Motif ID: Nfil3_Tef

Z-value: 1.714

Transcription factors associated with Nfil3_Tef:

Gene SymbolEntrez IDGene Name
Nfil3 ENSMUSG00000056749.7 Nfil3
Tef ENSMUSG00000022389.8 Tef

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfil3mm10_v2_chr13_-_52981027_529810830.462.9e-05Click!
Tefmm10_v2_chr15_+_81811414_818114910.342.6e-03Click!


Activity profile for motif Nfil3_Tef.

activity profile for motif Nfil3_Tef


Sorted Z-values histogram for motif Nfil3_Tef

Sorted Z-values for motif Nfil3_Tef



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfil3_Tef

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_-_22439570 33.953 ENSMUST00000170393.1
 Etv5
ets variant gene 5
chrX_-_51681703 26.948 ENSMUST00000088172.5
 Hs6st2
heparan sulfate 6-O-sulfotransferase 2
chrX_-_51681856 26.798 ENSMUST00000114871.1
 Hs6st2
heparan sulfate 6-O-sulfotransferase 2
chr13_+_76579670 23.356 ENSMUST00000126960.1
ENSMUST00000109583.2
 Mctp1

multiple C2 domains, transmembrane 1

chr14_+_65971049 21.189 ENSMUST00000128539.1
 Clu
clusterin
chr14_+_65970804 20.768 ENSMUST00000138191.1
 Clu
clusterin
chr12_+_74288735 18.630 ENSMUST00000095617.1
 1700086L19Rik
RIKEN cDNA 1700086L19 gene
chr11_-_101785252 18.292 ENSMUST00000164750.1
ENSMUST00000107176.1
ENSMUST00000017868.6
 Etv4


ets variant gene 4 (E1A enhancer binding protein, E1AF)


chr1_-_91459254 18.114 ENSMUST00000069620.8
 Per2
period circadian clock 2
chr14_+_65970610 17.659 ENSMUST00000127387.1
 Clu
clusterin
chr9_-_40346290 17.059 ENSMUST00000121357.1
 Gramd1b
GRAM domain containing 1B
chr5_+_117841839 16.577 ENSMUST00000142742.2
 Nos1
nitric oxide synthase 1, neuronal
chr3_+_141465564 15.249 ENSMUST00000106236.2
ENSMUST00000075282.3
 Unc5c

unc-5 homolog C (C. elegans)

chr13_+_16011851 15.120 ENSMUST00000042603.6
 Inhba
inhibin beta-A
chr15_-_8710734 14.361 ENSMUST00000005493.7
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr9_-_21037775 14.280 ENSMUST00000180870.1
 Gm26592
predicted gene, 26592
chr7_-_103827922 13.882 ENSMUST00000023934.6
ENSMUST00000153218.1
 Hbb-bs

hemoglobin, beta adult s chain

chr2_-_25469742 13.579 ENSMUST00000114259.2
ENSMUST00000015234.6
 Ptgds

prostaglandin D2 synthase (brain)

chr14_+_65971164 13.445 ENSMUST00000144619.1
 Clu
clusterin
chr2_-_25470031 12.700 ENSMUST00000114251.1
 Ptgds
prostaglandin D2 synthase (brain)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 122 entries
Log-likelihood per target Total log-likelihoodTermDescription
12.2 73.1 GO:1902998 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
9.0 53.7 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
7.5 52.2 GO:0060762 regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
6.6 26.4 GO:0043490 malate-aspartate shuttle(GO:0043490)
5.3 26.3 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
3.3 22.8 GO:1902856 negative regulation of nonmotile primary cilium assembly(GO:1902856)
0.1 18.9 GO:0031032 actomyosin structure organization(GO:0031032)
2.7 18.8 GO:1990416 cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
6.0 18.1 GO:0031554 regulation of DNA-templated transcription, termination(GO:0031554)
1.8 17.8 GO:0061470 interleukin-21 production(GO:0032625) T follicular helper cell differentiation(GO:0061470) interleukin-21 secretion(GO:0072619)
5.5 16.6 GO:0099548 drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738) retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by nitric oxide(GO:0099548)
1.9 15.2 GO:0033564 anterior/posterior axon guidance(GO:0033564)
3.0 15.1 GO:0042636 negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279)
3.4 13.5 GO:1901475 pyruvate transmembrane transport(GO:1901475)
2.1 12.7 GO:0072318 clathrin coat disassembly(GO:0072318)
3.9 11.8 GO:0001543 ovarian follicle rupture(GO:0001543)
2.3 11.4 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
1.8 11.0 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.8 11.0 GO:0045161 neuronal ion channel clustering(GO:0045161)
0.1 11.0 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 112.6 GO:0016021 integral component of membrane(GO:0016021)
10.4 73.1 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.2 46.1 GO:0016323 basolateral plasma membrane(GO:0016323)
0.2 22.4 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.2 18.2 GO:0031225 anchored component of membrane(GO:0031225)
1.5 16.6 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
5.0 15.1 GO:0043512 inhibin A complex(GO:0043512)
0.2 14.4 GO:0005930 axoneme(GO:0005930)
0.0 14.0 GO:0005730 nucleolus(GO:0005730)
3.5 13.9 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.1 13.2 GO:0005769 early endosome(GO:0005769)
0.0 13.2 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.3 12.7 GO:0060076 postsynaptic density(GO:0014069) excitatory synapse(GO:0060076) postsynaptic specialization(GO:0099572)
0.3 12.0 GO:0035371 microtubule plus-end(GO:0035371)
0.1 11.8 GO:0000118 histone deacetylase complex(GO:0000118)
0.2 11.7 GO:0072562 blood microparticle(GO:0072562)
2.8 11.4 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.7 11.0 GO:0005614 interstitial matrix(GO:0005614)
0.6 11.0 GO:0044224 juxtaparanode region of axon(GO:0044224)
1.2 10.7 GO:0005883 neurofilament(GO:0005883)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 102 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.0 73.1 GO:0051787 misfolded protein binding(GO:0051787)
13.4 53.7 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.1 36.4 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.1 29.2 GO:0005509 calcium ion binding(GO:0005509)
6.6 26.3 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
3.5 20.9 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
6.2 18.5 GO:0004517 nitric-oxide synthase activity(GO:0004517)
1.1 18.1 GO:1990226 histone methyltransferase binding(GO:1990226)
2.5 15.2 GO:0005042 netrin receptor activity(GO:0005042)
2.5 15.1 GO:0070699 type II activin receptor binding(GO:0070699)
0.1 14.1 GO:0008017 microtubule binding(GO:0008017)
0.0 14.1 GO:0008289 lipid binding(GO:0008289)
3.5 13.9 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
0.1 13.6 GO:0017124 SH3 domain binding(GO:0017124)
3.4 13.5 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.7 13.0 GO:0005540 hyaluronic acid binding(GO:0005540)
0.4 11.8 GO:0046965 retinoid X receptor binding(GO:0046965)
2.3 11.4 GO:0050816 phosphothreonine binding(GO:0050816)
2.7 11.0 GO:0001851 complement component C3b binding(GO:0001851)
0.5 11.0 GO:0004385 guanylate kinase activity(GO:0004385)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 73.1 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
1.1 34.0 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.3 18.8 PID_RHOA_PATHWAY RhoA signaling pathway
0.3 18.3 PID_LKB1_PATHWAY LKB1 signaling events
1.0 18.1 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.4 17.9 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.4 15.2 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.4 15.1 PID_ALK1_PATHWAY ALK1 signaling events
0.4 14.5 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.3 11.8 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.4 11.4 PID_MYC_PATHWAY C-MYC pathway
0.4 10.5 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.3 10.4 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.1 8.4 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 5.0 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 3.8 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 2.8 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.3 2.1 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.1 2.0 PID_VEGFR1_PATHWAY VEGFR1 specific signals
0.1 2.0 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 73.4 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
1.4 53.7 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.4 25.0 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.9 18.8 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.7 18.5 REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.4 18.2 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.4 18.1 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.3 15.7 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
3.8 15.1 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.2 14.0 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.5 13.7 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.3 13.3 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
1.2 11.2 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
2.2 11.0 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.3 10.4 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.2 10.3 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
1.0 10.2 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.7 9.6 REACTOME_IRAK1_RECRUITS_IKK_COMPLEX Genes involved in IRAK1 recruits IKK complex
0.2 8.5 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.3 7.9 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB