Motif ID: Nfix

Z-value: 1.013


Transcription factors associated with Nfix:

Gene SymbolEntrez IDGene Name
Nfix ENSMUSG00000001911.10 Nfix

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfixmm10_v2_chr8_-_84800024_848002830.912.7e-30Click!


Activity profile for motif Nfix.

activity profile for motif Nfix


Sorted Z-values histogram for motif Nfix

Sorted Z-values for motif Nfix



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfix

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_141524379 24.601 ENSMUST00000032362.9
 Slco1c1
solute carrier organic anion transporter family, member 1c1
chr16_+_41532851 22.074 ENSMUST00000078873.4
 Lsamp
limbic system-associated membrane protein
chr7_-_103827922 19.114 ENSMUST00000023934.6
ENSMUST00000153218.1
 Hbb-bs

hemoglobin, beta adult s chain

chr13_+_16014457 18.017 ENSMUST00000164993.1
 Inhba
inhibin beta-A
chr1_-_56969864 16.213 ENSMUST00000177424.1
 Satb2
special AT-rich sequence binding protein 2
chr1_-_56969827 15.433 ENSMUST00000176759.1
 Satb2
special AT-rich sequence binding protein 2
chr4_+_48045144 15.070 ENSMUST00000030025.3
 Nr4a3
nuclear receptor subfamily 4, group A, member 3
chr7_-_97417730 12.789 ENSMUST00000043077.7
 Thrsp
thyroid hormone responsive
chr5_+_66745835 11.135 ENSMUST00000101164.4
ENSMUST00000118242.1
ENSMUST00000119854.1
ENSMUST00000117601.1
 Limch1



LIM and calponin homology domains 1



chr16_+_42907563 10.964 ENSMUST00000151244.1
ENSMUST00000114694.2
 Zbtb20

zinc finger and BTB domain containing 20

chr5_+_66968961 10.841 ENSMUST00000132991.1
 Limch1
LIM and calponin homology domains 1
chr10_+_57784859 10.504 ENSMUST00000020024.5
 Fabp7
fatty acid binding protein 7, brain
chr10_+_57784914 9.811 ENSMUST00000165013.1
 Fabp7
fatty acid binding protein 7, brain
chr11_-_102897123 7.914 ENSMUST00000067444.3
 Gfap
glial fibrillary acidic protein
chr9_+_89909775 7.864 ENSMUST00000034912.4
ENSMUST00000034909.4
 Rasgrf1

RAS protein-specific guanine nucleotide-releasing factor 1

chr7_+_130936172 7.726 ENSMUST00000006367.7
 Htra1
HtrA serine peptidase 1
chr6_-_126166726 7.042 ENSMUST00000112244.2
ENSMUST00000050484.7
 Ntf3

neurotrophin 3

chr4_-_46991842 6.973 ENSMUST00000107749.2
 Gabbr2
gamma-aminobutyric acid (GABA) B receptor, 2
chr7_+_120842824 6.330 ENSMUST00000047875.8
 Eef2k
eukaryotic elongation factor-2 kinase
chr9_-_103222063 6.330 ENSMUST00000170904.1
 Trf
transferrin

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 113 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.0 31.6 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.1 25.8 GO:0031032 actomyosin structure organization(GO:0031032)
2.2 24.6 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.8 22.1 GO:0035641 locomotory exploration behavior(GO:0035641)
1.1 20.3 GO:0060134 prepulse inhibition(GO:0060134)
3.6 18.0 GO:0042636 negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279)
0.4 15.2 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
5.0 15.1 GO:0038095 positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095)
1.0 12.8 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
1.8 12.5 GO:0010624 regulation of Schwann cell proliferation(GO:0010624)
0.3 12.2 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
0.4 12.1 GO:0010866 regulation of triglyceride biosynthetic process(GO:0010866)
1.7 10.5 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
1.2 8.5 GO:0019532 oxalate transport(GO:0019532)
0.5 7.9 GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)
1.3 7.7 GO:0060718 chorionic trophoblast cell differentiation(GO:0060718)
1.4 7.0 GO:0007403 glial cell fate determination(GO:0007403)
0.2 7.0 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.3 6.6 GO:0071378 growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378)
0.7 5.8 GO:0098707 ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 54 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 29.7 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 22.0 GO:0031226 intrinsic component of plasma membrane(GO:0031226)
0.2 21.7 GO:0031225 anchored component of membrane(GO:0031225)
4.8 19.1 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
6.0 18.0 GO:0043512 inhibin A complex(GO:0043512)
0.0 13.8 GO:0005911 cell-cell junction(GO:0005911)
0.5 12.8 GO:0000930 gamma-tubulin complex(GO:0000930)
3.1 12.5 GO:0097450 astrocyte end-foot(GO:0097450)
0.4 7.9 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 7.3 GO:0014069 postsynaptic density(GO:0014069)
1.4 7.0 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.1 6.7 GO:0005901 caveola(GO:0005901)
0.8 6.3 GO:0097433 dense body(GO:0097433)
0.0 5.7 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 4.8 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.0 4.5 GO:0016607 nuclear speck(GO:0016607)
0.2 4.4 GO:0031430 M band(GO:0031430)
0.0 4.2 GO:0030017 sarcomere(GO:0030017)
0.2 3.9 GO:0071565 nBAF complex(GO:0071565)
0.1 3.8 GO:0099738 cell cortex region(GO:0099738)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 86 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 27.5 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)
6.2 24.6 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.5 19.6 GO:0005504 fatty acid binding(GO:0005504)
4.8 19.1 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
2.9 17.5 GO:0070699 type II activin receptor binding(GO:0070699)
0.4 14.4 GO:0001223 transcription coactivator binding(GO:0001223)
0.2 13.3 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.3 12.8 GO:0043015 gamma-tubulin binding(GO:0043015)
4.1 12.2 GO:0004686 elongation factor-2 kinase activity(GO:0004686)
0.0 12.0 GO:0003779 actin binding(GO:0003779)
0.3 10.5 GO:0070412 R-SMAD binding(GO:0070412)
0.8 8.5 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.4 7.7 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.1 7.6 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
1.4 7.0 GO:0005166 neurotrophin p75 receptor binding(GO:0005166)
1.2 7.0 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
1.3 6.6 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.1 6.6 GO:0008565 protein transporter activity(GO:0008565)
0.9 6.3 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.0 6.3 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 19.7 PID_ALK1_PATHWAY ALK1 signaling events
0.4 13.5 ST_GA12_PATHWAY G alpha 12 Pathway
0.3 11.6 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.5 8.8 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.3 7.5 PID_S1P_META_PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.1 6.6 PID_IL2_1PATHWAY IL2-mediated signaling events
0.2 6.5 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor Necrosis Factor Pathway.
0.1 6.1 PID_RAS_PATHWAY Regulation of Ras family activation
0.1 4.3 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 3.3 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.1 3.0 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.3 2.7 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.1 1.9 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.1 1.7 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0 1.6 PID_INTEGRIN1_PATHWAY Beta1 integrin cell surface interactions
0.0 1.5 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 1.5 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 1.4 PID_PTP1B_PATHWAY Signaling events mediated by PTP1B
0.1 1.1 PID_ARF6_PATHWAY Arf6 signaling events
0.0 1.0 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.1 24.6 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions
4.5 18.0 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.2 15.2 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.3 12.8 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.3 11.8 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.7 10.8 REACTOME_MTORC1_MEDIATED_SIGNALLING Genes involved in mTORC1-mediated signalling
0.1 9.1 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.3 7.9 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.5 7.0 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.3 6.6 REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING Genes involved in Growth hormone receptor signaling
0.3 6.1 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.2 5.3 REACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.5 4.1 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 3.8 REACTOME_ADP_SIGNALLING_THROUGH_P2RY12 Genes involved in ADP signalling through P2Y purinoceptor 12
0.1 3.6 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.3 2.6 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.0 2.5 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.1 2.4 REACTOME_IL1_SIGNALING Genes involved in Interleukin-1 signaling
0.1 2.2 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.3 2.1 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases