Motif ID: Nfatc1

Z-value: 6.529


Transcription factors associated with Nfatc1:

Gene SymbolEntrez IDGene Name
Nfatc1 ENSMUSG00000033016.9 Nfatc1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfatc1mm10_v2_chr18_-_80713062_807130800.234.8e-02Click!


Activity profile for motif Nfatc1.

activity profile for motif Nfatc1


Sorted Z-values histogram for motif Nfatc1

Sorted Z-values for motif Nfatc1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfatc1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_3000922 494.928 ENSMUST00000151376.2
 Gm10722
predicted gene 10722
chr9_+_3027439 485.627 ENSMUST00000177875.1
ENSMUST00000179982.1
 Gm10717

predicted gene 10717

chr9_+_3004457 465.533 ENSMUST00000178348.1
 Gm11168
predicted gene 11168
chr9_+_3013140 440.752 ENSMUST00000143083.2
 Gm10721
predicted gene 10721
chr9_+_3023547 425.405 ENSMUST00000099046.3
 Gm10718
predicted gene 10718
chr9_+_3037111 413.790 ENSMUST00000177969.1
 Gm10715
predicted gene 10715
chr9_+_3036877 386.271 ENSMUST00000155807.2
 Gm10715
predicted gene 10715
chr9_+_3025417 384.465 ENSMUST00000075573.6
 Gm10717
predicted gene 10717
chr9_+_3034599 380.446 ENSMUST00000178641.1
 Gm17535
predicted gene, 17535
chr9_+_3017408 375.003 ENSMUST00000099049.3
 Gm10719
predicted gene 10719
chr9_+_3005125 370.761 ENSMUST00000179881.1
 Gm11168
predicted gene 11168
chr14_-_19418930 322.493 ENSMUST00000177817.1
 Gm21738
predicted gene, 21738
chr9_+_3015654 321.611 ENSMUST00000099050.3
 Gm10720
predicted gene 10720
chr2_-_98667264 299.233 ENSMUST00000099683.1
 Gm10800
predicted gene 10800
chr9_+_3018753 283.984 ENSMUST00000179272.1
 Gm10719
predicted gene 10719
chr2_+_98662227 238.208 ENSMUST00000099684.3
 Gm10801
predicted gene 10801
chr10_-_130280218 31.194 ENSMUST00000061571.3
 Neurod4
neurogenic differentiation 4
chr14_+_120749352 27.826 ENSMUST00000138893.2
 Gm17613
predicted gene, 17613
chr11_-_11627824 25.942 ENSMUST00000081896.4
 4930512M02Rik
RIKEN cDNA 4930512M02 gene
chr9_+_118478182 24.326 ENSMUST00000111763.1
 Eomes
eomesodermin homolog (Xenopus laevis)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3339.9 GO:0008150 biological_process(GO:0008150)
15.4 46.2 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
2.4 31.2 GO:0035881 amacrine cell differentiation(GO:0035881)
0.6 28.4 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
6.5 25.9 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
5.9 17.7 GO:0031660 regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031660) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031662)
1.5 17.0 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
1.4 16.8 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
1.7 13.5 GO:1904627 response to phorbol 13-acetate 12-myristate(GO:1904627) cellular response to phorbol 13-acetate 12-myristate(GO:1904628)
2.2 13.3 GO:0060024 rhythmic synaptic transmission(GO:0060024)
1.8 12.9 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
4.2 12.6 GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598)
0.9 12.5 GO:0072189 ureter development(GO:0072189)
0.3 11.9 GO:0021591 ventricular system development(GO:0021591)
0.7 11.0 GO:1902170 cellular response to reactive nitrogen species(GO:1902170)
2.1 10.5 GO:1901526 negative regulation of mitochondrial membrane permeability(GO:0035795) positive regulation of macromitophagy(GO:1901526) positive regulation of mitophagy in response to mitochondrial depolarization(GO:1904925)
0.2 9.9 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
1.0 9.4 GO:0048251 elastic fiber assembly(GO:0048251)
2.2 9.0 GO:0097393 post-embryonic appendage morphogenesis(GO:0035120) post-embryonic limb morphogenesis(GO:0035127) post-embryonic forelimb morphogenesis(GO:0035128) telomeric repeat-containing RNA transcription(GO:0097393) telomeric repeat-containing RNA transcription from RNA pol II promoter(GO:0097394) regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901580) negative regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901581) positive regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901582)
1.1 8.8 GO:0072615 interleukin-17 secretion(GO:0072615)

Gene overrepresentation in cellular_component category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3612.8 GO:0005575 cellular_component(GO:0005575)
1.0 21.5 GO:0044300 cerebellar mossy fiber(GO:0044300)
4.4 17.7 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
0.9 12.9 GO:0043196 varicosity(GO:0043196)
0.8 11.7 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.2 11.6 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
2.2 11.0 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.7 9.4 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
2.2 9.0 GO:1990421 subtelomeric heterochromatin(GO:1990421) nuclear subtelomeric heterochromatin(GO:1990707)
0.9 8.5 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.2 7.1 GO:0034451 centriolar satellite(GO:0034451)
1.9 5.6 GO:0071914 prominosome(GO:0071914)
1.0 4.1 GO:0031673 H zone(GO:0031673)
0.2 3.6 GO:0097449 astrocyte projection(GO:0097449)
0.2 2.6 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.2 1.9 GO:0002177 manchette(GO:0002177)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3542.9 GO:0003674 molecular_function(GO:0003674)
0.7 41.6 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.7 25.9 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
2.7 24.3 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
4.4 17.7 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.3 13.9 GO:0030332 cyclin binding(GO:0030332)
4.5 13.5 GO:0098770 FBXO family protein binding(GO:0098770)
0.4 13.3 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
1.0 12.9 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.5 11.0 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
2.7 10.7 GO:0008142 oxysterol binding(GO:0008142)
2.1 10.5 GO:0008865 fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
1.3 9.0 GO:0015616 DNA translocase activity(GO:0015616)
2.0 7.8 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
1.3 7.6 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.3 7.4 GO:0003785 actin monomer binding(GO:0003785)
0.4 7.1 GO:0051393 alpha-actinin binding(GO:0051393)
1.5 6.0 GO:0004126 cytidine deaminase activity(GO:0004126)
0.3 5.9 GO:0043422 protein kinase B binding(GO:0043422)
0.6 5.8 GO:0097157 pre-mRNA intronic binding(GO:0097157)

Gene overrepresentation in C2:CP category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 32.0 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.5 22.9 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.3 22.0 PID_P73PATHWAY p73 transcription factor network
0.3 19.3 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.4 11.7 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.3 11.0 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.2 7.7 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.1 5.5 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 5.5 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.1 4.9 PID_BMP_PATHWAY BMP receptor signaling
0.3 4.5 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.0 1.1 NABA_COLLAGENS Genes encoding collagen proteins
0.0 1.1 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 1.0 PID_FCER1_PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 0.6 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.4 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 25.9 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
1.8 17.7 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.1 14.8 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.3 13.5 REACTOME_G1_PHASE Genes involved in G1 Phase
0.6 12.9 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.2 10.5 REACTOME_GLUCOSE_TRANSPORT Genes involved in Glucose transport
0.3 8.7 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.1 7.1 REACTOME_RECRUITMENT_OF_MITOTIC_CENTROSOME_PROTEINS_AND_COMPLEXES Genes involved in Recruitment of mitotic centrosome proteins and complexes
0.1 4.5 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.4 3.7 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.1 3.6 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.3 2.6 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.1 1.3 REACTOME_ENOS_ACTIVATION_AND_REGULATION Genes involved in eNOS activation and regulation
0.0 1.3 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.2 1.1 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.0 0.9 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.7 REACTOME_METABOLISM_OF_STEROID_HORMONES_AND_VITAMINS_A_AND_D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.0 0.7 REACTOME_DESTABILIZATION_OF_MRNA_BY_TRISTETRAPROLIN_TTP Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.0 0.5 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.4 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines