Motif ID: Nkx2-6

Z-value: 0.430


Transcription factors associated with Nkx2-6:

Gene SymbolEntrez IDGene Name
Nkx2-6 ENSMUSG00000044186.9 Nkx2-6



Activity profile for motif Nkx2-6.

activity profile for motif Nkx2-6


Sorted Z-values histogram for motif Nkx2-6

Sorted Z-values for motif Nkx2-6



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-6

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_116031047 8.716 ENSMUST00000106612.1
 Sox6
SRY-box containing gene 6
chr15_-_78773452 7.999 ENSMUST00000018313.5
 Mfng
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr4_-_91399984 5.834 ENSMUST00000102799.3
 Elavl2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr4_-_109665249 5.221 ENSMUST00000063531.4
 Cdkn2c
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
chr6_+_70726430 3.821 ENSMUST00000103410.1
 Igkc
immunoglobulin kappa constant
chr1_+_156035392 1.980 ENSMUST00000111757.3
 Tor1aip2
torsin A interacting protein 2
chr3_+_87525572 1.469 ENSMUST00000170036.1
ENSMUST00000117293.1
 Etv3

ets variant gene 3

chr1_-_156034800 1.467 ENSMUST00000169241.1
 Tor1aip1
torsin A interacting protein 1
chr2_+_23069210 1.420 ENSMUST00000155602.1
 Acbd5
acyl-Coenzyme A binding domain containing 5
chr5_+_110330697 1.245 ENSMUST00000112481.1
 Pole
polymerase (DNA directed), epsilon
chr10_+_100488289 1.182 ENSMUST00000164751.1
 Cep290
centrosomal protein 290
chr1_-_156034826 1.081 ENSMUST00000141878.1
ENSMUST00000123705.1
 Tor1aip1

torsin A interacting protein 1

chr7_-_116237767 1.039 ENSMUST00000182834.1
 Plekha7
pleckstrin homology domain containing, family A member 7
chr1_+_179960472 0.989 ENSMUST00000097453.2
ENSMUST00000111117.1
 Cdc42bpa

CDC42 binding protein kinase alpha

chr9_-_10904697 0.421 ENSMUST00000162484.1
 Cntn5
contactin 5
chr9_-_10904766 0.356 ENSMUST00000160216.1
 Cntn5
contactin 5
chr4_+_62619515 0.138 ENSMUST00000084521.4
ENSMUST00000107424.1
 Rgs3

regulator of G-protein signaling 3

chr12_-_108702265 0.062 ENSMUST00000167978.1
ENSMUST00000021691.4
 Degs2

degenerative spermatocyte homolog 2 (Drosophila), lipid desaturase

chr10_+_52358767 0.034 ENSMUST00000180473.1
 Gm26741
predicted gene, 26741

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 8.7 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.7 8.0 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.4 1.2 GO:0045004 DNA replication proofreading(GO:0045004)
0.3 2.5 GO:0071763 nuclear membrane organization(GO:0071763)
0.2 1.4 GO:0030242 pexophagy(GO:0030242)
0.2 5.2 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.2 3.8 GO:0006958 complement activation, classical pathway(GO:0006958)
0.2 1.0 GO:0045218 zonula adherens maintenance(GO:0045218)
0.2 2.0 GO:0090435 protein localization to nuclear envelope(GO:0090435)
0.1 1.5 GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus(GO:0097011)
0.0 0.9 GO:0007097 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)
0.0 1.2 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.0 0.1 GO:0006667 sphinganine metabolic process(GO:0006667)
0.0 2.2 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.8 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.2 1.2 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.2 1.5 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.2 8.0 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 1.0 GO:0005915 zonula adherens(GO:0005915)
0.1 1.2 GO:0036038 MKS complex(GO:0036038)
0.0 8.7 GO:0005667 transcription factor complex(GO:0005667)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 8.0 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.4 1.2 GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.4 5.2 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.2 3.8 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.1 1.5 GO:0017151 DEAD/H-box RNA helicase binding(GO:0017151)
0.1 4.5 GO:0001671 ATPase activator activity(GO:0001671)
0.1 1.0 GO:0070097 delta-catenin binding(GO:0070097)
0.0 8.7 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 1.4 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 0.1 GO:0042284 sphingolipid delta-4 desaturase activity(GO:0042284)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 5.2 PID_E2F_PATHWAY E2F transcription factor network
0.0 1.0 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 8.0 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 5.2 REACTOME_G1_PHASE Genes involved in G1 Phase
0.1 1.2 REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.0 1.2 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes