Motif ID: Nfatc4

Z-value: 0.620


Transcription factors associated with Nfatc4:

Gene SymbolEntrez IDGene Name
Nfatc4 ENSMUSG00000023411.5 Nfatc4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfatc4mm10_v2_chr14_+_55824795_55824889-0.768.0e-16Click!


Activity profile for motif Nfatc4.

activity profile for motif Nfatc4


Sorted Z-values histogram for motif Nfatc4

Sorted Z-values for motif Nfatc4



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfatc4

PNG image of the network

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Top targets:


Showing 1 to 20 of 60 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_+_83504032 13.310 ENSMUST00000163888.1
ENSMUST00000005722.7
 Mef2c

myocyte enhancer factor 2C

chr1_-_56978534 9.296 ENSMUST00000177282.1
 Satb2
special AT-rich sequence binding protein 2
chr15_+_92051153 7.081 ENSMUST00000169825.1
 Cntn1
contactin 1
chr1_-_56969864 6.778 ENSMUST00000177424.1
 Satb2
special AT-rich sequence binding protein 2
chr19_+_26623419 6.273 ENSMUST00000176584.1
 Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr15_+_3270767 5.971 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
 Sepp1



selenoprotein P, plasma, 1



chr11_+_97415527 5.405 ENSMUST00000121799.1
 Arhgap23
Rho GTPase activating protein 23
chr12_+_91400990 4.252 ENSMUST00000021346.7
ENSMUST00000021343.6
 Tshr

thyroid stimulating hormone receptor

chr4_+_48049080 4.143 ENSMUST00000153369.1
 Nr4a3
nuclear receptor subfamily 4, group A, member 3
chr13_+_31806627 3.900 ENSMUST00000062292.2
 Foxc1
forkhead box C1
chr1_-_193370225 3.839 ENSMUST00000169907.1
 Camk1g
calcium/calmodulin-dependent protein kinase I gamma
chr1_-_193370260 3.769 ENSMUST00000016323.4
 Camk1g
calcium/calmodulin-dependent protein kinase I gamma
chr19_-_4943049 3.748 ENSMUST00000133254.1
ENSMUST00000120475.1
ENSMUST00000025834.7
 Peli3


pellino 3


chr2_+_125136692 3.668 ENSMUST00000099452.2
 Ctxn2
cortexin 2
chr14_+_70555900 3.339 ENSMUST00000163060.1
 Hr
hairless
chr10_+_21993890 3.214 ENSMUST00000092673.4
 Sgk1
serum/glucocorticoid regulated kinase 1
chr3_+_84925476 3.108 ENSMUST00000107675.1
 Fbxw7
F-box and WD-40 domain protein 7
chr1_-_126830632 3.054 ENSMUST00000112583.1
ENSMUST00000094609.3
 Nckap5

NCK-associated protein 5

chr2_+_55435918 2.903 ENSMUST00000067101.3
 Kcnj3
potassium inwardly-rectifying channel, subfamily J, member 3
chr6_-_59024470 2.715 ENSMUST00000089860.5
 Fam13a
family with sequence similarity 13, member A

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 16.1 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
4.4 13.3 GO:0007521 muscle cell fate determination(GO:0007521) cellular response to parathyroid hormone stimulus(GO:0071374) positive regulation of macrophage apoptotic process(GO:2000111)
0.0 7.6 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)
0.1 6.7 GO:0010765 positive regulation of sodium ion transport(GO:0010765)
0.7 6.3 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.0 5.4 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.7 4.3 GO:1904587 response to glycoprotein(GO:1904587)
1.4 4.1 GO:0038095 positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095)
1.3 3.9 GO:1902256 apoptotic process involved in outflow tract morphogenesis(GO:0003275) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256) response to chemokine(GO:1990868) cellular response to chemokine(GO:1990869)
1.2 3.7 GO:0070428 regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424) regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070428) regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070432)
0.2 3.3 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.2 3.2 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.6 3.1 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.4 2.9 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.1 2.4 GO:0071353 cellular response to interleukin-4(GO:0071353)
0.4 2.1 GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480)
0.3 1.7 GO:0071787 endoplasmic reticulum tubular network assembly(GO:0071787)
0.3 1.3 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
0.2 1.2 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.1 1.2 GO:0008090 retrograde axonal transport(GO:0008090)

Gene overrepresentation in cellular_component category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 19.4 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 14.1 GO:0030017 sarcomere(GO:0030017)
0.1 7.1 GO:0031225 anchored component of membrane(GO:0031225)
0.3 6.3 GO:0071564 npBAF complex(GO:0071564)
0.0 4.3 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 3.9 GO:0005720 nuclear heterochromatin(GO:0005720)
0.8 3.1 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.1 2.9 GO:0030315 T-tubule(GO:0030315)
0.1 1.7 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.2 1.3 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.3 1.2 GO:0031673 H zone(GO:0031673)
0.3 1.2 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.1 0.7 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.2 0.5 GO:0090568 nuclear transcriptional repressor complex(GO:0090568) RNA polymerase II transcription repressor complex(GO:0090571)
0.0 0.4 GO:0035102 PRC1 complex(GO:0035102)
0.0 0.4 GO:0030123 AP-3 adaptor complex(GO:0030123)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 13.3 GO:0003680 AT DNA binding(GO:0003680)
0.2 7.6 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.1 6.3 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 4.7 GO:0030246 carbohydrate binding(GO:0030246)
0.4 4.3 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.1 4.1 GO:0001223 transcription coactivator binding(GO:0001223)
0.3 3.9 GO:0008301 DNA binding, bending(GO:0008301)
0.0 3.7 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.2 3.3 GO:0042809 vitamin D receptor binding(GO:0042809)
0.4 3.2 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.6 3.1 GO:0050816 phosphothreonine binding(GO:0050816)
0.6 2.9 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 2.4 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.7 2.1 GO:0003963 RNA-3'-phosphate cyclase activity(GO:0003963)
0.0 1.9 GO:0001671 ATPase activator activity(GO:0001671)
0.4 1.3 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.1 1.2 GO:0002162 dystroglycan binding(GO:0002162)
0.2 1.0 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.0 0.9 GO:0016790 thiolester hydrolase activity(GO:0016790)
0.1 0.8 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)

Gene overrepresentation in C2:CP category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 13.3 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.1 6.3 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.1 4.2 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.2 4.1 ST_GA12_PATHWAY G alpha 12 Pathway
0.1 4.1 PID_ARF6_PATHWAY Arf6 signaling events
0.1 3.1 PID_MYC_PATHWAY C-MYC pathway
0.1 2.9 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 1.7 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.0 1.3 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 1.2 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.9 PID_NOTCH_PATHWAY Notch signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 12.9 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.2 7.1 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1 5.5 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 5.3 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
1.4 4.3 REACTOME_HORMONE_LIGAND_BINDING_RECEPTORS Genes involved in Hormone ligand-binding receptors
0.3 3.7 REACTOME_IRAK1_RECRUITS_IKK_COMPLEX Genes involved in IRAK1 recruits IKK complex
0.1 3.7 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1 3.1 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 1.7 REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.0 1.0 REACTOME_IL_RECEPTOR_SHC_SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.9 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.5 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.0 0.2 REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease