Motif ID: Mzf1

Z-value: 1.135


Transcription factors associated with Mzf1:

Gene SymbolEntrez IDGene Name
Mzf1 ENSMUSG00000030380.10 Mzf1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mzf1mm10_v2_chr7_-_13054665_130547640.103.8e-01Click!


Activity profile for motif Mzf1.

activity profile for motif Mzf1


Sorted Z-values histogram for motif Mzf1

Sorted Z-values for motif Mzf1



Network of associatons between targets according to the STRING database.



First level regulatory network of Mzf1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_104367549 12.061 ENSMUST00000106830.2
 Dab1
disabled 1
chr4_-_68954351 11.837 ENSMUST00000030036.5
 Brinp1
bone morphogenic protein/retinoic acid inducible neural specific 1
chr14_-_39472825 9.721 ENSMUST00000168810.2
ENSMUST00000173780.1
ENSMUST00000166968.2
 Nrg3


neuregulin 3


chr13_+_91461050 9.303 ENSMUST00000004094.8
ENSMUST00000042122.8
 Ssbp2

single-stranded DNA binding protein 2

chr10_-_109010955 9.223 ENSMUST00000105276.1
ENSMUST00000064054.7
 Syt1

synaptotagmin I

chr11_-_89302545 8.591 ENSMUST00000061728.3
 Nog
noggin
chr3_+_96596628 8.263 ENSMUST00000058943.7
 Ankrd34a
ankyrin repeat domain 34A
chr17_+_28142267 8.190 ENSMUST00000043503.3
 Scube3
signal peptide, CUB domain, EGF-like 3
chr6_-_126740151 7.626 ENSMUST00000112242.1
 Kcna6
potassium voltage-gated channel, shaker-related, subfamily, member 6
chr9_+_34486125 7.400 ENSMUST00000115148.2
ENSMUST00000183580.1
 Kirrel3
RP24-225I21.1
kin of IRRE like 3 (Drosophila)
RP24-225I21.1
chr6_+_110645572 6.991 ENSMUST00000071076.6
ENSMUST00000172951.1
 Grm7

glutamate receptor, metabotropic 7

chr3_+_103575275 6.888 ENSMUST00000090697.4
 Syt6
synaptotagmin VI
chr2_+_180499893 6.742 ENSMUST00000029084.2
 Ntsr1
neurotensin receptor 1
chr6_-_23248264 6.649 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr12_+_105336922 6.606 ENSMUST00000180503.1
 2810011L19Rik
RIKEN cDNA 2810011L19 gene
chr3_+_103575231 6.470 ENSMUST00000121834.1
 Syt6
synaptotagmin VI
chr11_-_95514570 6.323 ENSMUST00000058866.7
 Nxph3
neurexophilin 3
chr1_-_154725920 6.230 ENSMUST00000004214.8
 Cacna1e
calcium channel, voltage-dependent, R type, alpha 1E subunit
chr1_+_75400070 6.214 ENSMUST00000113589.1
 Speg
SPEG complex locus
chr14_-_102982630 6.169 ENSMUST00000184744.1
 KCTD12
mmu-mir-5130

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 325 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 20.1 GO:0071625 vocalization behavior(GO:0071625)
1.5 19.7 GO:0099628 receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) neurotransmitter receptor diffusion trapping(GO:0099628)
5.9 17.8 GO:0060478 acrosomal vesicle exocytosis(GO:0060478)
0.2 13.7 GO:0007019 microtubule depolymerization(GO:0007019)
4.0 12.1 GO:0021577 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
1.9 11.1 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
1.1 10.1 GO:0071420 cellular response to histamine(GO:0071420)
1.2 9.2 GO:0005513 detection of calcium ion(GO:0005513)
0.2 8.7 GO:1901379 regulation of potassium ion transmembrane transport(GO:1901379)
2.1 8.6 GO:2000313 fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313)
0.0 8.1 GO:0051260 protein homooligomerization(GO:0051260)
1.1 8.0 GO:0014819 regulation of skeletal muscle contraction(GO:0014819)
1.3 7.9 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.8 7.7 GO:0090394 negative regulation of excitatory postsynaptic potential(GO:0090394)
0.8 7.6 GO:0030322 stabilization of membrane potential(GO:0030322)
1.5 7.4 GO:0002121 inter-male aggressive behavior(GO:0002121)
0.9 7.3 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.8 7.3 GO:0097623 potassium ion export across plasma membrane(GO:0097623)
1.4 7.0 GO:0015671 oxygen transport(GO:0015671)
1.4 7.0 GO:0001661 conditioned taste aversion(GO:0001661)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 154 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 38.8 GO:0060076 excitatory synapse(GO:0060076)
0.4 28.4 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
1.1 22.2 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.5 20.0 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.7 19.4 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
1.0 14.4 GO:1902711 GABA-A receptor complex(GO:1902711)
0.8 14.2 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.7 11.9 GO:0031045 dense core granule(GO:0031045)
0.5 11.3 GO:0071565 nBAF complex(GO:0071565)
0.1 9.2 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.2 9.0 GO:0043034 costamere(GO:0043034)
0.2 9.0 GO:0001750 photoreceptor outer segment(GO:0001750)
0.2 8.9 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 8.0 GO:0005874 microtubule(GO:0005874)
0.1 7.8 GO:0042383 sarcolemma(GO:0042383)
0.2 7.1 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.9 6.9 GO:0005833 hemoglobin complex(GO:0005833)
1.7 6.7 GO:0032280 symmetric synapse(GO:0032280)
0.2 6.6 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.2 6.6 GO:0043025 neuronal cell body(GO:0043025)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 209 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 22.4 GO:0005096 GTPase activator activity(GO:0005096)
0.5 19.6 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
2.1 16.8 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.9 12.5 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.1 12.1 GO:0004860 protein kinase inhibitor activity(GO:0004860)
1.7 10.1 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
0.3 10.0 GO:0046965 retinoid X receptor binding(GO:0046965)
0.1 10.0 GO:0003697 single-stranded DNA binding(GO:0003697)
0.6 9.9 GO:0045499 chemorepellent activity(GO:0045499)
2.3 9.2 GO:0030348 syntaxin-3 binding(GO:0030348)
0.9 8.9 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
1.4 8.6 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.2 8.5 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.2 8.5 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.2 8.1 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 8.0 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.5 7.9 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 7.9 GO:0016247 channel regulator activity(GO:0016247)
0.5 7.8 GO:0004385 guanylate kinase activity(GO:0004385)
0.7 7.6 GO:0022841 potassium ion leak channel activity(GO:0022841)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 63 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 18.3 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.5 16.1 ST_GA12_PATHWAY G alpha 12 Pathway
0.2 12.0 PID_LKB1_PATHWAY LKB1 signaling events
0.2 10.8 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.6 9.7 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.2 8.9 SIG_CD40PATHWAYMAP Genes related to CD40 signaling
0.2 7.9 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.2 5.2 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.1 4.8 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.2 4.7 PID_IFNG_PATHWAY IFN-gamma pathway
0.1 4.5 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.2 4.0 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.2 4.0 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 3.9 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 3.7 PID_RAS_PATHWAY Regulation of Ras family activation
0.1 3.4 PID_NFAT_3PATHWAY Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.1 3.3 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.2 3.1 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1 2.8 PID_REELIN_PATHWAY Reelin signaling pathway
0.1 2.6 PID_HIF2PATHWAY HIF-2-alpha transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 87 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 17.5 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
1.0 15.3 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.3 12.2 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.4 11.8 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.3 9.9 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.1 9.4 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.9 9.2 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.7 9.2 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.4 9.1 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.1 8.7 REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS Genes involved in G alpha (q) signalling events
0.3 8.1 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.2 7.5 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.2 6.3 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.1 5.6 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.2 5.1 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.3 4.9 REACTOME_MTORC1_MEDIATED_SIGNALLING Genes involved in mTORC1-mediated signalling
0.1 4.9 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.3 4.7 REACTOME_INHIBITION_OF_INSULIN_SECRETION_BY_ADRENALINE_NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.2 4.6 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.2 4.6 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins