Motif ID: Nkx2-1

Z-value: 0.410


Transcription factors associated with Nkx2-1:

Gene SymbolEntrez IDGene Name
Nkx2-1 ENSMUSG00000001496.9 Nkx2-1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx2-1mm10_v2_chr12_-_56535047_565351060.094.2e-01Click!


Activity profile for motif Nkx2-1.

activity profile for motif Nkx2-1


Sorted Z-values histogram for motif Nkx2-1

Sorted Z-values for motif Nkx2-1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-1

PNG image of the network

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Top targets:


Showing 1 to 20 of 111 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_89688196 6.772 ENSMUST00000052478.2
Dmrta1
doublesex and mab-3 related transcription factor like family A1
chr14_-_47411666 4.277 ENSMUST00000111778.3
Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr11_+_117849223 4.190 ENSMUST00000081387.4
Birc5
baculoviral IAP repeat-containing 5
chr16_+_48994185 3.615 ENSMUST00000117994.1
ENSMUST00000048374.5
C330027C09Rik

RIKEN cDNA C330027C09 gene

chr11_+_117849286 2.750 ENSMUST00000093906.4
Birc5
baculoviral IAP repeat-containing 5
chr14_+_75455957 2.657 ENSMUST00000164848.1
Siah3
seven in absentia homolog 3 (Drosophila)
chrX_+_58030622 2.593 ENSMUST00000088627.4
Zic3
zinc finger protein of the cerebellum 3
chrX_+_58030999 2.443 ENSMUST00000088631.4
ENSMUST00000088629.3
Zic3

zinc finger protein of the cerebellum 3

chr1_+_75450699 2.319 ENSMUST00000037708.9
Asic4
acid-sensing (proton-gated) ion channel family member 4
chr1_+_75450436 2.306 ENSMUST00000113577.1
Asic4
acid-sensing (proton-gated) ion channel family member 4
chr19_+_44493472 2.254 ENSMUST00000041163.4
Wnt8b
wingless related MMTV integration site 8b
chrX_-_142390334 2.073 ENSMUST00000112907.1
Acsl4
acyl-CoA synthetase long-chain family member 4
chr10_+_88091070 1.882 ENSMUST00000048621.7
Pmch
pro-melanin-concentrating hormone
chr7_+_51879041 1.794 ENSMUST00000107591.2
Gas2
growth arrest specific 2
chr7_+_51878967 1.718 ENSMUST00000051912.6
Gas2
growth arrest specific 2
chr4_+_9269285 1.544 ENSMUST00000038841.7
Clvs1
clavesin 1
chr9_+_75775355 1.540 ENSMUST00000012281.7
Bmp5
bone morphogenetic protein 5
chr2_-_121235689 1.516 ENSMUST00000142400.1
Trp53bp1
transformation related protein 53 binding protein 1
chr5_+_30105161 1.453 ENSMUST00000058045.4
Gareml
GRB2 associated, regulator of MAPK1-like
chr4_-_41517326 1.445 ENSMUST00000030152.6
ENSMUST00000095126.4
1110017D15Rik

RIKEN cDNA 1110017D15 gene


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 6.9 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
0.7 6.8 GO:0060179 male mating behavior(GO:0060179)
0.8 5.0 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.0 4.6 GO:0006814 sodium ion transport(GO:0006814)
0.0 3.6 GO:2000179 positive regulation of neural precursor cell proliferation(GO:2000179)
0.0 3.5 GO:0007050 cell cycle arrest(GO:0007050)
0.5 2.7 GO:1903215 negative regulation of protein targeting to mitochondrion(GO:1903215)
0.1 2.7 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.2 2.5 GO:2000381 negative regulation of mesoderm development(GO:2000381)
0.2 2.1 GO:0032306 regulation of prostaglandin secretion(GO:0032306)
0.6 1.9 GO:0042320 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938)
0.1 1.8 GO:0032288 myelin assembly(GO:0032288)
0.1 1.7 GO:0034472 snRNA 3'-end processing(GO:0034472)
0.4 1.5 GO:0021502 neural fold elevation formation(GO:0021502)
0.1 1.5 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.6 1.2 GO:0009814 defense response, incompatible interaction(GO:0009814)
0.1 1.2 GO:0035721 intraciliary retrograde transport(GO:0035721)
0.0 1.2 GO:0034067 protein localization to Golgi apparatus(GO:0034067)
0.0 1.2 GO:0016126 sterol biosynthetic process(GO:0016126)
0.0 1.2 GO:0080171 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 6.9 GO:0032133 interphase microtubule organizing center(GO:0031021) chromosome passenger complex(GO:0032133)
0.2 4.3 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 3.2 GO:0001650 fibrillar center(GO:0001650)
0.2 2.1 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.1 1.7 GO:0032039 integrator complex(GO:0032039)
0.0 1.5 GO:1990391 DNA repair complex(GO:1990391)
0.0 1.5 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.2 1.4 GO:0002177 manchette(GO:0002177)
0.1 1.2 GO:0030991 intraciliary transport particle A(GO:0030991)
0.1 1.2 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 1.1 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 1.0 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 0.8 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.1 0.8 GO:0035749 myelin sheath adaxonal region(GO:0035749)
0.0 0.7 GO:0071564 npBAF complex(GO:0071564)
0.0 0.5 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.4 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.0 0.3 GO:0042613 MHC class II protein complex(GO:0042613)
0.1 0.2 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.0 0.2 GO:0031415 NatA complex(GO:0031415)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.9 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 6.2 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.1 4.6 GO:0005272 sodium channel activity(GO:0005272)
0.0 4.3 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.0 3.5 GO:0008017 microtubule binding(GO:0008017)
0.3 3.2 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.2 2.1 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.1 1.9 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.3 1.7 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.2 1.5 GO:0070700 BMP receptor binding(GO:0070700)
0.1 1.5 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.1 1.4 GO:0043014 alpha-tubulin binding(GO:0043014)
0.2 1.2 GO:0070087 chromo shadow domain binding(GO:0070087)
0.0 1.2 GO:0042054 histone methyltransferase activity(GO:0042054)
0.1 1.1 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0 1.1 GO:0005109 frizzled binding(GO:0005109)
0.1 1.0 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.1 1.0 GO:0031702 angiotensin receptor binding(GO:0031701) type 1 angiotensin receptor binding(GO:0031702)
0.1 0.9 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 0.9 GO:0005355 glucose transmembrane transporter activity(GO:0005355)

Gene overrepresentation in C2:CP category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 11.2 PID_AURORA_A_PATHWAY Aurora A signaling
0.1 3.5 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 2.7 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 1.2 PID_E2F_PATHWAY E2F transcription factor network
0.0 1.1 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 1.0 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.0 1.0 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.0 0.9 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.0 0.8 PID_LKB1_PATHWAY LKB1 signaling events
0.0 0.6 PID_WNT_SIGNALING_PATHWAY Wnt signaling network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.9 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 3.9 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.2 3.5 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 2.5 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1
0.1 2.1 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 1.9 REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS Genes involved in G alpha (q) signalling events
0.1 1.2 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 1.1 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.1 0.9 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.1 0.9 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.9 REACTOME_G1_PHASE Genes involved in G1 Phase
0.0 0.8 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 0.8 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 0.4 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 0.2 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi