Motif ID: Nkx2-3

Z-value: 0.810


Transcription factors associated with Nkx2-3:

Gene SymbolEntrez IDGene Name
Nkx2-3 ENSMUSG00000044220.12 Nkx2-3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx2-3mm10_v2_chr19_+_43612299_436123250.225.2e-02Click!


Activity profile for motif Nkx2-3.

activity profile for motif Nkx2-3


Sorted Z-values histogram for motif Nkx2-3

Sorted Z-values for motif Nkx2-3



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_38783503 30.686 ENSMUST00000159334.1
 Etv1
ets variant gene 1
chr12_+_38783455 24.523 ENSMUST00000161980.1
ENSMUST00000160701.1
 Etv1

ets variant gene 1

chr6_-_23248264 16.181 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr5_+_139543889 9.491 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr12_+_38780284 9.346 ENSMUST00000162563.1
ENSMUST00000161164.1
ENSMUST00000160996.1
 Etv1


ets variant gene 1


chr12_+_38780817 8.655 ENSMUST00000160856.1
 Etv1
ets variant gene 1
chr10_-_6980376 7.835 ENSMUST00000105617.1
 Ipcef1
interaction protein for cytohesin exchange factors 1
chr1_+_6734827 6.684 ENSMUST00000139838.1
 St18
suppression of tumorigenicity 18
chr1_+_6730051 6.264 ENSMUST00000043578.6
ENSMUST00000131467.1
ENSMUST00000150761.1
ENSMUST00000151281.1
 St18



suppression of tumorigenicity 18



chr2_+_136057927 6.226 ENSMUST00000057503.6
 Lamp5
lysosomal-associated membrane protein family, member 5
chr3_+_134236483 5.985 ENSMUST00000181904.1
ENSMUST00000053048.9
 Cxxc4

CXXC finger 4

chr6_+_34354119 5.687 ENSMUST00000038406.6
 Akr1b8
aldo-keto reductase family 1, member B8
chr2_-_114013619 5.154 ENSMUST00000090275.4
 Gjd2
gap junction protein, delta 2
chr3_-_86548268 5.145 ENSMUST00000077524.3
 Mab21l2
mab-21-like 2 (C. elegans)
chr14_+_75455957 5.102 ENSMUST00000164848.1
 Siah3
seven in absentia homolog 3 (Drosophila)
chr3_+_55782500 5.076 ENSMUST00000075422.4
 Mab21l1
mab-21-like 1 (C. elegans)
chr3_+_102010138 5.028 ENSMUST00000066187.4
 Nhlh2
nescient helix loop helix 2
chr13_-_114458720 5.011 ENSMUST00000022287.5
 Fst
follistatin
chr12_+_38781093 4.989 ENSMUST00000161513.1
 Etv1
ets variant gene 1
chr1_+_110099295 4.751 ENSMUST00000134301.1
 Cdh7
cadherin 7, type 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 111 entries
Log-likelihood per target Total log-likelihoodTermDescription
7.1 78.2 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
2.9 17.1 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
1.1 12.9 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
1.7 6.7 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.6 6.3 GO:0060539 diaphragm development(GO:0060539)
0.1 6.2 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
1.9 5.7 GO:0016095 polyprenol catabolic process(GO:0016095) terpenoid catabolic process(GO:0016115) primary alcohol catabolic process(GO:0034310)
0.3 5.4 GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037)
1.0 5.1 GO:1903215 negative regulation of protein targeting to mitochondrion(GO:1903215)
0.5 5.1 GO:0051798 positive regulation of hair follicle development(GO:0051798)
0.2 5.0 GO:0007617 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.0 5.0 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)
0.2 4.8 GO:0010172 embryonic body morphogenesis(GO:0010172)
0.1 4.4 GO:0007601 visual perception(GO:0007601)
0.0 4.4 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.5 4.0 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.1 3.8 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.1 3.8 GO:0032611 interleukin-1 beta production(GO:0032611)
0.2 3.6 GO:0071392 cellular response to estradiol stimulus(GO:0071392)
1.1 3.4 GO:0097274 urea homeostasis(GO:0097274)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 57 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.7 GO:0032993 protein-DNA complex(GO:0032993)
1.0 6.2 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.4 6.0 GO:0005922 connexon complex(GO:0005922)
0.1 4.8 GO:0043034 costamere(GO:0043034)
0.0 4.0 GO:0016607 nuclear speck(GO:0016607)
0.4 3.6 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.2 2.9 GO:0042788 polysomal ribosome(GO:0042788)
0.2 2.8 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.5 2.7 GO:0001674 female germ cell nucleus(GO:0001674)
0.5 2.4 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.3 2.4 GO:0033269 internode region of axon(GO:0033269)
0.3 2.4 GO:0005818 aster(GO:0005818)
0.0 2.3 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 2.3 GO:0014069 postsynaptic density(GO:0014069)
0.3 2.0 GO:0001940 male pronucleus(GO:0001940)
0.1 2.0 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 2.0 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 2.0 GO:0043296 apical junction complex(GO:0043296)
0.1 1.9 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 1.9 GO:0035145 exon-exon junction complex(GO:0035145)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 78 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 82.9 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.1 23.7 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
1.3 6.7 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.9 6.1 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
1.1 5.7 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.3 5.3 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 5.3 GO:0051015 actin filament binding(GO:0051015)
0.0 5.1 GO:0016779 nucleotidyltransferase activity(GO:0016779)
0.5 5.0 GO:0048185 activin binding(GO:0048185)
0.1 4.9 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.0 4.7 GO:0030165 PDZ domain binding(GO:0030165)
0.4 4.5 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.1 4.4 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.1 4.4 GO:0097472 cyclin-dependent protein kinase activity(GO:0097472)
1.2 3.6 GO:0004994 somatostatin receptor activity(GO:0004994)
0.4 3.6 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.4 3.0 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.2 3.0 GO:0015197 peptide transporter activity(GO:0015197)
0.1 3.0 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.1 2.9 GO:0017091 AU-rich element binding(GO:0017091)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.1 78.8 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.2 7.8 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.2 6.0 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.1 5.0 PID_BMP_PATHWAY BMP receptor signaling
0.1 3.9 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 3.6 PID_LKB1_PATHWAY LKB1 signaling events
0.0 3.6 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 2.4 PID_AURORA_A_PATHWAY Aurora A signaling
0.1 2.4 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.1 2.2 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.1 2.1 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 2.0 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 1.7 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 1.5 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 1.2 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 1.1 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 1.0 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.0 0.9 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.0 0.8 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.8 PID_EPHB_FWD_PATHWAY EPHB forward signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.1 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.5 6.0 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.0 3.6 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.3 3.0 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.1 2.5 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.1 2.4 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1 2.4 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 2.0 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1 2.0 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.0 1.9 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 1.7 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.4 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.2 1.3 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.1 1.3 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 1.3 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 1.1 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.1 1.0 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.1 0.9 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.1 0.6 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.0 0.6 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates