Motif ID: Nfkb2

Z-value: 0.661


Transcription factors associated with Nfkb2:

Gene SymbolEntrez IDGene Name
Nfkb2 ENSMUSG00000025225.8 Nfkb2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfkb2mm10_v2_chr19_+_46305682_463057410.544.4e-07Click!


Activity profile for motif Nfkb2.

activity profile for motif Nfkb2


Sorted Z-values histogram for motif Nfkb2

Sorted Z-values for motif Nfkb2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfkb2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_74791516 13.776 ENSMUST00000006718.8
 Wnt10a
wingless related MMTV integration site 10a
chr2_+_172550991 12.237 ENSMUST00000170744.1
 Tfap2c
transcription factor AP-2, gamma
chr2_+_172550761 11.735 ENSMUST00000099058.3
 Tfap2c
transcription factor AP-2, gamma
chr19_+_7268296 8.520 ENSMUST00000066646.4
 Rcor2
REST corepressor 2
chr7_+_29289300 7.683 ENSMUST00000048187.4
 Ppp1r14a
protein phosphatase 1, regulatory (inhibitor) subunit 14A
chr14_-_118237016 6.787 ENSMUST00000170662.1
 Sox21
SRY-box containing gene 21
chr1_+_153740344 6.733 ENSMUST00000027748.7
 Rgs16
regulator of G-protein signaling 16
chr3_-_116424007 5.498 ENSMUST00000090464.4
 Cdc14a
CDC14 cell division cycle 14A
chr3_-_116423930 5.264 ENSMUST00000106491.2
 Cdc14a
CDC14 cell division cycle 14A
chr5_-_114690906 4.956 ENSMUST00000112212.1
ENSMUST00000112214.1
 Gltp

glycolipid transfer protein

chr1_-_5019342 3.588 ENSMUST00000002533.8
 Rgs20
regulator of G-protein signaling 20
chr17_+_35379608 3.333 ENSMUST00000081435.4
 H2-Q4
histocompatibility 2, Q region locus 4
chr11_+_101176041 3.285 ENSMUST00000103109.3
 Cntnap1
contactin associated protein-like 1
chr4_-_42168603 2.979 ENSMUST00000098121.3
 Gm13305
predicted gene 13305
chr11_+_70657687 2.936 ENSMUST00000134087.1
ENSMUST00000170716.1
 Eno3

enolase 3, beta muscle

chr19_+_46304709 2.850 ENSMUST00000073116.5
 Nfkb2
nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100
chr11_+_77686155 2.843 ENSMUST00000100802.4
ENSMUST00000181023.1
 Nufip2

nuclear fragile X mental retardation protein interacting protein 2

chr11_+_70657196 2.824 ENSMUST00000157027.1
ENSMUST00000072841.5
ENSMUST00000108548.1
ENSMUST00000126241.1
 Eno3



enolase 3, beta muscle



chr11_-_70656467 2.779 ENSMUST00000131642.1
 Gm12319
predicted gene 12319
chr3_+_89421619 2.652 ENSMUST00000094378.3
ENSMUST00000137793.1
 Shc1

src homology 2 domain-containing transforming protein C1

chr8_+_108714644 2.516 ENSMUST00000043896.8
 Zfhx3
zinc finger homeobox 3
chr11_-_70015346 2.230 ENSMUST00000018718.7
ENSMUST00000102574.3
 Acadvl

acyl-Coenzyme A dehydrogenase, very long chain

chr14_-_30607808 2.225 ENSMUST00000112207.1
ENSMUST00000112206.1
ENSMUST00000112202.1
ENSMUST00000112203.1
 Prkcd



protein kinase C, delta



chr11_-_54962903 2.166 ENSMUST00000108885.1
ENSMUST00000102730.2
ENSMUST00000018482.6
ENSMUST00000108886.1
ENSMUST00000102731.1
 Tnip1




TNFAIP3 interacting protein 1




chr2_-_37422869 2.157 ENSMUST00000112936.1
ENSMUST00000112934.1
 Rc3h2

ring finger and CCCH-type zinc finger domains 2

chr10_-_59221757 2.030 ENSMUST00000165971.1
 Sept10
septin 10
chr17_-_34287770 1.959 ENSMUST00000174751.1
ENSMUST00000040655.6
 H2-Aa

histocompatibility 2, class II antigen A, alpha

chrX_+_163909132 1.919 ENSMUST00000033734.7
ENSMUST00000112294.2
 Ap1s2

adaptor-related protein complex 1, sigma 2 subunit

chr8_+_79028317 1.902 ENSMUST00000087927.4
ENSMUST00000098614.2
 Zfp827

zinc finger protein 827

chr4_-_125127817 1.893 ENSMUST00000036188.7
 Zc3h12a
zinc finger CCCH type containing 12A
chr14_-_30626196 1.831 ENSMUST00000112210.3
ENSMUST00000112211.2
ENSMUST00000112208.1
 Prkcd


protein kinase C, delta


chr3_-_107760221 1.474 ENSMUST00000153114.1
ENSMUST00000118593.1
ENSMUST00000120243.1
 Csf1


colony stimulating factor 1 (macrophage)


chr5_+_135887988 1.416 ENSMUST00000111155.1
 Hspb1
heat shock protein 1
chr8_+_79028587 1.366 ENSMUST00000119254.1
 Zfp827
zinc finger protein 827
chr7_+_3290553 1.362 ENSMUST00000096744.5
 Myadm
myeloid-associated differentiation marker
chr4_+_100776664 1.337 ENSMUST00000030257.8
ENSMUST00000097955.2
 Cachd1

cache domain containing 1

chr1_-_63114516 1.305 ENSMUST00000097718.2
 Ino80d
INO80 complex subunit D
chr5_+_90759299 1.246 ENSMUST00000031318.4
 Cxcl5
chemokine (C-X-C motif) ligand 5
chr1_-_66817536 1.241 ENSMUST00000068168.3
ENSMUST00000113987.1
 Kansl1l

KAT8 regulatory NSL complex subunit 1-like

chr13_-_111490028 1.199 ENSMUST00000091236.4
 Gpbp1
GC-rich promoter binding protein 1
chr5_+_135887905 1.188 ENSMUST00000005077.6
 Hspb1
heat shock protein 1
chr13_-_111490111 1.185 ENSMUST00000047627.7
 Gpbp1
GC-rich promoter binding protein 1
chr18_-_77565050 1.107 ENSMUST00000182153.1
ENSMUST00000182146.1
ENSMUST00000026494.7
ENSMUST00000182024.1
 Rnf165



ring finger protein 165



chr11_-_68386821 1.080 ENSMUST00000021284.3
 Ntn1
netrin 1
chr16_+_32914094 1.064 ENSMUST00000023491.6
ENSMUST00000170899.1
ENSMUST00000171118.1
ENSMUST00000170201.1
ENSMUST00000165616.1
ENSMUST00000135193.2
 Lrch3





leucine-rich repeats and calponin homology (CH) domain containing 3





chr1_+_135133272 0.956 ENSMUST00000167080.1
 Ptpn7
protein tyrosine phosphatase, non-receptor type 7
chr17_+_35866606 0.942 ENSMUST00000113814.4
 Ppp1r18
protein phosphatase 1, regulatory subunit 18
chr1_+_135132693 0.854 ENSMUST00000049449.4
 Ptpn7
protein tyrosine phosphatase, non-receptor type 7
chr1_-_63114255 0.756 ENSMUST00000153992.1
ENSMUST00000165066.1
ENSMUST00000172416.1
ENSMUST00000137511.1
 Ino80d



INO80 complex subunit D



chr17_+_35866056 0.746 ENSMUST00000122899.1
 Ppp1r18
protein phosphatase 1, regulatory subunit 18
chr19_+_45015198 0.683 ENSMUST00000179108.1
 Lzts2
leucine zipper, putative tumor suppressor 2
chr2_+_102550012 0.607 ENSMUST00000028612.7
 Pamr1
peptidase domain containing associated with muscle regeneration 1
chr1_-_156718989 0.604 ENSMUST00000122424.1
 Fam20b
family with sequence similarity 20, member B
chr11_-_84870812 0.592 ENSMUST00000168434.1
 Ggnbp2
gametogenetin binding protein 2
chr17_+_35424842 0.553 ENSMUST00000174699.1
 H2-Q6
histocompatibility 2, Q region locus 6
chrX_-_7671341 0.546 ENSMUST00000033486.5
 Plp2
proteolipid protein 2
chr11_-_84870646 0.477 ENSMUST00000018547.2
 Ggnbp2
gametogenetin binding protein 2
chr11_-_84870188 0.428 ENSMUST00000154915.2
 Ggnbp2
gametogenetin binding protein 2
chr10_-_89686250 0.420 ENSMUST00000092227.5
ENSMUST00000174252.1
 Scyl2

SCY1-like 2 (S. cerevisiae)

chr10_+_127421208 0.404 ENSMUST00000168780.1
 R3hdm2
R3H domain containing 2
chr1_-_156718894 0.383 ENSMUST00000086153.6
 Fam20b
family with sequence similarity 20, member B
chr17_+_34898931 0.310 ENSMUST00000097342.3
ENSMUST00000013931.5
 Ehmt2

euchromatic histone lysine N-methyltransferase 2

chr11_-_84870712 0.214 ENSMUST00000170741.1
ENSMUST00000172405.1
ENSMUST00000100686.3
ENSMUST00000108081.2
 Ggnbp2



gametogenetin binding protein 2



chr7_-_34654342 0.168 ENSMUST00000108069.1
 Kctd15
potassium channel tetramerisation domain containing 15
chr17_+_35262730 0.015 ENSMUST00000172785.1
 H2-D1
histocompatibility 2, D region locus 1
chr11_-_68386974 0.007 ENSMUST00000135141.1
 Ntn1
netrin 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
8.0 24.0 GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598)
1.4 15.3 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
1.1 10.8 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.8 2.5 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.8 3.3 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.8 4.1 GO:0006680 glucosylceramide catabolic process(GO:0006680)
0.6 1.9 GO:0050713 negative regulation of interleukin-1 beta secretion(GO:0050713) negative regulation of interferon-gamma secretion(GO:1902714) response to chemokine(GO:1990868) cellular response to chemokine(GO:1990869)
0.5 2.7 GO:1990839 response to endothelin(GO:1990839)
0.4 2.6 GO:0042535 positive regulation of tumor necrosis factor biosynthetic process(GO:0042535)
0.4 1.2 GO:0070944 neutrophil mediated killing of bacterium(GO:0070944)
0.3 1.7 GO:0033140 negative regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033140)
0.3 2.2 GO:1903003 positive regulation of protein deubiquitination(GO:1903003)
0.3 1.4 GO:0090038 negative regulation of protein kinase C signaling(GO:0090038)
0.2 2.2 GO:0042760 very long-chain fatty acid catabolic process(GO:0042760)
0.2 2.2 GO:0061470 T follicular helper cell differentiation(GO:0061470)
0.2 2.9 GO:0002467 germinal center formation(GO:0002467)
0.2 2.0 GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
0.1 1.1 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.1 8.0 GO:0035690 cellular response to drug(GO:0035690)
0.1 3.9 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.1 0.4 GO:2000286 receptor internalization involved in canonical Wnt signaling pathway(GO:2000286)
0.1 5.8 GO:0006096 glycolytic process(GO:0006096) ATP generation from ADP(GO:0006757)
0.1 6.8 GO:0001942 hair follicle development(GO:0001942)
0.0 1.1 GO:0060384 innervation(GO:0060384)
0.0 1.9 GO:0060612 adipose tissue development(GO:0060612)
0.0 6.7 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.0 5.0 GO:0006869 lipid transport(GO:0006869)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 5.8 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.5 1.5 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.4 2.6 GO:0097512 cardiac myofibril(GO:0097512)
0.3 3.9 GO:0042612 MHC class I protein complex(GO:0042612)
0.3 1.9 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.3 2.0 GO:0042613 MHC class II protein complex(GO:0042613)
0.2 1.6 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.2 2.8 GO:0042788 polysomal ribosome(GO:0042788)
0.1 3.3 GO:0033270 paranode region of axon(GO:0033270)
0.1 10.8 GO:0000922 spindle pole(GO:0000922)
0.1 8.5 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 14.9 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 2.2 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 3.6 GO:0016363 nuclear matrix(GO:0016363)
0.0 8.1 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 1.9 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 2.7 GO:0010008 endosome membrane(GO:0010008)
0.0 3.6 GO:0005802 trans-Golgi network(GO:0005802)
0.0 1.2 GO:0000123 histone acetyltransferase complex(GO:0000123)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 4.1 GO:0070976 calcium-independent protein kinase C activity(GO:0004699) TIR domain binding(GO:0070976)
0.7 2.2 GO:0017099 very-long-chain-acyl-CoA dehydrogenase activity(GO:0017099)
0.7 2.7 GO:0048408 epidermal growth factor binding(GO:0048408)
0.6 5.8 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.3 13.8 GO:0005109 frizzled binding(GO:0005109)
0.3 3.9 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.3 5.0 GO:0051861 glycolipid binding(GO:0051861)
0.2 24.0 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.2 10.8 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.2 7.7 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.1 1.9 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.1 2.0 GO:0042605 peptide antigen binding(GO:0042605)
0.1 2.6 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 0.5 GO:0019956 chemokine binding(GO:0019956)
0.0 0.3 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.0 2.2 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.0 8.5 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 2.5 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.0 10.3 GO:0005096 GTPase activator activity(GO:0005096)
0.0 8.4 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 1.8 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 3.3 GO:0017124 SH3 domain binding(GO:0017124)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 23.8 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.2 1.8 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.1 1.5 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 13.8 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.1 7.7 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.1 6.2 ST_G_ALPHA_I_PATHWAY G alpha i Pathway
0.1 2.9 ST_GAQ_PATHWAY G alpha q Pathway
0.1 2.6 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 2.2 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.1 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 2.5 PID_CMYB_PATHWAY C-MYB transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 10.8 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.2 7.6 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events
0.1 12.3 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 5.8 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 1.9 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 2.2 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.1 2.9 REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_DAI Genes involved in RIP-mediated NFkB activation via DAI
0.1 2.7 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.1 1.1 REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 2.5 REACTOME_DESTABILIZATION_OF_MRNA_BY_AUF1_HNRNP_D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.0 3.3 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions