Z-value: 0.410
Transcription factors associated with Nkx2-1:
Activity-expression correlation:
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Gene overrepresentation in biological_process category:
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Log-likelihood per target Total log-likelihood Term Description
1.0
6.9
GO:0031536
positive regulation of exit from mitosis(GO:0031536)
0.7
6.8
GO:0060179
male mating behavior(GO:0060179)
0.8
5.0
GO:0035469
determination of pancreatic left/right asymmetry(GO:0035469)
0.0
4.6
GO:0006814
sodium ion transport(GO:0006814)
0.0
3.6
GO:2000179
positive regulation of neural precursor cell proliferation(GO:2000179)
0.0
3.5
GO:0007050
cell cycle arrest(GO:0007050)
0.5
2.7
GO:1903215
negative regulation of protein targeting to mitochondrion(GO:1903215)
0.1
2.7
GO:2000001
regulation of DNA damage checkpoint(GO:2000001)
0.2
2.5
GO:2000381
negative regulation of mesoderm development(GO:2000381)
0.2
2.1
GO:0032306
regulation of prostaglandin secretion(GO:0032306)
0.6
1.9
GO:0042320
regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938)
0.1
1.8
GO:0032288
myelin assembly(GO:0032288)
0.1
1.7
GO:0034472
snRNA 3'-end processing(GO:0034472)
0.4
1.5
GO:0021502
neural fold elevation formation(GO:0021502)
0.1
1.5
GO:2000042
negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.6
1.2
GO:0009814
defense response, incompatible interaction(GO:0009814)
0.1
1.2
GO:0035721
intraciliary retrograde transport(GO:0035721)
0.0
1.2
GO:0034067
protein localization to Golgi apparatus(GO:0034067)
0.0
1.2
GO:0016126
sterol biosynthetic process(GO:0016126)
0.0
1.2
GO:0080171
lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
Gene overrepresentation in cellular_component category:
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Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihood Term Description
1.4
6.9
GO:0032133
interphase microtubule organizing center(GO:0031021) chromosome passenger complex(GO:0032133)
0.2
4.3
GO:0031616
spindle pole centrosome(GO:0031616)
0.0
3.2
GO:0001650
fibrillar center(GO:0001650)
0.2
2.1
GO:0044233
ER-mitochondrion membrane contact site(GO:0044233)
0.1
1.7
GO:0032039
integrator complex(GO:0032039)
0.0
1.5
GO:1990391
DNA repair complex(GO:1990391)
0.0
1.5
GO:0030136
clathrin-coated vesicle(GO:0030136)
0.2
1.4
GO:0002177
manchette(GO:0002177)
0.1
1.2
GO:0030991
intraciliary transport particle A(GO:0030991)
0.1
1.2
GO:0031229
integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0
1.1
GO:0001669
acrosomal vesicle(GO:0001669)
0.0
1.0
GO:0005834
heterotrimeric G-protein complex(GO:0005834)
0.1
0.8
GO:0032541
cortical endoplasmic reticulum(GO:0032541)
0.1
0.8
GO:0035749
myelin sheath adaxonal region(GO:0035749)
0.0
0.7
GO:0071564
npBAF complex(GO:0071564)
0.0
0.5
GO:0034663
endoplasmic reticulum chaperone complex(GO:0034663)
0.0
0.4
GO:0043205
microfibril(GO:0001527) fibril(GO:0043205)
0.0
0.3
GO:0042613
MHC class II protein complex(GO:0042613)
0.1
0.2
GO:0070381
endosome to plasma membrane transport vesicle(GO:0070381)
0.0
0.2
GO:0031415
NatA complex(GO:0031415)
Gene overrepresentation in molecular_function category:
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Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihood Term Description
0.2
6.9
GO:0043027
cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0
6.2
GO:0001077
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.1
4.6
GO:0005272
sodium channel activity(GO:0005272)
0.0
4.3
GO:0004721
phosphoprotein phosphatase activity(GO:0004721)
0.0
3.5
GO:0008017
microtubule binding(GO:0008017)
0.3
3.2
GO:0008474
palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.2
2.1
GO:0031957
very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.1
1.9
GO:0071855
neuropeptide receptor binding(GO:0071855)
0.3
1.7
GO:0061649
ubiquitinated histone binding(GO:0061649)
0.2
1.5
GO:0070700
BMP receptor binding(GO:0070700)
0.1
1.5
GO:0080025
phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.1
1.4
GO:0043014
alpha-tubulin binding(GO:0043014)
0.2
1.2
GO:0070087
chromo shadow domain binding(GO:0070087)
0.0
1.2
GO:0042054
histone methyltransferase activity(GO:0042054)
0.1
1.1
GO:0004716
receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0
1.1
GO:0005109
frizzled binding(GO:0005109)
0.1
1.0
GO:0004726
non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.1
1.0
GO:0031702
angiotensin receptor binding(GO:0031701) type 1 angiotensin receptor binding(GO:0031702)
0.1
0.9
GO:0004861
cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1
0.9
GO:0005355
glucose transmembrane transporter activity(GO:0005355)
Gene overrepresentation in C2:CP category:
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Gene overrepresentation in C2:CP:REACTOME category:
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Showing 1 to 15 of 15 entries