Motif ID: Nfic_Nfib

Z-value: 1.612

Transcription factors associated with Nfic_Nfib:

Gene SymbolEntrez IDGene Name
Nfib ENSMUSG00000008575.11 Nfib
Nfic ENSMUSG00000055053.11 Nfic

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nficmm10_v2_chr10_-_81430966_814310390.462.0e-05Click!
Nfibmm10_v2_chr4_-_82505274_825053580.132.6e-01Click!


Activity profile for motif Nfic_Nfib.

activity profile for motif Nfic_Nfib


Sorted Z-values histogram for motif Nfic_Nfib

Sorted Z-values for motif Nfic_Nfib



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfic_Nfib

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_61485431 22.018 ENSMUST00000064783.3
ENSMUST00000040522.6
 Mfap4

microfibrillar-associated protein 4

chr2_-_25470031 21.053 ENSMUST00000114251.1
 Ptgds
prostaglandin D2 synthase (brain)
chr2_-_25469742 20.532 ENSMUST00000114259.2
ENSMUST00000015234.6
 Ptgds

prostaglandin D2 synthase (brain)

chr11_-_77894096 18.757 ENSMUST00000017597.4
 Pipox
pipecolic acid oxidase
chr1_+_43730593 18.042 ENSMUST00000027217.8
 1500015O10Rik
RIKEN cDNA 1500015O10 gene
chr3_+_94933041 17.037 ENSMUST00000090839.5
 Selenbp1
selenium binding protein 1
chr2_+_32646586 16.068 ENSMUST00000009705.7
ENSMUST00000167841.1
 Eng

endoglin

chr14_-_118052235 15.378 ENSMUST00000022725.2
 Dct
dopachrome tautomerase
chr13_-_97747373 14.140 ENSMUST00000123535.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr19_-_42752710 13.318 ENSMUST00000076505.3
 Pyroxd2
pyridine nucleotide-disulphide oxidoreductase domain 2
chr7_+_45017953 12.846 ENSMUST00000044111.7
 Rras
Harvey rat sarcoma oncogene, subgroup R
chr17_+_34969912 12.747 ENSMUST00000173680.1
 Gm20481
predicted gene 20481
chr3_-_85746266 12.702 ENSMUST00000118408.1
 Fam160a1
family with sequence similarity 160, member A1
chr13_-_97747399 11.500 ENSMUST00000144993.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr10_+_57784859 10.806 ENSMUST00000020024.5
 Fabp7
fatty acid binding protein 7, brain
chr14_+_31134853 10.737 ENSMUST00000090212.4
 Nt5dc2
5'-nucleotidase domain containing 2
chr3_+_94693556 10.707 ENSMUST00000090848.3
ENSMUST00000173981.1
ENSMUST00000173849.1
ENSMUST00000174223.1
 Selenbp2



selenium binding protein 2



chr2_-_180225812 10.488 ENSMUST00000015791.5
 Lama5
laminin, alpha 5
chr1_+_185454803 10.146 ENSMUST00000061093.6
 Slc30a10
solute carrier family 30, member 10
chr6_+_135362931 9.685 ENSMUST00000032330.9
 Emp1
epithelial membrane protein 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 214 entries
Log-likelihood per target Total log-likelihoodTermDescription
8.3 41.6 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
0.7 24.2 GO:0050873 brown fat cell differentiation(GO:0050873)
3.1 22.0 GO:0048251 elastic fiber assembly(GO:0048251)
6.3 18.8 GO:0006553 lysine metabolic process(GO:0006553)
2.0 18.1 GO:1904714 regulation of chaperone-mediated autophagy(GO:1904714)
2.3 18.0 GO:0070314 G1 to G0 transition(GO:0070314)
1.0 17.4 GO:0060134 prepulse inhibition(GO:0060134)
5.4 16.1 GO:1905072 detection of oxygen(GO:0003032) cardiac jelly development(GO:1905072)
2.6 15.4 GO:0006570 tyrosine metabolic process(GO:0006570)
0.3 14.6 GO:0060325 face morphogenesis(GO:0060325)
2.8 14.1 GO:1903609 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)
2.3 13.7 GO:0032804 negative regulation of low-density lipoprotein particle receptor catabolic process(GO:0032804)
1.3 13.3 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.2 11.5 GO:0048747 muscle fiber development(GO:0048747)
1.2 11.1 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.3 10.7 GO:0060445 branching involved in salivary gland morphogenesis(GO:0060445)
3.4 10.1 GO:0071579 regulation of zinc ion transport(GO:0071579)
0.3 10.1 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.7 9.7 GO:0014823 response to activity(GO:0014823)
0.9 9.5 GO:2000653 regulation of genetic imprinting(GO:2000653)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 94 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 34.6 GO:0005791 rough endoplasmic reticulum(GO:0005791)
9.3 28.0 GO:0071953 elastic fiber(GO:0071953)
0.1 27.4 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
1.2 19.6 GO:0031045 dense core granule(GO:0031045)
0.1 19.5 GO:0001650 fibrillar center(GO:0001650)
0.0 16.6 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.2 15.7 GO:0072562 blood microparticle(GO:0072562)
0.6 15.2 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
1.1 14.1 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
4.6 13.9 GO:0030934 collagen type XII trimer(GO:0005595) anchoring collagen complex(GO:0030934)
0.1 11.0 GO:0043292 contractile fiber(GO:0043292)
2.6 10.5 GO:0043259 laminin-10 complex(GO:0043259)
0.1 10.5 GO:0005844 polysome(GO:0005844)
0.2 10.1 GO:0030667 secretory granule membrane(GO:0030667)
0.1 10.1 GO:0005902 microvillus(GO:0005902)
0.0 9.9 GO:0005730 nucleolus(GO:0005730)
0.7 9.3 GO:0032593 insulin-responsive compartment(GO:0032593)
0.1 9.0 GO:0016528 sarcoplasm(GO:0016528)
2.9 8.7 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
1.4 8.7 GO:0032299 ribonuclease H2 complex(GO:0032299)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 148 entries
Log-likelihood per target Total log-likelihoodTermDescription
10.4 41.6 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
2.6 28.4 GO:0008430 selenium binding(GO:0008430)
0.6 24.9 GO:0005504 fatty acid binding(GO:0005504)
4.7 18.8 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
1.4 18.1 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
3.2 16.1 GO:0005534 galactose binding(GO:0005534)
0.2 14.5 GO:0005080 protein kinase C binding(GO:0005080)
2.8 14.1 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
0.2 13.9 GO:0005178 integrin binding(GO:0005178)
0.5 13.8 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
2.2 13.1 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.8 13.0 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.5 12.5 GO:0030506 ankyrin binding(GO:0030506)
0.2 11.6 GO:0019003 GDP binding(GO:0019003)
0.5 11.5 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
1.1 11.4 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 11.4 GO:0005525 GTP binding(GO:0005525)
0.6 11.0 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.2 10.1 GO:0050840 extracellular matrix binding(GO:0050840)
0.1 9.6 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 30.7 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.6 21.3 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.2 20.7 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.3 19.3 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.4 18.4 NABA_COLLAGENS Genes encoding collagen proteins
0.1 16.5 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2 13.6 PID_AP1_PATHWAY AP-1 transcription factor network
0.6 13.4 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.3 11.1 PID_RAS_PATHWAY Regulation of Ras family activation
0.3 10.9 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
1.3 10.5 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.2 8.1 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.8 7.6 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.2 6.9 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.4 6.5 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.4 5.8 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.2 5.8 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.4 5.7 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.3 4.8 ST_STAT3_PATHWAY STAT3 Pathway
0.2 2.9 PID_S1P_S1P1_PATHWAY S1P1 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 71 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 22.3 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.3 21.7 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.9 20.0 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
1.0 13.4 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.4 13.1 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.8 12.8 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.5 12.5 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.5 9.1 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.2 8.6 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.3 7.6 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.3 7.4 REACTOME_ACTIVATION_OF_GENES_BY_ATF4 Genes involved in Activation of Genes by ATF4
0.2 6.4 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.2 6.0 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.1 5.8 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 5.6 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.6 5.0 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.3 5.0 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 4.9 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.4 4.8 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.6 4.7 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases