Motif ID: Nkx2-5

Z-value: 0.735


Transcription factors associated with Nkx2-5:

Gene SymbolEntrez IDGene Name
Nkx2-5 ENSMUSG00000015579.4 Nkx2-5



Activity profile for motif Nkx2-5.

activity profile for motif Nkx2-5


Sorted Z-values histogram for motif Nkx2-5

Sorted Z-values for motif Nkx2-5



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-5

PNG image of the network

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Top targets:


Showing 1 to 20 of 100 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_88978958 13.755 ENSMUST00000042594.6
ENSMUST00000109368.1
 Mlc1

megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)

chr4_+_103619580 11.804 ENSMUST00000106827.1
 Dab1
disabled 1
chr8_+_124793061 9.047 ENSMUST00000041106.7
 Trim67
tripartite motif-containing 67
chr14_+_80000292 8.751 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr12_+_74297474 7.650 ENSMUST00000072100.3
 Dbpht2
DNA binding protein with his-thr domain
chr19_-_57360668 6.471 ENSMUST00000181921.1
 B230217O12Rik
RIKEN cDNA B230217O12 gene
chr19_+_26753588 6.040 ENSMUST00000177116.1
 Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr13_+_30136498 5.250 ENSMUST00000047311.8
 Mboat1
membrane bound O-acyltransferase domain containing 1
chrX_-_165327376 5.077 ENSMUST00000058787.8
 Glra2
glycine receptor, alpha 2 subunit
chr1_-_86359455 4.846 ENSMUST00000027438.6
 Ncl
nucleolin
chr12_+_91400990 4.745 ENSMUST00000021346.7
ENSMUST00000021343.6
 Tshr

thyroid stimulating hormone receptor

chr3_+_52268337 4.544 ENSMUST00000053764.5
 Foxo1
forkhead box O1
chr8_-_46294592 4.246 ENSMUST00000058636.7
 Helt
helt bHLH transcription factor
chr7_-_4844665 3.786 ENSMUST00000066041.5
ENSMUST00000172377.1
 Shisa7

shisa homolog 7 (Xenopus laevis)

chr9_-_53536608 3.445 ENSMUST00000150244.1
 Atm
ataxia telangiectasia mutated homolog (human)
chr15_-_10470490 3.429 ENSMUST00000136591.1
 Dnajc21
DnaJ (Hsp40) homolog, subfamily C, member 21
chr4_-_4138432 3.081 ENSMUST00000070375.7
 Penk
preproenkephalin
chr7_-_126897424 3.028 ENSMUST00000120007.1
 Tmem219
transmembrane protein 219
chrX_+_114474312 2.976 ENSMUST00000113371.1
ENSMUST00000040504.5
 Klhl4

kelch-like 4

chr1_+_128103297 2.900 ENSMUST00000036288.4
 R3hdm1
R3H domain containing 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 54 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 13.8 GO:0047484 regulation of response to osmotic stress(GO:0047484) cellular response to cholesterol(GO:0071397)
3.9 11.8 GO:0021577 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
0.3 9.0 GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000060)
0.2 8.8 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
2.0 6.0 GO:0032915 positive regulation of transforming growth factor beta2 production(GO:0032915)
0.7 6.0 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.8 5.7 GO:1990416 cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.8 5.1 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
0.6 4.8 GO:2000232 regulation of rRNA processing(GO:2000232)
0.8 4.7 GO:1904587 response to glycoprotein(GO:1904587)
0.4 4.5 GO:0071455 cellular response to hyperoxia(GO:0071455)
0.3 4.2 GO:0097154 GABAergic neuron differentiation(GO:0097154)
0.2 3.8 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
1.1 3.4 GO:0002331 pre-B cell allelic exclusion(GO:0002331) signal transduction involved in G2 DNA damage checkpoint(GO:0072425) signal transduction involved in mitotic G2 DNA damage checkpoint(GO:0072434) regulation of microglial cell activation(GO:1903978) telomerase catalytic core complex assembly(GO:1904868) regulation of telomerase catalytic core complex assembly(GO:1904882) positive regulation of telomerase catalytic core complex assembly(GO:1904884)
0.6 3.1 GO:2000987 positive regulation of fear response(GO:1903367) positive regulation of behavioral fear response(GO:2000987)
0.1 2.9 GO:0006829 zinc II ion transport(GO:0006829)
0.9 2.8 GO:0045204 MAPK export from nucleus(GO:0045204)
0.4 2.5 GO:0045218 zonula adherens maintenance(GO:0045218)
0.2 2.4 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.0 2.2 GO:0035725 sodium ion transmembrane transport(GO:0035725)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 13.8 GO:0005901 caveola(GO:0005901)
0.1 11.8 GO:0005903 brush border(GO:0005903)
0.8 10.9 GO:0042581 specific granule(GO:0042581)
0.3 6.0 GO:0071564 npBAF complex(GO:0071564)
0.2 6.0 GO:0035861 site of double-strand break(GO:0035861)
0.1 5.8 GO:0034707 chloride channel complex(GO:0034707)
1.2 4.8 GO:0001651 dense fibrillar component(GO:0001651)
0.0 4.7 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 4.2 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 3.8 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 3.4 GO:1990391 DNA repair complex(GO:1990391)
0.8 3.1 GO:0032280 symmetric synapse(GO:0032280)
0.0 3.0 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.2 2.5 GO:0005915 zonula adherens(GO:0005915)
0.0 2.4 GO:0008023 transcription elongation factor complex(GO:0008023)
0.4 2.2 GO:0044316 cone cell pedicle(GO:0044316)
0.0 2.0 GO:0000123 histone acetyltransferase complex(GO:0000123)
0.0 1.9 GO:0001772 immunological synapse(GO:0001772)
0.0 1.8 GO:0005902 microvillus(GO:0005902)
0.6 1.7 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 13.8 GO:0008565 protein transporter activity(GO:0008565)
0.3 11.8 GO:0042169 SH2 domain binding(GO:0042169)
0.0 11.5 GO:0008270 zinc ion binding(GO:0008270)
0.0 10.9 GO:0042803 protein homodimerization activity(GO:0042803)
0.5 6.0 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 6.0 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 5.3 GO:0016746 transferase activity, transferring acyl groups(GO:0016746)
1.7 5.1 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
1.0 4.8 GO:0042134 rRNA primary transcript binding(GO:0042134)
0.4 4.7 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.1 4.5 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 4.2 GO:0003924 GTPase activity(GO:0003924)
1.1 3.4 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)
0.0 3.2 GO:0036459 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.4 3.1 GO:0001515 opioid peptide activity(GO:0001515)
0.2 2.9 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 2.9 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.2 2.5 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.5 2.2 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.5 2.1 GO:0030348 syntaxin-3 binding(GO:0030348)

Gene overrepresentation in C2:CP category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 11.8 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.2 11.7 PID_RHOA_PATHWAY RhoA signaling pathway
0.1 6.0 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.2 4.8 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1 4.7 PID_ARF6_PATHWAY Arf6 signaling events
0.1 4.6 PID_AP1_PATHWAY AP-1 transcription factor network
0.2 4.5 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.1 3.4 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.1 2.5 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 2.1 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.4 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 1.1 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 8.0 REACTOME_ACYL_CHAIN_REMODELLING_OF_PS Genes involved in Acyl chain remodelling of PS
0.3 6.0 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.3 5.7 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.3 5.1 REACTOME_LIGAND_GATED_ION_CHANNEL_TRANSPORT Genes involved in Ligand-gated ion channel transport
1.6 4.7 REACTOME_HORMONE_LIGAND_BINDING_RECEPTORS Genes involved in Hormone ligand-binding receptors
0.2 4.5 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.3 3.4 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.2 2.9 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.1 2.5 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 2.2 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.1 2.1 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.2 1.9 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.0 1.8 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1 1.7 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 1.5 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 1.5 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.2 1.4 REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.1 1.4 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.0 1.4 REACTOME_GENERIC_TRANSCRIPTION_PATHWAY Genes involved in Generic Transcription Pathway
0.0 1.1 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling