Motif ID: Myog_Tcf12

Z-value: 0.830

Transcription factors associated with Myog_Tcf12:

Gene SymbolEntrez IDGene Name
Myog ENSMUSG00000026459.4 Myog
Tcf12 ENSMUSG00000032228.10 Tcf12

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tcf12mm10_v2_chr9_-_72111651_72111712-0.773.1e-16Click!


Activity profile for motif Myog_Tcf12.

activity profile for motif Myog_Tcf12


Sorted Z-values histogram for motif Myog_Tcf12

Sorted Z-values for motif Myog_Tcf12



Network of associatons between targets according to the STRING database.



First level regulatory network of Myog_Tcf12

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_122611238 19.640 ENSMUST00000028624.8
 Gatm
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr13_+_16011851 17.732 ENSMUST00000042603.6
 Inhba
inhibin beta-A
chr13_+_83504032 16.369 ENSMUST00000163888.1
ENSMUST00000005722.7
 Mef2c

myocyte enhancer factor 2C

chr6_-_148444336 14.677 ENSMUST00000060095.8
ENSMUST00000100772.3
 Tmtc1

transmembrane and tetratricopeptide repeat containing 1

chr15_-_71727815 13.093 ENSMUST00000022953.8
 Fam135b
family with sequence similarity 135, member B
chr1_+_75507077 12.619 ENSMUST00000037330.4
 Inha
inhibin alpha
chr16_+_91269759 12.269 ENSMUST00000056882.5
 Olig1
oligodendrocyte transcription factor 1
chr19_-_57197556 11.846 ENSMUST00000099294.2
 Ablim1
actin-binding LIM protein 1
chr19_-_57197435 11.750 ENSMUST00000111550.1
 Ablim1
actin-binding LIM protein 1
chr19_-_57197377 11.653 ENSMUST00000111546.1
 Ablim1
actin-binding LIM protein 1
chr15_-_66831625 11.582 ENSMUST00000164163.1
 Sla
src-like adaptor
chr19_-_57197496 11.476 ENSMUST00000111544.1
 Ablim1
actin-binding LIM protein 1
chr16_-_22439719 11.062 ENSMUST00000079601.6
 Etv5
ets variant gene 5
chr16_-_22439570 9.874 ENSMUST00000170393.1
 Etv5
ets variant gene 5
chr11_-_67922136 9.621 ENSMUST00000021288.3
ENSMUST00000108677.1
 Usp43

ubiquitin specific peptidase 43

chr10_+_123264076 9.617 ENSMUST00000050756.7
 Fam19a2
family with sequence similarity 19, member A2
chr11_+_111066154 9.076 ENSMUST00000042970.2
 Kcnj2
potassium inwardly-rectifying channel, subfamily J, member 2
chr4_-_64046925 8.921 ENSMUST00000107377.3
 Tnc
tenascin C
chr15_-_66812593 8.812 ENSMUST00000100572.3
 Sla
src-like adaptor
chr16_-_67620880 8.743 ENSMUST00000114292.1
ENSMUST00000120898.1
 Cadm2

cell adhesion molecule 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 383 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 46.9 GO:0030032 lamellipodium assembly(GO:0030032)
5.1 30.4 GO:0046880 regulation of follicle-stimulating hormone secretion(GO:0046880) follicle-stimulating hormone secretion(GO:0046884)
4.4 22.0 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
2.4 21.9 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
6.5 19.6 GO:0006601 creatine biosynthetic process(GO:0006601)
0.3 17.3 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
5.7 17.2 GO:0071374 cellular response to parathyroid hormone stimulus(GO:0071374)
2.8 13.8 GO:0032423 regulation of mismatch repair(GO:0032423)
0.4 12.8 GO:0050873 brown fat cell differentiation(GO:0050873)
0.3 12.8 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.3 11.3 GO:0006779 porphyrin-containing compound biosynthetic process(GO:0006779)
2.5 10.1 GO:0021586 pons maturation(GO:0021586)
1.4 10.1 GO:0014819 regulation of skeletal muscle contraction(GO:0014819)
2.2 8.9 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
2.9 8.7 GO:0032430 inhibitory G-protein coupled receptor phosphorylation(GO:0002030) positive regulation of phospholipase A2 activity(GO:0032430) activation of meiosis involved in egg activation(GO:0060466)
0.6 8.4 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260) negative regulation of voltage-gated potassium channel activity(GO:1903817)
0.1 8.4 GO:0016579 protein deubiquitination(GO:0016579)
1.7 8.3 GO:1902309 negative regulation of peptidyl-serine dephosphorylation(GO:1902309)
0.3 8.3 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.4 7.8 GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 149 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 59.3 GO:0097060 synaptic membrane(GO:0097060)
0.5 51.6 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
1.2 34.5 GO:0031430 M band(GO:0031430)
10.1 30.4 GO:0043512 inhibin A complex(GO:0043512)
0.3 26.7 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.3 18.8 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 16.2 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.4 13.4 GO:0032809 neuronal cell body membrane(GO:0032809)
0.8 13.3 GO:1990635 proximal dendrite(GO:1990635)
0.2 9.1 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.2 9.1 GO:0045335 phagocytic vesicle(GO:0045335)
0.5 9.0 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.3 8.7 GO:0051233 spindle midzone(GO:0051233)
0.6 8.6 GO:0005614 interstitial matrix(GO:0005614)
0.6 7.7 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
1.9 7.5 GO:0044307 dendritic branch(GO:0044307)
0.5 7.3 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
1.8 7.2 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.9 6.2 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
1.2 5.9 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 247 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 38.4 GO:0003779 actin binding(GO:0003779)
0.5 30.8 GO:0015459 potassium channel regulator activity(GO:0015459)
3.3 29.6 GO:0034711 inhibin binding(GO:0034711)
0.1 23.1 GO:0003924 GTPase activity(GO:0003924)
0.6 22.2 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.5 19.8 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.8 18.6 GO:0016769 transferase activity, transferring nitrogenous groups(GO:0016769)
1.0 16.4 GO:0003680 AT DNA binding(GO:0003680)
0.1 14.9 GO:0004860 protein kinase inhibitor activity(GO:0004860)
4.6 13.8 GO:0004698 calcium-dependent protein kinase C activity(GO:0004698)
0.8 13.4 GO:0045499 chemorepellent activity(GO:0045499)
1.6 12.7 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529)
0.6 12.4 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.1 11.3 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)
0.5 10.6 GO:0004385 guanylate kinase activity(GO:0004385)
0.1 10.2 GO:0036459 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.1 9.7 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
1.6 9.5 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
1.1 9.1 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008)
1.5 8.9 GO:0045545 syndecan binding(GO:0045545)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 26.6 PID_ALK1_PATHWAY ALK1 signaling events
0.7 22.8 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.7 21.6 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.4 16.9 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.6 16.3 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.1 15.8 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.6 13.8 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.6 10.3 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.2 9.3 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.2 8.8 PID_SHP2_PATHWAY SHP2 signaling
0.1 8.4 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.5 8.1 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.5 7.2 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.2 7.2 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.3 6.6 ST_GA12_PATHWAY G alpha 12 Pathway
0.3 6.4 PID_LYMPH_ANGIOGENESIS_PATHWAY VEGFR3 signaling in lymphatic endothelium
0.2 6.1 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.4 5.0 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.2 5.0 SIG_CD40PATHWAYMAP Genes related to CD40 signaling
0.2 4.4 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 93 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 50.5 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
1.2 34.5 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
7.6 30.4 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.9 20.7 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.2 18.2 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.4 17.7 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 16.7 REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.5 16.1 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.4 13.0 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.5 11.6 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.3 11.1 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.4 10.5 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.8 9.5 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.3 9.0 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.2 8.8 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.5 8.3 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.2 7.9 REACTOME_INWARDLY_RECTIFYING_K_CHANNELS Genes involved in Inwardly rectifying K+ channels
1.1 7.7 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
1.2 7.4 REACTOME_COMMON_PATHWAY Genes involved in Common Pathway
0.2 6.4 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA