Motif ID: Neurog2

Z-value: 0.470


Transcription factors associated with Neurog2:

Gene SymbolEntrez IDGene Name
Neurog2 ENSMUSG00000027967.7 Neurog2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Neurog2mm10_v2_chr3_+_127633134_127633140-0.122.9e-01Click!


Activity profile for motif Neurog2.

activity profile for motif Neurog2


Sorted Z-values histogram for motif Neurog2

Sorted Z-values for motif Neurog2



Network of associatons between targets according to the STRING database.



First level regulatory network of Neurog2

PNG image of the network

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Top targets:


Showing 1 to 20 of 159 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_42697146 3.533 ENSMUST00000054883.2
 Pou3f3
POU domain, class 3, transcription factor 3
chr5_+_129096740 2.983 ENSMUST00000056617.7
ENSMUST00000156437.1
 Gpr133

G protein-coupled receptor 133

chr3_+_54156039 2.653 ENSMUST00000029311.6
 Trpc4
transient receptor potential cation channel, subfamily C, member 4
chr13_-_97747373 2.360 ENSMUST00000123535.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr1_-_155232710 2.061 ENSMUST00000035914.3
 BC034090
cDNA sequence BC034090
chr19_-_53371766 1.960 ENSMUST00000086887.1
 Gm10197
predicted gene 10197
chr3_-_84259812 1.841 ENSMUST00000107691.1
 Trim2
tripartite motif-containing 2
chr9_-_58158498 1.804 ENSMUST00000168864.2
 Islr
immunoglobulin superfamily containing leucine-rich repeat
chr13_-_97747399 1.791 ENSMUST00000144993.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr4_+_155839675 1.790 ENSMUST00000141883.1
 Mxra8
matrix-remodelling associated 8
chr17_-_25792284 1.788 ENSMUST00000072735.7
 Fam173a
family with sequence similarity 173, member A
chr16_-_31314804 1.761 ENSMUST00000115230.1
ENSMUST00000130560.1
 Apod

apolipoprotein D

chr3_+_118430299 1.741 ENSMUST00000180774.1
 Gm26871
predicted gene, 26871
chr16_+_43235856 1.665 ENSMUST00000146708.1
 Zbtb20
zinc finger and BTB domain containing 20
chrX_+_141475385 1.660 ENSMUST00000112931.1
ENSMUST00000112930.1
 Col4a5

collagen, type IV, alpha 5

chr11_-_69602741 1.608 ENSMUST00000138694.1
 Atp1b2
ATPase, Na+/K+ transporting, beta 2 polypeptide
chr11_+_53433299 1.602 ENSMUST00000018382.6
 Gdf9
growth differentiation factor 9
chr9_-_58159201 1.586 ENSMUST00000041477.7
 Islr
immunoglobulin superfamily containing leucine-rich repeat
chr6_+_112273758 1.469 ENSMUST00000032376.5
 Lmcd1
LIM and cysteine-rich domains 1
chr3_+_138065052 1.464 ENSMUST00000163080.2
 1110002E22Rik
RIKEN cDNA 1110002E22 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 3.5 GO:0072236 DCT cell differentiation(GO:0072069) metanephric loop of Henle development(GO:0072236) metanephric DCT cell differentiation(GO:0072240)
0.1 2.7 GO:0014051 gamma-aminobutyric acid secretion(GO:0014051)
0.4 2.1 GO:0042701 progesterone secretion(GO:0042701)
0.0 1.9 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.6 1.8 GO:2000097 regulation of smooth muscle cell-matrix adhesion(GO:2000097) negative regulation of lymphocyte migration(GO:2000402)
0.4 1.8 GO:0060857 establishment of glial blood-brain barrier(GO:0060857)
0.1 1.7 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.0 1.7 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.4 1.6 GO:1903288 positive regulation of potassium ion import(GO:1903288)
0.4 1.6 GO:0002143 tRNA wobble position uridine thiolation(GO:0002143)
0.1 1.5 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.2 1.4 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.3 1.3 GO:2000319 negative regulation of T-helper 17 type immune response(GO:2000317) regulation of T-helper 17 cell differentiation(GO:2000319) negative regulation of T-helper 17 cell differentiation(GO:2000320)
0.3 1.3 GO:0030205 dermatan sulfate metabolic process(GO:0030205)
0.3 1.2 GO:0060729 intestinal epithelial structure maintenance(GO:0060729)
0.2 1.2 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.1 1.2 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 1.2 GO:0021766 hippocampus development(GO:0021766)
0.2 1.1 GO:0070171 negative regulation of tooth mineralization(GO:0070171)
0.3 1.0 GO:1902044 regulation of Fas signaling pathway(GO:1902044) negative regulation of Fas signaling pathway(GO:1902045)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.1 GO:0005770 late endosome(GO:0005770)
0.0 2.8 GO:0022626 cytosolic ribosome(GO:0022626)
0.0 2.7 GO:0034704 calcium channel complex(GO:0034704)
0.0 2.7 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 2.3 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.3 1.7 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.2 1.6 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 1.2 GO:0043189 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0 1.2 GO:0045171 intercellular bridge(GO:0045171)
0.1 1.0 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.1 0.8 GO:0000783 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)
0.0 0.8 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 0.7 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.0 0.7 GO:0031143 pseudopodium(GO:0031143)
0.0 0.7 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 0.6 GO:0031105 septin complex(GO:0031105)
0.2 0.5 GO:0043512 inhibin A complex(GO:0043512)
0.0 0.5 GO:0005642 annulate lamellae(GO:0005642)
0.0 0.5 GO:0000243 commitment complex(GO:0000243)
0.0 0.5 GO:0070938 contractile ring(GO:0070938)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.0 GO:0071837 HMG box domain binding(GO:0071837)
0.2 2.7 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 2.4 GO:0017022 myosin binding(GO:0017022)
0.0 2.2 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 1.9 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 1.8 GO:0015485 cholesterol binding(GO:0015485)
0.2 1.6 GO:0008556 sodium:potassium-exchanging ATPase activity(GO:0005391) potassium-transporting ATPase activity(GO:0008556)
0.1 1.6 GO:0016783 sulfurtransferase activity(GO:0016783)
0.0 1.6 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.1 1.3 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.1 1.2 GO:0016208 AMP binding(GO:0016208)
0.0 1.1 GO:0005518 collagen binding(GO:0005518)
0.1 1.0 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.1 1.0 GO:0005123 death receptor binding(GO:0005123)
0.0 1.0 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.1 0.9 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled adenosine receptor activity(GO:0001609) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.9 GO:0004536 deoxyribonuclease activity(GO:0004536)
0.2 0.8 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.2 0.8 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.1 0.8 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)

Gene overrepresentation in C2:CP category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.7 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 1.3 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.1 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.5 PID_ALK1_PATHWAY ALK1 signaling events
0.0 0.5 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.7 REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 1.7 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 1.6 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.0 1.2 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.1 0.9 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 0.8 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.8 REACTOME_TRANSPORT_TO_THE_GOLGI_AND_SUBSEQUENT_MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 0.7 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.1 0.5 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.0 0.5 REACTOME_COMPLEMENT_CASCADE Genes involved in Complement cascade
0.0 0.5 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.0 0.5 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 0.4 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.4 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.0 0.3 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.2 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.0 0.2 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation