Motif ID: Nkx2-2

Z-value: 1.712


Transcription factors associated with Nkx2-2:

Gene SymbolEntrez IDGene Name
Nkx2-2 ENSMUSG00000027434.10 Nkx2-2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx2-2mm10_v2_chr2_-_147186389_147186413-0.199.1e-02Click!


Activity profile for motif Nkx2-2.

activity profile for motif Nkx2-2


Sorted Z-values histogram for motif Nkx2-2

Sorted Z-values for motif Nkx2-2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_3018753 19.291 ENSMUST00000179272.1
 Gm10719
predicted gene 10719
chr14_-_19418930 19.059 ENSMUST00000177817.1
 Gm21738
predicted gene, 21738
chr9_+_3034599 17.858 ENSMUST00000178641.1
 Gm17535
predicted gene, 17535
chr3_+_5218516 17.330 ENSMUST00000175866.1
 Zfhx4
zinc finger homeodomain 4
chr9_+_3005125 16.966 ENSMUST00000179881.1
 Gm11168
predicted gene 11168
chr9_+_3015654 16.580 ENSMUST00000099050.3
 Gm10720
predicted gene 10720
chr9_+_3025417 16.047 ENSMUST00000075573.6
 Gm10717
predicted gene 10717
chr9_+_3017408 15.861 ENSMUST00000099049.3
 Gm10719
predicted gene 10719
chr1_-_135688094 15.519 ENSMUST00000112103.1
 Nav1
neuron navigator 1
chr11_+_78301529 14.920 ENSMUST00000045026.3
 Spag5
sperm associated antigen 5
chr9_+_72438534 14.663 ENSMUST00000034746.8
 Mns1
meiosis-specific nuclear structural protein 1
chr9_+_72438519 13.655 ENSMUST00000184604.1
 Mns1
meiosis-specific nuclear structural protein 1
chr2_-_140170528 12.010 ENSMUST00000046030.7
 Esf1
ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)
chr2_-_84775388 11.847 ENSMUST00000023994.3
 Serping1
serine (or cysteine) peptidase inhibitor, clade G, member 1
chr4_+_46039202 11.649 ENSMUST00000156200.1
 Tmod1
tropomodulin 1
chr2_-_84775420 11.345 ENSMUST00000111641.1
 Serping1
serine (or cysteine) peptidase inhibitor, clade G, member 1
chr4_+_59626189 10.851 ENSMUST00000070150.4
ENSMUST00000052420.6
 E130308A19Rik

RIKEN cDNA E130308A19 gene

chr2_-_114013619 10.741 ENSMUST00000090275.4
 Gjd2
gap junction protein, delta 2
chr10_+_88091070 10.590 ENSMUST00000048621.7
 Pmch
pro-melanin-concentrating hormone
chrX_+_9885622 10.482 ENSMUST00000067529.2
ENSMUST00000086165.3
 Sytl5

synaptotagmin-like 5


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 100 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.8 28.3 GO:0070986 left/right axis specification(GO:0070986)
7.7 23.2 GO:0001869 regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
6.0 18.0 GO:1904959 elastin biosynthetic process(GO:0051542) copper ion export(GO:0060003) regulation of electron carrier activity(GO:1904732) regulation of cytochrome-c oxidase activity(GO:1904959)
0.6 16.8 GO:0010960 magnesium ion homeostasis(GO:0010960)
0.2 15.5 GO:0001578 microtubule bundle formation(GO:0001578)
3.7 14.9 GO:0090235 regulation of metaphase plate congression(GO:0090235)
2.3 11.6 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.1 10.7 GO:0007601 visual perception(GO:0007601)
0.1 10.7 GO:0006275 regulation of DNA replication(GO:0006275)
3.5 10.6 GO:0042320 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938)
0.3 10.5 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.5 10.0 GO:1904707 positive regulation of vascular smooth muscle cell proliferation(GO:1904707)
2.0 9.8 GO:0034441 plasma lipoprotein particle oxidation(GO:0034441)
1.4 9.6 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
1.8 9.1 GO:0035063 nuclear speck organization(GO:0035063)
1.0 8.7 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
1.0 8.6 GO:0030035 microspike assembly(GO:0030035)
0.2 8.6 GO:0042462 eye photoreceptor cell development(GO:0042462)
2.8 8.5 GO:1904211 membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211)
0.1 8.4 GO:0017156 calcium ion regulated exocytosis(GO:0017156)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 35.7 GO:0072562 blood microparticle(GO:0072562)
0.4 28.3 GO:0005882 intermediate filament(GO:0005882)
0.0 21.9 GO:0005615 extracellular space(GO:0005615)
0.6 18.2 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.1 15.8 GO:0005813 centrosome(GO:0005813)
0.5 15.5 GO:0043194 axon initial segment(GO:0043194)
0.8 14.9 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 12.9 GO:0015629 actin cytoskeleton(GO:0015629)
0.4 11.6 GO:0005865 striated muscle thin filament(GO:0005865)
0.1 11.3 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.8 10.7 GO:0005922 connexon complex(GO:0005922)
0.7 9.8 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.0 9.7 GO:0016607 nuclear speck(GO:0016607)
0.1 9.0 GO:0000922 spindle pole(GO:0000922)
0.7 8.7 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.1 8.3 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 8.3 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
2.0 7.9 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006)
0.2 7.3 GO:0030673 axolemma(GO:0030673)
0.1 7.2 GO:0070382 exocytic vesicle(GO:0070382)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 66 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 24.7 GO:0042802 identical protein binding(GO:0042802)
1.2 23.2 GO:0001848 complement binding(GO:0001848)
0.0 18.7 GO:0008270 zinc ion binding(GO:0008270)
6.0 18.0 GO:0043682 copper-exporting ATPase activity(GO:0004008) copper-transporting ATPase activity(GO:0043682)
2.1 16.8 GO:0009019 tRNA (guanine-N1-)-methyltransferase activity(GO:0009019)
0.1 13.9 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.5 12.5 GO:0008327 methyl-CpG binding(GO:0008327)
1.3 11.6 GO:0005523 tropomyosin binding(GO:0005523)
0.3 10.7 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.5 10.6 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.2 10.5 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
1.1 9.8 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
0.4 9.6 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.5 8.7 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 8.7 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 8.6 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 8.5 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
2.1 8.3 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
1.7 8.3 GO:0004342 glucosamine-6-phosphate deaminase activity(GO:0004342)
0.6 8.1 GO:0016832 aldehyde-lyase activity(GO:0016832)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 23.5 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.3 10.1 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.2 9.8 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.3 9.6 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.3 8.7 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.2 6.6 PID_ATM_PATHWAY ATM pathway
0.2 6.6 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.1 5.5 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 5.4 PID_E2F_PATHWAY E2F transcription factor network
0.1 4.7 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.1 4.0 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway
0.1 3.0 PID_ERBB4_PATHWAY ErbB4 signaling events
0.1 2.9 PID_PLK1_PATHWAY PLK1 signaling events
0.0 2.7 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 2.3 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.1 2.1 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 2.0 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.1 1.7 PID_VEGFR1_PATHWAY VEGFR1 specific signals
0.1 1.6 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods
0.1 1.2 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.3 23.2 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.5 18.0 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.4 11.6 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.9 10.7 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.1 10.6 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.6 9.8 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.1 8.6 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.3 8.5 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.7 6.6 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.1 6.6 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 5.7 REACTOME_MEIOTIC_RECOMBINATION Genes involved in Meiotic Recombination
0.3 5.4 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.1 4.8 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.2 4.7 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.5 4.2 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.1 4.0 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 4.0 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
0.0 3.6 REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS Genes involved in G alpha (q) signalling events
0.2 3.4 REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.0 3.2 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation