Motif ID: Nkx6-1_Evx1_Hesx1

Z-value: 0.856

Transcription factors associated with Nkx6-1_Evx1_Hesx1:

Gene SymbolEntrez IDGene Name
Evx1 ENSMUSG00000005503.8 Evx1
Hesx1 ENSMUSG00000040726.8 Hesx1
Nkx6-1 ENSMUSG00000035187.8 Nkx6-1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx6-1mm10_v2_chr5_-_101665195_1016652260.181.1e-01Click!


Activity profile for motif Nkx6-1_Evx1_Hesx1.

activity profile for motif Nkx6-1_Evx1_Hesx1


Sorted Z-values histogram for motif Nkx6-1_Evx1_Hesx1

Sorted Z-values for motif Nkx6-1_Evx1_Hesx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx6-1_Evx1_Hesx1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_+_25773985 19.460 ENSMUST00000125667.1
 Myo10
myosin X
chr5_-_62766153 14.916 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr14_-_118052235 13.594 ENSMUST00000022725.2
 Dct
dopachrome tautomerase
chr3_-_49757257 12.039 ENSMUST00000035931.7
 Pcdh18
protocadherin 18
chr4_+_8690399 11.462 ENSMUST00000127476.1
 Chd7
chromodomain helicase DNA binding protein 7
chr2_-_79456750 11.439 ENSMUST00000041099.4
 Neurod1
neurogenic differentiation 1
chr9_+_118478182 10.608 ENSMUST00000111763.1
 Eomes
eomesodermin homolog (Xenopus laevis)
chr9_+_118478344 10.095 ENSMUST00000035020.8
 Eomes
eomesodermin homolog (Xenopus laevis)
chr2_+_20737306 9.829 ENSMUST00000114606.1
ENSMUST00000114608.1
 Etl4

enhancer trap locus 4

chr5_-_84417359 9.397 ENSMUST00000113401.1
 Epha5
Eph receptor A5
chrM_+_9870 8.976 ENSMUST00000084013.1
 mt-Nd4l
mitochondrially encoded NADH dehydrogenase 4L
chrX_+_56454871 8.885 ENSMUST00000039374.2
ENSMUST00000101553.2
 Ddx26b

DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B

chrM_+_11734 8.710 ENSMUST00000082418.1
 mt-Nd5
mitochondrially encoded NADH dehydrogenase 5
chr2_+_116067213 8.559 ENSMUST00000152412.1
 G630016G05Rik
RIKEN cDNA G630016G05 gene
chr13_+_44121167 8.518 ENSMUST00000163056.1
ENSMUST00000159595.1
 Gm5083

predicted gene 5083

chr1_-_24612700 8.388 ENSMUST00000088336.1
 Gm10222
predicted gene 10222
chr14_-_100149764 7.853 ENSMUST00000097079.4
 Klf12
Kruppel-like factor 12
chr1_-_172027269 7.849 ENSMUST00000027837.6
ENSMUST00000111264.1
 Vangl2

vang-like 2 (van gogh, Drosophila)

chr2_-_116067391 7.511 ENSMUST00000140185.1
 2700033N17Rik
RIKEN cDNA 2700033N17 gene
chrM_+_10167 6.617 ENSMUST00000082414.1
 mt-Nd4
mitochondrially encoded NADH dehydrogenase 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 215 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 31.4 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
6.9 20.7 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.2 16.3 GO:0051489 regulation of filopodium assembly(GO:0051489)
4.5 13.6 GO:0060489 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
2.3 13.6 GO:0006570 tyrosine metabolic process(GO:0006570)
3.8 11.5 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
2.9 11.4 GO:0060729 intestinal epithelial structure maintenance(GO:0060729)
0.3 11.4 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.5 11.2 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
3.2 9.6 GO:0090271 positive regulation of fibroblast growth factor production(GO:0090271)
1.0 9.4 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.2 7.0 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.5 6.9 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
1.2 6.2 GO:0051661 maintenance of centrosome location(GO:0051661)
2.0 6.1 GO:0090425 hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.1 5.5 GO:0007528 neuromuscular junction development(GO:0007528)
0.3 5.3 GO:0003334 keratinocyte development(GO:0003334)
0.9 5.2 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) phosphate ion transmembrane transport(GO:0035435) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.4 5.1 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 5.1 GO:0006261 DNA-dependent DNA replication(GO:0006261)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 101 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 37.2 GO:0070469 respiratory chain(GO:0070469)
0.4 21.2 GO:0016459 myosin complex(GO:0016459)
0.1 15.6 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
3.4 13.6 GO:0060187 cell pole(GO:0060187)
0.5 13.6 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 8.1 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.1 6.3 GO:0031594 neuromuscular junction(GO:0031594)
1.6 6.2 GO:0008623 CHRAC(GO:0008623)
1.2 6.2 GO:0036449 microtubule minus-end(GO:0036449)
0.0 6.2 GO:0005911 cell-cell junction(GO:0005911)
0.1 5.3 GO:0002102 podosome(GO:0002102)
0.3 4.9 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 4.6 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 4.4 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 4.3 GO:0036064 ciliary basal body(GO:0036064)
0.7 4.2 GO:0000444 MIS12/MIND type complex(GO:0000444)
1.3 4.0 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.4 3.8 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.2 3.5 GO:0051286 cell tip(GO:0051286)
0.1 3.4 GO:0097440 apical dendrite(GO:0097440)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 150 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 34.4 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
1.1 32.1 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.4 21.7 GO:0030507 spectrin binding(GO:0030507)
0.3 17.1 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
1.7 13.9 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
1.0 13.6 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.1 12.9 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.3 9.9 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 6.4 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.6 6.1 GO:0050693 LBD domain binding(GO:0050693)
0.8 5.8 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.1 5.5 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.6 5.4 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
1.7 5.2 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.6 5.1 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.2 5.1 GO:0008327 methyl-CpG binding(GO:0008327)
0.3 5.0 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 4.9 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.2 4.8 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 4.8 GO:0032452 histone demethylase activity(GO:0032452)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 25.9 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.4 21.4 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.4 16.0 PID_ARF6_PATHWAY Arf6 signaling events
0.5 13.9 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.4 12.4 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.1 8.2 PID_E2F_PATHWAY E2F transcription factor network
0.0 6.6 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 5.4 NABA_COLLAGENS Genes encoding collagen proteins
0.1 5.1 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.1 5.0 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.1 5.0 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 4.3 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.1 4.3 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.1 4.2 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 4.0 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.1 4.0 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.2 3.9 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.1 3.5 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 3.2 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.1 2.6 PID_AURORA_A_PATHWAY Aurora A signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 14.3 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.2 13.7 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.4 10.8 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.1 8.8 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.2 6.9 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.2 5.7 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.1 5.5 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 5.4 REACTOME_G1_PHASE Genes involved in G1 Phase
0.1 4.0 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1
0.2 3.9 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.1 3.8 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 3.5 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.2 3.2 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 2.8 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.3 2.5 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.1 2.5 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.1 2.4 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.3 2.2 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.2 2.2 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.1 2.2 REACTOME_ENOS_ACTIVATION_AND_REGULATION Genes involved in eNOS activation and regulation