Motif ID: Nfatc2

Z-value: 1.623


Transcription factors associated with Nfatc2:

Gene SymbolEntrez IDGene Name
Nfatc2 ENSMUSG00000027544.10 Nfatc2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfatc2mm10_v2_chr2_-_168590315_1685903720.243.5e-02Click!


Activity profile for motif Nfatc2.

activity profile for motif Nfatc2


Sorted Z-values histogram for motif Nfatc2

Sorted Z-values for motif Nfatc2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfatc2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_-_61185558 38.324 ENSMUST00000166381.1
 Cdr1
cerebellar degeneration related antigen 1
chr9_+_3000922 34.165 ENSMUST00000151376.2
 Gm10722
predicted gene 10722
chr9_+_3004457 32.138 ENSMUST00000178348.1
 Gm11168
predicted gene 11168
chr9_+_3027439 29.574 ENSMUST00000177875.1
ENSMUST00000179982.1
 Gm10717

predicted gene 10717

chr9_+_3023547 28.503 ENSMUST00000099046.3
 Gm10718
predicted gene 10718
chr9_+_3013140 27.961 ENSMUST00000143083.2
 Gm10721
predicted gene 10721
chr9_+_3017408 27.704 ENSMUST00000099049.3
 Gm10719
predicted gene 10719
chr9_+_3005125 27.611 ENSMUST00000179881.1
 Gm11168
predicted gene 11168
chr9_+_3037111 27.179 ENSMUST00000177969.1
 Gm10715
predicted gene 10715
chr9_+_3034599 26.821 ENSMUST00000178641.1
 Gm17535
predicted gene, 17535
chr9_+_3036877 25.645 ENSMUST00000155807.2
 Gm10715
predicted gene 10715
chr9_+_3015654 24.652 ENSMUST00000099050.3
 Gm10720
predicted gene 10720
chr9_+_3025417 24.178 ENSMUST00000075573.6
 Gm10717
predicted gene 10717
chr2_+_98662227 23.732 ENSMUST00000099684.3
 Gm10801
predicted gene 10801
chr2_-_98667264 22.749 ENSMUST00000099683.1
 Gm10800
predicted gene 10800
chr9_+_3018753 21.980 ENSMUST00000179272.1
 Gm10719
predicted gene 10719
chr14_-_19418930 21.028 ENSMUST00000177817.1
 Gm21738
predicted gene, 21738
chr19_-_5796924 11.838 ENSMUST00000174808.1
 Malat1
metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)
chrX_+_103422010 8.245 ENSMUST00000182089.1
 Gm26992
predicted gene, 26992
chr10_-_116972609 7.897 ENSMUST00000092165.4
 Gm10271
predicted gene 10271

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 279 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.8 19.0 GO:0035063 nuclear speck organization(GO:0035063)
0.3 11.8 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
1.4 11.6 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
2.5 9.9 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
1.7 6.7 GO:0090126 protein complex assembly involved in synapse maturation(GO:0090126)
1.1 6.4 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
1.3 6.3 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.2 5.7 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 5.1 GO:0007030 Golgi organization(GO:0007030)
1.2 4.7 GO:2000211 regulation of glutamate metabolic process(GO:2000211)
0.3 4.6 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.6 4.5 GO:1901525 negative regulation of macromitophagy(GO:1901525) regulation of mitophagy in response to mitochondrial depolarization(GO:1904923)
0.2 4.5 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194)
0.9 4.4 GO:0042636 negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279)
0.3 4.4 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
1.1 4.3 GO:0060486 Clara cell differentiation(GO:0060486)
0.4 4.3 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.2 4.2 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.5 4.1 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.1 4.1 GO:0061512 protein localization to cilium(GO:0061512)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 123 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 18.5 GO:0060076 excitatory synapse(GO:0060076)
0.0 13.9 GO:0016607 nuclear speck(GO:0016607)
0.3 12.7 GO:0043034 costamere(GO:0043034)
0.4 8.4 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 7.6 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.2 7.2 GO:0032809 neuronal cell body membrane(GO:0032809)
0.8 6.9 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 6.5 GO:0005814 centriole(GO:0005814)
0.2 5.6 GO:0071565 nBAF complex(GO:0071565)
0.3 5.1 GO:0032039 integrator complex(GO:0032039)
0.1 4.9 GO:0014704 intercalated disc(GO:0014704)
0.6 4.7 GO:0034750 Scrib-APC-beta-catenin complex(GO:0034750)
1.1 4.5 GO:0044307 dendritic branch(GO:0044307)
1.5 4.4 GO:0043512 inhibin A complex(GO:0043512)
0.2 4.3 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.2 4.2 GO:0098839 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.0 4.1 GO:0042641 actomyosin(GO:0042641)
0.3 3.1 GO:0008024 cyclin/CDK positive transcription elongation factor complex(GO:0008024)
0.2 3.1 GO:0036038 MKS complex(GO:0036038)
0.2 3.0 GO:0042788 polysomal ribosome(GO:0042788)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 177 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.4 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.5 7.0 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 6.3 GO:0030507 spectrin binding(GO:0030507)
0.2 6.0 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.2 5.7 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 5.5 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.4 5.3 GO:0097109 neuroligin family protein binding(GO:0097109)
0.3 5.3 GO:0051010 microtubule plus-end binding(GO:0051010)
0.3 5.3 GO:0043422 protein kinase B binding(GO:0043422)
0.9 5.2 GO:0070699 type II activin receptor binding(GO:0070699)
0.0 5.2 GO:0008017 microtubule binding(GO:0008017)
0.1 5.1 GO:0070412 R-SMAD binding(GO:0070412)
0.4 4.6 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.3 4.5 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.2 4.5 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.3 4.1 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.2 3.7 GO:0030553 cGMP binding(GO:0030553)
0.4 3.6 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 3.6 GO:0017091 AU-rich element binding(GO:0017091)
0.4 3.5 GO:0005523 tropomyosin binding(GO:0005523)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.7 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.2 6.8 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.1 5.1 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.1 4.7 PID_ATM_PATHWAY ATM pathway
0.1 4.3 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 3.8 PID_E2F_PATHWAY E2F transcription factor network
0.1 3.5 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.1 2.7 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.1 2.4 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.1 2.4 PID_TNF_PATHWAY TNF receptor signaling pathway
0.0 2.4 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.1 2.1 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.1 1.9 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.4 1.8 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 1.8 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 1.7 PID_CDC42_PATHWAY CDC42 signaling events
0.1 1.6 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 1.6 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 1.5 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.0 1.5 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 69 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 10.1 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.4 9.7 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.3 7.9 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.4 6.5 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.3 5.7 REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.1 5.5 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.2 4.9 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
1.1 4.4 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.2 4.3 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.1 3.8 REACTOME_TRANSPORT_OF_RIBONUCLEOPROTEINS_INTO_THE_HOST_NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.1 3.7 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.1 3.4 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.2 3.1 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.1 2.8 REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.1 2.7 REACTOME_TRANSFERRIN_ENDOCYTOSIS_AND_RECYCLING Genes involved in Transferrin endocytosis and recycling
0.0 2.6 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.1 2.5 REACTOME_ELONGATION_ARREST_AND_RECOVERY Genes involved in Elongation arrest and recovery
0.1 2.5 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.4 2.4 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 2.4 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins