Motif ID: Nfe2l1_Mafg

Z-value: 1.117

Transcription factors associated with Nfe2l1_Mafg:

Gene SymbolEntrez IDGene Name
Mafg ENSMUSG00000051510.7 Mafg
Mafg ENSMUSG00000053906.4 Mafg
Nfe2l1 ENSMUSG00000038615.11 Nfe2l1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mafgmm10_v2_chr11_-_120633594_120633605-0.664.7e-11Click!
Nfe2l1mm10_v2_chr11_-_96829483_968295020.252.7e-02Click!


Activity profile for motif Nfe2l1_Mafg.

activity profile for motif Nfe2l1_Mafg


Sorted Z-values histogram for motif Nfe2l1_Mafg

Sorted Z-values for motif Nfe2l1_Mafg



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfe2l1_Mafg

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 60.795 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr7_-_137314394 15.872 ENSMUST00000168203.1
ENSMUST00000106118.2
ENSMUST00000169486.2
ENSMUST00000033378.5
 Ebf3



early B cell factor 3



chr17_+_78491549 13.229 ENSMUST00000079363.4
 Gm10093
predicted pseudogene 10093
chr7_-_116038734 12.190 ENSMUST00000166877.1
 Sox6
SRY-box containing gene 6
chr7_+_51621830 9.940 ENSMUST00000032710.5
 Slc17a6
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
chr4_-_63403330 9.537 ENSMUST00000035724.4
 Akna
AT-hook transcription factor
chr17_+_93199348 9.428 ENSMUST00000064775.6
 Adcyap1
adenylate cyclase activating polypeptide 1
chr17_+_43952999 8.647 ENSMUST00000177857.1
 Rcan2
regulator of calcineurin 2
chr3_+_85915722 7.373 ENSMUST00000054148.7
 Gm9790
predicted gene 9790
chr1_+_135729147 7.266 ENSMUST00000027677.7
 Csrp1
cysteine and glycine-rich protein 1
chr12_-_54986363 7.247 ENSMUST00000173433.1
ENSMUST00000173803.1
 Baz1a
Gm20403
bromodomain adjacent to zinc finger domain 1A
predicted gene 20403
chr8_+_31091593 7.039 ENSMUST00000161713.1
 Dusp26
dual specificity phosphatase 26 (putative)
chr9_-_79977782 6.707 ENSMUST00000093811.4
 Filip1
filamin A interacting protein 1
chr11_+_44617310 6.517 ENSMUST00000081265.5
ENSMUST00000101326.3
ENSMUST00000109268.1
 Ebf1


early B cell factor 1


chr10_+_19356558 6.332 ENSMUST00000053225.5
 Olig3
oligodendrocyte transcription factor 3
chr12_-_10900296 6.323 ENSMUST00000085735.2
 Pgk1-rs7
phosphoglycerate kinase-1, related sequence-7
chr12_+_38783455 6.148 ENSMUST00000161980.1
ENSMUST00000160701.1
 Etv1

ets variant gene 1

chr12_+_38783503 6.019 ENSMUST00000159334.1
 Etv1
ets variant gene 1
chr18_-_62741387 5.939 ENSMUST00000097557.3
 Spink13
serine peptidase inhibitor, Kazal type 13
chr18_-_47333311 5.570 ENSMUST00000126684.1
ENSMUST00000156422.1
 Sema6a

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 106 entries
Log-likelihood per target Total log-likelihoodTermDescription
10.1 60.8 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
1.1 12.2 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
1.1 12.2 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
1.1 9.9 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
0.7 9.8 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
3.1 9.4 GO:0071649 negative regulation of acute inflammatory response to antigenic stimulus(GO:0002865) regulation of chemokine (C-C motif) ligand 5 production(GO:0071649) positive regulation of somatostatin secretion(GO:0090274)
0.5 8.6 GO:0031987 locomotion involved in locomotory behavior(GO:0031987)
0.0 8.4 GO:0006338 chromatin remodeling(GO:0006338)
0.1 7.9 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
0.1 7.7 GO:0070527 platelet aggregation(GO:0070527)
2.3 7.0 GO:1902310 positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
1.3 6.3 GO:0097476 spinal cord motor neuron migration(GO:0097476)
1.2 5.9 GO:0060467 negative regulation of fertilization(GO:0060467)
0.2 5.6 GO:2001224 positive regulation of neuron migration(GO:2001224)
1.8 5.5 GO:0016554 cytidine to uridine editing(GO:0016554)
0.1 5.2 GO:1901998 toxin transport(GO:1901998)
0.4 5.0 GO:0060013 righting reflex(GO:0060013)
0.6 4.9 GO:0071802 negative regulation of podosome assembly(GO:0071802)
0.6 4.5 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.8 4.2 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 74 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 52.7 GO:0005829 cytosol(GO:0005829)
0.0 13.4 GO:0005667 transcription factor complex(GO:0005667)
0.0 12.5 GO:0015629 actin cytoskeleton(GO:0015629)
0.3 10.7 GO:0035861 site of double-strand break(GO:0035861)
0.1 10.7 GO:0001650 fibrillar center(GO:0001650)
0.4 9.3 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 7.7 GO:0043195 terminal bouton(GO:0043195)
1.8 7.2 GO:0008623 CHRAC(GO:0008623)
0.1 6.0 GO:0001669 acrosomal vesicle(GO:0001669)
0.1 4.9 GO:0002102 podosome(GO:0002102)
0.3 4.5 GO:0043196 varicosity(GO:0043196)
0.5 3.9 GO:0070765 gamma-secretase complex(GO:0070765)
0.3 3.8 GO:0005641 nuclear envelope lumen(GO:0005641)
0.2 3.6 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.0 3.5 GO:0030863 cortical cytoskeleton(GO:0030863)
0.7 3.0 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.2 2.9 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 2.6 GO:0005811 lipid particle(GO:0005811)
0.2 2.5 GO:0070852 cell body fiber(GO:0070852)
0.1 2.5 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 90 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 75.3 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 36.9 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
1.8 10.7 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.5 9.9 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)
0.6 9.7 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.2 9.0 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
1.4 8.6 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.5 7.3 GO:0015197 peptide transporter activity(GO:0015197)
0.1 7.1 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
2.3 7.0 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.5 6.5 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.2 6.3 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 5.9 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.3 5.6 GO:0030215 semaphorin receptor binding(GO:0030215)
1.4 5.5 GO:0004126 cytidine deaminase activity(GO:0004126)
1.6 4.9 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.2 4.9 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 4.8 GO:0019905 syntaxin binding(GO:0019905)
0.3 4.5 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.1 4.4 GO:0005200 structural constituent of cytoskeleton(GO:0005200)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 12.2 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.2 8.9 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 6.1 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 4.9 PID_REELIN_PATHWAY Reelin signaling pathway
0.2 3.8 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 3.3 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 3.2 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.1 2.9 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 2.9 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 2.3 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.1 2.2 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.1 2.2 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.1 1.9 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.1 1.6 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 1.6 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.5 PID_BCR_5PATHWAY BCR signaling pathway
0.0 1.4 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.0 1.3 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 1.2 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.1 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 9.9 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.2 9.4 REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS Genes involved in Glucagon-type ligand receptors
0.1 7.6 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 5.6 REACTOME_RNA_POL_II_PRE_TRANSCRIPTION_EVENTS Genes involved in RNA Polymerase II Pre-transcription Events
0.5 5.0 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.1 4.9 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 4.8 REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.2 4.5 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 4.1 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.3 3.8 REACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR Genes involved in Regulated proteolysis of p75NTR
0.2 3.5 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.1 3.3 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.2 3.2 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.4 3.1 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions
0.8 2.5 REACTOME_SEROTONIN_RECEPTORS Genes involved in Serotonin receptors
0.0 2.3 REACTOME_VIF_MEDIATED_DEGRADATION_OF_APOBEC3G Genes involved in Vif-mediated degradation of APOBEC3G
0.2 2.2 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.1 2.1 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.1 1.9 REACTOME_RAF_MAP_KINASE_CASCADE Genes involved in RAF/MAP kinase cascade
0.1 1.8 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation