Motif ID: Nkx3-2

Z-value: 0.830


Transcription factors associated with Nkx3-2:

Gene SymbolEntrez IDGene Name
Nkx3-2 ENSMUSG00000049691.7 Nkx3-2



Activity profile for motif Nkx3-2.

activity profile for motif Nkx3-2


Sorted Z-values histogram for motif Nkx3-2

Sorted Z-values for motif Nkx3-2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx3-2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_+_41532851 9.881 ENSMUST00000078873.4
Lsamp
limbic system-associated membrane protein
chr15_-_66969616 8.958 ENSMUST00000170903.1
ENSMUST00000166420.1
ENSMUST00000005256.6
ENSMUST00000164070.1
Ndrg1



N-myc downstream regulated gene 1



chr10_+_38965515 8.466 ENSMUST00000019992.5
Lama4
laminin, alpha 4
chr15_-_88978958 7.160 ENSMUST00000042594.6
ENSMUST00000109368.1
Mlc1

megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)

chr3_-_82074639 6.951 ENSMUST00000029635.8
Gucy1b3
guanylate cyclase 1, soluble, beta 3
chr9_-_21037775 6.360 ENSMUST00000180870.1
Gm26592
predicted gene, 26592
chr5_-_139130159 5.952 ENSMUST00000129851.1
Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
chr4_+_102421518 5.435 ENSMUST00000106904.2
Pde4b
phosphodiesterase 4B, cAMP specific
chr2_-_104409992 5.353 ENSMUST00000149466.1
ENSMUST00000139015.1
D430041D05Rik

RIKEN cDNA D430041D05 gene

chr11_+_43474276 4.965 ENSMUST00000173002.1
ENSMUST00000057679.3
C1qtnf2

C1q and tumor necrosis factor related protein 2

chr17_+_70561739 4.730 ENSMUST00000097288.2
Dlgap1
discs, large (Drosophila) homolog-associated protein 1
chr9_+_57940104 4.660 ENSMUST00000043059.7
Sema7a
sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A
chr6_-_136171722 4.454 ENSMUST00000053880.6
Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr6_-_138421379 4.304 ENSMUST00000163065.1
Lmo3
LIM domain only 3
chr10_-_86732409 4.067 ENSMUST00000070435.4
Fabp3-ps1
fatty acid binding protein 3, muscle and heart, pseudogene 1
chr2_-_156992021 3.962 ENSMUST00000109558.1
ENSMUST00000069600.6
ENSMUST00000072298.6
Ndrg3


N-myc downstream regulated gene 3


chr8_+_104101625 3.947 ENSMUST00000034339.8
Cdh5
cadherin 5
chr3_+_86070915 3.700 ENSMUST00000182666.1
Sh3d19
SH3 domain protein D19
chr11_+_3332426 3.689 ENSMUST00000136474.1
Pik3ip1
phosphoinositide-3-kinase interacting protein 1
chr2_-_71546745 3.677 ENSMUST00000024159.6
Dlx2
distal-less homeobox 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 135 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 12.3 GO:0035641 locomotory exploration behavior(GO:0035641)
0.3 10.0 GO:0050873 brown fat cell differentiation(GO:0050873)
0.8 9.0 GO:0090232 positive regulation of spindle checkpoint(GO:0090232)
0.8 7.2 GO:0071397 cellular response to cholesterol(GO:0071397)
2.3 7.0 GO:0099548 trans-synaptic signaling by nitric oxide(GO:0099548)
0.5 6.0 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
1.1 5.4 GO:2000987 positive regulation of fear response(GO:1903367) positive regulation of behavioral fear response(GO:2000987)
0.4 5.4 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.3 5.0 GO:0046321 positive regulation of fatty acid oxidation(GO:0046321)
0.5 4.7 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
1.1 4.5 GO:0009597 detection of virus(GO:0009597)
1.1 4.5 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.7 3.9 GO:1901552 positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
0.0 3.9 GO:0007416 synapse assembly(GO:0007416)
1.2 3.7 GO:0061075 cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
0.2 3.7 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.1 3.7 GO:0071480 cellular response to gamma radiation(GO:0071480)
0.9 3.5 GO:0099527 postsynapse to nucleus signaling pathway(GO:0099527)
0.8 3.4 GO:0032227 negative regulation of synaptic transmission, dopaminergic(GO:0032227)
0.8 3.4 GO:0010986 positive regulation of lipoprotein particle clearance(GO:0010986)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 77 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 14.5 GO:0031225 anchored component of membrane(GO:0031225)
0.0 9.7 GO:0045211 postsynaptic membrane(GO:0045211)
0.4 8.5 GO:0005605 basal lamina(GO:0005605)
0.1 8.5 GO:0005923 bicellular tight junction(GO:0005923)
0.1 7.8 GO:0055037 recycling endosome(GO:0055037)
0.4 7.0 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.2 6.7 GO:0055038 recycling endosome membrane(GO:0055038)
0.5 6.0 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 5.5 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
1.4 5.4 GO:0032280 symmetric synapse(GO:0032280)
0.2 5.4 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 5.0 GO:0005581 collagen trimer(GO:0005581)
0.2 4.7 GO:0098839 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.4 4.5 GO:0043083 synaptic cleft(GO:0043083)
0.1 3.5 GO:0097440 apical dendrite(GO:0097440)
0.2 3.4 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.2 3.2 GO:0042581 specific granule(GO:0042581)
0.0 3.2 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 3.1 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.0 3.1 GO:0001650 fibrillar center(GO:0001650)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 100 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 14.4 GO:0043015 gamma-tubulin binding(GO:0043015)
0.1 7.2 GO:0008565 protein transporter activity(GO:0008565)
0.6 7.0 GO:0004016 adenylate cyclase activity(GO:0004016)
0.1 7.0 GO:0003727 single-stranded RNA binding(GO:0003727)
0.5 6.0 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.8 5.4 GO:0001515 opioid peptide activity(GO:0001515)
0.4 4.7 GO:0038191 neuropilin binding(GO:0038191)
0.6 4.5 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.1 4.5 GO:0005484 SNAP receptor activity(GO:0005484)
1.4 4.1 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0 3.9 GO:0044325 ion channel binding(GO:0044325)
1.2 3.7 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.0 3.7 GO:0005244 voltage-gated ion channel activity(GO:0005244) voltage-gated channel activity(GO:0022832)
0.0 3.5 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.0 3.5 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.8 3.4 GO:0035473 lipase binding(GO:0035473)
0.2 2.6 GO:0033549 MAP kinase phosphatase activity(GO:0033549)
0.6 2.5 GO:0016361 activin receptor activity, type I(GO:0016361)
0.4 2.5 GO:0047276 N-acetyllactosaminide 3-alpha-galactosyltransferase activity(GO:0047276)
0.1 2.5 GO:0050699 WW domain binding(GO:0050699)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 11.6 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2 8.5 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.1 8.5 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 6.0 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.1 5.6 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 5.6 NABA_MATRISOME_ASSOCIATED Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors
0.0 5.4 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 4.5 PID_REELIN_PATHWAY Reelin signaling pathway
0.2 4.3 PID_S1P_S1P2_PATHWAY S1P2 pathway
0.1 4.2 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.2 2.5 PID_ALK2_PATHWAY ALK2 signaling events
0.2 2.4 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.1 2.4 ST_GA12_PATHWAY G alpha 12 Pathway
0.1 2.3 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 2.2 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.7 PID_RB_1PATHWAY Regulation of retinoblastoma protein
0.0 1.5 PID_MTOR_4PATHWAY mTOR signaling pathway
0.0 1.4 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.2 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.0 0.9 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 11.4 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.2 7.0 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.2 6.7 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.1 6.4 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.2 4.7 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.3 4.5 REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.1 4.1 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.2 3.5 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.2 3.5 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.1 3.5 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.3 2.8 REACTOME_ACYL_CHAIN_REMODELLING_OF_PS Genes involved in Acyl chain remodelling of PS
0.3 2.6 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.8 2.4 REACTOME_EICOSANOID_LIGAND_BINDING_RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.1 2.2 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.1 1.9 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 1.9 REACTOME_TRANSPORT_TO_THE_GOLGI_AND_SUBSEQUENT_MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.1 1.8 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.1 1.8 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.1 1.7 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 1.7 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling