Motif ID: Neurod1

Z-value: 0.991


Transcription factors associated with Neurod1:

Gene SymbolEntrez IDGene Name
Neurod1 ENSMUSG00000034701.9 Neurod1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Neurod1mm10_v2_chr2_-_79456750_794567610.668.3e-11Click!


Activity profile for motif Neurod1.

activity profile for motif Neurod1


Sorted Z-values histogram for motif Neurod1

Sorted Z-values for motif Neurod1



Network of associatons between targets according to the STRING database.



First level regulatory network of Neurod1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_6730051 12.644 ENSMUST00000043578.6
ENSMUST00000131467.1
ENSMUST00000150761.1
ENSMUST00000151281.1
 St18



suppression of tumorigenicity 18



chr15_-_78773452 11.116 ENSMUST00000018313.5
 Mfng
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr2_-_84775388 8.726 ENSMUST00000023994.3
 Serping1
serine (or cysteine) peptidase inhibitor, clade G, member 1
chr1_+_6730135 8.636 ENSMUST00000155921.1
 St18
suppression of tumorigenicity 18
chr6_+_56017489 8.547 ENSMUST00000052827.4
 Ppp1r17
protein phosphatase 1, regulatory subunit 17
chr2_-_84775420 8.302 ENSMUST00000111641.1
 Serping1
serine (or cysteine) peptidase inhibitor, clade G, member 1
chr5_-_28210022 7.775 ENSMUST00000118882.1
 Cnpy1
canopy 1 homolog (zebrafish)
chr6_-_127151044 7.616 ENSMUST00000000188.8
 Ccnd2
cyclin D2
chr7_-_28302238 7.538 ENSMUST00000108315.3
 Dll3
delta-like 3 (Drosophila)
chr16_+_42907563 7.291 ENSMUST00000151244.1
ENSMUST00000114694.2
 Zbtb20

zinc finger and BTB domain containing 20

chr13_+_51846673 7.278 ENSMUST00000021903.2
 Gadd45g
growth arrest and DNA-damage-inducible 45 gamma
chr7_+_127211608 7.129 ENSMUST00000032910.6
 Mylpf
myosin light chain, phosphorylatable, fast skeletal muscle
chr12_-_34528844 6.894 ENSMUST00000110819.2
 Hdac9
histone deacetylase 9
chr6_+_120666388 6.852 ENSMUST00000112686.1
 Cecr2
cat eye syndrome chromosome region, candidate 2
chr15_+_25622525 6.796 ENSMUST00000110457.1
ENSMUST00000137601.1
 Myo10

myosin X

chr6_-_99666762 6.701 ENSMUST00000032151.2
 Eif4e3
eukaryotic translation initiation factor 4E member 3
chr9_+_46998931 6.539 ENSMUST00000178065.1
 Gm4791
predicted gene 4791
chr8_+_45507768 6.421 ENSMUST00000067065.7
ENSMUST00000098788.3
ENSMUST00000067107.7
ENSMUST00000171337.2
ENSMUST00000138049.1
ENSMUST00000141039.1
 Sorbs2





sorbin and SH3 domain containing 2





chr4_-_110287479 6.318 ENSMUST00000106598.1
ENSMUST00000102723.4
ENSMUST00000153906.1
 Elavl4


ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)


chr10_-_92164666 6.246 ENSMUST00000183123.1
ENSMUST00000182033.1
 Rmst

rhabdomyosarcoma 2 associated transcript (non-coding RNA)


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 130 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 19.0 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
5.7 17.0 GO:0001869 regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
0.1 11.2 GO:0043488 regulation of mRNA stability(GO:0043488)
1.2 11.1 GO:0002315 marginal zone B cell differentiation(GO:0002315)
1.2 10.6 GO:0030035 microspike assembly(GO:0030035)
1.5 9.1 GO:0003383 apical constriction(GO:0003383)
1.0 8.3 GO:1904627 response to phorbol 13-acetate 12-myristate(GO:1904627) cellular response to phorbol 13-acetate 12-myristate(GO:1904628)
0.8 7.9 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
0.6 7.6 GO:0071481 cellular response to X-ray(GO:0071481)
1.5 7.5 GO:0007386 compartment pattern specification(GO:0007386)
0.7 7.3 GO:0042095 interferon-gamma biosynthetic process(GO:0042095)
0.2 7.3 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.1 7.2 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.1 7.0 GO:0002028 regulation of sodium ion transport(GO:0002028)
0.8 6.9 GO:0001842 neural fold formation(GO:0001842)
0.1 6.4 GO:0006413 translational initiation(GO:0006413)
0.1 6.4 GO:0006334 nucleosome assembly(GO:0006334)
0.4 6.1 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.1 6.0 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 6.0 GO:0007162 negative regulation of cell adhesion(GO:0007162)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 57 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 24.3 GO:0032993 protein-DNA complex(GO:0032993)
1.0 15.0 GO:0042788 polysomal ribosome(GO:0042788)
0.2 14.7 GO:0072562 blood microparticle(GO:0072562)
0.2 13.6 GO:0016459 myosin complex(GO:0016459)
0.2 11.1 GO:0030173 integral component of Golgi membrane(GO:0030173)
2.4 9.8 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.1 9.1 GO:0035097 histone methyltransferase complex(GO:0035097)
0.1 9.1 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 8.5 GO:0030175 filopodium(GO:0030175)
0.1 8.1 GO:0005923 bicellular tight junction(GO:0005923)
1.7 6.9 GO:0090537 CERF complex(GO:0090537)
0.0 6.4 GO:0000775 chromosome, centromeric region(GO:0000775)
0.0 6.2 GO:0001726 ruffle(GO:0001726)
0.1 6.1 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.8 6.0 GO:0033269 internode region of axon(GO:0033269)
0.1 5.9 GO:0005720 nuclear heterochromatin(GO:0005720)
0.4 4.9 GO:0097542 ciliary tip(GO:0097542)
0.1 4.2 GO:0060170 ciliary membrane(GO:0060170)
0.2 3.6 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 3.6 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 99 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 17.0 GO:0001848 complement binding(GO:0001848)
0.1 16.1 GO:0001047 core promoter binding(GO:0001047)
0.1 12.8 GO:0051015 actin filament binding(GO:0051015)
0.3 11.9 GO:0017091 AU-rich element binding(GO:0017091)
3.7 11.1 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.2 9.4 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 8.7 GO:0017124 SH3 domain binding(GO:0017124)
1.1 8.5 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.3 7.7 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.1 7.6 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.2 7.5 GO:0005112 Notch binding(GO:0005112)
0.1 6.5 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 6.4 GO:0003743 translation initiation factor activity(GO:0003743)
2.0 6.1 GO:0098770 FBXO family protein binding(GO:0098770)
0.2 6.1 GO:0008307 structural constituent of muscle(GO:0008307)
0.2 5.1 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.1 4.9 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 4.9 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.3 4.8 GO:0035497 cAMP response element binding(GO:0035497)
0.3 4.5 GO:0016805 dipeptidase activity(GO:0016805)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 12.7 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.1 10.7 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2 10.4 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.2 7.3 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.1 6.8 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.1 6.2 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.1 6.0 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.1 6.0 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 5.9 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.1 5.3 PID_PLK1_PATHWAY PLK1 signaling events
0.2 5.1 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.1 4.8 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.1 4.3 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 4.0 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.1 3.6 PID_AURORA_B_PATHWAY Aurora B signaling
0.2 3.5 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.2 3.4 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 3.3 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 3.2 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1 3.0 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.7 17.0 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.3 15.9 REACTOME_G1_PHASE Genes involved in G1 Phase
0.6 11.1 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 10.0 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.2 8.9 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.3 7.9 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.1 6.7 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.1 6.3 REACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL Genes involved in Cell surface interactions at the vascular wall
0.3 6.0 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1 5.5 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 5.4 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 5.2 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.1 4.6 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.2 4.0 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.1 3.7 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.2 3.4 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.1 3.2 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.2 3.1 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.1 2.9 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 2.6 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo