Motif ID: Nkx3-2
Z-value: 0.830

Transcription factors associated with Nkx3-2:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Nkx3-2 | ENSMUSG00000049691.7 | Nkx3-2 |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 135 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.5 | 12.3 | GO:0035641 | locomotory exploration behavior(GO:0035641) |
0.3 | 10.0 | GO:0050873 | brown fat cell differentiation(GO:0050873) |
0.8 | 9.0 | GO:0090232 | positive regulation of spindle checkpoint(GO:0090232) |
0.8 | 7.2 | GO:0071397 | cellular response to cholesterol(GO:0071397) |
2.3 | 7.0 | GO:0099548 | trans-synaptic signaling by nitric oxide(GO:0099548) |
0.5 | 6.0 | GO:2000480 | negative regulation of cAMP-dependent protein kinase activity(GO:2000480) |
1.1 | 5.4 | GO:2000987 | positive regulation of fear response(GO:1903367) positive regulation of behavioral fear response(GO:2000987) |
0.4 | 5.4 | GO:1901898 | negative regulation of relaxation of cardiac muscle(GO:1901898) |
0.3 | 5.0 | GO:0046321 | positive regulation of fatty acid oxidation(GO:0046321) |
0.5 | 4.7 | GO:0060907 | positive regulation of macrophage cytokine production(GO:0060907) |
1.1 | 4.5 | GO:0009597 | detection of virus(GO:0009597) |
1.1 | 4.5 | GO:0099566 | regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566) |
0.7 | 3.9 | GO:1901552 | positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142) |
0.0 | 3.9 | GO:0007416 | synapse assembly(GO:0007416) |
1.2 | 3.7 | GO:0061075 | cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871) |
0.2 | 3.7 | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis(GO:0051044) |
0.1 | 3.7 | GO:0071480 | cellular response to gamma radiation(GO:0071480) |
0.9 | 3.5 | GO:0099527 | postsynapse to nucleus signaling pathway(GO:0099527) |
0.8 | 3.4 | GO:0032227 | negative regulation of synaptic transmission, dopaminergic(GO:0032227) |
0.8 | 3.4 | GO:0010986 | positive regulation of lipoprotein particle clearance(GO:0010986) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 77 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 14.5 | GO:0031225 | anchored component of membrane(GO:0031225) |
0.0 | 9.7 | GO:0045211 | postsynaptic membrane(GO:0045211) |
0.4 | 8.5 | GO:0005605 | basal lamina(GO:0005605) |
0.1 | 8.5 | GO:0005923 | bicellular tight junction(GO:0005923) |
0.1 | 7.8 | GO:0055037 | recycling endosome(GO:0055037) |
0.4 | 7.0 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
0.2 | 6.7 | GO:0055038 | recycling endosome membrane(GO:0055038) |
0.5 | 6.0 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
0.1 | 5.5 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
1.4 | 5.4 | GO:0032280 | symmetric synapse(GO:0032280) |
0.2 | 5.4 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
0.1 | 5.0 | GO:0005581 | collagen trimer(GO:0005581) |
0.2 | 4.7 | GO:0098839 | postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634) |
0.4 | 4.5 | GO:0043083 | synaptic cleft(GO:0043083) |
0.1 | 3.5 | GO:0097440 | apical dendrite(GO:0097440) |
0.2 | 3.4 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
0.2 | 3.2 | GO:0042581 | specific granule(GO:0042581) |
0.0 | 3.2 | GO:0098852 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
0.0 | 3.1 | GO:0016529 | sarcoplasmic reticulum(GO:0016529) |
0.0 | 3.1 | GO:0001650 | fibrillar center(GO:0001650) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 100 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.3 | 14.4 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
0.1 | 7.2 | GO:0008565 | protein transporter activity(GO:0008565) |
0.6 | 7.0 | GO:0004016 | adenylate cyclase activity(GO:0004016) |
0.1 | 7.0 | GO:0003727 | single-stranded RNA binding(GO:0003727) |
0.5 | 6.0 | GO:0008603 | cAMP-dependent protein kinase regulator activity(GO:0008603) |
0.8 | 5.4 | GO:0001515 | opioid peptide activity(GO:0001515) |
0.4 | 4.7 | GO:0038191 | neuropilin binding(GO:0038191) |
0.6 | 4.5 | GO:0099583 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583) |
0.1 | 4.5 | GO:0005484 | SNAP receptor activity(GO:0005484) |
1.4 | 4.1 | GO:0022833 | mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833) |
0.0 | 3.9 | GO:0044325 | ion channel binding(GO:0044325) |
1.2 | 3.7 | GO:0036313 | phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313) |
0.0 | 3.7 | GO:0005244 | voltage-gated ion channel activity(GO:0005244) voltage-gated channel activity(GO:0022832) |
0.0 | 3.5 | GO:0005249 | voltage-gated potassium channel activity(GO:0005249) |
0.0 | 3.5 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
0.8 | 3.4 | GO:0035473 | lipase binding(GO:0035473) |
0.2 | 2.6 | GO:0033549 | MAP kinase phosphatase activity(GO:0033549) |
0.6 | 2.5 | GO:0016361 | activin receptor activity, type I(GO:0016361) |
0.4 | 2.5 | GO:0047276 | N-acetyllactosaminide 3-alpha-galactosyltransferase activity(GO:0047276) |
0.1 | 2.5 | GO:0050699 | WW domain binding(GO:0050699) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 26 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 11.6 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
0.2 | 8.5 | NABA_BASEMENT_MEMBRANES | Genes encoding structural components of basement membranes |
0.1 | 8.5 | PID_HIF1_TFPATHWAY | HIF-1-alpha transcription factor network |
0.1 | 6.0 | PID_INTEGRIN_A4B1_PATHWAY | Alpha4 beta1 integrin signaling events |
0.1 | 5.6 | PID_AP1_PATHWAY | AP-1 transcription factor network |
0.0 | 5.6 | NABA_MATRISOME_ASSOCIATED | Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors |
0.0 | 5.4 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
0.1 | 4.5 | PID_REELIN_PATHWAY | Reelin signaling pathway |
0.2 | 4.3 | PID_S1P_S1P2_PATHWAY | S1P2 pathway |
0.1 | 4.2 | PID_A6B1_A6B4_INTEGRIN_PATHWAY | a6b1 and a6b4 Integrin signaling |
0.2 | 2.5 | PID_ALK2_PATHWAY | ALK2 signaling events |
0.2 | 2.4 | PID_ERBB_NETWORK_PATHWAY | ErbB receptor signaling network |
0.1 | 2.4 | ST_GA12_PATHWAY | G alpha 12 Pathway |
0.1 | 2.3 | PID_NCADHERIN_PATHWAY | N-cadherin signaling events |
0.0 | 2.2 | PID_MYC_ACTIV_PATHWAY | Validated targets of C-MYC transcriptional activation |
0.0 | 1.7 | PID_RB_1PATHWAY | Regulation of retinoblastoma protein |
0.0 | 1.5 | PID_MTOR_4PATHWAY | mTOR signaling pathway |
0.0 | 1.4 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
0.0 | 1.2 | PID_P53_DOWNSTREAM_PATHWAY | Direct p53 effectors |
0.0 | 0.9 | PID_IL8_CXCR1_PATHWAY | IL8- and CXCR1-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 38 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.3 | 11.4 | REACTOME_DARPP_32_EVENTS | Genes involved in DARPP-32 events |
0.2 | 7.0 | REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |
0.2 | 6.7 | REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |
0.1 | 6.4 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
0.2 | 4.7 | REACTOME_OTHER_SEMAPHORIN_INTERACTIONS | Genes involved in Other semaphorin interactions |
0.3 | 4.5 | REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |
0.1 | 4.1 | REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS | Genes involved in Adherens junctions interactions |
0.2 | 3.5 | REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
0.2 | 3.5 | REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
0.1 | 3.5 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
0.3 | 2.8 | REACTOME_ACYL_CHAIN_REMODELLING_OF_PS | Genes involved in Acyl chain remodelling of PS |
0.3 | 2.6 | REACTOME_ERKS_ARE_INACTIVATED | Genes involved in ERKs are inactivated |
0.8 | 2.4 | REACTOME_EICOSANOID_LIGAND_BINDING_RECEPTORS | Genes involved in Eicosanoid ligand-binding receptors |
0.1 | 2.2 | REACTOME_GLYCOLYSIS | Genes involved in Glycolysis |
0.1 | 1.9 | REACTOME_SULFUR_AMINO_ACID_METABOLISM | Genes involved in Sulfur amino acid metabolism |
0.1 | 1.9 | REACTOME_TRANSPORT_TO_THE_GOLGI_AND_SUBSEQUENT_MODIFICATION | Genes involved in Transport to the Golgi and subsequent modification |
0.1 | 1.8 | REACTOME_GAP_JUNCTION_DEGRADATION | Genes involved in Gap junction degradation |
0.1 | 1.8 | REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |
0.1 | 1.7 | REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
0.0 | 1.7 | REACTOME_NETRIN1_SIGNALING | Genes involved in Netrin-1 signaling |