Motif ID: Myf6

Z-value: 2.650


Transcription factors associated with Myf6:

Gene SymbolEntrez IDGene Name
Myf6 ENSMUSG00000035923.3 Myf6



Activity profile for motif Myf6.

activity profile for motif Myf6


Sorted Z-values histogram for motif Myf6

Sorted Z-values for motif Myf6



Network of associatons between targets according to the STRING database.



First level regulatory network of Myf6

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_-_9771018 47.232 ENSMUST00000110969.3
 Fam155a
family with sequence similarity 155, member A
chr18_-_36197343 45.497 ENSMUST00000115713.1
ENSMUST00000115712.1
 Nrg2

neuregulin 2

chr16_+_91269759 44.434 ENSMUST00000056882.5
 Olig1
oligodendrocyte transcription factor 1
chr8_+_125995102 44.034 ENSMUST00000046765.8
 Kcnk1
potassium channel, subfamily K, member 1
chr9_-_112185939 41.829 ENSMUST00000070218.5
 Arpp21
cyclic AMP-regulated phosphoprotein, 21
chr15_-_66812593 33.017 ENSMUST00000100572.3
 Sla
src-like adaptor
chr16_+_41532999 32.663 ENSMUST00000099761.3
 Lsamp
limbic system-associated membrane protein
chr3_+_118433797 32.496 ENSMUST00000180593.1
ENSMUST00000181926.1
ENSMUST00000181060.1
ENSMUST00000181310.1
 Gm26871



predicted gene, 26871



chr9_+_27790947 32.459 ENSMUST00000115243.2
 Opcml
opioid binding protein/cell adhesion molecule-like
chr2_-_122611238 32.303 ENSMUST00000028624.8
 Gatm
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr11_+_50602072 25.641 ENSMUST00000040523.8
 Adamts2
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 2
chr5_+_30588078 24.963 ENSMUST00000066295.2
 Kcnk3
potassium channel, subfamily K, member 3
chr7_-_138397704 24.297 ENSMUST00000160436.1
 Tcerg1l
transcription elongation regulator 1-like
chr6_-_126740151 23.651 ENSMUST00000112242.1
 Kcna6
potassium voltage-gated channel, shaker-related, subfamily, member 6
chr16_-_67620880 22.811 ENSMUST00000114292.1
ENSMUST00000120898.1
 Cadm2

cell adhesion molecule 2

chr18_+_65873478 22.291 ENSMUST00000025395.8
ENSMUST00000173530.1
 Grp

gastrin releasing peptide

chr13_-_76385028 21.694 ENSMUST00000099365.1
 Gm10760
predicted gene 10760
chr1_-_3671498 21.300 ENSMUST00000070533.4
 Xkr4
X Kell blood group precursor related family member 4
chr12_+_108334341 21.084 ENSMUST00000021684.4
 Cyp46a1
cytochrome P450, family 46, subfamily a, polypeptide 1
chr11_+_104231573 20.630 ENSMUST00000132977.1
ENSMUST00000132245.1
ENSMUST00000100347.4
 Mapt


microtubule-associated protein tau



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 285 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 79.0 GO:0071804 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
8.6 77.5 GO:1900034 regulation of cellular response to heat(GO:1900034)
2.5 68.3 GO:0035641 locomotory exploration behavior(GO:0035641)
1.2 62.6 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.7 62.0 GO:0030032 lamellipodium assembly(GO:0030032)
4.5 53.9 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
8.6 51.7 GO:0060075 regulation of resting membrane potential(GO:0060075)
7.1 49.5 GO:0098703 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
1.0 40.8 GO:0034605 cellular response to heat(GO:0034605)
0.4 36.1 GO:0007173 epidermal growth factor receptor signaling pathway(GO:0007173)
4.3 34.2 GO:0030322 stabilization of membrane potential(GO:0030322)
10.8 32.3 GO:0006601 creatine biosynthetic process(GO:0006601)
6.0 30.1 GO:0035405 histone-threonine phosphorylation(GO:0035405)
9.5 28.4 GO:1900673 olefin metabolic process(GO:1900673)
0.3 27.7 GO:0048709 oligodendrocyte differentiation(GO:0048709)
1.7 27.4 GO:0001573 ganglioside metabolic process(GO:0001573)
2.7 26.9 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
1.0 26.2 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
5.2 25.9 GO:0032423 regulation of mismatch repair(GO:0032423)
1.3 25.6 GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000060)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 150 entries
Log-likelihood per target Total log-likelihoodTermDescription
7.9 94.4 GO:0097418 neurofibrillary tangle(GO:0097418)
1.1 90.2 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.3 74.5 GO:0045211 postsynaptic membrane(GO:0045211)
1.7 67.4 GO:0032809 neuronal cell body membrane(GO:0032809)
0.5 63.0 GO:0031225 anchored component of membrane(GO:0031225)
0.5 58.4 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
11.0 44.0 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
6.6 33.1 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.9 30.0 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
1.9 29.0 GO:1902711 GABA-A receptor complex(GO:1902711)
7.1 28.4 GO:0044307 dendritic branch(GO:0044307)
0.4 28.3 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 25.2 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
1.5 23.9 GO:1990635 proximal dendrite(GO:1990635)
0.9 22.2 GO:0000930 gamma-tubulin complex(GO:0000930)
0.7 22.2 GO:0051233 spindle midzone(GO:0051233)
0.4 22.2 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 20.9 GO:0005615 extracellular space(GO:0005615)
1.3 20.1 GO:0005614 interstitial matrix(GO:0005614)
3.9 19.7 GO:1903440 calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 212 entries
Log-likelihood per target Total log-likelihoodTermDescription
7.1 78.5 GO:0022841 potassium ion leak channel activity(GO:0022841)
11.1 77.5 GO:0099609 microtubule lateral binding(GO:0099609)
1.0 55.7 GO:0046875 ephrin receptor binding(GO:0046875)
0.5 53.2 GO:0016247 channel regulator activity(GO:0016247)
16.5 49.5 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
15.2 45.5 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
13.0 39.1 GO:0004698 calcium-dependent protein kinase C activity(GO:0004698)
1.9 35.1 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
1.0 34.1 GO:0005201 extracellular matrix structural constituent(GO:0005201)
1.3 32.3 GO:0016769 transferase activity, transferring nitrogenous groups(GO:0016769)
0.4 31.6 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.7 31.3 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
1.5 29.2 GO:0005184 neuropeptide hormone activity(GO:0005184)
4.7 28.4 GO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.1 27.8 GO:0003779 actin binding(GO:0003779)
0.3 26.9 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.9 26.2 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
5.1 25.5 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.7 24.9 GO:0030552 cAMP binding(GO:0030552)
1.6 24.8 GO:0005388 calcium-transporting ATPase activity(GO:0005388)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 57 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 77.3 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
3.7 69.7 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
2.0 68.0 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
1.4 64.4 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
2.6 38.4 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
1.0 31.5 PID_NECTIN_PATHWAY Nectin adhesion pathway
1.1 24.7 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.2 21.9 PID_CMYB_PATHWAY C-MYB transcription factor network
0.2 21.6 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.3 18.7 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.6 17.6 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
2.1 16.6 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.2 16.0 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
2.1 15.0 PID_AVB3_INTEGRIN_PATHWAY Integrins in angiogenesis
0.1 14.0 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.2 13.7 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.4 13.4 PID_REELIN_PATHWAY Reelin signaling pathway
0.5 11.0 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.3 10.0 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.3 9.3 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 93 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.2 94.4 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
11.2 78.5 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
2.0 69.7 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
1.4 66.2 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
2.3 56.0 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
2.1 55.5 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
2.4 47.8 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
1.8 42.4 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
1.7 38.4 REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.8 34.1 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.2 33.2 REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
1.8 29.0 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
2.3 27.2 REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTERGRINS_ Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.7 26.7 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.4 26.3 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.8 24.2 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
1.3 22.3 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
3.0 21.1 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
1.3 19.3 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.5 17.6 REACTOME_G_PROTEIN_ACTIVATION Genes involved in G-protein activation