Motif ID: Mybl2

Z-value: 2.116


Transcription factors associated with Mybl2:

Gene SymbolEntrez IDGene Name
Mybl2 ENSMUSG00000017861.5 Mybl2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mybl2mm10_v2_chr2_+_163054682_1630546930.838.6e-21Click!


Activity profile for motif Mybl2.

activity profile for motif Mybl2


Sorted Z-values histogram for motif Mybl2

Sorted Z-values for motif Mybl2



Network of associatons between targets according to the STRING database.



First level regulatory network of Mybl2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_+_5591860 42.667 ENSMUST00000025081.5
ENSMUST00000159390.1
 Zeb1

zinc finger E-box binding homeobox 1

chr1_-_169531343 28.662 ENSMUST00000028000.7
 Nuf2
NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr1_+_57995971 26.767 ENSMUST00000027202.8
 Sgol2
shugoshin-like 2 (S. pombe)
chr14_-_67715585 26.404 ENSMUST00000163100.1
ENSMUST00000132705.1
ENSMUST00000124045.1
 Cdca2


cell division cycle associated 2


chr1_-_169531447 23.323 ENSMUST00000111368.1
 Nuf2
NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr2_+_13573927 23.259 ENSMUST00000141365.1
ENSMUST00000028062.2
 Vim

vimentin

chr19_-_41802028 22.294 ENSMUST00000026150.8
ENSMUST00000177495.1
ENSMUST00000163265.1
 Arhgap19


Rho GTPase activating protein 19


chr1_+_191821444 18.736 ENSMUST00000027931.7
 Nek2
NIMA (never in mitosis gene a)-related expressed kinase 2
chr13_+_51645232 18.367 ENSMUST00000075853.5
 Cks2
CDC28 protein kinase regulatory subunit 2
chrX_-_143827391 17.512 ENSMUST00000087316.5
 Capn6
calpain 6
chr4_-_124936852 16.574 ENSMUST00000030690.5
ENSMUST00000084296.3
 Cdca8

cell division cycle associated 8

chr6_+_113531675 15.692 ENSMUST00000036340.5
ENSMUST00000101051.2
 Fancd2

Fanconi anemia, complementation group D2

chr9_+_65890237 15.297 ENSMUST00000045802.6
 2810417H13Rik
RIKEN cDNA 2810417H13 gene
chr3_-_36571952 14.893 ENSMUST00000029270.3
 Ccna2
cyclin A2
chr9_-_52168111 14.653 ENSMUST00000165519.1
 Zc3h12c
zinc finger CCCH type containing 12C
chr13_-_59675754 14.570 ENSMUST00000022039.5
ENSMUST00000095739.2
 Golm1

golgi membrane protein 1

chr16_+_14163275 14.430 ENSMUST00000023359.6
ENSMUST00000117958.1
 Nde1

nuclear distribution gene E homolog 1 (A nidulans)

chr9_-_94538075 14.395 ENSMUST00000113028.1
 1190002N15Rik
RIKEN cDNA 1190002N15 gene
chr8_-_80739497 14.355 ENSMUST00000043359.8
 Smarca5
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
chr2_+_25372315 14.248 ENSMUST00000028329.6
ENSMUST00000114293.2
ENSMUST00000100323.2
 Sapcd2


suppressor APC domain containing 2



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 173 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 54.8 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
4.7 42.7 GO:0048752 semicircular canal morphogenesis(GO:0048752)
1.3 33.9 GO:0006336 DNA replication-independent nucleosome assembly(GO:0006336)
0.9 29.7 GO:0007099 centriole replication(GO:0007099)
0.5 27.1 GO:0035307 positive regulation of protein dephosphorylation(GO:0035307)
4.7 23.3 GO:1900147 Schwann cell migration(GO:0036135) regulation of Schwann cell migration(GO:1900147)
5.4 21.8 GO:0030997 regulation of centriole-centriole cohesion(GO:0030997)
1.2 21.6 GO:0000920 cell separation after cytokinesis(GO:0000920)
3.4 20.5 GO:0034080 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.4 18.4 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
2.3 18.1 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.2 17.9 GO:0006413 translational initiation(GO:0006413)
1.0 17.6 GO:0007080 mitotic metaphase plate congression(GO:0007080)
0.9 17.6 GO:0060009 Sertoli cell development(GO:0060009)
0.8 17.3 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
2.2 15.7 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
0.1 15.1 GO:0006997 nucleus organization(GO:0006997)
0.5 14.9 GO:0016572 histone phosphorylation(GO:0016572)
2.1 14.4 GO:0016584 nucleosome positioning(GO:0016584)
1.0 14.4 GO:0048199 vesicle targeting, to, from or within Golgi(GO:0048199)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 103 entries
Log-likelihood per target Total log-likelihoodTermDescription
10.3 61.7 GO:0031262 Ndc80 complex(GO:0031262)
0.1 45.1 GO:0005667 transcription factor complex(GO:0005667)
0.1 41.1 GO:0005694 chromosome(GO:0005694)
0.4 39.7 GO:0000922 spindle pole(GO:0000922)
0.3 23.7 GO:0005643 nuclear pore(GO:0005643)
5.8 23.3 GO:0045098 type III intermediate filament(GO:0045098)
0.4 21.6 GO:0005871 kinesin complex(GO:0005871)
0.2 18.8 GO:0005814 centriole(GO:0005814)
1.0 17.5 GO:0031616 spindle pole centrosome(GO:0031616)
0.5 17.5 GO:0005876 spindle microtubule(GO:0005876)
3.3 16.6 GO:0032133 chromosome passenger complex(GO:0032133)
2.3 16.1 GO:0001940 male pronucleus(GO:0001940)
0.3 15.3 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
1.3 14.4 GO:0005677 chromatin silencing complex(GO:0005677)
1.0 14.4 GO:0030126 COPI vesicle coat(GO:0030126)
0.2 14.4 GO:0001669 acrosomal vesicle(GO:0001669)
0.4 12.3 GO:0030992 intraciliary transport particle B(GO:0030992)
0.4 12.1 GO:0000777 condensed chromosome kinetochore(GO:0000777)
1.7 11.9 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.4 11.8 GO:0000788 nuclear nucleosome(GO:0000788)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 133 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 47.6 GO:0042393 histone binding(GO:0042393)
0.9 42.7 GO:0070888 E-box binding(GO:0070888)
0.4 25.4 GO:0003743 translation initiation factor activity(GO:0003743)
0.6 24.9 GO:0051879 Hsp90 protein binding(GO:0051879)
5.8 23.3 GO:1990254 keratin filament binding(GO:1990254)
0.3 21.6 GO:0003777 microtubule motor activity(GO:0003777)
0.6 19.4 GO:0008139 nuclear localization sequence binding(GO:0008139)
4.6 18.4 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.6 18.3 GO:0070182 DNA polymerase binding(GO:0070182)
2.6 18.1 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.9 17.5 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.3 14.9 GO:0097472 cyclin-dependent protein kinase activity(GO:0097472)
0.8 13.8 GO:0051393 alpha-actinin binding(GO:0051393)
0.1 12.1 GO:0008017 microtubule binding(GO:0008017)
0.1 12.0 GO:0019902 phosphatase binding(GO:0019902)
0.2 11.4 GO:0048487 beta-tubulin binding(GO:0048487)
0.5 10.3 GO:0070300 phosphatidic acid binding(GO:0070300)
0.2 10.2 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
3.3 10.0 GO:0051870 methotrexate binding(GO:0051870)
1.7 10.0 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 61.4 PID_AURORA_B_PATHWAY Aurora B signaling
0.6 36.9 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.8 23.0 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.6 20.4 PID_BARD1_PATHWAY BARD1 signaling events
0.4 19.9 PID_PLK1_PATHWAY PLK1 signaling events
0.5 18.7 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.2 15.5 PID_E2F_PATHWAY E2F transcription factor network
1.1 14.9 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.7 8.1 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.2 7.5 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events
0.2 6.4 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.6 5.8 PID_ALK2_PATHWAY ALK2 signaling events
0.1 5.6 PID_RHOA_PATHWAY RhoA signaling pathway
0.1 4.7 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K
0.5 4.6 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.1 4.2 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.1 4.0 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 3.3 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.1 3.1 NABA_COLLAGENS Genes encoding collagen proteins
0.1 2.8 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 125.3 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.9 38.6 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.3 25.3 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
1.0 23.3 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.9 21.6 REACTOME_KINESINS Genes involved in Kinesins
0.1 21.2 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
1.2 20.9 REACTOME_APC_CDC20_MEDIATED_DEGRADATION_OF_NEK2A Genes involved in APC-Cdc20 mediated degradation of Nek2A
0.3 18.3 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
1.6 15.7 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
1.1 14.9 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.6 10.0 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.2 8.2 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.3 8.1 REACTOME_ENOS_ACTIVATION_AND_REGULATION Genes involved in eNOS activation and regulation
0.3 7.3 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.4 6.4 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 6.1 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.1 6.1 REACTOME_ACTIVATION_OF_THE_MRNA_UPON_BINDING_OF_THE_CAP_BINDING_COMPLEX_AND_EIFS_AND_SUBSEQUENT_BINDING_TO_43S Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
0.2 6.0 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.7 5.8 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.3 5.8 REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle