Motif ID: Nkx3-1
Z-value: 0.615
Transcription factors associated with Nkx3-1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Nkx3-1 | ENSMUSG00000022061.8 | Nkx3-1 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.9 | 8.8 | GO:0001869 | regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869) |
| 1.1 | 4.3 | GO:0035609 | C-terminal protein deglutamylation(GO:0035609) |
| 1.0 | 5.1 | GO:0035617 | stress granule disassembly(GO:0035617) plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386) regulation of voltage-gated sodium channel activity(GO:1905150) |
| 0.9 | 8.2 | GO:0051256 | mitotic spindle midzone assembly(GO:0051256) |
| 0.9 | 2.7 | GO:0015938 | coenzyme A catabolic process(GO:0015938) nucleoside bisphosphate catabolic process(GO:0033869) ribonucleoside bisphosphate catabolic process(GO:0034031) purine nucleoside bisphosphate catabolic process(GO:0034034) acetyl-CoA catabolic process(GO:0046356) |
| 0.8 | 2.4 | GO:0007525 | somatic muscle development(GO:0007525) |
| 0.8 | 4.6 | GO:0036394 | amylase secretion(GO:0036394) |
| 0.7 | 5.2 | GO:0030242 | pexophagy(GO:0030242) |
| 0.6 | 9.2 | GO:0070986 | left/right axis specification(GO:0070986) |
| 0.5 | 2.7 | GO:0090310 | negative regulation of methylation-dependent chromatin silencing(GO:0090310) |
| 0.5 | 5.3 | GO:2000781 | positive regulation of double-strand break repair(GO:2000781) |
| 0.5 | 2.7 | GO:0007089 | traversing start control point of mitotic cell cycle(GO:0007089) |
| 0.5 | 3.0 | GO:0036337 | Fas signaling pathway(GO:0036337) |
| 0.5 | 1.5 | GO:0090327 | negative regulation of locomotion involved in locomotory behavior(GO:0090327) |
| 0.4 | 1.3 | GO:0070093 | negative regulation of glucagon secretion(GO:0070093) |
| 0.4 | 1.2 | GO:0010845 | positive regulation of reciprocal meiotic recombination(GO:0010845) |
| 0.4 | 1.5 | GO:0006561 | proline biosynthetic process(GO:0006561) |
| 0.4 | 1.5 | GO:0042905 | 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905) |
| 0.4 | 2.6 | GO:2000348 | regulation of CD40 signaling pathway(GO:2000348) |
| 0.3 | 2.1 | GO:0071883 | activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883) |
| 0.3 | 2.8 | GO:0090308 | regulation of methylation-dependent chromatin silencing(GO:0090308) |
| 0.3 | 0.8 | GO:0045819 | plasmacytoid dendritic cell activation(GO:0002270) positive regulation of glycogen catabolic process(GO:0045819) |
| 0.3 | 2.5 | GO:1900194 | negative regulation of oocyte maturation(GO:1900194) |
| 0.3 | 2.4 | GO:0019240 | citrulline biosynthetic process(GO:0019240) |
| 0.3 | 1.8 | GO:0072257 | metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307) |
| 0.2 | 1.8 | GO:0018344 | protein geranylgeranylation(GO:0018344) |
| 0.2 | 1.1 | GO:1903361 | protein localization to basolateral plasma membrane(GO:1903361) |
| 0.2 | 0.8 | GO:0010920 | negative regulation of inositol phosphate biosynthetic process(GO:0010920) |
| 0.2 | 1.9 | GO:1900262 | regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264) |
| 0.2 | 2.7 | GO:0045974 | miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974) |
| 0.2 | 0.7 | GO:0060800 | regulation of cell differentiation involved in embryonic placenta development(GO:0060800) |
| 0.2 | 1.6 | GO:0006620 | posttranslational protein targeting to membrane(GO:0006620) |
| 0.1 | 1.4 | GO:0071763 | nuclear membrane organization(GO:0071763) |
| 0.1 | 0.7 | GO:0003376 | sphingosine-1-phosphate signaling pathway(GO:0003376) sphingolipid mediated signaling pathway(GO:0090520) |
| 0.1 | 0.4 | GO:2000642 | negative regulation of early endosome to late endosome transport(GO:2000642) |
| 0.1 | 0.9 | GO:0009396 | folic acid-containing compound biosynthetic process(GO:0009396) |
| 0.1 | 1.4 | GO:2000381 | negative regulation of mesoderm development(GO:2000381) |
| 0.1 | 1.1 | GO:2000270 | negative regulation of fibroblast apoptotic process(GO:2000270) |
| 0.1 | 1.3 | GO:0048664 | neuron fate determination(GO:0048664) |
| 0.1 | 1.1 | GO:0046512 | sphingosine biosynthetic process(GO:0046512) sphingoid biosynthetic process(GO:0046520) |
| 0.1 | 0.3 | GO:2001206 | positive regulation of osteoclast development(GO:2001206) |
| 0.1 | 1.2 | GO:0006750 | glutathione biosynthetic process(GO:0006750) |
| 0.1 | 1.6 | GO:0006044 | N-acetylglucosamine metabolic process(GO:0006044) |
| 0.1 | 2.3 | GO:0030224 | monocyte differentiation(GO:0030224) |
| 0.1 | 0.6 | GO:0006370 | 7-methylguanosine mRNA capping(GO:0006370) |
| 0.1 | 2.4 | GO:0050873 | brown fat cell differentiation(GO:0050873) |
| 0.1 | 1.8 | GO:0006298 | mismatch repair(GO:0006298) |
| 0.1 | 1.0 | GO:0097034 | mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034) |
| 0.1 | 0.9 | GO:0050860 | negative regulation of T cell receptor signaling pathway(GO:0050860) |
| 0.1 | 5.5 | GO:0016525 | negative regulation of angiogenesis(GO:0016525) |
| 0.1 | 1.3 | GO:0010758 | regulation of macrophage chemotaxis(GO:0010758) |
| 0.1 | 0.6 | GO:0009143 | nucleoside triphosphate catabolic process(GO:0009143) ribonucleoside diphosphate catabolic process(GO:0009191) |
| 0.0 | 2.3 | GO:0002053 | positive regulation of mesenchymal cell proliferation(GO:0002053) |
| 0.0 | 1.9 | GO:0045494 | photoreceptor cell maintenance(GO:0045494) |
| 0.0 | 0.6 | GO:0045647 | negative regulation of erythrocyte differentiation(GO:0045647) |
| 0.0 | 1.2 | GO:0071158 | positive regulation of cell cycle arrest(GO:0071158) |
| 0.0 | 0.4 | GO:0036371 | protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) |
| 0.0 | 0.3 | GO:0009301 | snRNA transcription(GO:0009301) |
| 0.0 | 0.7 | GO:1990126 | retrograde transport, endosome to plasma membrane(GO:1990126) |
| 0.0 | 1.0 | GO:0007020 | microtubule nucleation(GO:0007020) |
| 0.0 | 0.6 | GO:1902043 | positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043) |
| 0.0 | 1.0 | GO:0007026 | negative regulation of microtubule depolymerization(GO:0007026) |
| 0.0 | 0.9 | GO:2000279 | negative regulation of DNA biosynthetic process(GO:2000279) |
| 0.0 | 0.7 | GO:1900087 | positive regulation of G1/S transition of mitotic cell cycle(GO:1900087) |
| 0.0 | 0.2 | GO:0070633 | transepithelial transport(GO:0070633) |
| 0.0 | 0.1 | GO:2000407 | T cell extravasation(GO:0072683) regulation of T cell extravasation(GO:2000407) |
| 0.0 | 0.9 | GO:1903078 | positive regulation of protein localization to plasma membrane(GO:1903078) |
| 0.0 | 0.1 | GO:0000727 | double-strand break repair via break-induced replication(GO:0000727) |
| 0.0 | 0.1 | GO:0060056 | mammary gland involution(GO:0060056) |
| 0.0 | 0.4 | GO:0090382 | phagosome maturation(GO:0090382) |
| 0.0 | 0.2 | GO:0090161 | Golgi ribbon formation(GO:0090161) |
| 0.0 | 0.2 | GO:0043277 | apoptotic cell clearance(GO:0043277) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 4.6 | GO:0032591 | dendritic spine membrane(GO:0032591) |
| 0.4 | 1.8 | GO:0005968 | Rab-protein geranylgeranyltransferase complex(GO:0005968) |
| 0.4 | 1.8 | GO:0032389 | MutLalpha complex(GO:0032389) |
| 0.3 | 2.7 | GO:0035068 | micro-ribonucleoprotein complex(GO:0035068) |
| 0.2 | 5.1 | GO:0035253 | ciliary rootlet(GO:0035253) |
| 0.2 | 2.6 | GO:0043240 | Fanconi anaemia nuclear complex(GO:0043240) |
| 0.2 | 1.9 | GO:0031390 | Ctf18 RFC-like complex(GO:0031390) |
| 0.2 | 0.7 | GO:0030906 | retromer, cargo-selective complex(GO:0030906) |
| 0.2 | 2.4 | GO:0070938 | contractile ring(GO:0070938) |
| 0.1 | 8.2 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.1 | 9.2 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.1 | 1.9 | GO:0036038 | MKS complex(GO:0036038) |
| 0.1 | 1.0 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
| 0.1 | 7.6 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.1 | 0.7 | GO:0005922 | connexon complex(GO:0005922) |
| 0.0 | 2.8 | GO:0000791 | euchromatin(GO:0000791) |
| 0.0 | 4.3 | GO:0005814 | centriole(GO:0005814) |
| 0.0 | 7.0 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.0 | 1.0 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.0 | 0.5 | GO:0012506 | vesicle membrane(GO:0012506) cytoplasmic vesicle membrane(GO:0030659) cytoplasmic vesicle part(GO:0044433) |
| 0.0 | 3.0 | GO:0016605 | PML body(GO:0016605) |
| 0.0 | 0.2 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.0 | 5.5 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.0 | 0.1 | GO:0000811 | GINS complex(GO:0000811) |
| 0.0 | 1.4 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
| 0.0 | 0.1 | GO:0032807 | DNA ligase IV complex(GO:0032807) |
| 0.0 | 1.0 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.0 | 1.5 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.0 | 0.4 | GO:0031430 | M band(GO:0031430) |
| 0.0 | 0.4 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.0 | 1.4 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 0.2 | GO:0000506 | glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506) |
| 0.0 | 0.4 | GO:0071339 | MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 2.7 | GO:0003986 | acetyl-CoA hydrolase activity(GO:0003986) |
| 0.7 | 5.1 | GO:0099609 | microtubule lateral binding(GO:0099609) |
| 0.7 | 2.8 | GO:0044729 | hemi-methylated DNA-binding(GO:0044729) |
| 0.6 | 2.4 | GO:0034618 | arginine binding(GO:0034618) |
| 0.4 | 2.7 | GO:0070579 | methylcytosine dioxygenase activity(GO:0070579) |
| 0.4 | 8.8 | GO:0001848 | complement binding(GO:0001848) |
| 0.4 | 3.0 | GO:0032184 | SUMO polymer binding(GO:0032184) |
| 0.4 | 1.5 | GO:0004735 | pyrroline-5-carboxylate reductase activity(GO:0004735) |
| 0.4 | 1.1 | GO:0071633 | dihydroceramidase activity(GO:0071633) |
| 0.3 | 1.6 | GO:0004342 | glucosamine-6-phosphate deaminase activity(GO:0004342) |
| 0.3 | 4.6 | GO:0030346 | protein phosphatase 2B binding(GO:0030346) |
| 0.3 | 1.5 | GO:0004028 | 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028) |
| 0.3 | 0.8 | GO:0000402 | open form four-way junction DNA binding(GO:0000401) crossed form four-way junction DNA binding(GO:0000402) |
| 0.3 | 8.2 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.2 | 1.6 | GO:0015129 | lactate transmembrane transporter activity(GO:0015129) |
| 0.2 | 2.3 | GO:0016701 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702) |
| 0.2 | 3.4 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.2 | 1.9 | GO:0003689 | DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170) |
| 0.2 | 5.2 | GO:0000062 | fatty-acyl-CoA binding(GO:0000062) |
| 0.2 | 0.9 | GO:0061649 | ubiquitinated histone binding(GO:0061649) |
| 0.1 | 2.4 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.1 | 0.7 | GO:0070568 | guanylyltransferase activity(GO:0070568) |
| 0.1 | 3.3 | GO:1900750 | glutathione binding(GO:0043295) oligopeptide binding(GO:1900750) |
| 0.1 | 1.0 | GO:0005519 | cytoskeletal regulatory protein binding(GO:0005519) |
| 0.1 | 2.1 | GO:0005078 | MAP-kinase scaffold activity(GO:0005078) |
| 0.1 | 0.7 | GO:0004865 | protein serine/threonine phosphatase inhibitor activity(GO:0004865) |
| 0.1 | 1.8 | GO:0005092 | GDP-dissociation inhibitor activity(GO:0005092) |
| 0.1 | 1.3 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.1 | 1.2 | GO:0042800 | histone methyltransferase activity (H3-K4 specific)(GO:0042800) |
| 0.1 | 2.3 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 0.1 | 2.5 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.1 | 1.1 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.1 | 1.1 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.1 | 0.9 | GO:0005542 | folic acid binding(GO:0005542) |
| 0.0 | 1.5 | GO:0031690 | adrenergic receptor binding(GO:0031690) |
| 0.0 | 1.3 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 0.0 | 0.3 | GO:0008420 | CTD phosphatase activity(GO:0008420) |
| 0.0 | 1.4 | GO:0001671 | ATPase activator activity(GO:0001671) |
| 0.0 | 0.8 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
| 0.0 | 2.1 | GO:0032947 | protein complex scaffold(GO:0032947) |
| 0.0 | 0.6 | GO:0017110 | nucleoside-diphosphatase activity(GO:0017110) |
| 0.0 | 1.2 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.0 | 2.4 | GO:0033613 | activating transcription factor binding(GO:0033613) |
| 0.0 | 0.2 | GO:0015037 | peptide disulfide oxidoreductase activity(GO:0015037) |
| 0.0 | 1.2 | GO:0019894 | kinesin binding(GO:0019894) |
| 0.0 | 2.3 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.0 | 0.2 | GO:0017176 | phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176) |
| 0.0 | 0.1 | GO:0004704 | NF-kappaB-inducing kinase activity(GO:0004704) |
| 0.0 | 0.1 | GO:0043138 | 3'-5' DNA helicase activity(GO:0043138) |
| 0.0 | 0.1 | GO:0016151 | nickel cation binding(GO:0016151) |
| 0.0 | 0.1 | GO:0003847 | 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847) |
| 0.0 | 1.6 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.0 | 7.9 | GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 5.5 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 3.0 | SA_PROGRAMMED_CELL_DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.1 | 4.6 | PID_TCR_CALCIUM_PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 5.1 | PID_NCADHERIN_PATHWAY | N-cadherin signaling events |
| 0.1 | 2.5 | PID_PDGFRA_PATHWAY | PDGFR-alpha signaling pathway |
| 0.1 | 3.2 | PID_FOXM1_PATHWAY | FOXM1 transcription factor network |
| 0.1 | 2.6 | PID_BARD1_PATHWAY | BARD1 signaling events |
| 0.1 | 4.4 | PID_RHOA_REG_PATHWAY | Regulation of RhoA activity |
| 0.1 | 7.7 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 0.5 | PID_TCR_RAS_PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.0 | 0.8 | PID_TOLL_ENDOGENOUS_PATHWAY | Endogenous TLR signaling |
| 0.0 | 0.7 | PID_S1P_S1P2_PATHWAY | S1P2 pathway |
| 0.0 | 0.6 | PID_IL2_STAT5_PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.0 | 3.6 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 0.8 | PID_LKB1_PATHWAY | LKB1 signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 8.8 | REACTOME_INTRINSIC_PATHWAY | Genes involved in Intrinsic Pathway |
| 0.4 | 1.5 | REACTOME_ETHANOL_OXIDATION | Genes involved in Ethanol oxidation |
| 0.2 | 5.1 | REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.1 | 3.3 | REACTOME_GLUTATHIONE_CONJUGATION | Genes involved in Glutathione conjugation |
| 0.1 | 2.6 | REACTOME_FANCONI_ANEMIA_PATHWAY | Genes involved in Fanconi Anemia pathway |
| 0.1 | 2.7 | REACTOME_REGULATORY_RNA_PATHWAYS | Genes involved in Regulatory RNA pathways |
| 0.1 | 0.9 | REACTOME_REGULATION_OF_WATER_BALANCE_BY_RENAL_AQUAPORINS | Genes involved in Regulation of Water Balance by Renal Aquaporins |
| 0.1 | 2.7 | REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX | Genes involved in Activation of the pre-replicative complex |
| 0.1 | 3.2 | REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS | Genes involved in Trafficking of AMPA receptors |
| 0.1 | 1.8 | REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.1 | 0.8 | REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 0.0 | 0.3 | REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES | Genes involved in The activation of arylsulfatases |
| 0.0 | 0.6 | REACTOME_MRNA_CAPPING | Genes involved in mRNA Capping |
| 0.0 | 1.4 | REACTOME_RECYCLING_PATHWAY_OF_L1 | Genes involved in Recycling pathway of L1 |
| 0.0 | 2.1 | REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK | Genes involved in NRAGE signals death through JNK |
| 0.0 | 1.1 | REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.0 | 1.9 | REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.0 | 0.3 | REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.0 | 0.2 | REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.0 | 0.1 | REACTOME_UNWINDING_OF_DNA | Genes involved in Unwinding of DNA |
| 0.0 | 1.0 | REACTOME_MEIOTIC_RECOMBINATION | Genes involved in Meiotic Recombination |
| 0.0 | 0.8 | REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ | Genes involved in Response to elevated platelet cytosolic Ca2+ |
