Motif ID: Nfe2l1_Mafg
Z-value: 1.117
Transcription factors associated with Nfe2l1_Mafg:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Mafg | ENSMUSG00000051510.7 | Mafg |
| Mafg | ENSMUSG00000053906.4 | Mafg |
| Nfe2l1 | ENSMUSG00000038615.11 | Nfe2l1 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Mafg | mm10_v2_chr11_-_120633594_120633605 | -0.66 | 4.7e-11 | Click! |
| Nfe2l1 | mm10_v2_chr11_-_96829483_96829502 | 0.25 | 2.7e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 10.1 | 60.8 | GO:0021797 | forebrain anterior/posterior pattern specification(GO:0021797) |
| 3.1 | 9.4 | GO:0071649 | negative regulation of acute inflammatory response to antigenic stimulus(GO:0002865) regulation of chemokine (C-C motif) ligand 5 production(GO:0071649) positive regulation of somatostatin secretion(GO:0090274) |
| 2.3 | 7.0 | GO:1902310 | positive regulation of peptidyl-serine dephosphorylation(GO:1902310) |
| 1.8 | 5.5 | GO:0016554 | cytidine to uridine editing(GO:0016554) |
| 1.3 | 6.3 | GO:0097476 | spinal cord motor neuron migration(GO:0097476) |
| 1.2 | 5.9 | GO:0060467 | negative regulation of fertilization(GO:0060467) |
| 1.2 | 3.5 | GO:0032918 | polyamine acetylation(GO:0032917) spermidine acetylation(GO:0032918) |
| 1.1 | 12.2 | GO:2000741 | positive regulation of mesenchymal stem cell differentiation(GO:2000741) |
| 1.1 | 12.2 | GO:0048934 | peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935) |
| 1.1 | 9.9 | GO:0098700 | neurotransmitter loading into synaptic vesicle(GO:0098700) |
| 0.8 | 4.2 | GO:0007197 | adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207) |
| 0.8 | 2.3 | GO:1900133 | renin secretion into blood stream(GO:0002001) regulation of renin secretion into blood stream(GO:1900133) |
| 0.7 | 2.1 | GO:0010845 | positive regulation of reciprocal meiotic recombination(GO:0010845) |
| 0.7 | 9.8 | GO:2000042 | negative regulation of double-strand break repair via homologous recombination(GO:2000042) |
| 0.6 | 4.5 | GO:2000124 | regulation of endocannabinoid signaling pathway(GO:2000124) |
| 0.6 | 2.5 | GO:0010511 | regulation of phosphatidylinositol biosynthetic process(GO:0010511) |
| 0.6 | 4.9 | GO:0071802 | negative regulation of podosome assembly(GO:0071802) |
| 0.6 | 1.8 | GO:0019085 | early viral transcription(GO:0019085) |
| 0.6 | 1.7 | GO:0070649 | formin-nucleated actin cable assembly(GO:0070649) |
| 0.5 | 1.6 | GO:0021759 | globus pallidus development(GO:0021759) |
| 0.5 | 2.1 | GO:0001561 | fatty acid alpha-oxidation(GO:0001561) |
| 0.5 | 3.6 | GO:1901029 | negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901029) |
| 0.5 | 2.5 | GO:0090164 | asymmetric Golgi ribbon formation(GO:0090164) |
| 0.5 | 1.5 | GO:0032474 | otolith morphogenesis(GO:0032474) |
| 0.5 | 1.4 | GO:0060399 | positive regulation of growth hormone receptor signaling pathway(GO:0060399) |
| 0.5 | 8.6 | GO:0031987 | locomotion involved in locomotory behavior(GO:0031987) |
| 0.4 | 1.3 | GO:1903774 | positive regulation of viral budding via host ESCRT complex(GO:1903774) |
| 0.4 | 3.0 | GO:0016560 | protein import into peroxisome matrix, docking(GO:0016560) |
| 0.4 | 4.2 | GO:0060539 | diaphragm development(GO:0060539) |
| 0.4 | 1.5 | GO:0060830 | ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830) |
| 0.4 | 1.9 | GO:1904659 | glucose transmembrane transport(GO:1904659) |
| 0.4 | 1.1 | GO:0034140 | negative regulation of toll-like receptor 3 signaling pathway(GO:0034140) aggrephagy(GO:0035973) |
| 0.4 | 5.0 | GO:0060013 | righting reflex(GO:0060013) |
| 0.3 | 1.3 | GO:2000182 | regulation of progesterone biosynthetic process(GO:2000182) |
| 0.3 | 1.8 | GO:0060242 | contact inhibition(GO:0060242) |
| 0.3 | 0.8 | GO:1904245 | regulation of polynucleotide adenylyltransferase activity(GO:1904245) |
| 0.3 | 0.8 | GO:0036228 | protein targeting to nuclear inner membrane(GO:0036228) |
| 0.3 | 1.6 | GO:0072318 | clathrin coat disassembly(GO:0072318) |
| 0.3 | 2.2 | GO:0007016 | cytoskeletal anchoring at plasma membrane(GO:0007016) |
| 0.3 | 1.3 | GO:0018171 | peptidyl-cysteine oxidation(GO:0018171) |
| 0.3 | 3.9 | GO:0007220 | Notch receptor processing(GO:0007220) |
| 0.2 | 1.0 | GO:0015786 | UDP-glucose transport(GO:0015786) |
| 0.2 | 2.1 | GO:0031424 | keratinization(GO:0031424) |
| 0.2 | 3.1 | GO:0043252 | sodium-independent organic anion transport(GO:0043252) |
| 0.2 | 5.6 | GO:2001224 | positive regulation of neuron migration(GO:2001224) |
| 0.2 | 1.0 | GO:0045578 | negative regulation of B cell differentiation(GO:0045578) |
| 0.2 | 1.6 | GO:0038031 | non-canonical Wnt signaling pathway via JNK cascade(GO:0038031) |
| 0.2 | 0.5 | GO:0060854 | patterning of lymph vessels(GO:0060854) |
| 0.2 | 2.7 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.2 | 0.9 | GO:0042364 | water-soluble vitamin biosynthetic process(GO:0042364) |
| 0.2 | 1.2 | GO:0031087 | deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087) |
| 0.2 | 1.5 | GO:0010745 | negative regulation of macrophage derived foam cell differentiation(GO:0010745) |
| 0.2 | 1.9 | GO:0072600 | establishment of protein localization to Golgi(GO:0072600) |
| 0.2 | 0.6 | GO:0002188 | translation reinitiation(GO:0002188) |
| 0.2 | 0.8 | GO:0010735 | positive regulation of transcription via serum response element binding(GO:0010735) |
| 0.1 | 1.2 | GO:2000270 | negative regulation of fibroblast apoptotic process(GO:2000270) |
| 0.1 | 7.9 | GO:0070936 | protein K48-linked ubiquitination(GO:0070936) |
| 0.1 | 0.6 | GO:0032929 | negative regulation of superoxide anion generation(GO:0032929) |
| 0.1 | 7.7 | GO:0070527 | platelet aggregation(GO:0070527) |
| 0.1 | 2.1 | GO:0006625 | protein targeting to peroxisome(GO:0006625) peroxisomal transport(GO:0043574) protein localization to peroxisome(GO:0072662) establishment of protein localization to peroxisome(GO:0072663) |
| 0.1 | 3.5 | GO:0090022 | regulation of neutrophil chemotaxis(GO:0090022) |
| 0.1 | 5.2 | GO:1901998 | toxin transport(GO:1901998) |
| 0.1 | 0.7 | GO:0090073 | positive regulation of protein homodimerization activity(GO:0090073) |
| 0.1 | 1.5 | GO:1902004 | positive regulation of beta-amyloid formation(GO:1902004) |
| 0.1 | 0.3 | GO:0009106 | lipoate metabolic process(GO:0009106) |
| 0.1 | 1.0 | GO:0007168 | receptor guanylyl cyclase signaling pathway(GO:0007168) |
| 0.1 | 0.3 | GO:2000850 | negative regulation of corticosteroid hormone secretion(GO:2000847) negative regulation of glucocorticoid secretion(GO:2000850) |
| 0.1 | 1.8 | GO:0048172 | regulation of short-term neuronal synaptic plasticity(GO:0048172) |
| 0.1 | 1.2 | GO:0045899 | positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899) |
| 0.1 | 2.5 | GO:0070207 | protein homotrimerization(GO:0070207) |
| 0.1 | 0.5 | GO:0051189 | molybdopterin cofactor biosynthetic process(GO:0032324) molybdopterin cofactor metabolic process(GO:0043545) prosthetic group metabolic process(GO:0051189) |
| 0.1 | 1.0 | GO:0070389 | chaperone cofactor-dependent protein refolding(GO:0070389) |
| 0.1 | 1.0 | GO:0051123 | RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123) |
| 0.1 | 1.4 | GO:0002088 | lens development in camera-type eye(GO:0002088) |
| 0.1 | 0.3 | GO:1903756 | regulation of postsynaptic density protein 95 clustering(GO:1902897) regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758) |
| 0.1 | 0.4 | GO:0034143 | regulation of toll-like receptor 4 signaling pathway(GO:0034143) |
| 0.1 | 2.9 | GO:0006367 | transcription initiation from RNA polymerase II promoter(GO:0006367) |
| 0.1 | 0.8 | GO:0061072 | embryonic retina morphogenesis in camera-type eye(GO:0060059) iris morphogenesis(GO:0061072) |
| 0.1 | 0.9 | GO:1903504 | regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504) |
| 0.1 | 1.9 | GO:0000154 | rRNA modification(GO:0000154) |
| 0.1 | 0.8 | GO:0050860 | negative regulation of T cell receptor signaling pathway(GO:0050860) |
| 0.1 | 0.6 | GO:0031468 | nuclear envelope reassembly(GO:0031468) |
| 0.1 | 1.1 | GO:0031115 | negative regulation of microtubule polymerization(GO:0031115) |
| 0.0 | 8.4 | GO:0006338 | chromatin remodeling(GO:0006338) |
| 0.0 | 0.8 | GO:0060009 | Sertoli cell development(GO:0060009) |
| 0.0 | 0.4 | GO:0014029 | neural crest formation(GO:0014029) |
| 0.0 | 2.1 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 0.0 | 1.3 | GO:0007608 | sensory perception of smell(GO:0007608) |
| 0.0 | 2.2 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 0.0 | 0.1 | GO:0046013 | regulation of T cell homeostatic proliferation(GO:0046013) |
| 0.0 | 1.8 | GO:0051865 | protein autoubiquitination(GO:0051865) |
| 0.0 | 0.2 | GO:0006452 | translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905) |
| 0.0 | 1.3 | GO:0032781 | positive regulation of ATPase activity(GO:0032781) |
| 0.0 | 0.6 | GO:0006379 | mRNA cleavage(GO:0006379) |
| 0.0 | 0.5 | GO:2001222 | regulation of neuron migration(GO:2001222) |
| 0.0 | 1.4 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.0 | 3.2 | GO:0042113 | B cell activation(GO:0042113) |
| 0.0 | 0.2 | GO:0045292 | mRNA cis splicing, via spliceosome(GO:0045292) |
| 0.0 | 0.2 | GO:0031915 | positive regulation of synaptic plasticity(GO:0031915) |
| 0.0 | 0.8 | GO:0043966 | histone H3 acetylation(GO:0043966) |
| 0.0 | 0.3 | GO:0010591 | regulation of lamellipodium assembly(GO:0010591) |
| 0.0 | 0.2 | GO:0031340 | positive regulation of vesicle fusion(GO:0031340) |
| 0.0 | 0.3 | GO:0034453 | microtubule anchoring(GO:0034453) |
| 0.0 | 0.4 | GO:0046039 | GTP metabolic process(GO:0046039) |
| 0.0 | 1.1 | GO:0051092 | positive regulation of NF-kappaB transcription factor activity(GO:0051092) |
| 0.0 | 1.6 | GO:0008360 | regulation of cell shape(GO:0008360) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 7.2 | GO:0008623 | CHRAC(GO:0008623) |
| 0.7 | 3.0 | GO:0017071 | intracellular cyclic nucleotide activated cation channel complex(GO:0017071) |
| 0.6 | 1.8 | GO:0071149 | TEAD-2-YAP complex(GO:0071149) |
| 0.5 | 0.5 | GO:0035061 | interchromatin granule(GO:0035061) |
| 0.5 | 3.9 | GO:0070765 | gamma-secretase complex(GO:0070765) |
| 0.4 | 2.1 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.4 | 2.4 | GO:0071817 | MMXD complex(GO:0071817) |
| 0.4 | 9.3 | GO:0030285 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 0.3 | 3.8 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
| 0.3 | 0.6 | GO:1990730 | VCP-NSFL1C complex(GO:1990730) |
| 0.3 | 2.1 | GO:0033503 | HULC complex(GO:0033503) |
| 0.3 | 10.7 | GO:0035861 | site of double-strand break(GO:0035861) |
| 0.3 | 4.5 | GO:0043196 | varicosity(GO:0043196) |
| 0.3 | 1.9 | GO:0031428 | box C/D snoRNP complex(GO:0031428) |
| 0.2 | 2.0 | GO:0005786 | signal recognition particle, endoplasmic reticulum targeting(GO:0005786) |
| 0.2 | 2.9 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 0.2 | 2.5 | GO:0070852 | cell body fiber(GO:0070852) |
| 0.2 | 3.6 | GO:0033276 | transcription factor TFTC complex(GO:0033276) |
| 0.2 | 1.8 | GO:0008024 | cyclin/CDK positive transcription elongation factor complex(GO:0008024) |
| 0.2 | 0.8 | GO:0044611 | nuclear pore inner ring(GO:0044611) |
| 0.1 | 1.2 | GO:0031595 | nuclear proteasome complex(GO:0031595) |
| 0.1 | 1.2 | GO:0000813 | ESCRT I complex(GO:0000813) |
| 0.1 | 1.4 | GO:0008541 | proteasome regulatory particle, lid subcomplex(GO:0008541) |
| 0.1 | 4.9 | GO:0002102 | podosome(GO:0002102) |
| 0.1 | 1.8 | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex(GO:0017101) |
| 0.1 | 2.5 | GO:0008305 | integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636) |
| 0.1 | 1.1 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
| 0.1 | 1.3 | GO:0008385 | IkappaB kinase complex(GO:0008385) |
| 0.1 | 0.7 | GO:0005785 | signal recognition particle receptor complex(GO:0005785) |
| 0.1 | 0.7 | GO:0072357 | PTW/PP1 phosphatase complex(GO:0072357) |
| 0.1 | 1.5 | GO:0031083 | BLOC-1 complex(GO:0031083) |
| 0.1 | 1.6 | GO:0016460 | myosin II complex(GO:0016460) |
| 0.1 | 1.1 | GO:0031011 | Ino80 complex(GO:0031011) |
| 0.1 | 0.9 | GO:0036513 | Derlin-1 retrotranslocation complex(GO:0036513) |
| 0.1 | 6.0 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.1 | 10.7 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.1 | 0.8 | GO:0042405 | nuclear inclusion body(GO:0042405) |
| 0.1 | 7.7 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.1 | 0.7 | GO:0000177 | cytoplasmic exosome (RNase complex)(GO:0000177) |
| 0.1 | 2.2 | GO:0043034 | costamere(GO:0043034) |
| 0.0 | 2.3 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.0 | 1.8 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.0 | 2.4 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.0 | 1.1 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 0.0 | 1.2 | GO:0071339 | MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339) |
| 0.0 | 0.5 | GO:0005671 | Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671) |
| 0.0 | 0.4 | GO:0090543 | Flemming body(GO:0090543) |
| 0.0 | 0.1 | GO:0090661 | box H/ACA telomerase RNP complex(GO:0090661) |
| 0.0 | 1.3 | GO:0005719 | nuclear euchromatin(GO:0005719) |
| 0.0 | 0.3 | GO:0005964 | phosphorylase kinase complex(GO:0005964) |
| 0.0 | 2.6 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 1.0 | GO:0005669 | transcription factor TFIID complex(GO:0005669) |
| 0.0 | 2.5 | GO:0031985 | Golgi cisterna(GO:0031985) |
| 0.0 | 13.4 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.0 | 12.5 | GO:0015629 | actin cytoskeleton(GO:0015629) |
| 0.0 | 1.0 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.0 | 3.5 | GO:0030863 | cortical cytoskeleton(GO:0030863) |
| 0.0 | 2.2 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.0 | 0.5 | GO:0032420 | stereocilium(GO:0032420) |
| 0.0 | 1.1 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.0 | 0.2 | GO:0005642 | annulate lamellae(GO:0005642) |
| 0.0 | 0.4 | GO:0005686 | U2 snRNP(GO:0005686) |
| 0.0 | 1.1 | GO:0016235 | aggresome(GO:0016235) |
| 0.0 | 2.0 | GO:0036064 | ciliary basal body(GO:0036064) |
| 0.0 | 0.5 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
| 0.0 | 0.3 | GO:0071565 | nBAF complex(GO:0071565) |
| 0.0 | 52.7 | GO:0005829 | cytosol(GO:0005829) |
| 0.0 | 1.2 | GO:0030426 | growth cone(GO:0030426) |
| 0.0 | 1.7 | GO:0030659 | cytoplasmic vesicle membrane(GO:0030659) |
| 0.0 | 1.7 | GO:0005769 | early endosome(GO:0005769) |
| 0.0 | 0.4 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.0 | 1.6 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.0 | 0.1 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.0 | 0.6 | GO:0000786 | nucleosome(GO:0000786) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 7.0 | GO:0004647 | phosphoserine phosphatase activity(GO:0004647) |
| 1.8 | 10.7 | GO:0061649 | ubiquitinated histone binding(GO:0061649) |
| 1.6 | 4.9 | GO:0016934 | extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934) |
| 1.4 | 8.6 | GO:0008597 | calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597) |
| 1.4 | 5.5 | GO:0004126 | cytidine deaminase activity(GO:0004126) |
| 1.2 | 3.5 | GO:0004145 | diamine N-acetyltransferase activity(GO:0004145) |
| 0.8 | 2.5 | GO:0004993 | G-protein coupled serotonin receptor activity(GO:0004993) |
| 0.8 | 2.3 | GO:0051379 | epinephrine binding(GO:0051379) |
| 0.6 | 9.7 | GO:0051428 | peptide hormone receptor binding(GO:0051428) |
| 0.6 | 3.0 | GO:0005052 | peroxisome matrix targeting signal-1 binding(GO:0005052) |
| 0.5 | 7.3 | GO:0015197 | peptide transporter activity(GO:0015197) |
| 0.5 | 9.9 | GO:0005313 | L-glutamate transmembrane transporter activity(GO:0005313) |
| 0.5 | 2.5 | GO:0098634 | protein binding involved in cell-matrix adhesion(GO:0098634) |
| 0.5 | 6.5 | GO:0070742 | C2H2 zinc finger domain binding(GO:0070742) |
| 0.4 | 2.0 | GO:0030942 | endoplasmic reticulum signal peptide binding(GO:0030942) |
| 0.4 | 75.3 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.4 | 4.2 | GO:0030306 | ADP-ribosylation factor binding(GO:0030306) |
| 0.3 | 4.5 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.3 | 1.2 | GO:0031800 | type 3 metabotropic glutamate receptor binding(GO:0031800) |
| 0.3 | 2.6 | GO:0034711 | inhibin binding(GO:0034711) |
| 0.3 | 2.9 | GO:0017162 | aryl hydrocarbon receptor binding(GO:0017162) |
| 0.3 | 5.6 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.2 | 2.2 | GO:0030274 | LIM domain binding(GO:0030274) |
| 0.2 | 2.4 | GO:0015217 | ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217) |
| 0.2 | 2.1 | GO:0030976 | thiamine pyrophosphate binding(GO:0030976) |
| 0.2 | 1.8 | GO:0097322 | 7SK snRNA binding(GO:0097322) |
| 0.2 | 1.3 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.2 | 1.1 | GO:0032767 | copper-dependent protein binding(GO:0032767) |
| 0.2 | 1.2 | GO:0036402 | proteasome-activating ATPase activity(GO:0036402) |
| 0.2 | 1.0 | GO:0016941 | natriuretic peptide receptor activity(GO:0016941) |
| 0.2 | 6.3 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
| 0.2 | 9.0 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.2 | 0.5 | GO:0001225 | RNA polymerase II transcription coactivator binding(GO:0001225) |
| 0.2 | 1.6 | GO:0001161 | intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) |
| 0.2 | 1.4 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.2 | 4.9 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.2 | 1.4 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
| 0.1 | 0.7 | GO:0005047 | signal recognition particle binding(GO:0005047) |
| 0.1 | 1.3 | GO:0008379 | thioredoxin peroxidase activity(GO:0008379) |
| 0.1 | 5.9 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 1.9 | GO:0005355 | glucose transmembrane transporter activity(GO:0005355) |
| 0.1 | 0.9 | GO:0031419 | cobalamin binding(GO:0031419) |
| 0.1 | 1.9 | GO:1990226 | histone methyltransferase binding(GO:1990226) |
| 0.1 | 36.9 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.1 | 1.2 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.1 | 0.3 | GO:0016979 | lipoate-protein ligase activity(GO:0016979) |
| 0.1 | 0.8 | GO:0043522 | leucine zipper domain binding(GO:0043522) |
| 0.1 | 1.1 | GO:0019215 | intermediate filament binding(GO:0019215) |
| 0.1 | 0.4 | GO:0030144 | alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144) |
| 0.1 | 1.6 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.1 | 0.3 | GO:0030292 | protein tyrosine kinase inhibitor activity(GO:0030292) |
| 0.1 | 1.3 | GO:0042975 | peroxisome proliferator activated receptor binding(GO:0042975) |
| 0.1 | 1.0 | GO:0042809 | vitamin D receptor binding(GO:0042809) |
| 0.1 | 0.6 | GO:0003993 | acid phosphatase activity(GO:0003993) |
| 0.1 | 1.7 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.1 | 7.1 | GO:0004725 | protein tyrosine phosphatase activity(GO:0004725) |
| 0.1 | 4.4 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.1 | 0.9 | GO:1904264 | ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264) |
| 0.1 | 0.4 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 0.1 | 1.1 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.0 | 4.8 | GO:0019905 | syntaxin binding(GO:0019905) |
| 0.0 | 0.4 | GO:0004865 | protein serine/threonine phosphatase inhibitor activity(GO:0004865) |
| 0.0 | 0.1 | GO:0016716 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716) |
| 0.0 | 0.4 | GO:0031996 | thioesterase binding(GO:0031996) |
| 0.0 | 1.7 | GO:0051879 | Hsp90 protein binding(GO:0051879) |
| 0.0 | 0.5 | GO:0016783 | sulfurtransferase activity(GO:0016783) |
| 0.0 | 1.4 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.0 | 1.3 | GO:0008198 | ferrous iron binding(GO:0008198) |
| 0.0 | 0.8 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
| 0.0 | 0.3 | GO:0004689 | phosphorylase kinase activity(GO:0004689) |
| 0.0 | 0.8 | GO:0008143 | poly(A) binding(GO:0008143) |
| 0.0 | 1.8 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 0.0 | 1.8 | GO:0016876 | aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876) |
| 0.0 | 1.0 | GO:0070273 | phosphatidylinositol-4-phosphate binding(GO:0070273) |
| 0.0 | 1.0 | GO:0030544 | Hsp70 protein binding(GO:0030544) |
| 0.0 | 2.2 | GO:0019843 | rRNA binding(GO:0019843) |
| 0.0 | 1.2 | GO:0051018 | protein kinase A binding(GO:0051018) |
| 0.0 | 1.3 | GO:0004402 | histone acetyltransferase activity(GO:0004402) |
| 0.0 | 2.8 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.0 | 1.3 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
| 0.0 | 0.3 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 0.0 | 0.4 | GO:0017049 | GTP-Rho binding(GO:0017049) |
| 0.0 | 1.1 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.0 | 0.2 | GO:0017070 | U6 snRNA binding(GO:0017070) |
| 0.0 | 0.4 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
| 0.0 | 3.5 | GO:0004175 | endopeptidase activity(GO:0004175) |
| 0.0 | 0.1 | GO:0034513 | box H/ACA snoRNA binding(GO:0034513) |
| 0.0 | 0.6 | GO:0043022 | ribosome binding(GO:0043022) |
| 0.0 | 0.5 | GO:0030332 | cyclin binding(GO:0030332) |
| 0.0 | 0.6 | GO:0043130 | ubiquitin binding(GO:0043130) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 12.2 | PID_P38_MK2_PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.2 | 8.9 | PID_TCR_CALCIUM_PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.2 | 3.8 | PID_SYNDECAN_3_PATHWAY | Syndecan-3-mediated signaling events |
| 0.1 | 6.1 | PID_DELTA_NP63_PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.1 | 1.9 | PID_TCR_RAS_PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.1 | 2.9 | PID_INTEGRIN_A9B1_PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.1 | 3.2 | PID_NFKAPPAB_CANONICAL_PATHWAY | Canonical NF-kappaB pathway |
| 0.1 | 4.9 | PID_REELIN_PATHWAY | Reelin signaling pathway |
| 0.1 | 2.2 | PID_NECTIN_PATHWAY | Nectin adhesion pathway |
| 0.1 | 2.3 | ST_MYOCYTE_AD_PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.1 | 2.2 | SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.1 | 1.6 | PID_WNT_SIGNALING_PATHWAY | Wnt signaling network |
| 0.0 | 1.5 | PID_BCR_5PATHWAY | BCR signaling pathway |
| 0.0 | 1.6 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 1.3 | PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.0 | 1.0 | PID_IL2_STAT5_PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.0 | 3.3 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 0.4 | PID_RB_1PATHWAY | Regulation of retinoblastoma protein |
| 0.0 | 0.4 | PID_ARF6_DOWNSTREAM_PATHWAY | Arf6 downstream pathway |
| 0.0 | 2.9 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 0.8 | PID_RHOA_PATHWAY | RhoA signaling pathway |
| 0.0 | 1.4 | PID_TELOMERASE_PATHWAY | Regulation of Telomerase |
| 0.0 | 1.1 | PID_REG_GR_PATHWAY | Glucocorticoid receptor regulatory network |
| 0.0 | 1.2 | PID_BETA_CATENIN_NUC_PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 1.1 | PID_CXCR4_PATHWAY | CXCR4-mediated signaling events |
| 0.0 | 0.8 | PID_E2F_PATHWAY | E2F transcription factor network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 2.5 | REACTOME_SEROTONIN_RECEPTORS | Genes involved in Serotonin receptors |
| 0.5 | 5.0 | REACTOME_AMINE_LIGAND_BINDING_RECEPTORS | Genes involved in Amine ligand-binding receptors |
| 0.4 | 3.1 | REACTOME_TRANSPORT_OF_ORGANIC_ANIONS | Genes involved in Transport of organic anions |
| 0.3 | 3.8 | REACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR | Genes involved in Regulated proteolysis of p75NTR |
| 0.2 | 3.5 | REACTOME_METABOLISM_OF_POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.2 | 9.4 | REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS | Genes involved in Glucagon-type ligand receptors |
| 0.2 | 4.5 | REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.2 | 9.9 | REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.2 | 2.2 | REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
| 0.2 | 3.2 | REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 0.1 | 1.2 | REACTOME_MEMBRANE_BINDING_AND_TARGETTING_OF_GAG_PROTEINS | Genes involved in Membrane binding and targetting of GAG proteins |
| 0.1 | 3.3 | REACTOME_OTHER_SEMAPHORIN_INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.1 | 1.9 | REACTOME_RAF_MAP_KINASE_CASCADE | Genes involved in RAF/MAP kinase cascade |
| 0.1 | 5.6 | REACTOME_RNA_POL_II_PRE_TRANSCRIPTION_EVENTS | Genes involved in RNA Polymerase II Pre-transcription Events |
| 0.1 | 7.6 | REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.1 | 1.8 | REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |
| 0.1 | 1.8 | REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 | Genes involved in Nuclear signaling by ERBB4 |
| 0.1 | 1.4 | REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.1 | 2.1 | REACTOME_PEROXISOMAL_LIPID_METABOLISM | Genes involved in Peroxisomal lipid metabolism |
| 0.1 | 4.9 | REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK | Genes involved in NRAGE signals death through JNK |
| 0.1 | 0.8 | REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS | Genes involved in Processing of Intronless Pre-mRNAs |
| 0.0 | 2.3 | REACTOME_VIF_MEDIATED_DEGRADATION_OF_APOBEC3G | Genes involved in Vif-mediated degradation of APOBEC3G |
| 0.0 | 1.6 | REACTOME_LYSOSOME_VESICLE_BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
| 0.0 | 1.4 | REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.0 | 1.7 | REACTOME_INTERACTIONS_OF_VPR_WITH_HOST_CELLULAR_PROTEINS | Genes involved in Interactions of Vpr with host cellular proteins |
| 0.0 | 1.6 | REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 4.8 | REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
| 0.0 | 0.9 | REACTOME_MRNA_SPLICING_MINOR_PATHWAY | Genes involved in mRNA Splicing - Minor Pathway |
| 0.0 | 0.4 | REACTOME_N_GLYCAN_ANTENNAE_ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.0 | 4.1 | REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.0 | 1.3 | REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
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