Motif ID: Nkx1-1_Nkx1-2

Z-value: 0.649

Transcription factors associated with Nkx1-1_Nkx1-2:

Gene SymbolEntrez IDGene Name
Nkx1-1 ENSMUSG00000029112.5 Nkx1-1
Nkx1-2 ENSMUSG00000048528.7 Nkx1-2






Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx1-1_Nkx1-2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_+_55782500 15.513 ENSMUST00000075422.4
Mab21l1
mab-21-like 1 (C. elegans)
chr6_-_23248264 6.668 ENSMUST00000031709.5
Fezf1
Fez family zinc finger 1
chr4_-_141599835 5.360 ENSMUST00000141518.1
ENSMUST00000127455.1
ENSMUST00000105784.1
ENSMUST00000147785.1
Fblim1



filamin binding LIM protein 1



chr13_-_102906046 5.319 ENSMUST00000171791.1
Mast4
microtubule associated serine/threonine kinase family member 4
chr4_-_14621805 4.621 ENSMUST00000042221.7
Slc26a7
solute carrier family 26, member 7
chr12_-_40037387 4.620 ENSMUST00000146905.1
Arl4a
ADP-ribosylation factor-like 4A
chr13_-_102905740 4.161 ENSMUST00000167462.1
Mast4
microtubule associated serine/threonine kinase family member 4
chr5_+_140607334 4.044 ENSMUST00000031555.1
Lfng
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr16_+_52031549 3.911 ENSMUST00000114471.1
Cblb
Casitas B-lineage lymphoma b
chr4_-_14621669 3.318 ENSMUST00000143105.1
Slc26a7
solute carrier family 26, member 7
chr4_-_14621494 3.119 ENSMUST00000149633.1
Slc26a7
solute carrier family 26, member 7
chr7_-_143460989 2.883 ENSMUST00000167912.1
ENSMUST00000037287.6
Cdkn1c

cyclin-dependent kinase inhibitor 1C (P57)

chr11_+_43682038 2.693 ENSMUST00000094294.4
Pwwp2a
PWWP domain containing 2A
chr14_-_5863663 2.475 ENSMUST00000178594.1
Gm8237
predicted gene 8237
chrX_-_60893430 2.393 ENSMUST00000135107.2
Sox3
SRY-box containing gene 3
chr19_+_5490475 2.163 ENSMUST00000116560.2
Cfl1
cofilin 1, non-muscle
chr11_+_43681998 2.035 ENSMUST00000061070.5
Pwwp2a
PWWP domain containing 2A
chr4_+_102570065 2.007 ENSMUST00000097950.2
Pde4b
phosphodiesterase 4B, cAMP specific
chr3_-_89101907 1.920 ENSMUST00000081848.8
Fdps
farnesyl diphosphate synthetase
chr3_+_121953213 1.784 ENSMUST00000037958.7
ENSMUST00000128366.1
Arhgap29

Rho GTPase activating protein 29

chr7_-_27195727 1.631 ENSMUST00000163311.2
ENSMUST00000126211.1
Snrpa

small nuclear ribonucleoprotein polypeptide A

chr5_+_37185897 1.601 ENSMUST00000094840.3
Gm1043
predicted gene 1043
chr4_-_119294520 1.586 ENSMUST00000079644.6
Ybx1
Y box protein 1
chr17_-_63863791 1.425 ENSMUST00000050753.3
A930002H24Rik
RIKEN cDNA A930002H24 gene
chr10_+_128337761 1.308 ENSMUST00000005826.7
Cs
citrate synthase
chr14_-_6266620 1.267 ENSMUST00000096172.5
Gm3411
predicted gene 3411
chrX_+_106015699 1.235 ENSMUST00000033582.4
Cox7b
cytochrome c oxidase subunit VIIb
chr14_+_4198185 1.230 ENSMUST00000180184.1
Gm2974
predicted gene 2974
chr18_+_12741324 1.227 ENSMUST00000115857.2
ENSMUST00000121018.1
ENSMUST00000119108.1
Cabyr


calcium-binding tyrosine-(Y)-phosphorylation regulated (fibrousheathin 2)


chr7_-_44929410 1.218 ENSMUST00000107857.3
ENSMUST00000085399.6
ENSMUST00000167930.1
ENSMUST00000166972.1
Ap2a1



adaptor-related protein complex 2, alpha 1 subunit



chr11_-_21371143 1.207 ENSMUST00000060895.5
Ugp2
UDP-glucose pyrophosphorylase 2
chr2_-_69712461 1.143 ENSMUST00000102706.3
ENSMUST00000073152.6
Fastkd1

FAST kinase domains 1

chr10_+_94575257 1.120 ENSMUST00000121471.1
Tmcc3
transmembrane and coiled coil domains 3
chr18_+_4993795 1.074 ENSMUST00000153016.1
Svil
supervillin
chr17_-_57031468 1.025 ENSMUST00000007814.8
Khsrp
KH-type splicing regulatory protein
chr5_-_143909782 0.987 ENSMUST00000031613.4
ENSMUST00000100483.2
Aimp2

aminoacyl tRNA synthetase complex-interacting multifunctional protein 2

chr12_+_4769375 0.976 ENSMUST00000178879.1
Pfn4
profilin family, member 4
chr11_+_87109221 0.968 ENSMUST00000020794.5
Ska2
spindle and kinetochore associated complex subunit 2
chr11_+_121237216 0.959 ENSMUST00000103015.3
Narf
nuclear prelamin A recognition factor
chr1_+_174501796 0.944 ENSMUST00000030039.7
Fmn2
formin 2
chr19_+_41933464 0.939 ENSMUST00000026154.7
Zdhhc16
zinc finger, DHHC domain containing 16
chr5_-_118244861 0.898 ENSMUST00000117177.1
ENSMUST00000133372.1
ENSMUST00000154786.1
ENSMUST00000121369.1
Rnft2



ring finger protein, transmembrane 2



chr8_+_83972951 0.890 ENSMUST00000005606.6
Prkaca
protein kinase, cAMP dependent, catalytic, alpha
chr9_-_55919605 0.881 ENSMUST00000037408.8
Scaper
S phase cyclin A-associated protein in the ER
chr12_+_4769278 0.862 ENSMUST00000020967.4
Pfn4
profilin family, member 4
chr7_-_100964371 0.842 ENSMUST00000060174.4
P2ry6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr3_-_90389884 0.803 ENSMUST00000029541.5
Slc27a3
solute carrier family 27 (fatty acid transporter), member 3
chr19_+_29367447 0.684 ENSMUST00000016640.7
Cd274
CD274 antigen
chr14_-_52104015 0.671 ENSMUST00000111610.4
ENSMUST00000164655.1
Hnrnpc

heterogeneous nuclear ribonucleoprotein C

chr7_+_101896817 0.645 ENSMUST00000143835.1
Anapc15
anaphase prompoting complex C subunit 15
chr8_+_113635550 0.626 ENSMUST00000179926.1
Mon1b
MON1 homolog b (yeast)
chr8_-_86580664 0.613 ENSMUST00000131423.1
ENSMUST00000152438.1
Abcc12

ATP-binding cassette, sub-family C (CFTR/MRP), member 12

chr15_+_81663889 0.575 ENSMUST00000023029.8
ENSMUST00000174229.1
ENSMUST00000172748.1
L3mbtl2


l(3)mbt-like 2 (Drosophila)


chr5_+_9100681 0.573 ENSMUST00000115365.1
Tmem243
transmembrane protein 243, mitochondrial
chr16_-_16359016 0.567 ENSMUST00000023477.7
ENSMUST00000096229.3
ENSMUST00000115749.1
Dnm1l


dynamin 1-like


chr7_+_101896340 0.551 ENSMUST00000035395.7
ENSMUST00000106973.1
ENSMUST00000144207.1
Anapc15


anaphase prompoting complex C subunit 15


chr8_-_3694167 0.530 ENSMUST00000005678.4
Fcer2a
Fc receptor, IgE, low affinity II, alpha polypeptide
chr5_-_34660068 0.507 ENSMUST00000041364.9
Nop14
NOP14 nucleolar protein
chr4_-_140774196 0.462 ENSMUST00000026381.6
Padi4
peptidyl arginine deiminase, type IV
chr8_+_113635787 0.456 ENSMUST00000035777.8
Mon1b
MON1 homolog b (yeast)
chr8_+_33599608 0.452 ENSMUST00000009774.9
Ppp2cb
protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform
chr18_+_24603952 0.431 ENSMUST00000025120.6
Elp2
elongator acetyltransferase complex subunit 2
chr9_-_107872403 0.409 ENSMUST00000183035.1
Rbm6
RNA binding motif protein 6
chr11_+_21572221 0.384 ENSMUST00000020568.3
ENSMUST00000131135.1
Wdpcp

WD repeat containing planar cell polarity effector

chr2_-_102400257 0.378 ENSMUST00000152929.1
Trim44
tripartite motif-containing 44
chr6_-_124779686 0.376 ENSMUST00000147669.1
ENSMUST00000128697.1
ENSMUST00000032218.3
ENSMUST00000112475.2
Lrrc23



leucine rich repeat containing 23



chr12_+_52699297 0.372 ENSMUST00000095737.3
Akap6
A kinase (PRKA) anchor protein 6
chr18_-_24603791 0.368 ENSMUST00000070726.3
Slc39a6
solute carrier family 39 (metal ion transporter), member 6
chr9_-_20959785 0.354 ENSMUST00000177754.1
Dnmt1
DNA methyltransferase (cytosine-5) 1
chr5_+_143909964 0.349 ENSMUST00000148011.1
ENSMUST00000110709.3
Pms2

postmeiotic segregation increased 2 (S. cerevisiae)

chr2_+_151494182 0.321 ENSMUST00000089140.6
Nsfl1c
NSFL1 (p97) cofactor (p47)
chr10_+_88146992 0.309 ENSMUST00000052355.7
Nup37
nucleoporin 37
chr6_+_68161415 0.306 ENSMUST00000168090.1
Igkv1-115
immunoglobulin kappa variable 1-115
chr12_+_84417196 0.277 ENSMUST00000183146.1
Rnf113a2
ring finger protein 113A2
chr9_+_66126611 0.273 ENSMUST00000034945.5
Fam96a
family with sequence similarity 96, member A
chr19_-_29367294 0.271 ENSMUST00000138051.1
Plgrkt
plasminogen receptor, C-terminal lysine transmembrane protein
chr7_+_128744870 0.267 ENSMUST00000042942.8
Sec23ip
Sec23 interacting protein
chr2_-_37703845 0.260 ENSMUST00000155237.1
Strbp
spermatid perinuclear RNA binding protein
chr7_+_3645267 0.236 ENSMUST00000038913.9
Cnot3
CCR4-NOT transcription complex, subunit 3
chr18_-_24603464 0.218 ENSMUST00000154205.1
Slc39a6
solute carrier family 39 (metal ion transporter), member 6
chr15_+_98092569 0.207 ENSMUST00000163507.1
Pfkm
phosphofructokinase, muscle
chr8_-_34965631 0.196 ENSMUST00000033929.4
Tnks
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
chr19_+_11965817 0.173 ENSMUST00000025590.9
Osbp
oxysterol binding protein
chr10_+_88147061 0.154 ENSMUST00000169309.1
Nup37
nucleoporin 37
chr14_-_59365410 0.141 ENSMUST00000161031.1
ENSMUST00000160425.1
Phf11d

PHD finger protein 11D

chr6_+_37870786 0.131 ENSMUST00000120428.1
ENSMUST00000031859.7
Trim24

tripartite motif-containing 24

chr7_+_27195781 0.095 ENSMUST00000108379.1
ENSMUST00000179391.1
BC024978

cDNA sequence BC024978

chr5_+_115605642 0.095 ENSMUST00000094427.3
Gcn1l1
GCN1 general control of amino-acid synthesis 1-like 1 (yeast)
chrX_-_160138375 0.092 ENSMUST00000033662.8
Pdha1
pyruvate dehydrogenase E1 alpha 1
chr17_-_48432723 0.060 ENSMUST00000046549.3
Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr19_+_8802486 0.059 ENSMUST00000172175.1
Zbtb3
zinc finger and BTB domain containing 3
chr3_-_34351685 0.055 ENSMUST00000174114.1
Gm20514
predicted gene 20514
chr2_-_45112890 0.041 ENSMUST00000076836.6
Zeb2
zinc finger E-box binding homeobox 2
chr11_-_43747963 0.036 ENSMUST00000048578.2
ENSMUST00000109278.1
Ttc1

tetratricopeptide repeat domain 1

chrX_+_170009892 0.033 ENSMUST00000180251.1
Gm21887
predicted gene, 21887
chr5_+_118245226 0.032 ENSMUST00000049138.7
2410131K14Rik
RIKEN cDNA 2410131K14 gene
chr13_+_75967704 0.006 ENSMUST00000022081.1
Spata9
spermatogenesis associated 9

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 11.1 GO:0019532 oxalate transport(GO:0019532)
1.3 3.9 GO:0002669 positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
1.1 6.7 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.8 4.0 GO:0007386 compartment pattern specification(GO:0007386)
0.7 2.2 GO:2000812 unidimensional cell growth(GO:0009826) establishment or maintenance of cell polarity regulating cell shape(GO:0071963) regulation of barbed-end actin filament capping(GO:2000812)
0.4 0.8 GO:0030321 transepithelial chloride transport(GO:0030321)
0.4 1.2 GO:1900126 negative regulation of hyaluronan biosynthetic process(GO:1900126)
0.4 1.2 GO:0006011 UDP-glucose metabolic process(GO:0006011) glucose 1-phosphate metabolic process(GO:0019255)
0.4 2.9 GO:1902746 regulation of lens fiber cell differentiation(GO:1902746)
0.4 1.1 GO:0019085 early viral transcription(GO:0019085)
0.4 5.4 GO:0033623 regulation of integrin activation(GO:0033623)
0.3 1.0 GO:1903630 regulation of aminoacyl-tRNA ligase activity(GO:1903630) positive regulation of aminoacyl-tRNA ligase activity(GO:1903632)
0.3 1.6 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.3 0.9 GO:0070649 meiotic chromosome movement towards spindle pole(GO:0016344) formin-nucleated actin cable assembly(GO:0070649)
0.3 0.9 GO:0071374 cellular response to parathyroid hormone stimulus(GO:0071374)
0.2 1.9 GO:0016114 terpenoid biosynthetic process(GO:0016114)
0.2 0.6 GO:1904578 response to thapsigargin(GO:1904578) cellular response to thapsigargin(GO:1904579)
0.2 1.8 GO:0042989 sequestering of actin monomers(GO:0042989)
0.2 0.5 GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002925)
0.2 0.7 GO:0090365 regulation of mRNA modification(GO:0090365)
0.2 2.0 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 4.6 GO:0050873 brown fat cell differentiation(GO:0050873)
0.1 0.3 GO:0048298 positive regulation of isotype switching to IgA isotypes(GO:0048298)
0.1 0.7 GO:2001181 positive regulation of interleukin-10 secretion(GO:2001181)
0.1 2.4 GO:0007530 sex determination(GO:0007530)
0.1 1.0 GO:2000628 regulation of miRNA metabolic process(GO:2000628)
0.1 0.4 GO:2000481 positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316) positive regulation of cAMP-dependent protein kinase activity(GO:2000481)
0.1 0.4 GO:0090309 positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.1 1.3 GO:0006107 oxaloacetate metabolic process(GO:0006107)
0.1 1.2 GO:1903504 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.1 0.4 GO:0090521 glomerular visceral epithelial cell migration(GO:0090521)
0.1 1.2 GO:0048240 sperm capacitation(GO:0048240)
0.1 0.3 GO:0010756 positive regulation of plasminogen activation(GO:0010756)
0.1 0.5 GO:0019240 citrulline biosynthetic process(GO:0019240)
0.1 0.2 GO:1904742 regulation of telomeric DNA binding(GO:1904742)
0.1 0.1 GO:0016554 cytidine to uridine editing(GO:0016554)
0.1 0.6 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.0 15.5 GO:0043010 camera-type eye development(GO:0043010)
0.0 0.2 GO:0061622 glycolytic process through glucose-1-phosphate(GO:0061622)
0.0 0.6 GO:0007398 ectoderm development(GO:0007398)
0.0 0.9 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.3 GO:0043144 snoRNA processing(GO:0043144)
0.0 0.3 GO:0031468 nuclear envelope reassembly(GO:0031468)
0.0 0.1 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.0 0.3 GO:0001675 acrosome assembly(GO:0001675)
0.0 6.9 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.0 0.1 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.0 0.2 GO:0044144 regulation of growth of symbiont in host(GO:0044126) modulation of growth of symbiont involved in interaction with host(GO:0044144)
0.0 0.5 GO:0046677 response to antibiotic(GO:0046677)
0.0 0.8 GO:0035383 acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)
0.0 0.3 GO:0007638 mechanosensory behavior(GO:0007638)
0.0 0.1 GO:1990253 cellular response to leucine starvation(GO:1990253)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.6 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.1 1.0 GO:0005638 lamin filament(GO:0005638)
0.1 0.3 GO:1990730 VCP-NSFL1C complex(GO:1990730)
0.1 0.5 GO:0030689 Noc complex(GO:0030689)
0.1 4.0 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 1.2 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 1.2 GO:0045277 respiratory chain complex IV(GO:0045277)
0.1 1.0 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.1 0.3 GO:0032389 MutLalpha complex(GO:0032389)
0.1 0.9 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 1.6 GO:0005685 U1 snRNP(GO:0005685)
0.1 1.2 GO:0032433 filopodium tip(GO:0032433)
0.1 1.0 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.1 0.4 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.1 0.2 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.0 1.2 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 2.0 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.5 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 11.9 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 0.6 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 4.5 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 1.1 GO:0043034 costamere(GO:0043034)
0.0 0.7 GO:0045120 pronucleus(GO:0045120)
0.0 2.2 GO:0030175 filopodium(GO:0030175)
0.0 0.2 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.4 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 0.1 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 0.5 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.4 GO:0044447 axoneme part(GO:0044447)
0.0 0.9 GO:0005902 microvillus(GO:0005902)
0.0 1.0 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 3.9 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 0.3 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.1 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 0.4 GO:0005721 pericentric heterochromatin(GO:0005721)
0.0 3.2 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 0.3 GO:0005684 U2-type spliceosomal complex(GO:0005684)
0.0 0.2 GO:0097431 mitotic spindle pole(GO:0097431)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 4.0 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
1.0 11.1 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.4 5.4 GO:0031005 filamin binding(GO:0031005)
0.3 1.6 GO:0035614 snRNA stem-loop binding(GO:0035614)
0.3 1.9 GO:0004311 farnesyltranstransferase activity(GO:0004311)
0.2 1.3 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.2 2.9 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.2 0.8 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
0.1 0.5 GO:0019863 IgE binding(GO:0019863)
0.1 2.0 GO:0019103 pyrimidine nucleotide binding(GO:0019103)
0.1 15.5 GO:0016779 nucleotidyltransferase activity(GO:0016779)
0.1 0.5 GO:0034618 arginine binding(GO:0034618)
0.1 0.9 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.1 0.3 GO:0032138 single base insertion or deletion binding(GO:0032138)
0.1 1.0 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.1 3.9 GO:0001784 phosphotyrosine binding(GO:0001784)
0.1 0.7 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.1 1.8 GO:0003785 actin monomer binding(GO:0003785)
0.1 2.4 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 2.0 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 0.2 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.0 0.9 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.4 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 1.0 GO:0005521 lamin binding(GO:0005521)
0.0 0.4 GO:0043495 protein anchor(GO:0043495)
0.0 1.2 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.0 0.6 GO:0051400 BH domain binding(GO:0051400)
0.0 0.9 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 6.9 GO:0000287 magnesium ion binding(GO:0000287)
0.0 2.2 GO:1902936 phosphatidylinositol bisphosphate binding(GO:1902936)
0.0 0.6 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 1.7 GO:0002039 p53 binding(GO:0002039)
0.0 0.6 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.1 GO:0034604 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
0.0 3.2 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 4.6 GO:0003924 GTPase activity(GO:0003924)
0.0 0.1 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 1.8 GO:0030165 PDZ domain binding(GO:0030165)
0.0 0.4 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 1.0 GO:0032947 protein complex scaffold(GO:0032947)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.2 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.1 3.9 PID_CD40_PATHWAY CD40/CD40L signaling
0.1 0.9 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 1.2 PID_ARF_3PATHWAY Arf1 pathway
0.0 0.4 ST_INTERFERON_GAMMA_PATHWAY Interferon gamma pathway.
0.0 1.6 PID_PTP1B_PATHWAY Signaling events mediated by PTP1B
0.0 1.1 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 0.9 PID_TELOMERASE_PATHWAY Regulation of Telomerase

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 5.4 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.2 4.0 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 1.2 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.1 3.9 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1 10.7 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 2.2 REACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.1 0.8 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.1 3.3 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 1.9 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 0.7 REACTOME_PD1_SIGNALING Genes involved in PD-1 signaling
0.1 1.2 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.1 1.3 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 1.0 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.6 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.0 0.7 REACTOME_DESTABILIZATION_OF_MRNA_BY_KSRP Genes involved in Destabilization of mRNA by KSRP
0.0 3.9 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.0 1.2 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.0 0.5 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 1.8 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases