Motif ID: Nfic_Nfib
Z-value: 1.612
Transcription factors associated with Nfic_Nfib:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Nfib | ENSMUSG00000008575.11 | Nfib |
| Nfic | ENSMUSG00000055053.11 | Nfic |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nfic | mm10_v2_chr10_-_81430966_81431039 | 0.46 | 2.0e-05 | Click! |
| Nfib | mm10_v2_chr4_-_82505274_82505358 | 0.13 | 2.6e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.3 | 41.6 | GO:2000255 | negative regulation of male germ cell proliferation(GO:2000255) |
| 6.3 | 18.8 | GO:0006553 | lysine metabolic process(GO:0006553) |
| 5.4 | 16.1 | GO:1905072 | detection of oxygen(GO:0003032) cardiac jelly development(GO:1905072) |
| 3.4 | 10.1 | GO:0071579 | regulation of zinc ion transport(GO:0071579) |
| 3.1 | 22.0 | GO:0048251 | elastic fiber assembly(GO:0048251) |
| 2.8 | 14.1 | GO:1903609 | negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609) |
| 2.6 | 15.4 | GO:0006570 | tyrosine metabolic process(GO:0006570) |
| 2.5 | 7.6 | GO:1904139 | microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139) |
| 2.3 | 13.7 | GO:0032804 | negative regulation of low-density lipoprotein particle receptor catabolic process(GO:0032804) |
| 2.3 | 18.0 | GO:0070314 | G1 to G0 transition(GO:0070314) |
| 2.0 | 18.1 | GO:1904714 | regulation of chaperone-mediated autophagy(GO:1904714) |
| 2.0 | 6.0 | GO:1902714 | negative regulation of interferon-gamma secretion(GO:1902714) |
| 1.8 | 7.3 | GO:1990022 | RNA polymerase II complex import to nucleus(GO:0044376) RNA polymerase III complex localization to nucleus(GO:1990022) |
| 1.8 | 5.3 | GO:1904020 | regulation of G-protein coupled receptor internalization(GO:1904020) |
| 1.6 | 4.8 | GO:2000659 | regulation of interleukin-1-mediated signaling pathway(GO:2000659) |
| 1.6 | 4.7 | GO:0090271 | positive regulation of fibroblast growth factor production(GO:0090271) |
| 1.6 | 9.3 | GO:0097473 | cellular response to light intensity(GO:0071484) cellular response to high light intensity(GO:0071486) retinal rod cell apoptotic process(GO:0097473) |
| 1.6 | 3.1 | GO:0015675 | nickel cation transport(GO:0015675) |
| 1.5 | 4.6 | GO:0002030 | inhibitory G-protein coupled receptor phosphorylation(GO:0002030) |
| 1.5 | 4.4 | GO:0048014 | Tie signaling pathway(GO:0048014) |
| 1.4 | 4.2 | GO:0071921 | establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922) |
| 1.3 | 13.3 | GO:0030388 | fructose 1,6-bisphosphate metabolic process(GO:0030388) |
| 1.2 | 5.0 | GO:0051933 | amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935) |
| 1.2 | 11.1 | GO:0070236 | negative regulation of activation-induced cell death of T cells(GO:0070236) |
| 1.2 | 4.7 | GO:0060316 | positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316) |
| 1.1 | 4.6 | GO:0051045 | negative regulation of membrane protein ectodomain proteolysis(GO:0051045) |
| 1.1 | 3.3 | GO:0072180 | mesenchymal cell proliferation involved in ureteric bud development(GO:0072138) mesonephric duct development(GO:0072177) mesonephric duct morphogenesis(GO:0072180) |
| 1.1 | 5.5 | GO:0051611 | negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 1.1 | 4.3 | GO:0006982 | response to lipid hydroperoxide(GO:0006982) cellular response to lipid hydroperoxide(GO:0071449) |
| 1.0 | 6.2 | GO:0060718 | chorionic trophoblast cell differentiation(GO:0060718) |
| 1.0 | 17.4 | GO:0060134 | prepulse inhibition(GO:0060134) |
| 1.0 | 4.1 | GO:0060709 | glycogen cell differentiation involved in embryonic placenta development(GO:0060709) |
| 1.0 | 4.0 | GO:1903984 | positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984) |
| 1.0 | 3.8 | GO:0010046 | arginine biosynthetic process(GO:0006526) response to mycotoxin(GO:0010046) |
| 1.0 | 2.9 | GO:0003104 | positive regulation of glomerular filtration(GO:0003104) negative regulation of phosphatidylinositol biosynthetic process(GO:0010512) phenotypic switching(GO:0036166) metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262) |
| 0.9 | 3.5 | GO:0031999 | negative regulation of fatty acid beta-oxidation(GO:0031999) |
| 0.9 | 2.6 | GO:1901420 | negative regulation of response to alcohol(GO:1901420) |
| 0.9 | 9.5 | GO:2000653 | regulation of genetic imprinting(GO:2000653) |
| 0.9 | 1.7 | GO:0010700 | negative regulation of norepinephrine secretion(GO:0010700) |
| 0.8 | 2.5 | GO:0070428 | granuloma formation(GO:0002432) negative regulation of toll-like receptor 3 signaling pathway(GO:0034140) toll-like receptor 5 signaling pathway(GO:0034146) regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424) regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070428) regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070432) |
| 0.8 | 3.3 | GO:0043415 | positive regulation of skeletal muscle tissue regeneration(GO:0043415) |
| 0.8 | 4.9 | GO:0034080 | CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641) |
| 0.8 | 7.3 | GO:1900194 | negative regulation of oocyte maturation(GO:1900194) |
| 0.8 | 3.2 | GO:2000256 | endomitotic cell cycle(GO:0007113) thrombopoietin-mediated signaling pathway(GO:0038163) positive regulation of male germ cell proliferation(GO:2000256) |
| 0.8 | 3.0 | GO:0046210 | nitrate catabolic process(GO:0043602) nitric oxide catabolic process(GO:0046210) cellular organohalogen metabolic process(GO:0090345) cellular organofluorine metabolic process(GO:0090346) |
| 0.7 | 9.7 | GO:0014823 | response to activity(GO:0014823) |
| 0.7 | 1.5 | GO:0035787 | cell migration involved in kidney development(GO:0035787) |
| 0.7 | 4.7 | GO:2001199 | negative regulation of dendritic cell differentiation(GO:2001199) |
| 0.7 | 24.2 | GO:0050873 | brown fat cell differentiation(GO:0050873) |
| 0.7 | 4.0 | GO:0042535 | positive regulation of tumor necrosis factor biosynthetic process(GO:0042535) |
| 0.6 | 5.8 | GO:0070574 | cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574) |
| 0.6 | 1.3 | GO:2000338 | chemokine (C-X-C motif) ligand 1 production(GO:0072566) regulation of chemokine (C-X-C motif) ligand 1 production(GO:2000338) |
| 0.6 | 3.1 | GO:0060414 | response to potassium ion(GO:0035864) cellular response to potassium ion(GO:0035865) aorta smooth muscle tissue morphogenesis(GO:0060414) |
| 0.6 | 1.8 | GO:0002489 | antigen processing and presentation of endogenous peptide antigen via MHC class Ib(GO:0002476) antigen processing and presentation of exogenous peptide antigen via MHC class Ib(GO:0002477) antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent(GO:0002481) antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway(GO:0002488) antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent(GO:0002489) |
| 0.6 | 1.8 | GO:0038095 | positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095) |
| 0.6 | 5.3 | GO:1901386 | negative regulation of voltage-gated calcium channel activity(GO:1901386) |
| 0.6 | 1.8 | GO:0002408 | myeloid dendritic cell chemotaxis(GO:0002408) |
| 0.6 | 2.3 | GO:0043973 | histone H3-K4 acetylation(GO:0043973) |
| 0.6 | 1.7 | GO:0035811 | negative regulation of urine volume(GO:0035811) |
| 0.5 | 1.6 | GO:0002191 | cap-dependent translational initiation(GO:0002191) |
| 0.5 | 1.6 | GO:0030070 | insulin processing(GO:0030070) |
| 0.5 | 5.3 | GO:0006691 | leukotriene metabolic process(GO:0006691) |
| 0.5 | 5.3 | GO:0043568 | positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568) |
| 0.5 | 4.2 | GO:0042167 | porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149) |
| 0.5 | 1.0 | GO:0001743 | optic placode formation(GO:0001743) |
| 0.5 | 3.1 | GO:1902998 | macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998) |
| 0.5 | 1.5 | GO:0034035 | sulfate assimilation(GO:0000103) purine ribonucleoside bisphosphate metabolic process(GO:0034035) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427) |
| 0.5 | 2.5 | GO:0070458 | detoxification of nitrogen compound(GO:0051410) cellular detoxification of nitrogen compound(GO:0070458) |
| 0.5 | 2.4 | GO:0008655 | pyrimidine-containing compound salvage(GO:0008655) pyrimidine nucleoside salvage(GO:0043097) |
| 0.5 | 4.7 | GO:0061032 | visceral serous pericardium development(GO:0061032) |
| 0.5 | 0.9 | GO:0006566 | threonine metabolic process(GO:0006566) |
| 0.5 | 4.6 | GO:0051256 | mitotic spindle midzone assembly(GO:0051256) |
| 0.5 | 7.3 | GO:0046697 | decidualization(GO:0046697) |
| 0.4 | 4.0 | GO:0060907 | positive regulation of macrophage cytokine production(GO:0060907) |
| 0.4 | 8.4 | GO:0032060 | bleb assembly(GO:0032060) |
| 0.4 | 3.9 | GO:0010745 | negative regulation of macrophage derived foam cell differentiation(GO:0010745) |
| 0.4 | 1.3 | GO:0019074 | viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074) |
| 0.4 | 2.5 | GO:0071455 | response to hyperoxia(GO:0055093) cellular response to hyperoxia(GO:0071455) |
| 0.4 | 1.2 | GO:0071918 | urea transmembrane transport(GO:0071918) |
| 0.4 | 8.7 | GO:2000001 | regulation of DNA damage checkpoint(GO:2000001) |
| 0.4 | 3.9 | GO:0033631 | cell-cell adhesion mediated by integrin(GO:0033631) |
| 0.4 | 4.2 | GO:0009404 | toxin metabolic process(GO:0009404) |
| 0.4 | 2.5 | GO:0015862 | uridine transport(GO:0015862) |
| 0.4 | 2.8 | GO:0071802 | negative regulation of podosome assembly(GO:0071802) |
| 0.4 | 2.8 | GO:0046415 | urate metabolic process(GO:0046415) |
| 0.3 | 2.4 | GO:0019885 | antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885) |
| 0.3 | 10.7 | GO:0060445 | branching involved in salivary gland morphogenesis(GO:0060445) |
| 0.3 | 2.0 | GO:2001185 | regulation of CD8-positive, alpha-beta T cell activation(GO:2001185) |
| 0.3 | 1.6 | GO:0060576 | intestinal epithelial cell development(GO:0060576) |
| 0.3 | 1.3 | GO:0072365 | regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter(GO:0072365) |
| 0.3 | 0.6 | GO:2000820 | negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000820) |
| 0.3 | 14.6 | GO:0060325 | face morphogenesis(GO:0060325) |
| 0.3 | 0.6 | GO:0060620 | regulation of cholesterol import(GO:0060620) regulation of sterol import(GO:2000909) |
| 0.3 | 0.9 | GO:0006011 | UDP-glucose metabolic process(GO:0006011) |
| 0.3 | 1.5 | GO:0034162 | toll-like receptor 9 signaling pathway(GO:0034162) |
| 0.3 | 0.9 | GO:0006533 | aspartate catabolic process(GO:0006533) D-amino acid metabolic process(GO:0046416) |
| 0.3 | 1.5 | GO:0060591 | chondroblast differentiation(GO:0060591) |
| 0.3 | 4.4 | GO:0030574 | collagen catabolic process(GO:0030574) |
| 0.3 | 1.5 | GO:0035360 | positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360) |
| 0.3 | 8.0 | GO:0010866 | regulation of triglyceride biosynthetic process(GO:0010866) |
| 0.3 | 1.7 | GO:0006701 | progesterone biosynthetic process(GO:0006701) |
| 0.3 | 1.6 | GO:0021987 | cerebral cortex development(GO:0021987) |
| 0.3 | 2.1 | GO:1990845 | adaptive thermogenesis(GO:1990845) |
| 0.3 | 0.8 | GO:0021562 | vestibulocochlear nerve development(GO:0021562) |
| 0.3 | 10.1 | GO:0006904 | vesicle docking involved in exocytosis(GO:0006904) |
| 0.3 | 2.3 | GO:0046085 | adenosine metabolic process(GO:0046085) |
| 0.2 | 1.2 | GO:0090050 | positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) |
| 0.2 | 2.4 | GO:0035336 | long-chain fatty-acyl-CoA metabolic process(GO:0035336) |
| 0.2 | 0.7 | GO:2000435 | regulation of protein neddylation(GO:2000434) negative regulation of protein neddylation(GO:2000435) |
| 0.2 | 2.6 | GO:0021891 | olfactory bulb interneuron development(GO:0021891) |
| 0.2 | 0.7 | GO:0014063 | negative regulation of serotonin secretion(GO:0014063) |
| 0.2 | 1.3 | GO:0070294 | renal sodium ion absorption(GO:0070294) |
| 0.2 | 1.5 | GO:0046549 | phenol-containing compound catabolic process(GO:0019336) retinal cone cell development(GO:0046549) |
| 0.2 | 1.5 | GO:0070779 | D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779) |
| 0.2 | 0.6 | GO:0045004 | DNA replication proofreading(GO:0045004) |
| 0.2 | 2.8 | GO:0006654 | phosphatidic acid biosynthetic process(GO:0006654) |
| 0.2 | 2.7 | GO:0045199 | maintenance of epithelial cell apical/basal polarity(GO:0045199) |
| 0.2 | 11.5 | GO:0048747 | muscle fiber development(GO:0048747) |
| 0.2 | 0.8 | GO:2000319 | negative regulation of T-helper 17 type immune response(GO:2000317) regulation of T-helper 17 cell differentiation(GO:2000319) negative regulation of T-helper 17 cell differentiation(GO:2000320) |
| 0.2 | 0.9 | GO:2000767 | positive regulation of cytoplasmic translation(GO:2000767) |
| 0.2 | 1.6 | GO:0006560 | proline metabolic process(GO:0006560) |
| 0.2 | 4.7 | GO:0060351 | cartilage development involved in endochondral bone morphogenesis(GO:0060351) |
| 0.2 | 5.7 | GO:0050919 | negative chemotaxis(GO:0050919) |
| 0.2 | 1.0 | GO:2000664 | positive regulation of interleukin-5 secretion(GO:2000664) positive regulation of interleukin-13 secretion(GO:2000667) |
| 0.2 | 0.6 | GO:1902340 | telomeric heterochromatin assembly(GO:0031509) negative regulation of chromosome condensation(GO:1902340) |
| 0.2 | 3.5 | GO:0001539 | cilium or flagellum-dependent cell motility(GO:0001539) cilium-dependent cell motility(GO:0060285) |
| 0.2 | 1.6 | GO:0000289 | nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289) |
| 0.2 | 0.9 | GO:0048146 | fibroblast proliferation(GO:0048144) regulation of fibroblast proliferation(GO:0048145) positive regulation of fibroblast proliferation(GO:0048146) |
| 0.2 | 1.7 | GO:0001886 | endothelial cell morphogenesis(GO:0001886) |
| 0.1 | 1.3 | GO:0035428 | hexose transmembrane transport(GO:0035428) |
| 0.1 | 1.6 | GO:0050995 | negative regulation of lipid catabolic process(GO:0050995) |
| 0.1 | 1.5 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 0.1 | 1.3 | GO:2000194 | regulation of female gonad development(GO:2000194) |
| 0.1 | 0.9 | GO:0002317 | plasma cell differentiation(GO:0002317) negative regulation of amyloid precursor protein biosynthetic process(GO:0042985) |
| 0.1 | 1.4 | GO:0033689 | negative regulation of osteoblast proliferation(GO:0033689) |
| 0.1 | 2.7 | GO:0042311 | vasodilation(GO:0042311) |
| 0.1 | 2.6 | GO:0006044 | N-acetylglucosamine metabolic process(GO:0006044) |
| 0.1 | 1.9 | GO:0050860 | negative regulation of T cell receptor signaling pathway(GO:0050860) |
| 0.1 | 0.5 | GO:0048793 | pronephros development(GO:0048793) |
| 0.1 | 0.7 | GO:0006452 | translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905) |
| 0.1 | 1.3 | GO:0042118 | endothelial cell activation(GO:0042118) |
| 0.1 | 4.3 | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) |
| 0.1 | 0.7 | GO:0097475 | motor neuron migration(GO:0097475) |
| 0.1 | 0.8 | GO:0036506 | maintenance of unfolded protein(GO:0036506) tail-anchored membrane protein insertion into ER membrane(GO:0071816) maintenance of unfolded protein involved in ERAD pathway(GO:1904378) |
| 0.1 | 0.4 | GO:0042866 | pyruvate biosynthetic process(GO:0042866) |
| 0.1 | 1.6 | GO:0000338 | protein deneddylation(GO:0000338) |
| 0.1 | 1.5 | GO:0019884 | antigen processing and presentation of exogenous antigen(GO:0019884) |
| 0.1 | 0.5 | GO:0051694 | pointed-end actin filament capping(GO:0051694) |
| 0.1 | 2.4 | GO:0010667 | negative regulation of cardiac muscle cell apoptotic process(GO:0010667) |
| 0.1 | 1.0 | GO:0031639 | plasminogen activation(GO:0031639) |
| 0.1 | 1.4 | GO:0014887 | muscle hypertrophy in response to stress(GO:0003299) cardiac muscle adaptation(GO:0014887) cardiac muscle hypertrophy in response to stress(GO:0014898) |
| 0.1 | 0.2 | GO:0006556 | S-adenosylmethionine biosynthetic process(GO:0006556) |
| 0.1 | 0.6 | GO:0002536 | respiratory burst involved in inflammatory response(GO:0002536) respiratory burst involved in defense response(GO:0002679) negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665) |
| 0.1 | 5.9 | GO:0007601 | visual perception(GO:0007601) |
| 0.1 | 0.3 | GO:0033580 | protein glycosylation at cell surface(GO:0033575) protein galactosylation at cell surface(GO:0033580) protein galactosylation(GO:0042125) |
| 0.1 | 1.5 | GO:0061036 | positive regulation of cartilage development(GO:0061036) |
| 0.1 | 1.7 | GO:0006182 | cGMP biosynthetic process(GO:0006182) |
| 0.1 | 0.2 | GO:0032782 | bile acid secretion(GO:0032782) |
| 0.1 | 0.5 | GO:2000480 | negative regulation of cAMP-dependent protein kinase activity(GO:2000480) |
| 0.1 | 0.6 | GO:0019368 | fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626) |
| 0.1 | 0.2 | GO:1900369 | negative regulation of RNA interference(GO:1900369) |
| 0.1 | 1.5 | GO:0000038 | very long-chain fatty acid metabolic process(GO:0000038) |
| 0.1 | 0.4 | GO:0090073 | positive regulation of protein homodimerization activity(GO:0090073) |
| 0.1 | 2.7 | GO:0006635 | fatty acid beta-oxidation(GO:0006635) |
| 0.1 | 0.6 | GO:2000773 | negative regulation of cellular senescence(GO:2000773) |
| 0.1 | 7.9 | GO:0016042 | lipid catabolic process(GO:0016042) |
| 0.1 | 0.5 | GO:0032780 | negative regulation of ATPase activity(GO:0032780) |
| 0.1 | 0.4 | GO:0006206 | pyrimidine nucleobase metabolic process(GO:0006206) |
| 0.1 | 1.2 | GO:0031954 | positive regulation of protein autophosphorylation(GO:0031954) |
| 0.1 | 0.8 | GO:0048820 | hair follicle maturation(GO:0048820) |
| 0.0 | 0.6 | GO:1902231 | positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231) |
| 0.0 | 0.7 | GO:0032331 | negative regulation of chondrocyte differentiation(GO:0032331) |
| 0.0 | 2.5 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 0.0 | 1.2 | GO:0070584 | mitochondrion morphogenesis(GO:0070584) |
| 0.0 | 0.9 | GO:0060561 | apoptotic process involved in morphogenesis(GO:0060561) |
| 0.0 | 0.8 | GO:0032211 | negative regulation of telomere maintenance via telomerase(GO:0032211) |
| 0.0 | 0.5 | GO:2000035 | regulation of stem cell division(GO:2000035) |
| 0.0 | 6.0 | GO:0007519 | skeletal muscle tissue development(GO:0007519) |
| 0.0 | 1.7 | GO:0045214 | sarcomere organization(GO:0045214) |
| 0.0 | 2.0 | GO:0051438 | regulation of ubiquitin-protein transferase activity(GO:0051438) |
| 0.0 | 0.1 | GO:0007161 | calcium-independent cell-matrix adhesion(GO:0007161) |
| 0.0 | 2.0 | GO:0018105 | peptidyl-serine phosphorylation(GO:0018105) |
| 0.0 | 0.4 | GO:0010606 | positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606) |
| 0.0 | 0.1 | GO:0039692 | single stranded viral RNA replication via double stranded DNA intermediate(GO:0039692) |
| 0.0 | 0.5 | GO:0043488 | regulation of mRNA stability(GO:0043488) |
| 0.0 | 0.8 | GO:0006469 | negative regulation of protein kinase activity(GO:0006469) |
| 0.0 | 1.5 | GO:0051607 | defense response to virus(GO:0051607) |
| 0.0 | 0.2 | GO:1903003 | positive regulation of protein deubiquitination(GO:1903003) |
| 0.0 | 1.6 | GO:0018279 | protein N-linked glycosylation via asparagine(GO:0018279) |
| 0.0 | 2.2 | GO:0051865 | protein autoubiquitination(GO:0051865) |
| 0.0 | 0.9 | GO:0097178 | ruffle assembly(GO:0097178) |
| 0.0 | 0.3 | GO:0010825 | positive regulation of centrosome duplication(GO:0010825) |
| 0.0 | 0.7 | GO:0040015 | negative regulation of multicellular organism growth(GO:0040015) |
| 0.0 | 0.6 | GO:0048147 | negative regulation of fibroblast proliferation(GO:0048147) |
| 0.0 | 0.7 | GO:0090200 | positive regulation of release of cytochrome c from mitochondria(GO:0090200) |
| 0.0 | 1.3 | GO:0030968 | endoplasmic reticulum unfolded protein response(GO:0030968) |
| 0.0 | 1.0 | GO:0006383 | transcription from RNA polymerase III promoter(GO:0006383) |
| 0.0 | 0.1 | GO:0045218 | zonula adherens maintenance(GO:0045218) |
| 0.0 | 3.6 | GO:1990830 | response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830) |
| 0.0 | 0.8 | GO:0006956 | complement activation(GO:0006956) |
| 0.0 | 0.2 | GO:0031053 | primary miRNA processing(GO:0031053) |
| 0.0 | 1.0 | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER(GO:0006890) |
| 0.0 | 0.9 | GO:0045669 | positive regulation of osteoblast differentiation(GO:0045669) |
| 0.0 | 0.1 | GO:0010993 | regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994) |
| 0.0 | 0.7 | GO:0046329 | negative regulation of JNK cascade(GO:0046329) |
| 0.0 | 0.1 | GO:0036296 | cellular response to increased oxygen levels(GO:0036295) response to increased oxygen levels(GO:0036296) |
| 0.0 | 5.0 | GO:0016311 | dephosphorylation(GO:0016311) |
| 0.0 | 3.2 | GO:0006790 | sulfur compound metabolic process(GO:0006790) |
| 0.0 | 0.7 | GO:0031102 | neuron projection regeneration(GO:0031102) |
| 0.0 | 0.1 | GO:0001887 | selenium compound metabolic process(GO:0001887) selenocysteine metabolic process(GO:0016259) |
| 0.0 | 4.9 | GO:0008380 | RNA splicing(GO:0008380) |
| 0.0 | 1.0 | GO:1901800 | positive regulation of proteasomal protein catabolic process(GO:1901800) |
| 0.0 | 0.4 | GO:0009880 | embryonic pattern specification(GO:0009880) |
| 0.0 | 0.8 | GO:0006821 | chloride transport(GO:0006821) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 9.3 | 28.0 | GO:0071953 | elastic fiber(GO:0071953) |
| 4.6 | 13.9 | GO:0030934 | collagen type XII trimer(GO:0005595) anchoring collagen complex(GO:0030934) |
| 2.9 | 8.7 | GO:1990667 | PCSK9-AnxA2 complex(GO:1990667) |
| 2.6 | 10.5 | GO:0043259 | laminin-10 complex(GO:0043259) |
| 2.5 | 7.6 | GO:1990682 | CSF1-CSF1R complex(GO:1990682) |
| 2.1 | 8.6 | GO:0097450 | astrocyte end-foot(GO:0097450) |
| 1.6 | 4.8 | GO:0005896 | interleukin-6 receptor complex(GO:0005896) |
| 1.4 | 8.7 | GO:0032299 | ribonuclease H2 complex(GO:0032299) |
| 1.2 | 19.6 | GO:0031045 | dense core granule(GO:0031045) |
| 1.1 | 14.1 | GO:0034098 | VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098) |
| 0.7 | 9.3 | GO:0032593 | insulin-responsive compartment(GO:0032593) |
| 0.6 | 3.7 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.6 | 4.2 | GO:0008278 | cohesin complex(GO:0008278) |
| 0.6 | 15.2 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.6 | 1.7 | GO:0005927 | muscle tendon junction(GO:0005927) |
| 0.5 | 1.9 | GO:0042567 | insulin-like growth factor ternary complex(GO:0042567) |
| 0.4 | 3.1 | GO:0034366 | spherical high-density lipoprotein particle(GO:0034366) |
| 0.4 | 34.6 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.4 | 1.5 | GO:0060187 | cell pole(GO:0060187) |
| 0.3 | 5.0 | GO:0012510 | trans-Golgi network transport vesicle membrane(GO:0012510) |
| 0.3 | 6.5 | GO:0008305 | integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636) |
| 0.3 | 7.1 | GO:0005682 | U5 snRNP(GO:0005682) |
| 0.3 | 1.2 | GO:0030670 | phagocytic vesicle membrane(GO:0030670) tertiary granule(GO:0070820) |
| 0.3 | 4.7 | GO:0005605 | basal lamina(GO:0005605) |
| 0.3 | 1.8 | GO:0042825 | TAP complex(GO:0042825) |
| 0.3 | 1.0 | GO:0008537 | proteasome activator complex(GO:0008537) |
| 0.2 | 3.2 | GO:0032433 | filopodium tip(GO:0032433) |
| 0.2 | 3.1 | GO:0072546 | ER membrane protein complex(GO:0072546) |
| 0.2 | 10.1 | GO:0030667 | secretory granule membrane(GO:0030667) |
| 0.2 | 15.7 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.2 | 1.5 | GO:0046581 | intercellular canaliculus(GO:0046581) |
| 0.2 | 2.5 | GO:0035686 | sperm fibrous sheath(GO:0035686) |
| 0.2 | 3.4 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.2 | 5.1 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.2 | 2.0 | GO:0031462 | Cul2-RING ubiquitin ligase complex(GO:0031462) |
| 0.2 | 0.9 | GO:0071986 | Ragulator complex(GO:0071986) |
| 0.2 | 4.9 | GO:0000777 | condensed chromosome kinetochore(GO:0000777) |
| 0.2 | 1.7 | GO:0044232 | organelle membrane contact site(GO:0044232) |
| 0.1 | 27.4 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.1 | 10.5 | GO:0005844 | polysome(GO:0005844) |
| 0.1 | 10.1 | GO:0005902 | microvillus(GO:0005902) |
| 0.1 | 1.2 | GO:0000813 | ESCRT I complex(GO:0000813) |
| 0.1 | 1.0 | GO:1990909 | Wnt signalosome(GO:1990909) |
| 0.1 | 0.6 | GO:0008622 | epsilon DNA polymerase complex(GO:0008622) |
| 0.1 | 3.5 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.1 | 1.6 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.1 | 19.5 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.1 | 1.0 | GO:0000127 | transcription factor TFIIIC complex(GO:0000127) |
| 0.1 | 0.4 | GO:0031251 | PAN complex(GO:0031251) |
| 0.1 | 3.9 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.1 | 0.8 | GO:0071818 | BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379) |
| 0.1 | 9.0 | GO:0016528 | sarcoplasm(GO:0016528) |
| 0.1 | 1.5 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
| 0.1 | 0.6 | GO:0070847 | core mediator complex(GO:0070847) |
| 0.1 | 0.8 | GO:0000783 | telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783) |
| 0.1 | 0.7 | GO:0005642 | annulate lamellae(GO:0005642) |
| 0.1 | 0.2 | GO:0048269 | methionine adenosyltransferase complex(GO:0048269) |
| 0.1 | 3.9 | GO:0097610 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.1 | 4.5 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.1 | 0.8 | GO:0031464 | Cul4A-RING E3 ubiquitin ligase complex(GO:0031464) |
| 0.1 | 2.2 | GO:0031902 | late endosome membrane(GO:0031902) |
| 0.1 | 5.2 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.1 | 11.0 | GO:0043292 | contractile fiber(GO:0043292) |
| 0.1 | 6.5 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.1 | 1.0 | GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex(GO:0005847) |
| 0.1 | 0.5 | GO:0000502 | proteasome complex(GO:0000502) |
| 0.1 | 0.3 | GO:0060293 | P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293) |
| 0.1 | 0.2 | GO:1903095 | microprocessor complex(GO:0070877) ribonuclease III complex(GO:1903095) |
| 0.0 | 1.5 | GO:0030673 | axolemma(GO:0030673) |
| 0.0 | 0.1 | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116) |
| 0.0 | 0.2 | GO:0005945 | 6-phosphofructokinase complex(GO:0005945) |
| 0.0 | 1.7 | GO:0001750 | photoreceptor outer segment(GO:0001750) |
| 0.0 | 1.6 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 0.0 | 16.6 | GO:0005764 | lytic vacuole(GO:0000323) lysosome(GO:0005764) |
| 0.0 | 2.1 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.0 | 4.1 | GO:0036064 | ciliary basal body(GO:0036064) |
| 0.0 | 6.4 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.0 | 1.0 | GO:0000314 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 0.0 | 1.6 | GO:0005770 | late endosome(GO:0005770) |
| 0.0 | 2.7 | GO:0045121 | membrane raft(GO:0045121) membrane microdomain(GO:0098857) |
| 0.0 | 0.2 | GO:0044530 | supraspliceosomal complex(GO:0044530) |
| 0.0 | 0.2 | GO:0000172 | ribonuclease MRP complex(GO:0000172) |
| 0.0 | 4.3 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.0 | 1.6 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.0 | 7.1 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.0 | 2.9 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 0.7 | GO:0060077 | inhibitory synapse(GO:0060077) |
| 0.0 | 1.5 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.0 | 1.1 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 0.7 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.0 | 2.5 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.0 | 9.9 | GO:0005730 | nucleolus(GO:0005730) |
| 0.0 | 0.4 | GO:0005776 | autophagosome(GO:0005776) |
| 0.0 | 0.7 | GO:0001726 | ruffle(GO:0001726) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 10.4 | 41.6 | GO:0004667 | prostaglandin-D synthase activity(GO:0004667) |
| 4.7 | 18.8 | GO:0016647 | oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647) |
| 3.2 | 16.1 | GO:0005534 | galactose binding(GO:0005534) |
| 2.8 | 14.1 | GO:0070320 | inward rectifier potassium channel inhibitor activity(GO:0070320) |
| 2.6 | 28.4 | GO:0008430 | selenium binding(GO:0008430) |
| 2.2 | 13.1 | GO:0004332 | fructose-bisphosphate aldolase activity(GO:0004332) |
| 2.2 | 8.7 | GO:0004859 | phospholipase inhibitor activity(GO:0004859) phospholipase A2 inhibitor activity(GO:0019834) |
| 1.8 | 7.3 | GO:0004921 | interleukin-11 receptor activity(GO:0004921) interleukin-11 binding(GO:0019970) |
| 1.7 | 5.0 | GO:0015272 | ATP-activated inward rectifier potassium channel activity(GO:0015272) |
| 1.4 | 18.1 | GO:0016863 | intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863) |
| 1.2 | 8.7 | GO:0004523 | RNA-DNA hybrid ribonuclease activity(GO:0004523) |
| 1.2 | 7.2 | GO:0005138 | interleukin-6 receptor binding(GO:0005138) |
| 1.2 | 3.5 | GO:0030156 | benzodiazepine receptor binding(GO:0030156) |
| 1.2 | 4.7 | GO:0008131 | primary amine oxidase activity(GO:0008131) |
| 1.1 | 11.4 | GO:0004185 | serine-type carboxypeptidase activity(GO:0004185) |
| 1.1 | 4.2 | GO:0004074 | biliverdin reductase activity(GO:0004074) |
| 1.0 | 6.2 | GO:0005520 | insulin-like growth factor binding(GO:0005520) |
| 1.0 | 9.1 | GO:0003857 | 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857) |
| 1.0 | 6.0 | GO:0016936 | galactoside binding(GO:0016936) |
| 1.0 | 5.7 | GO:0019841 | retinol binding(GO:0019841) |
| 0.8 | 4.2 | GO:0004499 | N,N-dimethylaniline monooxygenase activity(GO:0004499) |
| 0.8 | 13.0 | GO:0008253 | 5'-nucleotidase activity(GO:0008253) |
| 0.8 | 2.4 | GO:0005118 | sevenless binding(GO:0005118) |
| 0.8 | 3.0 | GO:0016708 | nitric oxide dioxygenase activity(GO:0008941) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor(GO:0016708) iron-cytochrome-c reductase activity(GO:0047726) |
| 0.7 | 2.7 | GO:0098639 | collagen binding involved in cell-matrix adhesion(GO:0098639) |
| 0.6 | 3.2 | GO:0008427 | calcium-dependent protein kinase inhibitor activity(GO:0008427) |
| 0.6 | 24.9 | GO:0005504 | fatty acid binding(GO:0005504) |
| 0.6 | 5.0 | GO:0031995 | insulin-like growth factor II binding(GO:0031995) |
| 0.6 | 11.0 | GO:0004435 | phosphatidylinositol phospholipase C activity(GO:0004435) |
| 0.5 | 2.1 | GO:0017077 | oxidative phosphorylation uncoupler activity(GO:0017077) |
| 0.5 | 2.6 | GO:0001517 | N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) |
| 0.5 | 12.5 | GO:0030506 | ankyrin binding(GO:0030506) |
| 0.5 | 13.8 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.5 | 2.4 | GO:0004849 | uridine kinase activity(GO:0004849) |
| 0.5 | 2.9 | GO:0016176 | superoxide-generating NADPH oxidase activator activity(GO:0016176) |
| 0.5 | 11.5 | GO:1900750 | glutathione binding(GO:0043295) oligopeptide binding(GO:1900750) |
| 0.5 | 1.8 | GO:0015433 | peptide antigen-transporting ATPase activity(GO:0015433) tapasin binding(GO:0046980) |
| 0.5 | 5.0 | GO:0048406 | nerve growth factor binding(GO:0048406) |
| 0.4 | 3.1 | GO:0015099 | nickel cation transmembrane transporter activity(GO:0015099) |
| 0.4 | 1.7 | GO:0015143 | urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702) |
| 0.4 | 5.1 | GO:0005314 | high-affinity glutamate transmembrane transporter activity(GO:0005314) |
| 0.4 | 4.3 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.4 | 2.5 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
| 0.3 | 0.7 | GO:0005006 | epidermal growth factor-activated receptor activity(GO:0005006) |
| 0.3 | 4.7 | GO:0008484 | sulfuric ester hydrolase activity(GO:0008484) |
| 0.3 | 1.0 | GO:0030368 | interleukin-17 receptor activity(GO:0030368) |
| 0.3 | 1.3 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.3 | 1.3 | GO:0070976 | TIR domain binding(GO:0070976) |
| 0.3 | 0.9 | GO:0008732 | threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732) |
| 0.3 | 3.8 | GO:0015643 | toxic substance binding(GO:0015643) |
| 0.3 | 2.3 | GO:0005095 | GTPase inhibitor activity(GO:0005095) |
| 0.3 | 1.7 | GO:0008294 | calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294) |
| 0.3 | 3.5 | GO:0038191 | neuropilin binding(GO:0038191) |
| 0.3 | 1.6 | GO:0071074 | eukaryotic initiation factor eIF2 binding(GO:0071074) |
| 0.3 | 2.4 | GO:0008420 | CTD phosphatase activity(GO:0008420) |
| 0.3 | 5.3 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
| 0.3 | 1.5 | GO:0004920 | interleukin-10 receptor activity(GO:0004920) |
| 0.3 | 2.3 | GO:0030274 | LIM domain binding(GO:0030274) |
| 0.2 | 4.2 | GO:0030235 | nitric-oxide synthase regulator activity(GO:0030235) |
| 0.2 | 1.4 | GO:0015204 | urea transmembrane transporter activity(GO:0015204) |
| 0.2 | 1.2 | GO:0071532 | ankyrin repeat binding(GO:0071532) |
| 0.2 | 0.6 | GO:0008310 | single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310) |
| 0.2 | 10.1 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.2 | 1.3 | GO:0051525 | NFAT protein binding(GO:0051525) |
| 0.2 | 0.6 | GO:0035939 | microsatellite binding(GO:0035939) |
| 0.2 | 1.3 | GO:0009374 | biotin binding(GO:0009374) |
| 0.2 | 2.7 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 0.2 | 14.5 | GO:0005080 | protein kinase C binding(GO:0005080) |
| 0.2 | 1.2 | GO:0005384 | manganese ion transmembrane transporter activity(GO:0005384) |
| 0.2 | 0.8 | GO:0004720 | protein-lysine 6-oxidase activity(GO:0004720) |
| 0.2 | 1.5 | GO:0036122 | BMP binding(GO:0036122) |
| 0.2 | 3.3 | GO:0043395 | heparan sulfate proteoglycan binding(GO:0043395) |
| 0.2 | 11.6 | GO:0019003 | GDP binding(GO:0019003) |
| 0.2 | 1.5 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
| 0.2 | 3.1 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.2 | 3.2 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
| 0.2 | 13.9 | GO:0005178 | integrin binding(GO:0005178) |
| 0.1 | 2.4 | GO:0016290 | palmitoyl-CoA hydrolase activity(GO:0016290) |
| 0.1 | 0.9 | GO:0016641 | oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641) |
| 0.1 | 7.3 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
| 0.1 | 0.7 | GO:1990948 | ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948) |
| 0.1 | 0.7 | GO:0098631 | protein binding involved in cell adhesion(GO:0098631) protein binding involved in cell-cell adhesion(GO:0098632) |
| 0.1 | 2.8 | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) |
| 0.1 | 4.2 | GO:0001223 | transcription coactivator binding(GO:0001223) |
| 0.1 | 1.7 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
| 0.1 | 1.4 | GO:0031957 | very long-chain fatty acid-CoA ligase activity(GO:0031957) |
| 0.1 | 1.0 | GO:0016308 | 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308) |
| 0.1 | 0.8 | GO:0001849 | complement component C1q binding(GO:0001849) |
| 0.1 | 0.4 | GO:0004743 | pyruvate kinase activity(GO:0004743) |
| 0.1 | 1.3 | GO:0005355 | glucose transmembrane transporter activity(GO:0005355) |
| 0.1 | 3.1 | GO:0005337 | nucleoside transmembrane transporter activity(GO:0005337) |
| 0.1 | 2.0 | GO:0004697 | protein kinase C activity(GO:0004697) |
| 0.1 | 1.7 | GO:0017127 | cholesterol transporter activity(GO:0017127) |
| 0.1 | 4.5 | GO:0030170 | pyridoxal phosphate binding(GO:0030170) |
| 0.1 | 0.9 | GO:0008097 | 5S rRNA binding(GO:0008097) |
| 0.1 | 4.5 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 0.1 | 2.8 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.1 | 0.9 | GO:0070569 | uridylyltransferase activity(GO:0070569) |
| 0.1 | 0.5 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.1 | 1.6 | GO:0016646 | oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646) |
| 0.1 | 1.3 | GO:0035497 | cAMP response element binding(GO:0035497) |
| 0.1 | 1.5 | GO:0070530 | K63-linked polyubiquitin binding(GO:0070530) |
| 0.1 | 0.3 | GO:0008273 | calcium, potassium:sodium antiporter activity(GO:0008273) |
| 0.1 | 1.5 | GO:0070566 | adenylyltransferase activity(GO:0070566) |
| 0.1 | 1.5 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.1 | 0.2 | GO:0070061 | fructose binding(GO:0070061) |
| 0.1 | 0.6 | GO:0009922 | fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338) |
| 0.1 | 1.7 | GO:0004601 | peroxidase activity(GO:0004601) |
| 0.1 | 0.2 | GO:0003692 | left-handed Z-DNA binding(GO:0003692) |
| 0.1 | 1.0 | GO:0070411 | I-SMAD binding(GO:0070411) |
| 0.1 | 1.5 | GO:0008373 | sialyltransferase activity(GO:0008373) |
| 0.1 | 9.6 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.1 | 0.3 | GO:0047276 | N-acetyllactosaminide 3-alpha-galactosyltransferase activity(GO:0047276) |
| 0.0 | 4.7 | GO:0008201 | heparin binding(GO:0008201) |
| 0.0 | 0.7 | GO:0017070 | U6 snRNA binding(GO:0017070) |
| 0.0 | 1.5 | GO:0005518 | collagen binding(GO:0005518) |
| 0.0 | 1.1 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.0 | 1.3 | GO:0046965 | retinoid X receptor binding(GO:0046965) |
| 0.0 | 0.5 | GO:0004862 | cAMP-dependent protein kinase inhibitor activity(GO:0004862) |
| 0.0 | 2.6 | GO:0004714 | transmembrane receptor protein tyrosine kinase activity(GO:0004714) |
| 0.0 | 2.7 | GO:0030295 | protein kinase activator activity(GO:0030295) |
| 0.0 | 0.5 | GO:0043022 | ribosome binding(GO:0043022) |
| 0.0 | 0.7 | GO:0020037 | heme binding(GO:0020037) |
| 0.0 | 11.4 | GO:0005525 | GTP binding(GO:0005525) |
| 0.0 | 3.2 | GO:0051087 | chaperone binding(GO:0051087) |
| 0.0 | 0.6 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
| 0.0 | 3.0 | GO:0002020 | protease binding(GO:0002020) |
| 0.0 | 0.2 | GO:0004525 | ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296) |
| 0.0 | 0.1 | GO:0045340 | mercury ion binding(GO:0045340) |
| 0.0 | 1.1 | GO:0008028 | monocarboxylic acid transmembrane transporter activity(GO:0008028) |
| 0.0 | 1.0 | GO:0032934 | cholesterol binding(GO:0015485) sterol binding(GO:0032934) |
| 0.0 | 0.7 | GO:0051183 | vitamin transporter activity(GO:0051183) |
| 0.0 | 0.3 | GO:0005172 | vascular endothelial growth factor receptor binding(GO:0005172) |
| 0.0 | 1.5 | GO:0035326 | enhancer binding(GO:0035326) |
| 0.0 | 1.5 | GO:0050660 | flavin adenine dinucleotide binding(GO:0050660) |
| 0.0 | 0.1 | GO:0070097 | delta-catenin binding(GO:0070097) |
| 0.0 | 0.8 | GO:0042162 | telomeric DNA binding(GO:0042162) |
| 0.0 | 2.9 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.0 | 7.4 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.0 | 1.6 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.0 | 0.2 | GO:0004526 | ribonuclease P activity(GO:0004526) |
| 0.0 | 0.2 | GO:0004622 | lysophospholipase activity(GO:0004622) |
| 0.0 | 2.9 | GO:0042393 | histone binding(GO:0042393) |
| 0.0 | 5.8 | GO:0043565 | sequence-specific DNA binding(GO:0043565) |
| 0.0 | 0.2 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 0.0 | 2.6 | GO:0008022 | protein C-terminus binding(GO:0008022) |
| 0.0 | 0.6 | GO:0001104 | RNA polymerase II transcription cofactor activity(GO:0001104) |
| 0.0 | 0.1 | GO:0004576 | oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 10.5 | PID_INTEGRIN4_PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.8 | 7.6 | SA_MMP_CYTOKINE_CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.6 | 21.3 | PID_PDGFRA_PATHWAY | PDGFR-alpha signaling pathway |
| 0.6 | 13.4 | SA_TRKA_RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
| 0.4 | 5.8 | NABA_BASEMENT_MEMBRANES | Genes encoding structural components of basement membranes |
| 0.4 | 6.5 | PID_INTEGRIN_CS_PATHWAY | Integrin family cell surface interactions |
| 0.4 | 5.7 | PID_INTEGRIN2_PATHWAY | Beta2 integrin cell surface interactions |
| 0.4 | 18.4 | NABA_COLLAGENS | Genes encoding collagen proteins |
| 0.3 | 11.1 | PID_RAS_PATHWAY | Regulation of Ras family activation |
| 0.3 | 4.8 | ST_STAT3_PATHWAY | STAT3 Pathway |
| 0.3 | 10.9 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.3 | 19.3 | PID_HIF1_TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.2 | 30.7 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.2 | 13.6 | PID_AP1_PATHWAY | AP-1 transcription factor network |
| 0.2 | 6.9 | SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.2 | 5.8 | PID_ANGIOPOIETIN_RECEPTOR_PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.2 | 8.1 | PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.2 | 2.9 | PID_S1P_S1P1_PATHWAY | S1P1 pathway |
| 0.2 | 20.7 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 16.5 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 2.5 | PID_CD40_PATHWAY | CD40/CD40L signaling |
| 0.1 | 1.0 | PID_ECADHERIN_KERATINOCYTE_PATHWAY | E-cadherin signaling in keratinocytes |
| 0.1 | 1.8 | ST_GA12_PATHWAY | G alpha 12 Pathway |
| 0.1 | 2.6 | PID_RXR_VDR_PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.1 | 2.8 | PID_REELIN_PATHWAY | Reelin signaling pathway |
| 0.1 | 1.8 | PID_FCER1_PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.1 | 1.3 | PID_IL1_PATHWAY | IL1-mediated signaling events |
| 0.0 | 1.0 | PID_WNT_CANONICAL_PATHWAY | Canonical Wnt signaling pathway |
| 0.0 | 1.4 | PID_ARF6_TRAFFICKING_PATHWAY | Arf6 trafficking events |
| 0.0 | 1.6 | PID_AR_TF_PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 0.7 | PID_TRAIL_PATHWAY | TRAIL signaling pathway |
| 0.0 | 0.9 | PID_PI3KCI_PATHWAY | Class I PI3K signaling events |
| 0.0 | 0.2 | PID_UPA_UPAR_PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.0 | 0.3 | ST_G_ALPHA_I_PATHWAY | G alpha i Pathway |
| 0.0 | 1.3 | PID_BETA_CATENIN_NUC_PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 0.1 | PID_ERB_GENOMIC_PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 0.9 | PID_CMYB_PATHWAY | C-MYB transcription factor network |
| 0.0 | 0.4 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 0.7 | PID_P53_REGULATION_PATHWAY | p53 pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 13.4 | REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |
| 0.9 | 20.0 | REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.8 | 12.8 | REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.6 | 4.7 | REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES | Genes involved in The activation of arylsulfatases |
| 0.6 | 5.0 | REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| 0.5 | 9.1 | REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
| 0.5 | 12.5 | REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.4 | 4.8 | REACTOME_IL_6_SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.4 | 4.7 | REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.4 | 22.3 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
| 0.4 | 13.1 | REACTOME_GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.3 | 7.4 | REACTOME_ACTIVATION_OF_GENES_BY_ATF4 | Genes involved in Activation of Genes by ATF4 |
| 0.3 | 5.0 | REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.3 | 21.7 | REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.3 | 3.0 | REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 0.3 | 7.6 | REACTOME_GLYCOSPHINGOLIPID_METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.3 | 1.3 | REACTOME_DESTABILIZATION_OF_MRNA_BY_KSRP | Genes involved in Destabilization of mRNA by KSRP |
| 0.2 | 6.4 | REACTOME_GLUTATHIONE_CONJUGATION | Genes involved in Glutathione conjugation |
| 0.2 | 4.3 | REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.2 | 6.0 | REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
| 0.2 | 8.6 | REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 | Genes involved in Nuclear signaling by ERBB4 |
| 0.2 | 3.7 | REACTOME_ZINC_TRANSPORTERS | Genes involved in Zinc transporters |
| 0.2 | 1.5 | REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.2 | 2.3 | REACTOME_PURINE_CATABOLISM | Genes involved in Purine catabolism |
| 0.2 | 4.2 | REACTOME_METABOLISM_OF_PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.2 | 2.5 | REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.2 | 1.3 | REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION_IN_TLR7_8_OR_9_SIGNALING | Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling |
| 0.1 | 1.5 | REACTOME_AMINE_DERIVED_HORMONES | Genes involved in Amine-derived hormones |
| 0.1 | 1.8 | REACTOME_SIGNAL_ATTENUATION | Genes involved in Signal attenuation |
| 0.1 | 5.6 | REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.1 | 1.2 | REACTOME_METAL_ION_SLC_TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.1 | 1.7 | REACTOME_INHIBITION_OF_INSULIN_SECRETION_BY_ADRENALINE_NORADRENALINE | Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline |
| 0.1 | 1.5 | REACTOME_IL1_SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.1 | 3.3 | REACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS | Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis |
| 0.1 | 1.2 | REACTOME_MEMBRANE_BINDING_AND_TARGETTING_OF_GAG_PROTEINS | Genes involved in Membrane binding and targetting of GAG proteins |
| 0.1 | 2.6 | REACTOME_KERATAN_SULFATE_BIOSYNTHESIS | Genes involved in Keratan sulfate biosynthesis |
| 0.1 | 2.0 | REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE | Genes involved in Beta-catenin phosphorylation cascade |
| 0.1 | 0.5 | REACTOME_ER_PHAGOSOME_PATHWAY | Genes involved in ER-Phagosome pathway |
| 0.1 | 2.5 | REACTOME_NOD1_2_SIGNALING_PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.1 | 3.1 | REACTOME_SMOOTH_MUSCLE_CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.1 | 4.9 | REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.1 | 2.8 | REACTOME_SYNTHESIS_OF_PA | Genes involved in Synthesis of PA |
| 0.1 | 5.8 | REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.1 | 1.6 | REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.1 | 0.7 | REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION | Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation |
| 0.1 | 1.6 | REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.1 | 0.6 | REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.1 | 1.2 | REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS | Genes involved in Amine compound SLC transporters |
| 0.1 | 0.7 | REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.1 | 0.4 | REACTOME_PYRIMIDINE_CATABOLISM | Genes involved in Pyrimidine catabolism |
| 0.1 | 3.1 | REACTOME_DESTABILIZATION_OF_MRNA_BY_AUF1_HNRNP_D0 | Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0) |
| 0.0 | 3.1 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 3.1 | REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.0 | 4.3 | REACTOME_G_ALPHA_I_SIGNALLING_EVENTS | Genes involved in G alpha (i) signalling events |
| 0.0 | 0.6 | REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER | Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER |
| 0.0 | 1.0 | REACTOME_SIGNALING_BY_PDGF | Genes involved in Signaling by PDGF |
| 0.0 | 0.6 | REACTOME_RNA_POL_I_PROMOTER_OPENING | Genes involved in RNA Polymerase I Promoter Opening |
| 0.0 | 1.0 | REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_2_PROMOTER | Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter |
| 0.0 | 0.9 | REACTOME_MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 0.2 | REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.0 | 0.2 | REACTOME_TIE2_SIGNALING | Genes involved in Tie2 Signaling |
| 0.0 | 1.0 | REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.0 | 0.2 | REACTOME_N_GLYCAN_TRIMMING_IN_THE_ER_AND_CALNEXIN_CALRETICULIN_CYCLE | Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle |
| 0.0 | 1.9 | REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| 0.0 | 1.8 | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.0 | 0.3 | REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE | Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase |
| 0.0 | 0.2 | REACTOME_GLYCOLYSIS | Genes involved in Glycolysis |
| 0.0 | 1.7 | REACTOME_PEPTIDE_CHAIN_ELONGATION | Genes involved in Peptide chain elongation |
| 0.0 | 0.2 | REACTOME_PHASE_II_CONJUGATION | Genes involved in Phase II conjugation |
| 0.0 | 1.2 | REACTOME_GENERIC_TRANSCRIPTION_PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.0 | 0.3 | REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS | Genes involved in Adherens junctions interactions |
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