Motif ID: Nhlh1

Z-value: 1.113


Transcription factors associated with Nhlh1:

Gene SymbolEntrez IDGene Name
Nhlh1 ENSMUSG00000051251.3 Nhlh1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nhlh1mm10_v2_chr1_-_172057573_1720575980.216.4e-02Click!


Activity profile for motif Nhlh1.

activity profile for motif Nhlh1


Sorted Z-values histogram for motif Nhlh1

Sorted Z-values for motif Nhlh1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nhlh1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_+_56887795 6.955 ENSMUST00000022511.8
 Zmym2
zinc finger, MYM-type 2
chrX_+_35888808 6.846 ENSMUST00000033419.6
 Dock11
dedicator of cytokinesis 11
chr6_-_56362356 6.577 ENSMUST00000044505.7
ENSMUST00000166102.1
ENSMUST00000164037.1
ENSMUST00000114327.2
 Pde1c



phosphodiesterase 1C



chr13_-_111808938 6.212 ENSMUST00000109267.2
 Map3k1
mitogen-activated protein kinase kinase kinase 1
chr7_-_28302238 6.208 ENSMUST00000108315.3
 Dll3
delta-like 3 (Drosophila)
chr2_+_158375638 6.140 ENSMUST00000109488.1
 Snhg11
small nucleolar RNA host gene 11
chr1_-_52500679 5.786 ENSMUST00000069792.7
 Nab1
Ngfi-A binding protein 1
chr9_+_83834684 5.685 ENSMUST00000070326.7
 Ttk
Ttk protein kinase
chr5_+_139543889 5.125 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr2_+_102658640 4.740 ENSMUST00000080210.3
 Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr8_+_105518736 4.652 ENSMUST00000034363.5
 Hsd11b2
hydroxysteroid 11-beta dehydrogenase 2
chr7_+_122289297 4.520 ENSMUST00000064989.5
ENSMUST00000064921.4
 Prkcb

protein kinase C, beta

chr7_+_62376979 4.396 ENSMUST00000080403.5
 Magel2
melanoma antigen, family L, 2
chr1_-_84696182 4.283 ENSMUST00000049126.6
 Dner
delta/notch-like EGF-related receptor
chr14_+_34673888 4.023 ENSMUST00000048263.7
 Wapal
wings apart-like homolog (Drosophila)
chr6_+_14901344 3.991 ENSMUST00000115477.1
 Foxp2
forkhead box P2
chr4_+_95967205 3.948 ENSMUST00000030306.7
 Hook1
hook homolog 1 (Drosophila)
chr8_+_45658273 3.942 ENSMUST00000153798.1
 Sorbs2
sorbin and SH3 domain containing 2
chr4_+_45184815 3.901 ENSMUST00000134280.1
ENSMUST00000044773.5
 Frmpd1

FERM and PDZ domain containing 1

chr9_-_57836706 3.849 ENSMUST00000164010.1
ENSMUST00000171444.1
ENSMUST00000098686.3
 Arid3b


AT rich interactive domain 3B (BRIGHT-like)



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 440 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 12.6 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.2 8.9 GO:0045022 early endosome to late endosome transport(GO:0045022)
0.3 8.3 GO:0007608 sensory perception of smell(GO:0007608)
0.1 8.3 GO:0050821 protein stabilization(GO:0050821)
0.9 7.4 GO:0016321 female meiosis chromosome segregation(GO:0016321)
0.8 7.4 GO:0002315 marginal zone B cell differentiation(GO:0002315)
1.4 7.1 GO:0007386 compartment pattern specification(GO:0007386)
1.0 6.9 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
0.6 6.7 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.3 6.5 GO:0010763 positive regulation of fibroblast migration(GO:0010763)
0.7 6.0 GO:0098712 L-glutamate import across plasma membrane(GO:0098712)
1.9 5.7 GO:0003349 epicardium-derived cardiac endothelial cell differentiation(GO:0003349)
0.6 5.4 GO:0044336 canonical Wnt signaling pathway involved in negative regulation of apoptotic process(GO:0044336)
0.2 5.4 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
1.7 5.2 GO:0021698 cerebellar cortex structural organization(GO:0021698)
0.6 5.1 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.4 5.0 GO:0060052 neurofilament cytoskeleton organization(GO:0060052)
0.4 5.0 GO:0051127 positive regulation of actin nucleation(GO:0051127)
0.4 4.6 GO:0060136 embryonic process involved in female pregnancy(GO:0060136)
0.2 4.6 GO:0061029 eyelid development in camera-type eye(GO:0061029)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 169 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 15.5 GO:0016605 PML body(GO:0016605)
0.0 12.1 GO:0005813 centrosome(GO:0005813)
0.0 10.6 GO:0005730 nucleolus(GO:0005730)
0.2 9.2 GO:0031941 filamentous actin(GO:0031941)
0.1 7.6 GO:0005871 kinesin complex(GO:0005871)
0.1 7.3 GO:0000776 kinetochore(GO:0000776)
0.1 7.0 GO:0005923 bicellular tight junction(GO:0005923)
1.4 6.9 GO:0032133 interphase microtubule organizing center(GO:0031021) chromosome passenger complex(GO:0032133)
0.9 6.5 GO:0070695 FHF complex(GO:0070695)
0.2 6.5 GO:0030904 retromer complex(GO:0030904)
0.2 6.0 GO:0030673 axolemma(GO:0030673)
0.6 5.9 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.0 5.5 GO:0032993 protein-DNA complex(GO:0032993)
0.4 4.8 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 4.6 GO:0090544 BAF-type complex(GO:0090544)
0.5 4.5 GO:0005883 neurofilament(GO:0005883)
0.1 4.3 GO:0005902 microvillus(GO:0005902)
0.1 4.3 GO:0005814 centriole(GO:0005814)
1.0 4.1 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.3 4.1 GO:0005862 muscle thin filament tropomyosin(GO:0005862)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 260 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 18.6 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.5 16.2 GO:0005112 Notch binding(GO:0005112)
0.1 10.8 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 10.4 GO:0003774 motor activity(GO:0003774)
0.2 10.1 GO:0008536 Ran GTPase binding(GO:0008536)
0.2 9.5 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.2 9.2 GO:0070888 E-box binding(GO:0070888)
0.1 8.4 GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982)
0.3 8.2 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.4 7.8 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.3 6.5 GO:0070410 co-SMAD binding(GO:0070410)
0.2 6.5 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.1 6.5 GO:0001047 core promoter binding(GO:0001047)
0.2 6.4 GO:0005109 frizzled binding(GO:0005109)
1.6 6.2 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
1.1 5.7 GO:0043515 kinetochore binding(GO:0043515)
0.0 5.0 GO:0003714 transcription corepressor activity(GO:0003714)
0.1 4.9 GO:1990841 promoter-specific chromatin binding(GO:1990841)
1.0 4.8 GO:0042289 MHC class II protein binding(GO:0042289)
0.1 4.8 GO:0003730 mRNA 3'-UTR binding(GO:0003730)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 16.9 PID_AURORA_B_PATHWAY Aurora B signaling
0.2 16.9 PID_NOTCH_PATHWAY Notch signaling pathway
0.3 12.4 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.2 11.1 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.8 10.7 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.1 5.0 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 4.4 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 4.2 NABA_COLLAGENS Genes encoding collagen proteins
0.1 3.8 PID_BARD1_PATHWAY BARD1 signaling events
0.1 3.5 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 3.5 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.1 3.3 PID_ERBB4_PATHWAY ErbB4 signaling events
0.1 3.2 PID_E2F_PATHWAY E2F transcription factor network
0.2 3.1 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.3 3.0 PID_ALK2_PATHWAY ALK2 signaling events
0.1 2.7 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 2.5 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.1 2.3 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 2.2 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.5 2.1 PID_ALK1_PATHWAY ALK1 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 99 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 17.6 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.2 8.3 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS Genes involved in Trafficking of AMPA receptors
0.2 8.2 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.2 7.3 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.2 7.1 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 6.7 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 5.8 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.2 5.0 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.2 5.0 REACTOME_KINESINS Genes involved in Kinesins
0.2 4.8 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.2 4.3 REACTOME_TRAF6_MEDIATED_NFKB_ACTIVATION Genes involved in TRAF6 mediated NF-kB activation
0.3 4.2 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.0 4.2 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 4.0 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.1 3.8 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 3.7 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 3.6 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1 3.6 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.2 3.5 REACTOME_INCRETIN_SYNTHESIS_SECRETION_AND_INACTIVATION Genes involved in Incretin Synthesis, Secretion, and Inactivation
0.1 3.2 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1