Motif ID: Neurod2_Bhlha15_Bhlhe22_Olig1
Z-value: 0.692
Transcription factors associated with Neurod2_Bhlha15_Bhlhe22_Olig1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Bhlha15 | ENSMUSG00000052271.7 | Bhlha15 |
| Bhlhe22 | ENSMUSG00000025128.6 | Bhlhe22 |
| Neurod2 | ENSMUSG00000038255.6 | Neurod2 |
| Olig1 | ENSMUSG00000046160.5 | Olig1 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Neurod2 | mm10_v2_chr11_-_98329641_98329654 | 0.45 | 4.9e-05 | Click! |
| Bhlhe22 | mm10_v2_chr3_+_18054258_18054325 | 0.33 | 3.5e-03 | Click! |
| Olig1 | mm10_v2_chr16_+_91269759_91269778 | 0.04 | 7.3e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 6.5 | GO:0032240 | RNA import into nucleus(GO:0006404) mRNA export from nucleus in response to heat stress(GO:0031990) negative regulation of nucleobase-containing compound transport(GO:0032240) negative regulation of RNA export from nucleus(GO:0046832) |
| 0.9 | 3.7 | GO:2001106 | regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106) |
| 0.9 | 4.5 | GO:0030205 | dermatan sulfate metabolic process(GO:0030205) |
| 0.8 | 2.3 | GO:0098923 | retrograde trans-synaptic signaling by soluble gas(GO:0098923) |
| 0.6 | 1.9 | GO:2000297 | negative regulation of synapse maturation(GO:2000297) |
| 0.6 | 3.6 | GO:1902261 | positive regulation of delayed rectifier potassium channel activity(GO:1902261) |
| 0.6 | 5.3 | GO:0036371 | protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) |
| 0.5 | 2.7 | GO:0002121 | inter-male aggressive behavior(GO:0002121) |
| 0.5 | 1.6 | GO:0002182 | cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248) |
| 0.5 | 9.4 | GO:0031340 | positive regulation of vesicle fusion(GO:0031340) |
| 0.5 | 1.4 | GO:0001928 | regulation of exocyst assembly(GO:0001928) |
| 0.4 | 1.2 | GO:2000373 | regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373) |
| 0.3 | 2.7 | GO:0035887 | aortic smooth muscle cell differentiation(GO:0035887) |
| 0.3 | 1.2 | GO:1904457 | positive regulation of neuronal action potential(GO:1904457) |
| 0.3 | 5.2 | GO:0046069 | cGMP catabolic process(GO:0046069) |
| 0.3 | 0.8 | GO:1904139 | microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139) |
| 0.3 | 3.0 | GO:0060510 | Type II pneumocyte differentiation(GO:0060510) |
| 0.3 | 0.8 | GO:0002159 | desmosome assembly(GO:0002159) adherens junction maintenance(GO:0034334) intermediate filament bundle assembly(GO:0045110) maintenance of organ identity(GO:0048496) |
| 0.3 | 3.9 | GO:0033623 | regulation of integrin activation(GO:0033623) |
| 0.2 | 1.5 | GO:1990928 | response to amino acid starvation(GO:1990928) |
| 0.2 | 1.8 | GO:2000766 | negative regulation of cytoplasmic translation(GO:2000766) |
| 0.2 | 2.0 | GO:0060732 | positive regulation of inositol phosphate biosynthetic process(GO:0060732) |
| 0.1 | 0.8 | GO:0051790 | short-chain fatty acid biosynthetic process(GO:0051790) |
| 0.1 | 0.8 | GO:2000304 | positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304) |
| 0.1 | 2.9 | GO:0021860 | pyramidal neuron development(GO:0021860) |
| 0.1 | 0.9 | GO:0061368 | maternal process involved in parturition(GO:0060137) behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368) |
| 0.1 | 7.4 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
| 0.1 | 0.3 | GO:0043490 | malate-aspartate shuttle(GO:0043490) |
| 0.1 | 0.7 | GO:0010459 | negative regulation of heart rate(GO:0010459) |
| 0.1 | 0.8 | GO:0007221 | positive regulation of transcription of Notch receptor target(GO:0007221) |
| 0.1 | 0.9 | GO:0007213 | G-protein coupled acetylcholine receptor signaling pathway(GO:0007213) |
| 0.1 | 0.6 | GO:0019432 | triglyceride biosynthetic process(GO:0019432) |
| 0.1 | 0.2 | GO:0000715 | nucleotide-excision repair, DNA damage recognition(GO:0000715) |
| 0.1 | 0.4 | GO:0043416 | regulation of skeletal muscle tissue regeneration(GO:0043416) |
| 0.1 | 0.5 | GO:0042118 | endothelial cell activation(GO:0042118) |
| 0.1 | 0.8 | GO:0032525 | somite rostral/caudal axis specification(GO:0032525) |
| 0.0 | 1.9 | GO:0007218 | neuropeptide signaling pathway(GO:0007218) |
| 0.0 | 0.8 | GO:0045760 | positive regulation of action potential(GO:0045760) |
| 0.0 | 1.3 | GO:0001523 | retinoid metabolic process(GO:0001523) |
| 0.0 | 0.8 | GO:0021702 | cerebellar Purkinje cell differentiation(GO:0021702) |
| 0.0 | 1.2 | GO:0071539 | protein localization to centrosome(GO:0071539) |
| 0.0 | 0.4 | GO:0030397 | membrane disassembly(GO:0030397) nuclear envelope disassembly(GO:0051081) |
| 0.0 | 0.4 | GO:2000381 | negative regulation of mesoderm development(GO:2000381) |
| 0.0 | 1.0 | GO:0007193 | adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway(GO:0007193) |
| 0.0 | 0.1 | GO:0046886 | positive regulation of hormone biosynthetic process(GO:0046886) |
| 0.0 | 0.3 | GO:0033184 | positive regulation of histone ubiquitination(GO:0033184) |
| 0.0 | 0.9 | GO:0001921 | positive regulation of receptor recycling(GO:0001921) |
| 0.0 | 2.9 | GO:0046889 | positive regulation of lipid biosynthetic process(GO:0046889) |
| 0.0 | 1.2 | GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I(GO:0002474) |
| 0.0 | 4.2 | GO:0030048 | actin filament-based movement(GO:0030048) |
| 0.0 | 0.2 | GO:0008343 | adult feeding behavior(GO:0008343) |
| 0.0 | 0.4 | GO:0045292 | mRNA cis splicing, via spliceosome(GO:0045292) |
| 0.0 | 0.2 | GO:0051418 | interphase microtubule nucleation by interphase microtubule organizing center(GO:0051415) microtubule nucleation by microtubule organizing center(GO:0051418) |
| 0.0 | 0.2 | GO:2000671 | regulation of motor neuron apoptotic process(GO:2000671) |
| 0.0 | 1.0 | GO:0006446 | regulation of translational initiation(GO:0006446) |
| 0.0 | 0.0 | GO:0014846 | esophagus smooth muscle contraction(GO:0014846) |
| 0.0 | 2.3 | GO:0007519 | skeletal muscle tissue development(GO:0007519) |
| 0.0 | 0.2 | GO:0003334 | keratinocyte development(GO:0003334) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 6.5 | GO:0044615 | nuclear pore nuclear basket(GO:0044615) |
| 0.6 | 2.9 | GO:0097441 | basilar dendrite(GO:0097441) |
| 0.2 | 1.2 | GO:0044316 | cone cell pedicle(GO:0044316) |
| 0.2 | 0.7 | GO:0034457 | Mpp10 complex(GO:0034457) |
| 0.2 | 1.2 | GO:0070937 | CRD-mediated mRNA stability complex(GO:0070937) |
| 0.2 | 4.8 | GO:0031430 | M band(GO:0031430) |
| 0.2 | 3.4 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.2 | 9.4 | GO:0031201 | SNARE complex(GO:0031201) |
| 0.1 | 1.2 | GO:0031313 | extrinsic component of endosome membrane(GO:0031313) |
| 0.1 | 2.3 | GO:0032433 | filopodium tip(GO:0032433) |
| 0.1 | 2.7 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.1 | 1.3 | GO:0005850 | eukaryotic translation initiation factor 2 complex(GO:0005850) |
| 0.1 | 1.5 | GO:0031462 | Cul2-RING ubiquitin ligase complex(GO:0031462) |
| 0.1 | 0.8 | GO:0000137 | Golgi cis cisterna(GO:0000137) |
| 0.1 | 0.8 | GO:0030057 | desmosome(GO:0030057) |
| 0.1 | 2.9 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.0 | 0.2 | GO:0071942 | XPC complex(GO:0071942) |
| 0.0 | 3.6 | GO:0016529 | sarcoplasmic reticulum(GO:0016529) |
| 0.0 | 0.4 | GO:0060053 | neurofilament cytoskeleton(GO:0060053) |
| 0.0 | 0.2 | GO:0000931 | gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274) |
| 0.0 | 2.9 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 3.6 | GO:0043198 | dendritic shaft(GO:0043198) |
| 0.0 | 1.3 | GO:0032809 | neuronal cell body membrane(GO:0032809) |
| 0.0 | 0.7 | GO:0097038 | perinuclear endoplasmic reticulum(GO:0097038) |
| 0.0 | 2.0 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.0 | 4.4 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.0 | 0.4 | GO:0031229 | integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) |
| 0.0 | 1.0 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.0 | 0.8 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.0 | 1.0 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.0 | 0.6 | GO:0016592 | mediator complex(GO:0016592) |
| 0.0 | 1.4 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 3.0 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.0 | 0.8 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 5.2 | GO:0048101 | calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101) |
| 0.3 | 3.9 | GO:0031005 | filamin binding(GO:0031005) |
| 0.3 | 4.5 | GO:0016857 | racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857) |
| 0.2 | 9.4 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.2 | 6.5 | GO:0005487 | nucleocytoplasmic transporter activity(GO:0005487) |
| 0.2 | 0.6 | GO:0008195 | phosphatidate phosphatase activity(GO:0008195) |
| 0.2 | 0.8 | GO:0004315 | 3-oxoacyl-[acyl-carrier-protein] synthase activity(GO:0004315) |
| 0.2 | 3.4 | GO:0000900 | translation repressor activity, nucleic acid binding(GO:0000900) |
| 0.2 | 3.6 | GO:0016208 | AMP binding(GO:0016208) |
| 0.2 | 0.7 | GO:0043125 | ErbB-3 class receptor binding(GO:0043125) |
| 0.1 | 2.3 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.1 | 1.0 | GO:0031821 | G-protein coupled serotonin receptor binding(GO:0031821) |
| 0.1 | 1.5 | GO:0004745 | retinol dehydrogenase activity(GO:0004745) |
| 0.1 | 0.5 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.1 | 1.2 | GO:0034046 | poly(G) binding(GO:0034046) |
| 0.1 | 2.1 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
| 0.1 | 0.8 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled adenosine receptor activity(GO:0001609) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 0.1 | 0.8 | GO:0004767 | sphingomyelin phosphodiesterase activity(GO:0004767) |
| 0.1 | 5.3 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.1 | 0.4 | GO:0070012 | oligopeptidase activity(GO:0070012) |
| 0.1 | 1.1 | GO:0005225 | volume-sensitive anion channel activity(GO:0005225) |
| 0.1 | 3.7 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 0.1 | 0.3 | GO:0015183 | L-aspartate transmembrane transporter activity(GO:0015183) |
| 0.1 | 1.4 | GO:0030275 | LRR domain binding(GO:0030275) |
| 0.1 | 1.2 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
| 0.1 | 0.4 | GO:0001614 | purinergic nucleotide receptor activity(GO:0001614) nucleotide receptor activity(GO:0016502) purinergic receptor activity(GO:0035586) |
| 0.1 | 2.0 | GO:0017046 | peptide hormone binding(GO:0017046) |
| 0.1 | 0.9 | GO:0031748 | D1 dopamine receptor binding(GO:0031748) |
| 0.1 | 0.3 | GO:0045322 | unmethylated CpG binding(GO:0045322) |
| 0.1 | 0.8 | GO:0045294 | alpha-catenin binding(GO:0045294) |
| 0.1 | 1.0 | GO:0008143 | poly(A) binding(GO:0008143) |
| 0.1 | 4.4 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 1.1 | GO:0042605 | peptide antigen binding(GO:0042605) |
| 0.0 | 0.2 | GO:0008545 | JUN kinase kinase activity(GO:0008545) |
| 0.0 | 1.2 | GO:0030552 | cAMP binding(GO:0030552) |
| 0.0 | 0.9 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.0 | 0.9 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
| 0.0 | 3.1 | GO:0030165 | PDZ domain binding(GO:0030165) |
| 0.0 | 0.2 | GO:0051011 | microtubule minus-end binding(GO:0051011) |
| 0.0 | 1.3 | GO:0000049 | tRNA binding(GO:0000049) |
| 0.0 | 0.4 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
| 0.0 | 0.2 | GO:0030371 | translation repressor activity(GO:0030371) |
| 0.0 | 0.1 | GO:0017162 | aryl hydrocarbon receptor binding(GO:0017162) |
| 0.0 | 0.4 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.0 | 0.7 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
| 0.0 | 0.8 | GO:0015459 | potassium channel regulator activity(GO:0015459) |
| 0.0 | 2.5 | GO:0004386 | helicase activity(GO:0004386) |
| 0.0 | 0.7 | GO:0004712 | protein serine/threonine/tyrosine kinase activity(GO:0004712) |
| 0.0 | 2.5 | GO:0008168 | methyltransferase activity(GO:0008168) |
| 0.0 | 0.1 | GO:0019770 | IgG receptor activity(GO:0019770) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.0 | PID_S1P_S1P4_PATHWAY | S1P4 pathway |
| 0.1 | 0.7 | PID_VEGF_VEGFR_PATHWAY | VEGF and VEGFR signaling network |
| 0.0 | 0.7 | PID_IL5_PATHWAY | IL5-mediated signaling events |
| 0.0 | 2.7 | PID_E2F_PATHWAY | E2F transcription factor network |
| 0.0 | 4.5 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 2.0 | PID_CERAMIDE_PATHWAY | Ceramide signaling pathway |
| 0.0 | 0.6 | PID_ARF6_DOWNSTREAM_PATHWAY | Arf6 downstream pathway |
| 0.0 | 1.4 | PID_FGF_PATHWAY | FGF signaling pathway |
| 0.0 | 0.2 | PID_ANTHRAX_PATHWAY | Cellular roles of Anthrax toxin |
| 0.0 | 0.7 | PID_ERBB1_INTERNALIZATION_PATHWAY | Internalization of ErbB1 |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 6.5 | REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN | Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein |
| 0.2 | 5.2 | REACTOME_CGMP_EFFECTS | Genes involved in cGMP effects |
| 0.2 | 4.6 | REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.1 | 3.3 | REACTOME_NEPHRIN_INTERACTIONS | Genes involved in Nephrin interactions |
| 0.1 | 0.8 | REACTOME_P2Y_RECEPTORS | Genes involved in P2Y receptors |
| 0.1 | 0.7 | REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.1 | 0.6 | REACTOME_SYNTHESIS_OF_PE | Genes involved in Synthesis of PE |
| 0.0 | 0.9 | REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 0.0 | 1.2 | REACTOME_RAP1_SIGNALLING | Genes involved in Rap1 signalling |
| 0.0 | 1.8 | REACTOME_SIGNAL_TRANSDUCTION_BY_L1 | Genes involved in Signal transduction by L1 |
| 0.0 | 3.0 | REACTOME_G_ALPHA_S_SIGNALLING_EVENTS | Genes involved in G alpha (s) signalling events |
| 0.0 | 0.7 | REACTOME_EGFR_DOWNREGULATION | Genes involved in EGFR downregulation |
| 0.0 | 0.8 | REACTOME_GLYCOSPHINGOLIPID_METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.0 | 0.2 | REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES | Genes involved in Recruitment of NuMA to mitotic centrosomes |
| 0.0 | 0.9 | REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK | Genes involved in NRAGE signals death through JNK |
| 0.0 | 0.2 | REACTOME_MTORC1_MEDIATED_SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.0 | 0.9 | REACTOME_G_ALPHA_I_SIGNALLING_EVENTS | Genes involved in G alpha (i) signalling events |
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