Motif ID: Nfatc3

Z-value: 1.578


Transcription factors associated with Nfatc3:

Gene SymbolEntrez IDGene Name
Nfatc3 ENSMUSG00000031902.9 Nfatc3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfatc3mm10_v2_chr8_+_106059562_106059623-0.028.7e-01Click!


Activity profile for motif Nfatc3.

activity profile for motif Nfatc3


Sorted Z-values histogram for motif Nfatc3

Sorted Z-values for motif Nfatc3



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfatc3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 13.129 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr18_-_80713062 11.098 ENSMUST00000170905.1
ENSMUST00000078049.4
 Nfatc1

nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1

chr14_-_16575456 9.980 ENSMUST00000063750.6
 Rarb
retinoic acid receptor, beta
chr9_+_118478344 9.903 ENSMUST00000035020.8
 Eomes
eomesodermin homolog (Xenopus laevis)
chr9_+_118478182 9.863 ENSMUST00000111763.1
 Eomes
eomesodermin homolog (Xenopus laevis)
chr4_-_97584605 9.046 ENSMUST00000107067.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr4_-_97584612 8.702 ENSMUST00000107068.2
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr10_+_4611971 8.634 ENSMUST00000105590.1
ENSMUST00000067086.7
 Esr1

estrogen receptor 1 (alpha)

chr15_-_91191733 8.547 ENSMUST00000069511.6
 Abcd2
ATP-binding cassette, sub-family D (ALD), member 2
chr3_-_61365951 8.439 ENSMUST00000066298.2
 B430305J03Rik
RIKEN cDNA B430305J03 gene
chr7_+_99466004 7.779 ENSMUST00000037359.2
 Klhl35
kelch-like 35
chr16_-_59555752 6.983 ENSMUST00000179383.1
ENSMUST00000044604.8
 Crybg3

beta-gamma crystallin domain containing 3

chr2_-_118549668 6.828 ENSMUST00000090219.6
 Bmf
BCL2 modifying factor
chr8_+_104101625 6.267 ENSMUST00000034339.8
 Cdh5
cadherin 5
chr5_-_114273702 6.102 ENSMUST00000144050.1
ENSMUST00000044790.5
 Foxn4

forkhead box N4

chr6_+_48841633 5.932 ENSMUST00000168406.1
 Tmem176a
transmembrane protein 176A
chr6_+_48841476 5.842 ENSMUST00000101426.4
 Tmem176a
transmembrane protein 176A
chr7_-_70366735 5.444 ENSMUST00000089565.5
 Nr2f2
nuclear receptor subfamily 2, group F, member 2
chr7_-_70360593 5.397 ENSMUST00000032768.7
 Nr2f2
nuclear receptor subfamily 2, group F, member 2
chr13_-_114388057 5.334 ENSMUST00000022286.6
 Ndufs4
NADH dehydrogenase (ubiquinone) Fe-S protein 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 185 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.8 26.7 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
6.6 19.8 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
2.2 13.1 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
3.7 11.1 GO:0060854 patterning of lymph vessels(GO:0060854)
2.2 10.8 GO:0060849 regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
1.2 10.8 GO:0042760 very long-chain fatty acid catabolic process(GO:0042760)
0.5 10.7 GO:0060579 ventral spinal cord interneuron fate commitment(GO:0060579) cell fate commitment involved in pattern specification(GO:0060581)
2.0 10.0 GO:0003406 retinal pigment epithelium development(GO:0003406)
1.2 9.5 GO:0072615 interleukin-17 secretion(GO:0072615)
2.2 8.6 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
2.5 7.4 GO:0032918 polyamine acetylation(GO:0032917) spermidine acetylation(GO:0032918)
0.4 6.9 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.8 6.8 GO:0048102 autophagic cell death(GO:0048102)
1.1 6.4 GO:0003278 apoptotic process involved in heart morphogenesis(GO:0003278)
1.0 6.3 GO:1901552 positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
0.7 6.3 GO:1990845 adaptive thermogenesis(GO:1990845)
0.3 6.3 GO:0032060 bleb assembly(GO:0032060)
0.1 6.0 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.3 5.9 GO:0051451 myoblast migration(GO:0051451)
1.4 5.6 GO:2000319 negative regulation of T-helper 17 type immune response(GO:2000317) regulation of T-helper 17 cell differentiation(GO:2000319) negative regulation of T-helper 17 cell differentiation(GO:2000320)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 92 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 75.2 GO:0005634 nucleus(GO:0005634)
0.2 14.8 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 12.3 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 11.0 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 9.3 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 8.8 GO:0000790 nuclear chromatin(GO:0000790)
1.2 8.6 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.1 8.3 GO:0016459 myosin complex(GO:0016459)
0.1 7.8 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.3 6.5 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 6.5 GO:0005903 brush border(GO:0005903)
0.3 6.3 GO:0043218 compact myelin(GO:0043218)
0.0 6.1 GO:0000139 Golgi membrane(GO:0000139)
0.8 5.9 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.5 5.9 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.2 5.7 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.1 5.7 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 5.3 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
1.0 5.2 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.3 5.2 GO:0044224 juxtaparanode region of axon(GO:0044224)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 145 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 19.7 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 16.2 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
3.7 11.1 GO:0001225 RNA polymerase II transcription coactivator binding(GO:0001225)
0.1 11.1 GO:0035326 enhancer binding(GO:0035326)
0.8 10.8 GO:0001972 retinoic acid binding(GO:0001972)
0.8 10.0 GO:0003708 retinoic acid receptor activity(GO:0003708)
2.4 9.5 GO:0008142 oxysterol binding(GO:0008142)
0.1 9.2 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
2.9 8.6 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.1 8.6 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 8.2 GO:0030246 carbohydrate binding(GO:0030246)
0.2 7.8 GO:0008307 structural constituent of muscle(GO:0008307)
0.2 7.7 GO:0032452 histone demethylase activity(GO:0032452)
2.5 7.4 GO:0004145 diamine N-acetyltransferase activity(GO:0004145)
0.3 6.9 GO:0070410 co-SMAD binding(GO:0070410)
1.6 6.3 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.1 6.3 GO:0008013 beta-catenin binding(GO:0008013)
0.2 5.9 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.3 5.8 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 5.7 GO:0003712 transcription cofactor activity(GO:0003712)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 34.5 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.2 15.9 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.3 15.3 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.2 10.0 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.4 9.8 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.1 6.4 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.3 6.3 PID_S1P_S1P2_PATHWAY S1P2 pathway
0.2 6.3 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 6.3 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.1 5.5 ST_FAS_SIGNALING_PATHWAY Fas Signaling Pathway
0.1 5.1 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 4.8 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.0 4.8 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.2 4.5 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.1 4.5 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.2 4.4 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.3 4.3 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.1 4.1 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 3.3 NABA_COLLAGENS Genes encoding collagen proteins
0.1 3.3 PID_REELIN_PATHWAY Reelin signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 11.6 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 11.6 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.5 10.8 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.2 9.3 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.5 7.4 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.0 7.1 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.2 6.9 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.2 6.3 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.2 5.9 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.3 5.2 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.3 4.1 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 4.0 REACTOME_IL_RECEPTOR_SHC_SIGNALING Genes involved in Interleukin receptor SHC signaling
0.2 3.9 REACTOME_PYRUVATE_METABOLISM Genes involved in Pyruvate metabolism
0.1 3.8 REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.0 3.5 REACTOME_GASTRIN_CREB_SIGNALLING_PATHWAY_VIA_PKC_AND_MAPK Genes involved in Gastrin-CREB signalling pathway via PKC and MAPK
0.1 3.4 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.1 3.3 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 3.0 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 2.9 REACTOME_G1_PHASE Genes involved in G1 Phase
0.1 2.8 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus