Motif ID: Nkx2-9

Z-value: 0.490


Transcription factors associated with Nkx2-9:

Gene SymbolEntrez IDGene Name
Nkx2-9 ENSMUSG00000058669.7 Nkx2-9

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx2-9mm10_v2_chr12_-_56613270_56613291-0.019.0e-01Click!


Activity profile for motif Nkx2-9.

activity profile for motif Nkx2-9


Sorted Z-values histogram for motif Nkx2-9

Sorted Z-values for motif Nkx2-9



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-9

PNG image of the network

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Top targets:


Showing 1 to 20 of 129 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_117849223 4.867 ENSMUST00000081387.4
 Birc5
baculoviral IAP repeat-containing 5
chr11_-_84068766 3.976 ENSMUST00000018792.5
 Dusp14
dual specificity phosphatase 14
chr4_+_8690399 3.422 ENSMUST00000127476.1
 Chd7
chromodomain helicase DNA binding protein 7
chr2_+_181767040 3.391 ENSMUST00000108756.1
 Myt1
myelin transcription factor 1
chr11_+_117849286 3.228 ENSMUST00000093906.4
 Birc5
baculoviral IAP repeat-containing 5
chr2_+_173022360 3.193 ENSMUST00000173997.1
 Rbm38
RNA binding motif protein 38
chr5_+_30105161 3.186 ENSMUST00000058045.4
 Gareml
GRB2 associated, regulator of MAPK1-like
chr10_+_88091070 2.724 ENSMUST00000048621.7
 Pmch
pro-melanin-concentrating hormone
chr13_-_71963713 2.690 ENSMUST00000077337.8
 Irx1
Iroquois related homeobox 1 (Drosophila)
chr14_+_75455957 2.667 ENSMUST00000164848.1
 Siah3
seven in absentia homolog 3 (Drosophila)
chr8_+_95633500 2.225 ENSMUST00000034094.9
 Gins3
GINS complex subunit 3 (Psf3 homolog)
chr16_-_33380717 2.082 ENSMUST00000180923.1
 1700007L15Rik
RIKEN cDNA 1700007L15 gene
chr8_-_70700070 1.741 ENSMUST00000116172.1
 Gm11175
predicted gene 11175
chr6_-_6217023 1.736 ENSMUST00000015256.8
 Slc25a13
solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13
chr16_-_59555752 1.730 ENSMUST00000179383.1
ENSMUST00000044604.8
 Crybg3

beta-gamma crystallin domain containing 3

chr1_-_135688094 1.727 ENSMUST00000112103.1
 Nav1
neuron navigator 1
chr1_-_131097535 1.700 ENSMUST00000016672.4
 Mapkapk2
MAP kinase-activated protein kinase 2
chr6_-_142507805 1.658 ENSMUST00000134191.1
ENSMUST00000032373.5
 Ldhb

lactate dehydrogenase B

chr1_-_181842334 1.608 ENSMUST00000005003.6
 Lbr
lamin B receptor
chr8_-_80880479 1.582 ENSMUST00000034150.8
 Gab1
growth factor receptor bound protein 2-associated protein 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 8.1 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
0.3 4.9 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.1 4.0 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.9 3.6 GO:0072272 proximal/distal pattern formation involved in metanephric nephron development(GO:0072272)
1.1 3.4 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.3 3.4 GO:0060539 diaphragm development(GO:0060539)
0.9 2.7 GO:0042320 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938)
0.5 2.7 GO:1903215 negative regulation of protein targeting to mitochondrion(GO:1903215)
0.4 1.7 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.3 1.7 GO:0019244 lactate biosynthetic process from pyruvate(GO:0019244)
0.1 1.6 GO:0035728 response to hepatocyte growth factor(GO:0035728)
0.0 1.6 GO:0016126 sterol biosynthetic process(GO:0016126)
0.1 1.4 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.2 1.3 GO:0071883 activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
0.1 1.2 GO:0055070 copper ion homeostasis(GO:0055070)
0.1 1.1 GO:0048251 elastic fiber assembly(GO:0048251)
0.1 1.0 GO:0009162 deoxyribonucleoside monophosphate metabolic process(GO:0009162)
0.0 1.0 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 1.0 GO:0007588 excretion(GO:0007588)
0.0 1.0 GO:0042775 mitochondrial ATP synthesis coupled electron transport(GO:0042775)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 8.1 GO:0032133 interphase microtubule organizing center(GO:0031021) chromosome passenger complex(GO:0032133)
0.0 1.6 GO:0005844 polysome(GO:0005844)
0.1 1.4 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 1.3 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.1 1.2 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 1.2 GO:0043209 myelin sheath(GO:0043209)
0.1 1.1 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.1 0.9 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.0 0.9 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.9 GO:0031594 neuromuscular junction(GO:0031594)
0.0 0.7 GO:0043194 axon initial segment(GO:0043194)
0.0 0.6 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.1 0.5 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.1 0.5 GO:0097513 myosin II filament(GO:0097513)
0.0 0.4 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.1 0.3 GO:0031251 PAN complex(GO:0031251)
0.0 0.3 GO:0031931 TORC1 complex(GO:0031931)
0.0 0.3 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 0.2 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.2 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.1 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.3 4.0 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 3.4 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.0 3.2 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.1 3.1 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 2.7 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.4 1.7 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.4 1.7 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.1 1.7 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.2 1.6 GO:0070087 chromo shadow domain binding(GO:0070087)
0.3 1.5 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0 1.4 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.1 1.3 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 1.2 GO:0005507 copper ion binding(GO:0005507)
0.2 1.0 GO:0003844 1,4-alpha-glucan branching enzyme activity(GO:0003844)
0.1 1.0 GO:0001515 opioid peptide activity(GO:0001515)
0.1 1.0 GO:0016618 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.0 1.0 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds(GO:0016799)
0.0 1.0 GO:0042054 histone methyltransferase activity(GO:0042054)
0.1 0.9 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)

Gene overrepresentation in C2:CP category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.1 PID_AURORA_A_PATHWAY Aurora A signaling
0.1 3.4 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.1 2.2 ST_P38_MAPK_PATHWAY p38 MAPK Pathway
0.1 1.6 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway
0.0 1.3 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events
0.0 0.9 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.9 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.8 PID_IL27_PATHWAY IL27-mediated signaling events
0.0 0.8 PID_PLK1_PATHWAY PLK1 signaling events
0.0 0.7 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 0.3 PID_ALK2_PATHWAY ALK2 signaling events
0.0 0.3 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.9 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 3.8 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 1.7 REACTOME_P38MAPK_EVENTS Genes involved in p38MAPK events
0.1 1.7 REACTOME_PYRUVATE_METABOLISM Genes involved in Pyruvate metabolism
0.0 1.7 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 1.6 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 1.6 REACTOME_SIGNALING_BY_CONSTITUTIVELY_ACTIVE_EGFR Genes involved in Signaling by constitutively active EGFR
0.0 1.0 REACTOME_GLUCOSE_METABOLISM Genes involved in Glucose metabolism
0.0 0.9 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 0.9 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.0 0.8 REACTOME_IL_RECEPTOR_SHC_SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.5 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.0 0.5 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 0.5 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.3 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.3 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.0 0.3 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 0.2 REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT Genes involved in Regulation of beta-cell development