Motif ID: Nfia

Z-value: 2.010


Transcription factors associated with Nfia:

Gene SymbolEntrez IDGene Name
Nfia ENSMUSG00000028565.12 Nfia

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfiamm10_v2_chr4_+_97772734_97772848-0.056.4e-01Click!


Activity profile for motif Nfia.

activity profile for motif Nfia


Sorted Z-values histogram for motif Nfia

Sorted Z-values for motif Nfia



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfia

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_+_20665250 34.584 ENSMUST00000075312.3
 Ttr
transthyretin
chr19_+_5740885 31.503 ENSMUST00000081496.5
 Ltbp3
latent transforming growth factor beta binding protein 3
chr6_+_141524379 28.084 ENSMUST00000032362.9
 Slco1c1
solute carrier organic anion transporter family, member 1c1
chr10_+_127725392 22.529 ENSMUST00000026466.3
 Tac2
tachykinin 2
chr7_+_130936172 21.451 ENSMUST00000006367.7
 Htra1
HtrA serine peptidase 1
chr13_-_97747373 18.900 ENSMUST00000123535.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr11_-_102897123 18.508 ENSMUST00000067444.3
 Gfap
glial fibrillary acidic protein
chr7_-_97417730 17.731 ENSMUST00000043077.7
 Thrsp
thyroid hormone responsive
chr1_+_42229726 17.150 ENSMUST00000066196.1
 Gm9915
predicted gene 9915
chr13_-_97747399 16.114 ENSMUST00000144993.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr12_+_85473883 15.655 ENSMUST00000021674.6
 Fos
FBJ osteosarcoma oncogene
chr13_+_94173992 15.023 ENSMUST00000121618.1
 Lhfpl2
lipoma HMGIC fusion partner-like 2
chr4_+_48045144 14.639 ENSMUST00000030025.3
 Nr4a3
nuclear receptor subfamily 4, group A, member 3
chr11_-_77894096 14.338 ENSMUST00000017597.4
 Pipox
pipecolic acid oxidase
chr11_-_102897146 14.153 ENSMUST00000077902.4
 Gfap
glial fibrillary acidic protein
chr10_+_58813359 14.083 ENSMUST00000135526.2
ENSMUST00000153031.1
 Sh3rf3

SH3 domain containing ring finger 3

chr3_-_116129615 13.316 ENSMUST00000029574.8
 Vcam1
vascular cell adhesion molecule 1
chr3_+_89520152 12.394 ENSMUST00000000811.7
 Kcnn3
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
chr2_-_25469742 12.376 ENSMUST00000114259.2
ENSMUST00000015234.6
 Ptgds

prostaglandin D2 synthase (brain)

chr2_-_170194033 12.351 ENSMUST00000180625.1
 Gm17619
predicted gene, 17619

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 416 entries
Log-likelihood per target Total log-likelihoodTermDescription
8.6 42.9 GO:0070327 thyroid hormone transport(GO:0070327)
4.7 32.7 GO:0010624 regulation of Schwann cell proliferation(GO:0010624)
10.5 31.5 GO:1902460 transforming growth factor beta activation(GO:0036363) regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
2.5 27.4 GO:0015721 bile acid and bile salt transport(GO:0015721)
4.9 24.3 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
5.6 22.5 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
3.6 21.5 GO:0060718 chorionic trophoblast cell differentiation(GO:0060718)
1.3 18.8 GO:0035994 response to muscle stretch(GO:0035994)
0.9 18.0 GO:0040034 regulation of development, heterochronic(GO:0040034)
2.5 17.7 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
1.7 15.7 GO:0048251 elastic fiber assembly(GO:0048251)
1.3 15.5 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
2.2 15.1 GO:0021847 ventricular zone neuroblast division(GO:0021847)
4.9 14.6 GO:0038095 positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095)
4.5 13.6 GO:0006553 lysine metabolic process(GO:0006553)
1.2 13.6 GO:0061032 visceral serous pericardium development(GO:0061032)
0.2 12.9 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.4 12.2 GO:0010866 regulation of triglyceride biosynthetic process(GO:0010866)
1.2 11.6 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
1.9 11.3 GO:0032196 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529) transposition(GO:0032196)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 164 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 54.7 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 54.0 GO:0005615 extracellular space(GO:0005615)
0.3 36.1 GO:0030175 filopodium(GO:0030175)
8.2 32.7 GO:0097450 astrocyte end-foot(GO:0097450)
0.2 31.9 GO:0031012 extracellular matrix(GO:0031012)
0.1 26.7 GO:0005925 focal adhesion(GO:0005925)
0.1 25.9 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.3 25.6 GO:0072562 blood microparticle(GO:0072562)
0.1 19.2 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.2 16.7 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
2.7 16.3 GO:0035976 AP1 complex(GO:0035976)
0.0 15.8 GO:0005739 mitochondrion(GO:0005739)
0.2 15.2 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.1 15.1 GO:0005769 early endosome(GO:0005769)
1.2 15.0 GO:0042612 MHC class I protein complex(GO:0042612)
0.4 14.1 GO:0051233 spindle midzone(GO:0051233)
0.2 13.6 GO:0005581 collagen trimer(GO:0005581)
0.5 12.1 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 11.3 GO:0005667 transcription factor complex(GO:0005667)
0.3 11.2 GO:0030173 integral component of Golgi membrane(GO:0030173)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 264 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.8 42.9 GO:0070324 thyroid hormone binding(GO:0070324)
0.3 33.8 GO:0005178 integrin binding(GO:0005178)
1.4 31.5 GO:0050431 transforming growth factor beta binding(GO:0050431)
7.0 28.1 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.6 24.9 GO:0070412 R-SMAD binding(GO:0070412)
6.1 24.3 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
7.7 23.1 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
1.0 22.5 GO:0005520 insulin-like growth factor binding(GO:0005520)
2.5 22.4 GO:0036122 BMP binding(GO:0036122)
0.3 17.6 GO:0019003 GDP binding(GO:0019003)
3.6 14.3 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
1.2 14.3 GO:0050693 LBD domain binding(GO:0050693)
3.3 13.3 GO:0008131 primary amine oxidase activity(GO:0008131)
1.2 12.4 GO:0070700 BMP receptor binding(GO:0070700)
3.1 12.3 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.3 12.1 GO:0019838 growth factor binding(GO:0019838)
0.8 11.8 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.2 11.7 GO:0005518 collagen binding(GO:0005518)
1.9 11.6 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.4 11.5 GO:0001223 transcription coactivator binding(GO:0001223)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 69 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 78.4 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.8 39.8 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.2 38.5 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.3 35.5 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.6 29.6 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.3 24.6 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
1.2 21.1 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
1.1 19.7 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.9 17.0 ST_STAT3_PATHWAY STAT3 Pathway
0.7 15.6 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.5 14.8 PID_VEGFR1_PATHWAY VEGFR1 specific signals
0.3 14.8 PID_CD8_TCR_PATHWAY TCR signaling in naïve CD8+ T cells
0.5 13.0 PID_SHP2_PATHWAY SHP2 signaling
0.4 13.0 NABA_COLLAGENS Genes encoding collagen proteins
0.3 9.5 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.6 9.2 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.1 8.7 PID_CDC42_PATHWAY CDC42 signaling events
0.1 8.2 PID_NOTCH_PATHWAY Notch signaling pathway
0.2 7.6 PID_MET_PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.4 7.5 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 101 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 47.9 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.7 39.0 REACTOME_AMYLOIDS Genes involved in Amyloids
0.3 20.6 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.8 20.5 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.4 19.3 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.9 17.0 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
2.1 16.7 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions
0.5 14.4 REACTOME_ENOS_ACTIVATION_AND_REGULATION Genes involved in eNOS activation and regulation
0.7 14.0 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.7 11.7 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.3 11.7 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.2 11.1 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.4 10.9 REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT Genes involved in ABC-family proteins mediated transport
0.2 10.8 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.4 10.0 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.5 9.9 REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING Genes involved in Growth hormone receptor signaling
0.5 9.6 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.6 9.2 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
1.2 8.7 REACTOME_SIGNALING_BY_NOTCH4 Genes involved in Signaling by NOTCH4
0.8 8.0 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway