Motif ID: Nfe2l2

Z-value: 0.601


Transcription factors associated with Nfe2l2:

Gene SymbolEntrez IDGene Name
Nfe2l2 ENSMUSG00000015839.6 Nfe2l2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfe2l2mm10_v2_chr2_-_75704535_757046410.075.3e-01Click!


Activity profile for motif Nfe2l2.

activity profile for motif Nfe2l2


Sorted Z-values histogram for motif Nfe2l2

Sorted Z-values for motif Nfe2l2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfe2l2

PNG image of the network

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Top targets:


Showing 1 to 20 of 172 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_118961578 4.277 ENSMUST00000058651.4
 Lao1
L-amino acid oxidase 1
chr17_-_24644933 3.681 ENSMUST00000019684.5
 Slc9a3r2
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2
chr9_-_58313189 3.432 ENSMUST00000061799.8
 Loxl1
lysyl oxidase-like 1
chr3_-_116968827 3.316 ENSMUST00000119557.1
 Palmd
palmdelphin
chr1_-_172219715 3.109 ENSMUST00000170700.1
ENSMUST00000003554.4
 Casq1

calsequestrin 1

chr17_-_25570678 2.965 ENSMUST00000025003.3
ENSMUST00000173447.1
 Sox8

SRY-box containing gene 8

chr3_-_116968969 2.668 ENSMUST00000143611.1
ENSMUST00000040097.7
 Palmd

palmdelphin

chr1_+_165769392 2.642 ENSMUST00000040298.4
 Creg1
cellular repressor of E1A-stimulated genes 1
chr7_-_105482197 2.507 ENSMUST00000047040.2
 Prkcdbp
protein kinase C, delta binding protein
chr2_+_155775333 2.426 ENSMUST00000029141.5
 Mmp24
matrix metallopeptidase 24
chr6_+_17463927 2.322 ENSMUST00000115442.1
 Met
met proto-oncogene
chr1_-_155146755 2.255 ENSMUST00000027744.8
 Mr1
major histocompatibility complex, class I-related
chr6_+_5725639 2.231 ENSMUST00000115556.1
ENSMUST00000115555.1
ENSMUST00000115559.3
 Dync1i1


dynein cytoplasmic 1 intermediate chain 1


chr19_-_4037910 2.103 ENSMUST00000169613.1
 Gstp1
glutathione S-transferase, pi 1
chr9_-_116175318 2.029 ENSMUST00000061101.4
ENSMUST00000035014.6
 Tgfbr2

transforming growth factor, beta receptor II

chr2_+_25395866 2.013 ENSMUST00000028328.2
 Entpd2
ectonucleoside triphosphate diphosphohydrolase 2
chr4_-_126321669 1.968 ENSMUST00000102617.4
 Adprhl2
ADP-ribosylhydrolase like 2
chr14_-_20393473 1.911 ENSMUST00000061444.3
 Mrps16
mitochondrial ribosomal protein S16
chr8_+_65967157 1.895 ENSMUST00000072482.6
 March1
membrane-associated ring finger (C3HC4) 1
chr5_-_139484420 1.865 ENSMUST00000150992.1
 Zfand2a
zinc finger, AN1-type domain 2A

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 78 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.7 GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067)
0.0 3.6 GO:0009063 cellular amino acid catabolic process(GO:0009063)
0.3 3.5 GO:0071243 cellular response to arsenic-containing substance(GO:0071243)
0.1 3.2 GO:0071451 cellular response to oxygen radical(GO:0071450) cellular response to superoxide(GO:0071451)
1.0 3.1 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.5 3.1 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
1.0 3.0 GO:0072034 renal vesicle induction(GO:0072034)
0.2 2.4 GO:0044331 cell-cell adhesion mediated by cadherin(GO:0044331)
0.3 2.3 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.3 2.3 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.1 2.3 GO:0032620 interleukin-17 production(GO:0032620)
0.0 2.3 GO:0032543 mitochondrial translation(GO:0032543)
0.2 2.2 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.7 2.1 GO:0070488 negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771) neutrophil aggregation(GO:0070488)
0.7 2.0 GO:0003274 endocardial cushion fusion(GO:0003274)
0.3 2.0 GO:0009181 purine nucleoside diphosphate catabolic process(GO:0009137) purine ribonucleoside diphosphate catabolic process(GO:0009181)
0.3 2.0 GO:0006729 tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146)
0.0 2.0 GO:0072583 clathrin-mediated endocytosis(GO:0072583)
0.0 2.0 GO:0042098 T cell proliferation(GO:0042098)
0.1 1.9 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.4 GO:0000502 proteasome complex(GO:0000502)
0.1 4.8 GO:0005604 basement membrane(GO:0005604)
0.0 4.8 GO:0043197 dendritic spine(GO:0043197)
0.1 4.3 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 3.5 GO:0005770 late endosome(GO:0005770)
0.8 3.1 GO:0014802 terminal cisterna(GO:0014802)
1.0 3.0 GO:0097057 TRAF2-GSTP1 complex(GO:0097057)
0.3 3.0 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.3 2.3 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.2 2.3 GO:0042612 MHC class I protein complex(GO:0042612)
0.1 2.3 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.1 2.3 GO:0032420 stereocilium(GO:0032420)
0.0 2.3 GO:0009925 basal plasma membrane(GO:0009925)
0.7 2.2 GO:1990257 piccolo-bassoon transport vesicle(GO:1990257)
0.1 2.0 GO:0005605 basal lamina(GO:0005605)
0.1 1.6 GO:0031045 dense core granule(GO:0031045)
0.0 1.6 GO:0005901 caveola(GO:0005901)
0.0 1.4 GO:0032587 ruffle membrane(GO:0032587)
0.2 1.3 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.1 1.3 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 54 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 4.3 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.1 3.7 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.3 3.4 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.8 3.1 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.2 3.0 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.1 3.0 GO:1900750 glutathione peroxidase activity(GO:0004602) glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.0 3.0 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 3.0 GO:0003735 structural constituent of ribosome(GO:0003735)
0.6 2.3 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.4 2.3 GO:0070699 type II activin receptor binding(GO:0070699)
0.7 2.0 GO:0004155 6,7-dihydropteridine reductase activity(GO:0004155)
0.5 2.0 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.2 2.0 GO:0043262 adenosine-diphosphatase activity(GO:0043262)
0.0 2.0 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.1 1.9 GO:0045504 dynein heavy chain binding(GO:0045504)
0.1 1.9 GO:0042287 MHC protein binding(GO:0042287)
0.1 1.9 GO:0001968 fibronectin binding(GO:0001968)
0.4 1.8 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.1 1.8 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.4 1.6 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)

Gene overrepresentation in C2:CP category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.9 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 3.8 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.1 3.5 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1 3.0 PID_ARF_3PATHWAY Arf1 pathway
0.1 2.3 PID_ARF6_PATHWAY Arf6 signaling events
0.1 2.0 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.0 1.7 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.6 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 1.4 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 1.3 ST_B_CELL_ANTIGEN_RECEPTOR B Cell Antigen Receptor
0.0 1.3 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 1.1 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 1.0 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.0 0.8 PID_CXCR3_PATHWAY CXCR3-mediated signaling events
0.0 0.7 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.5 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.2 PID_IL27_PATHWAY IL27-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 4.2 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.1 4.0 REACTOME_AUTODEGRADATION_OF_CDH1_BY_CDH1_APC_C Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C
0.1 3.9 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 3.6 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.2 3.0 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.1 2.3 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.0 2.3 REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION Genes involved in Downstream signal transduction
0.0 2.1 REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.1 2.0 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 1.7 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.4 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 1.2 REACTOME_CELL_JUNCTION_ORGANIZATION Genes involved in Cell junction organization
0.0 1.0 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.0 1.0 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
0.0 0.8 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.8 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.7 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 0.5 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events
0.0 0.5 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.4 REACTOME_NFKB_IS_ACTIVATED_AND_SIGNALS_SURVIVAL Genes involved in NF-kB is activated and signals survival