Motif ID: Nkx1-1_Nkx1-2

Z-value: 0.649

Transcription factors associated with Nkx1-1_Nkx1-2:

Gene SymbolEntrez IDGene Name
Nkx1-1 ENSMUSG00000029112.5 Nkx1-1
Nkx1-2 ENSMUSG00000048528.7 Nkx1-2



Activity profile for motif Nkx1-1_Nkx1-2.

activity profile for motif Nkx1-1_Nkx1-2


Sorted Z-values histogram for motif Nkx1-1_Nkx1-2

Sorted Z-values for motif Nkx1-1_Nkx1-2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx1-1_Nkx1-2

PNG image of the network

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Top targets:


Showing 1 to 20 of 97 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_55782500 15.513 ENSMUST00000075422.4
 Mab21l1
mab-21-like 1 (C. elegans)
chr6_-_23248264 6.668 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr4_-_141599835 5.360 ENSMUST00000141518.1
ENSMUST00000127455.1
ENSMUST00000105784.1
ENSMUST00000147785.1
 Fblim1



filamin binding LIM protein 1



chr13_-_102906046 5.319 ENSMUST00000171791.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr4_-_14621805 4.621 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7
chr12_-_40037387 4.620 ENSMUST00000146905.1
 Arl4a
ADP-ribosylation factor-like 4A
chr13_-_102905740 4.161 ENSMUST00000167462.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr5_+_140607334 4.044 ENSMUST00000031555.1
 Lfng
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr16_+_52031549 3.911 ENSMUST00000114471.1
 Cblb
Casitas B-lineage lymphoma b
chr4_-_14621669 3.318 ENSMUST00000143105.1
 Slc26a7
solute carrier family 26, member 7
chr4_-_14621494 3.119 ENSMUST00000149633.1
 Slc26a7
solute carrier family 26, member 7
chr7_-_143460989 2.883 ENSMUST00000167912.1
ENSMUST00000037287.6
 Cdkn1c

cyclin-dependent kinase inhibitor 1C (P57)

chr11_+_43682038 2.693 ENSMUST00000094294.4
 Pwwp2a
PWWP domain containing 2A
chr14_-_5863663 2.475 ENSMUST00000178594.1
 Gm8237
predicted gene 8237
chrX_-_60893430 2.393 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3
chr19_+_5490475 2.163 ENSMUST00000116560.2
 Cfl1
cofilin 1, non-muscle
chr11_+_43681998 2.035 ENSMUST00000061070.5
 Pwwp2a
PWWP domain containing 2A
chr4_+_102570065 2.007 ENSMUST00000097950.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr3_-_89101907 1.920 ENSMUST00000081848.8
 Fdps
farnesyl diphosphate synthetase
chr3_+_121953213 1.784 ENSMUST00000037958.7
ENSMUST00000128366.1
 Arhgap29

Rho GTPase activating protein 29


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 15.5 GO:0043010 camera-type eye development(GO:0043010)
1.6 11.1 GO:0019532 oxalate transport(GO:0019532)
0.0 6.9 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
1.1 6.7 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.4 5.4 GO:0033623 regulation of integrin activation(GO:0033623)
0.1 4.6 GO:0050873 brown fat cell differentiation(GO:0050873)
0.8 4.0 GO:0007386 compartment pattern specification(GO:0007386)
1.3 3.9 GO:0002669 positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
0.4 2.9 GO:1902746 regulation of lens fiber cell differentiation(GO:1902746)
0.1 2.4 GO:0007530 sex determination(GO:0007530)
0.7 2.2 GO:2000812 unidimensional cell growth(GO:0009826) establishment or maintenance of cell polarity regulating cell shape(GO:0071963) regulation of barbed-end actin filament capping(GO:2000812)
0.2 2.0 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.2 1.9 GO:0016114 terpenoid biosynthetic process(GO:0016114)
0.2 1.8 GO:0042989 sequestering of actin monomers(GO:0042989)
0.3 1.6 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.1 1.3 GO:0006107 oxaloacetate metabolic process(GO:0006107)
0.4 1.2 GO:1900126 negative regulation of hyaluronan biosynthetic process(GO:1900126)
0.4 1.2 GO:0006011 UDP-glucose metabolic process(GO:0006011) glucose 1-phosphate metabolic process(GO:0019255)
0.1 1.2 GO:1903504 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.1 1.2 GO:0048240 sperm capacitation(GO:0048240)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 11.9 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 4.5 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 4.0 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 3.9 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 3.2 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 2.2 GO:0030175 filopodium(GO:0030175)
0.0 2.0 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.3 1.6 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.1 1.6 GO:0005685 U1 snRNP(GO:0005685)
0.1 1.2 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 1.2 GO:0045277 respiratory chain complex IV(GO:0045277)
0.1 1.2 GO:0032433 filopodium tip(GO:0032433)
0.0 1.2 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 1.1 GO:0043034 costamere(GO:0043034)
0.1 1.0 GO:0005638 lamin filament(GO:0005638)
0.1 1.0 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.1 1.0 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 1.0 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 0.9 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.9 GO:0005902 microvillus(GO:0005902)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 15.5 GO:0016779 nucleotidyltransferase activity(GO:0016779)
1.0 11.1 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.0 6.9 GO:0000287 magnesium ion binding(GO:0000287)
0.4 5.4 GO:0031005 filamin binding(GO:0031005)
0.0 4.6 GO:0003924 GTPase activity(GO:0003924)
1.3 4.0 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.1 3.9 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 3.2 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.2 2.9 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 2.4 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 2.2 GO:1902936 phosphatidylinositol bisphosphate binding(GO:1902936)
0.1 2.0 GO:0019103 pyrimidine nucleotide binding(GO:0019103)
0.1 2.0 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.3 1.9 GO:0004311 farnesyltranstransferase activity(GO:0004311)
0.1 1.8 GO:0003785 actin monomer binding(GO:0003785)
0.0 1.8 GO:0030165 PDZ domain binding(GO:0030165)
0.0 1.7 GO:0002039 p53 binding(GO:0002039)
0.3 1.6 GO:0035614 snRNA stem-loop binding(GO:0035614)
0.2 1.3 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0 1.2 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)

Gene overrepresentation in C2:CP category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.9 PID_CD40_PATHWAY CD40/CD40L signaling
0.2 2.2 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 1.6 PID_PTP1B_PATHWAY Signaling events mediated by PTP1B
0.0 1.2 PID_ARF_3PATHWAY Arf1 pathway
0.0 1.1 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 0.9 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 0.9 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.0 0.4 ST_INTERFERON_GAMMA_PATHWAY Interferon gamma pathway.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.7 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.2 5.4 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.2 4.0 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 3.9 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 3.9 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.1 3.3 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 2.2 REACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.1 1.9 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 1.8 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 1.3 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.1 1.2 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.1 1.2 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 1.2 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.0 1.0 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.1 0.8 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.1 0.7 REACTOME_PD1_SIGNALING Genes involved in PD-1 signaling
0.0 0.7 REACTOME_DESTABILIZATION_OF_MRNA_BY_KSRP Genes involved in Destabilization of mRNA by KSRP
0.0 0.6 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.0 0.5 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein