Motif ID: Nkx3-1

Z-value: 0.615


Transcription factors associated with Nkx3-1:

Gene SymbolEntrez IDGene Name
Nkx3-1 ENSMUSG00000022061.8 Nkx3-1



Activity profile for motif Nkx3-1.

activity profile for motif Nkx3-1


Sorted Z-values histogram for motif Nkx3-1

Sorted Z-values for motif Nkx3-1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx3-1

PNG image of the network

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Top targets:


Showing 1 to 20 of 145 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_+_100625737 8.213 ENSMUST00000048962.3
 Kif4
kinesin family member 4
chr6_+_128362919 5.335 ENSMUST00000073316.6
 Foxm1
forkhead box M1
chr9_+_72438534 4.702 ENSMUST00000034746.8
 Mns1
meiosis-specific nuclear structural protein 1
chr2_-_84775388 4.539 ENSMUST00000023994.3
 Serping1
serine (or cysteine) peptidase inhibitor, clade G, member 1
chr9_+_72438519 4.481 ENSMUST00000184604.1
 Mns1
meiosis-specific nuclear structural protein 1
chr2_-_84775420 4.275 ENSMUST00000111641.1
 Serping1
serine (or cysteine) peptidase inhibitor, clade G, member 1
chrX_+_56454871 3.630 ENSMUST00000039374.2
ENSMUST00000101553.2
 Ddx26b

DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B

chr10_-_13324160 3.530 ENSMUST00000105545.4
 Phactr2
phosphatase and actin regulator 2
chr2_+_23069210 3.409 ENSMUST00000155602.1
 Acbd5
acyl-Coenzyme A binding domain containing 5
chr4_+_116708571 3.239 ENSMUST00000106462.2
ENSMUST00000138305.1
ENSMUST00000125671.1
ENSMUST00000130828.1
 Ccdc163



coiled-coil domain containing 163



chr1_-_133907053 3.132 ENSMUST00000149380.1
ENSMUST00000124051.2
 Optc

opticin

chr4_+_32623985 2.980 ENSMUST00000108178.1
 Casp8ap2
caspase 8 associated protein 2
chr17_+_56304313 2.832 ENSMUST00000113035.1
ENSMUST00000113039.2
ENSMUST00000142387.1
 Uhrf1


ubiquitin-like, containing PHD and RING finger domains, 1


chr10_-_62814539 2.688 ENSMUST00000173087.1
ENSMUST00000174121.1
 Tet1

tet methylcytosine dioxygenase 1

chr18_-_6241486 2.684 ENSMUST00000025083.7
 Kif5b
kinesin family member 5B
chr7_+_123123870 2.661 ENSMUST00000094053.5
 Tnrc6a
trinucleotide repeat containing 6a
chr5_-_8422582 2.657 ENSMUST00000168500.1
ENSMUST00000002368.9
 Dbf4

DBF4 homolog (S. cerevisiae)

chr9_-_62537036 2.619 ENSMUST00000048043.5
 Coro2b
coronin, actin binding protein, 2B
chr8_-_123318553 2.569 ENSMUST00000118395.1
ENSMUST00000035495.8
 Fanca

Fanconi anemia, complementation group A

chr2_-_93849679 2.473 ENSMUST00000068513.4
ENSMUST00000041593.8
ENSMUST00000130077.1
 Accs


1-aminocyclopropane-1-carboxylate synthase (non-functional)



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 72 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 9.2 GO:0070986 left/right axis specification(GO:0070986)
2.9 8.8 GO:0001869 regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
0.9 8.2 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.1 5.5 GO:0016525 negative regulation of angiogenesis(GO:0016525)
0.5 5.3 GO:2000781 positive regulation of double-strand break repair(GO:2000781)
0.7 5.2 GO:0030242 pexophagy(GO:0030242)
1.0 5.1 GO:0035617 stress granule disassembly(GO:0035617) plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386) regulation of voltage-gated sodium channel activity(GO:1905150)
0.8 4.6 GO:0036394 amylase secretion(GO:0036394)
1.1 4.3 GO:0035609 C-terminal protein deglutamylation(GO:0035609)
0.5 3.0 GO:0036337 Fas signaling pathway(GO:0036337)
0.3 2.8 GO:0090308 regulation of methylation-dependent chromatin silencing(GO:0090308)
0.9 2.7 GO:0015938 coenzyme A catabolic process(GO:0015938) nucleoside bisphosphate catabolic process(GO:0033869) ribonucleoside bisphosphate catabolic process(GO:0034031) purine nucleoside bisphosphate catabolic process(GO:0034034) acetyl-CoA catabolic process(GO:0046356)
0.5 2.7 GO:0090310 negative regulation of methylation-dependent chromatin silencing(GO:0090310)
0.5 2.7 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
0.2 2.7 GO:0045974 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.4 2.6 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
0.3 2.5 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.8 2.4 GO:0007525 somatic muscle development(GO:0007525)
0.3 2.4 GO:0019240 citrulline biosynthetic process(GO:0019240)
0.1 2.4 GO:0050873 brown fat cell differentiation(GO:0050873)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.2 GO:0005882 intermediate filament(GO:0005882)
0.1 8.2 GO:0005871 kinesin complex(GO:0005871)
0.1 7.6 GO:0072562 blood microparticle(GO:0072562)
0.0 7.0 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 5.5 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.2 5.1 GO:0035253 ciliary rootlet(GO:0035253)
0.5 4.6 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 4.3 GO:0005814 centriole(GO:0005814)
0.0 3.0 GO:0016605 PML body(GO:0016605)
0.0 2.8 GO:0000791 euchromatin(GO:0000791)
0.3 2.7 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.2 2.6 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.2 2.4 GO:0070938 contractile ring(GO:0070938)
0.2 1.9 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.1 1.9 GO:0036038 MKS complex(GO:0036038)
0.4 1.8 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.4 1.8 GO:0032389 MutLalpha complex(GO:0032389)
0.0 1.5 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 1.4 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 1.4 GO:0031225 anchored component of membrane(GO:0031225)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 8.8 GO:0001848 complement binding(GO:0001848)
0.3 8.2 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 7.9 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)
0.2 5.2 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.7 5.1 GO:0099609 microtubule lateral binding(GO:0099609)
0.3 4.6 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.2 3.4 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 3.3 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.4 3.0 GO:0032184 SUMO polymer binding(GO:0032184)
0.7 2.8 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
0.9 2.7 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.4 2.7 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
0.1 2.5 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.6 2.4 GO:0034618 arginine binding(GO:0034618)
0.1 2.4 GO:0017166 vinculin binding(GO:0017166)
0.0 2.4 GO:0033613 activating transcription factor binding(GO:0033613)
0.2 2.3 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.1 2.3 GO:0042169 SH2 domain binding(GO:0042169)
0.0 2.3 GO:0008565 protein transporter activity(GO:0008565)
0.1 2.1 GO:0005078 MAP-kinase scaffold activity(GO:0005078)

Gene overrepresentation in C2:CP category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.7 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2 5.5 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 5.1 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.1 4.6 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 4.4 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 3.6 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 3.2 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.1 3.0 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1 2.6 PID_BARD1_PATHWAY BARD1 signaling events
0.1 2.5 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.0 0.8 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 0.8 PID_LKB1_PATHWAY LKB1 signaling events
0.0 0.7 PID_S1P_S1P2_PATHWAY S1P2 pathway
0.0 0.6 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 0.5 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 8.8 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.2 5.1 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.1 3.3 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.1 3.2 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS Genes involved in Trafficking of AMPA receptors
0.1 2.7 REACTOME_REGULATORY_RNA_PATHWAYS Genes involved in Regulatory RNA pathways
0.1 2.7 REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Activation of the pre-replicative complex
0.1 2.6 REACTOME_FANCONI_ANEMIA_PATHWAY Genes involved in Fanconi Anemia pathway
0.0 2.1 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 1.9 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 1.8 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.4 1.5 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.0 1.4 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1
0.0 1.1 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 1.0 REACTOME_MEIOTIC_RECOMBINATION Genes involved in Meiotic Recombination
0.1 0.9 REACTOME_REGULATION_OF_WATER_BALANCE_BY_RENAL_AQUAPORINS Genes involved in Regulation of Water Balance by Renal Aquaporins
0.1 0.8 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.0 0.8 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.6 REACTOME_MRNA_CAPPING Genes involved in mRNA Capping
0.0 0.3 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.3 REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis