 0.0 | 1.4 | GO:0000314 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 0.0 | 3.1 | GO:0005795 | Golgi stack(GO:0005795) |
| 0.0 | 0.8 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.0 | 0.8 | GO:0031307 | integral component of mitochondrial outer membrane(GO:0031307) |
| 0.0 | 0.1 | GO:0042382 | paraspeckles(GO:0042382) |
| 0.0 | 0.2 | GO:0030123 | AP-3 adaptor complex(GO:0030123) |
| 0.0 | 2.5 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.0 | 0.4 | GO:0016592 | mediator complex(GO:0016592) |
| 0.0 | 7.1 | GO:0005730 | nucleolus(GO:0005730) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.8 | 23.3 | GO:1990254 | keratin filament binding(GO:1990254) |
| 4.6 | 18.4 | GO:0061575 | cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575) |
| 3.3 | 10.0 | GO:0051870 | methotrexate binding(GO:0051870) |
| 3.0 | 8.9 | GO:0001129 | RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly(GO:0001129) RNA polymerase II transcription factor activity, TBP-class protein binding(GO:0001132) |
| 2.6 | 18.1 | GO:0071558 | histone demethylase activity (H3-K27 specific)(GO:0071558) |
| 2.5 | 7.4 | GO:0004357 | glutamate-cysteine ligase activity(GO:0004357) |
| 1.9 | 5.8 | GO:0001565 | phorbol ester receptor activity(GO:0001565) non-kinase phorbol ester receptor activity(GO:0001566) |
| 1.7 | 10.0 | GO:0004897 | ciliary neurotrophic factor receptor activity(GO:0004897) |
| 1.5 | 6.0 | GO:0047844 | deoxycytidine deaminase activity(GO:0047844) |
| 1.3 | 3.9 | GO:0004335 | galactokinase activity(GO:0004335) |
| 1.2 | 3.7 | GO:0016262 | protein N-acetylglucosaminyltransferase activity(GO:0016262) |
| 1.2 | 3.5 | GO:0030156 | benzodiazepine receptor binding(GO:0030156) |
| 1.1 | 3.3 | GO:0000402 | open form four-way junction DNA binding(GO:0000401) crossed form four-way junction DNA binding(GO:0000402) |
| 1.1 | 4.2 | GO:0070573 | metallodipeptidase activity(GO:0070573) |
| 1.0 | 6.9 | GO:0031419 | cobalamin binding(GO:0031419) |
| 0.9 | 17.5 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.9 | 8.8 | GO:0008474 | palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599) |
| 0.9 | 42.7 | GO:0070888 | E-box binding(GO:0070888) |
| 0.8 | 2.4 | GO:0004647 | phosphoserine phosphatase activity(GO:0004647) |
| 0.8 | 4.8 | GO:0008467 | [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467) |
| 0.8 | 2.4 | GO:0035500 | MH2 domain binding(GO:0035500) |
| 0.8 | 6.4 | GO:0031995 | insulin-like growth factor II binding(GO:0031995) |
| 0.8 | 8.7 | GO:0008525 | phosphatidylcholine transporter activity(GO:0008525) |
| 0.8 | 5.5 | GO:0046976 | histone methyltransferase activity (H3-K27 specific)(GO:0046976) |
| 0.8 | 6.9 | GO:0042609 | CD4 receptor binding(GO:0042609) |
| 0.8 | 13.8 | GO:0051393 | alpha-actinin binding(GO:0051393) |
| 0.7 | 5.2 | GO:0034452 | dynactin binding(GO:0034452) |
| 0.7 | 4.6 | GO:0031821 | G-protein coupled serotonin receptor binding(GO:0031821) |
| 0.6 | 19.4 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.6 | 3.1 | GO:0035174 | nucleosomal histone binding(GO:0031493) histone serine kinase activity(GO:0035174) |
| 0.6 | 3.1 | GO:0034604 | pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604) |
| 0.6 | 18.3 | GO:0070182 | DNA polymerase binding(GO:0070182) |
| 0.6 | 6.6 | GO:0003689 | DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170) |
| 0.6 | 5.8 | GO:0017151 | DEAD/H-box RNA helicase binding(GO:0017151) |
| 0.6 | 5.8 | GO:0022848 | acetylcholine-gated cation channel activity(GO:0022848) |
| 0.6 | 24.9 | GO:0051879 | Hsp90 protein binding(GO:0051879) |
| 0.6 | 3.4 | GO:0046404 | ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734) |
| 0.5 | 1.5 | GO:0042954 | lipoprotein transporter activity(GO:0042954) |
| 0.5 | 2.6 | GO:0030621 | U4 snRNA binding(GO:0030621) |
| 0.5 | 10.3 | GO:0070300 | phosphatidic acid binding(GO:0070300) |
| 0.5 | 3.0 | GO:0016813 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813) |
| 0.5 | 3.3 | GO:0015016 | [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016) |
| 0.4 | 7.5 | GO:0005078 | MAP-kinase scaffold activity(GO:0005078) |
| 0.4 | 7.3 | GO:0009982 | pseudouridine synthase activity(GO:0009982) |
| 0.4 | 5.6 | GO:0070513 | death domain binding(GO:0070513) |
| 0.4 | 5.8 | GO:0035497 | cAMP response element binding(GO:0035497) |
| 0.4 | 25.4 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.4 | 2.8 | GO:0033592 | RNA strand annealing activity(GO:0033592) |
| 0.4 | 1.9 | GO:0030229 | very-low-density lipoprotein particle receptor activity(GO:0030229) |
| 0.4 | 9.6 | GO:0097602 | cullin family protein binding(GO:0097602) |
| 0.4 | 8.2 | GO:0005521 | lamin binding(GO:0005521) |
| 0.4 | 2.1 | GO:0097001 | ceramide binding(GO:0097001) |
| 0.3 | 1.7 | GO:0044547 | DNA topoisomerase binding(GO:0044547) |
| 0.3 | 4.5 | GO:0051861 | glycolipid binding(GO:0051861) |
| 0.3 | 9.1 | GO:0019789 | SUMO transferase activity(GO:0019789) |
| 0.3 | 3.4 | GO:0051959 | dynein light intermediate chain binding(GO:0051959) |
| 0.3 | 14.9 | GO:0097472 | cyclin-dependent protein kinase activity(GO:0097472) |
| 0.3 | 1.5 | GO:0016941 | natriuretic peptide receptor activity(GO:0016941) |
| 0.3 | 2.3 | GO:0019992 | diacylglycerol binding(GO:0019992) |
| 0.3 | 6.0 | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) |
| 0.3 | 6.8 | GO:0004697 | protein kinase C activity(GO:0004697) |
| 0.3 | 1.4 | GO:0047184 | 1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184) |
| 0.3 | 21.6 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.2 | 4.6 | GO:0001222 | transcription corepressor binding(GO:0001222) |
| 0.2 | 0.7 | GO:0047179 | platelet-activating factor acetyltransferase activity(GO:0047179) |
| 0.2 | 11.4 | GO:0048487 | beta-tubulin binding(GO:0048487) |
| 0.2 | 10.2 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 0.2 | 47.6 | GO:0042393 | histone binding(GO:0042393) |
| 0.2 | 0.9 | GO:0045131 | pre-mRNA branch point binding(GO:0045131) |
| 0.2 | 0.4 | GO:0001034 | RNA polymerase III transcription factor activity, sequence-specific DNA binding(GO:0001034) |
| 0.2 | 4.4 | GO:0005092 | GDP-dissociation inhibitor activity(GO:0005092) |
| 0.2 | 1.9 | GO:0000268 | peroxisome targeting sequence binding(GO:0000268) |
| 0.2 | 2.3 | GO:0048531 | beta-1,3-galactosyltransferase activity(GO:0048531) |
| 0.2 | 1.0 | GO:0010521 | telomerase inhibitor activity(GO:0010521) |
| 0.2 | 3.4 | GO:0004435 | phosphatidylinositol phospholipase C activity(GO:0004435) |
| 0.2 | 4.8 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
| 0.2 | 5.0 | GO:0050431 | transforming growth factor beta binding(GO:0050431) |
| 0.2 | 2.8 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.2 | 2.2 | GO:0016861 | intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861) |
| 0.2 | 2.4 | GO:0038191 | neuropilin binding(GO:0038191) |
| 0.2 | 3.8 | GO:0008143 | poly(A) binding(GO:0008143) |
| 0.2 | 2.0 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.2 | 7.9 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650) |
| 0.2 | 2.1 | GO:0043008 | ATP-dependent protein binding(GO:0043008) |
| 0.2 | 5.2 | GO:0050750 | low-density lipoprotein particle receptor binding(GO:0050750) |
| 0.2 | 5.7 | GO:0016655 | oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor(GO:0016655) |
| 0.1 | 0.6 | GO:0036033 | mediator complex binding(GO:0036033) |
| 0.1 | 1.2 | GO:0042500 | aspartic endopeptidase activity, intramembrane cleaving(GO:0042500) |
| 0.1 | 2.6 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
| 0.1 | 0.9 | GO:0002151 | G-quadruplex RNA binding(GO:0002151) G-quadruplex DNA binding(GO:0051880) |
| 0.1 | 1.1 | GO:0016312 | inositol bisphosphate phosphatase activity(GO:0016312) |
| 0.1 | 0.4 | GO:0016979 | lipoate-protein ligase activity(GO:0016979) |
| 0.1 | 2.7 | GO:0016864 | protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864) |
| 0.1 | 1.7 | GO:0000014 | single-stranded DNA endodeoxyribonuclease activity(GO:0000014) |
| 0.1 | 0.8 | GO:0070699 | type II activin receptor binding(GO:0070699) |
| 0.1 | 5.7 | GO:0003684 | damaged DNA binding(GO:0003684) |
| 0.1 | 0.9 | GO:0008395 | steroid hydroxylase activity(GO:0008395) |
| 0.1 | 3.2 | GO:0051721 | protein phosphatase 2A binding(GO:0051721) |
| 0.1 | 3.7 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.1 | 4.7 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 0.1 | 2.8 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 0.1 | 4.2 | GO:0070063 | RNA polymerase binding(GO:0070063) |
| 0.1 | 0.7 | GO:0008889 | glycerophosphodiester phosphodiesterase activity(GO:0008889) |
| 0.1 | 3.4 | GO:0005158 | insulin receptor binding(GO:0005158) |
| 0.1 | 2.9 | GO:0001103 | RNA polymerase II repressing transcription factor binding(GO:0001103) |
| 0.1 | 4.1 | GO:0003774 | motor activity(GO:0003774) |
| 0.1 | 0.5 | GO:1990247 | N6-methyladenosine-containing RNA binding(GO:1990247) |
| 0.1 | 12.1 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.1 | 6.4 | GO:0008013 | beta-catenin binding(GO:0008013) |
| 0.1 | 0.2 | GO:0008853 | exodeoxyribonuclease III activity(GO:0008853) |
| 0.1 | 6.6 | GO:0004519 | endonuclease activity(GO:0004519) |
| 0.1 | 2.8 | GO:0008094 | DNA-dependent ATPase activity(GO:0008094) |
| 0.1 | 12.0 | GO:0019902 | phosphatase binding(GO:0019902) |
| 0.1 | 0.2 | GO:0004415 | hyalurononglucosaminidase activity(GO:0004415) |
| 0.1 | 2.0 | GO:0015631 | tubulin binding(GO:0015631) |
| 0.0 | 6.3 | GO:0008022 | protein C-terminus binding(GO:0008022) |
| 0.0 | 0.6 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 0.0 | 3.0 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.0 | 0.9 | GO:0005351 | sugar:proton symporter activity(GO:0005351) |
| 0.0 | 2.2 | GO:0016879 | ligase activity, forming carbon-nitrogen bonds(GO:0016879) |
| 0.0 | 1.6 | GO:0004879 | RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531) |
| 0.0 | 1.8 | GO:0008026 | ATP-dependent helicase activity(GO:0008026) purine NTP-dependent helicase activity(GO:0070035) |
| 0.0 | 5.1 | GO:0003700 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 0.0 | 0.3 | GO:0050897 | cobalt ion binding(GO:0050897) |
| 0.0 | 0.8 | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding(GO:0005546) |
| 0.0 | 0.1 | GO:0004703 | G-protein coupled receptor kinase activity(GO:0004703) |
| 0.0 | 0.5 | GO:0005160 | transforming growth factor beta receptor binding(GO:0005160) |
| 0.0 | 0.7 | GO:0003727 | single-stranded RNA binding(GO:0003727) |
| 0.0 | 1.5 | GO:0004860 | protein kinase inhibitor activity(GO:0004860) |
| 0.0 | 0.4 | GO:0030331 | estrogen receptor binding(GO:0030331) |
| 0.0 | 0.5 | GO:0003899 | DNA-directed RNA polymerase activity(GO:0003899) |
| 0.0 | 1.3 | GO:0005057 | receptor signaling protein activity(GO:0005057) |
| 0.0 | 1.8 | GO:0008168 | methyltransferase activity(GO:0008168) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 61.4 | PID_AURORA_B_PATHWAY | Aurora B signaling |
| 1.1 | 14.9 | SA_REG_CASCADE_OF_CYCLIN_EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.8 | 23.0 | PID_SMAD2_3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.7 | 8.1 | PID_RANBP2_PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.6 | 36.9 | PID_ILK_PATHWAY | Integrin-linked kinase signaling |
| 0.6 | 5.8 | PID_ALK2_PATHWAY | ALK2 signaling events |
| 0.6 | 20.4 | PID_BARD1_PATHWAY | BARD1 signaling events |
| 0.5 | 18.7 | PID_FOXM1_PATHWAY | FOXM1 transcription factor network |
| 0.5 | 4.6 | PID_S1P_S1P4_PATHWAY | S1P4 pathway |
| 0.4 | 19.9 | PID_PLK1_PATHWAY | PLK1 signaling events |
| 0.2 | 15.5 | PID_E2F_PATHWAY | E2F transcription factor network |
| 0.2 | 6.4 | PID_WNT_SIGNALING_PATHWAY | Wnt signaling network |
| 0.2 | 7.5 | PID_THROMBIN_PAR1_PATHWAY | PAR1-mediated thrombin signaling events |
| 0.1 | 2.8 | PID_BETA_CATENIN_DEG_PATHWAY | Degradation of beta catenin |
| 0.1 | 5.6 | PID_RHOA_PATHWAY | RhoA signaling pathway |
| 0.1 | 3.3 | PID_TOLL_ENDOGENOUS_PATHWAY | Endogenous TLR signaling |
| 0.1 | 4.7 | PID_IL2_PI3K_PATHWAY | IL2 signaling events mediated by PI3K |
| 0.1 | 4.0 | PID_HEDGEHOG_GLI_PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.1 | 4.2 | PID_TELOMERASE_PATHWAY | Regulation of Telomerase |
| 0.1 | 1.5 | PID_DNA_PK_PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.1 | 3.1 | NABA_COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 2.1 | ST_JNK_MAPK_PATHWAY | JNK MAPK Pathway |
| 0.0 | 1.6 | PID_FCER1_PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.0 | 1.2 | PID_RB_1PATHWAY | Regulation of retinoblastoma protein |
| 0.0 | 1.3 | PID_CASPASE_PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 0.7 | PID_LIS1_PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.0 | 0.6 | SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 2.4 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 0.6 | PID_RXR_VDR_PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 0.8 | PID_HDAC_CLASSI_PATHWAY | Signaling events mediated by HDAC Class I |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 15.7 | REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY | Genes involved in Regulation of the Fanconi anemia pathway |
| 1.2 | 20.9 | REACTOME_APC_CDC20_MEDIATED_DEGRADATION_OF_NEK2A | Genes involved in APC-Cdc20 mediated degradation of Nek2A |
| 1.2 | 125.3 | REACTOME_MITOTIC_PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 1.1 | 14.9 | REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 1.0 | 23.3 | REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.9 | 21.6 | REACTOME_KINESINS | Genes involved in Kinesins |
| 0.9 | 38.6 | REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.7 | 5.8 | REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS | Genes involved in Presynaptic nicotinic acetylcholine receptors |
| 0.6 | 10.0 | REACTOME_G1_S_SPECIFIC_TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.4 | 4.8 | REACTOME_PURINE_CATABOLISM | Genes involved in Purine catabolism |
| 0.4 | 6.4 | REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.3 | 25.3 | REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.3 | 4.6 | REACTOME_ADENYLATE_CYCLASE_INHIBITORY_PATHWAY | Genes involved in Adenylate cyclase inhibitory pathway |
| 0.3 | 8.1 | REACTOME_ENOS_ACTIVATION_AND_REGULATION | Genes involved in eNOS activation and regulation |
| 0.3 | 7.3 | REACTOME_SULFUR_AMINO_ACID_METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.3 | 5.8 | REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE | Genes involved in Glutamate Neurotransmitter Release Cycle |
| 0.3 | 2.8 | REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE | Genes involved in Beta-catenin phosphorylation cascade |
| 0.3 | 3.3 | REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.3 | 18.3 | REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.2 | 3.1 | REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.2 | 4.7 | REACTOME_RNA_POL_III_CHAIN_ELONGATION | Genes involved in RNA Polymerase III Chain Elongation |
| 0.2 | 8.2 | REACTOME_HS_GAG_BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.2 | 1.6 | REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_2_PROMOTER | Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter |
| 0.2 | 5.5 | REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.2 | 5.8 | REACTOME_SIGNALING_BY_BMP | Genes involved in Signaling by BMP |
| 0.2 | 6.0 | REACTOME_SYNTHESIS_OF_PA | Genes involved in Synthesis of PA |
| 0.2 | 1.9 | REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.2 | 4.5 | REACTOME_MEIOTIC_SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.2 | 2.2 | REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 0.1 | 6.1 | REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.1 | 4.0 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |
| 0.1 | 21.2 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 2.0 | REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS | Genes involved in Processing of Intronless Pre-mRNAs |
| 0.1 | 6.1 | REACTOME_ACTIVATION_OF_THE_MRNA_UPON_BINDING_OF_THE_CAP_BINDING_COMPLEX_AND_EIFS_AND_SUBSEQUENT_BINDING_TO_43S | Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| 0.1 | 2.0 | REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.1 | 3.0 | REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.1 | 2.0 | REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 1.0 | REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.1 | 2.6 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.1 | 1.7 | REACTOME_MRNA_3_END_PROCESSING | Genes involved in mRNA 3'-end processing |
| 0.1 | 2.6 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.1 | 2.1 | REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.1 | 3.1 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
| 0.1 | 0.6 | REACTOME_ACTIVATION_OF_RAC | Genes involved in Activation of Rac |
| 0.0 | 0.5 | REACTOME_DOUBLE_STRAND_BREAK_REPAIR | Genes involved in Double-Strand Break Repair |
| 0.0 | 2.3 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 2.6 | REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.0 | 2.9 | REACTOME_GENERIC_TRANSCRIPTION_PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.0 | 5.4 | REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.0 | 0.9 | REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.0 | 0.8 | REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
